Latest & greatest articles for tuberculosis

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Top results for tuberculosis

41. Do chain pharmacies perform better than independent pharmacies? Evidence from a standardised patient study of the management of childhood diarrhoea and suspected tuberculosis in urban India

Do chain pharmacies perform better than independent pharmacies? Evidence from a standardised patient study of the management of childhood diarrhoea and suspected tuberculosis in urban India 29018588 2018 11 13 2059-7908 2 3 2017 BMJ global health BMJ Glob Health Do chain pharmacies perform better than independent pharmacies? Evidence from a standardised patient study of the management of childhood diarrhoea and suspected tuberculosis in urban India. e000457 10.1136/bmjgh-2017-000457 Pharmacies (...) a stratified sample of chain and independent pharmacies in urban Bengaluru. Standardised patients (SPs) visited pharmacies and presented a scripted case of diarrhoea for a child and suspected tuberculosis (TB). SPs were debriefed immediately after the visit using a structured questionnaire. We measured the quality of history taking, therapeutic management and advice giving against national (Government of India) and international (WHO) guidelines. We used Pearson's χ 2 tests to examine associations between

BMJ global health2017 Full Text: Link to full Text with Trip Pro

42. Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis.

Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis. BACKGROUND: Fluoroquinolones and second-line injectable drugs are the backbone of treatment regimens for multidrug-resistant tuberculosis, and resistance to these drugs defines extensively drug-resistant tuberculosis. We assessed the accuracy of an automated, cartridge-based molecular assay for the detection, directly from sputum specimens, of Mycobacterium tuberculosis with resistance to fluoroquinolones (...) , aminoglycosides, and isoniazid. METHODS: We conducted a prospective diagnostic accuracy study to compare the investigational assay against phenotypic drug-susceptibility testing and DNA sequencing among adults in China and South Korea who had symptoms of tuberculosis. The Xpert MTB/RIF assay and sputum culture were performed. M. tuberculosis isolates underwent phenotypic drug-susceptibility testing and DNA sequencing of the genes katG, gyrA, gyrB, and rrs and of the eis and inhA promoter regions. RESULTS

NEJM2017

43. Out-of-Pocket Expenditures, Indirect Costs and Health-Related Quality of Life of Patients with Pulmonary Tuberculosis in Thailand

Out-of-Pocket Expenditures, Indirect Costs and Health-Related Quality of Life of Patients with Pulmonary Tuberculosis in Thailand 29623632 2018 11 14 2509-4254 2 3 2018 Sep PharmacoEconomics - open Pharmacoecon Open Out-of-Pocket Expenditures, Indirect Costs and Health-Related Quality of Life of Patients with Pulmonary Tuberculosis in Thailand. 281-296 10.1007/s41669-017-0057-9 Thailand's hospitals may adopt different supervision approaches to improve tuberculosis (TB) treatment adherence

PharmacoEconomics open2017 Full Text: Link to full Text with Trip Pro

44. High-Dose Vitamin D3 during Tuberculosis Treatment in Mongolia. A Randomized Controlled Trial

High-Dose Vitamin D3 during Tuberculosis Treatment in Mongolia. A Randomized Controlled Trial 28692301 2017 07 10 2017 09 13 2017 09 13 1535-4970 196 5 2017 Sep 01 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. High-Dose Vitamin D3 during Tuberculosis Treatment in Mongolia. A Randomized Controlled Trial. 628-637 10.1164/rccm.201705-0936OC Existing trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB) are variously limited (...) -2 Vitamin D 1C6V77QF41 Cholecalciferol 64719-49-9 25-hydroxyvitamin D AIM IM Adult Antitubercular Agents therapeutic use Cholecalciferol metabolism therapeutic use Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Drug Therapy, Combination Female Humans Male Middle Aged Mongolia Polymorphism, Single Nucleotide drug effects Sputum drug effects metabolism Treatment Outcome Tuberculosis, Pulmonary drug therapy Vitamin D analogs & derivatives metabolism Vitamins metabolism

EvidenceUpdates2017

45. Isoniazid for preventing tuberculosis in HIV-infected children.

Isoniazid for preventing tuberculosis in HIV-infected children. BACKGROUND: Tuberculosis (TB) is an important cause of illness and death in HIV-positive children living in areas of high TB prevalence. We know that isoniazid prophylaxis prevents TB in HIV-negative children following TB exposure, but there is uncertainty related to its role in TB preventive treatment in HIV-positive children. OBJECTIVES: To summarise the effects of TB preventive treatment versus placebo in HIV-positive children

Cochrane2017

46. Observational study to estimate the changes in the effectiveness of bacillus Calmette Guerin (BCG) vaccination with time since vaccination for preventing tuberculosis in the UK

Observational study to estimate the changes in the effectiveness of bacillus Calmette Guerin (BCG) vaccination with time since vaccination for preventing tuberculosis in the UK Observational study to estimate the changes in the effectiveness of bacillus Calmette Guerin (BCG) vaccination with time since vaccination for preventing tuberculosis in the UK Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page (...) you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> {{metadata.Title}} {{metadata.Headline}} BCG for tuberculosis in minority ethnic groups lasted at least 10 years and at least 20 years in white school-age children. {{author}} {{($index , , , , , , , , , , , & . Punam Mangtani 1, * , Patrick Nguipdop-Djomo 1 , Ruth H Keogh 1 , Lucy Trinder 1 , Peter G

NIHR HTA programme2017

47. An evaluation of automated chest radiography reading software for tuberculosis screening among public- and private-sector patients

An evaluation of automated chest radiography reading software for tuberculosis screening among public- and private-sector patients 28529202 2017 05 22 2017 06 11 1399-3003 49 5 2017 May The European respiratory journal Eur. Respir. J. An evaluation of automated chest radiography reading software for tuberculosis screening among public- and private-sector patients. 1602159 10.1183/13993003.02159-2016 Computer-aided reading (CAR) of medical images is becoming increasingly common, but few studies (...) exist for CAR in tuberculosis (TB). We designed a prospective study evaluating CAR for chest radiography (CXR) as a triage tool before Xpert MTB/RIF (Xpert).Consecutively enrolled adults in Dhaka, Bangladesh, with TB symptoms received CXR and Xpert. Each image was scored by CAR and graded by a radiologist. We compared CAR with the radiologist for sensitivity and specificity, area under the receiver operating characteristic curve (AUC), and calculated the potential Xpert tests saved.A total of 18 036

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro

48. World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update

World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update 28331043 2017 03 23 2017 04 25 1399-3003 49 3 2017 Mar The European respiratory journal Eur. Respir. J. World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update. 1602308 10.1183/13993003.02308-2016 Antimicrobial resistance is a major global concern. Tuberculosis (TB) strains resistant to rifampicin and other TB medicines challenge patient survival and public health

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro

49. Do incentives and enablers improve adherence to tuberculosis treatment?

Do incentives and enablers improve adherence to tuberculosis treatment? Do incentives and enablers improve adherence to tuberculosis treatment? - NIPH Selected items added to basket Close Vis søkefelt How can we help you today? Search for: Søk Menu • • Do incentives and enablers improve adherence to tuberculosis treatment? Søk i Folkehelsa.no Search for: Søk Infectious diseases & Vaccines Close Mental & Physical health Close Environment & Lifestyle Close Health in Norway Close Quality

Norwegian Institute of Public Health2017

50. Delamanid (Deltyba) and multidrug-resistant pulmonary tuberculosis. For selected patients, with cardiac monitoring

Delamanid (Deltyba) and multidrug-resistant pulmonary tuberculosis. For selected patients, with cardiac monitoring Prescrire IN ENGLISH - Spotlight ''Delamanid (Deltyba°) and multidrug-resistant pulmonary tuberculosis. For selected patients, with cardiac monitoring'', 1 April 2017 {1} {1} {1} | | > > > Delamanid (Deltyba°) and multidrug-resistant pulmonary tuberculosis. For selected patients, with cardiac monitoring Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent (...) :  |   |   |   |   |   |   |   |   |  Spotlight Delamanid (Deltyba°) and multidrug-resistant pulmonary tuberculosis. For selected patients, with cardiac monitoring FEATURED REVIEW Despite delamanid's rather shaky evaluation, the available data suggest that this antibiotic should be offered to patients with multidrug-resistant tuberculosis. The noteworthy impact of delamanid on the QT interval warrants electrocardiographic

Prescrire2017

51. The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition

The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition 27780773 2017 05 03 2018 11 13 1769-714X 19 3 2017 Mar Microbes and infection Microbes Infect. The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition. 177-192 S1286-4579(16)30146-0 10.1016/j.micinf.2016.10.001 Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark (...) , the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines. Copyright © 2016 The Author(s). Published by Elsevier Masson SAS.. All rights reserved. Prosser Gareth G Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892, United States

Microbes and infection2017 Full Text: Link to full Text with Trip Pro

52. Fumarase deficiency causes protein and metabolite succination and intoxicates Mycobacterium tuberculosis

Fumarase deficiency causes protein and metabolite succination and intoxicates Mycobacterium tuberculosis 28219662 2017 11 21 2018 11 13 2451-9448 24 3 2017 Mar 16 Cell chemical biology Cell Chem Biol Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis. 306-315 S2451-9456(17)30024-7 10.1016/j.chembiol.2017.01.005 Enzymes of central carbon metabolism are essential mediators of Mycobacterium tuberculosis (Mtb) physiology and pathogenicity (...) Citric Acid Cycle Cysteine chemistry Female Fumarate Hydratase deficiency genetics metabolism Fumarates analysis metabolism Mice Mice, Inbred C57BL Mycobacterium tuberculosis enzymology genetics pathogenicity Oxidative Stress Peptides analysis chemistry Protein Processing, Post-Translational Tandem Mass Spectrometry central carbon metabolism drug target fumarase succination tuberculosis 2016 09 11 2016 12 07 2017 01 19 2017 2 22 6 0 2017 11 29 6 0 2017 2 22 6 0 ppublish 28219662 S2451-9456(17)30024-7

Cell chemical biology2017 Full Text: Link to full Text with Trip Pro

53. Tuberculosis.

Tuberculosis. This issue provides a clinical overview of tuberculosis, focusing on screening, prevention, diagnosis, and treatment. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance

Annals of Internal Medicine2017

54. Interventions to improve contact tracing for tuberculosis in specific groups and in wider populations: an evidence synthesis

Interventions to improve contact tracing for tuberculosis in specific groups and in wider populations: an evidence synthesis Interventions to improve contact tracing for tuberculosis in specific groups and in wider populations: an evidence synthesis Interventions to improve contact tracing for tuberculosis in specific groups and in wider populations: an evidence synthesis Baxter S, Goyder E, Chambers D, Johnson M, Preston L & Booth A. Record Status This is a bibliographic record of a published (...) health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Baxter S, Goyder E, Chambers D, Johnson M, Preston L & Booth A.. Interventions to improve contact tracing for tuberculosis in specific groups and in wider populations: an evidence synthesis. Health Services and Delivery Research 2017; 5(1) Authors' objectives The tracing and screening of people who have had contact with an active case of tuberculosis (TB

Health Technology Assessment (HTA) Database.2017

55. Multiple large clusters of tuberculosis in London: a cross-sectional analysis of molecular and spatial data

Multiple large clusters of tuberculosis in London: a cross-sectional analysis of molecular and spatial data 28149918 2018 11 13 2312-0541 3 1 2017 Jan ERJ open research ERJ Open Res Multiple large clusters of tuberculosis in London: a cross-sectional analysis of molecular and spatial data. 00098-2016 10.1183/23120541.00098-2016 Large outbreaks of tuberculosis (TB) represent a particular threat to disease control because they reflect multiple instances of active transmission. The extent to which

ERJ open research2017 Full Text: Link to full Text with Trip Pro

56. Who pays for cooperation in global health? A comparative analysis of WHO, the World Bank, the Global Fund to Fight HIV/AIDS, Tuberculosis and Malaria, and Gavi, the Vaccine Alliance.

Who pays for cooperation in global health? A comparative analysis of WHO, the World Bank, the Global Fund to Fight HIV/AIDS, Tuberculosis and Malaria, and Gavi, the Vaccine Alliance. In this report we assess who pays for cooperation in global health through an analysis of the financial flows of WHO, the World Bank, the Global Fund to Fight HIV/AIDS, TB and Malaria, and Gavi, the Vaccine Alliance. The past few decades have seen the consolidation of influence in the disproportionate roles the USA

Lancet2017

57. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa.

Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. BACKGROUND: Drug-resistant tuberculosis threatens recent gains in the treatment of tuberculosis and human immunodeficiency virus (HIV) infection worldwide. A widespread epidemic of extensively drug-resistant (XDR) tuberculosis is occurring in South Africa, where cases have increased substantially since 2002. The factors driving this rapid increase have not been fully elucidated, but such knowledge is needed to guide public (...) health interventions. METHODS: We conducted a prospective study involving 404 participants in KwaZulu-Natal Province, South Africa, with a diagnosis of XDR tuberculosis between 2011 and 2014. Interviews and medical-record reviews were used to elicit information on the participants' history of tuberculosis and HIV infection, hospitalizations, and social networks. Mycobacterium tuberculosis isolates underwent insertion sequence (IS)6110 restriction-fragment-length polymorphism analysis, targeted gene

NEJM2017

58. The impact of ISGylation during Mycobacterium tuberculosis infection in mice

The impact of ISGylation during Mycobacterium tuberculosis infection in mice 28087453 2017 10 13 2018 11 13 1769-714X 19 4-5 2017 Apr - May Microbes and infection Microbes Infect. The impact of ISGylation during Mycobacterium tuberculosis infection in mice. 249-258 S1286-4579(17)30003-5 10.1016/j.micinf.2016.12.006 Mycobacterium tuberculosis infection results in 1.5 million deaths annually. Type I interferon (IFN) signaling through its receptor IFNAR correlates with increased severity (...) of disease, although how this increases susceptibility to M. tuberculosis remains uncertain. ISG15 is one of the most highly induced interferon stimulated genes (ISGs) during M. tuberculosis infection. ISG15 functions by conjugation to target proteins (ISGylation), by noncovalent association with intracellular proteins, and by release from the cell. Recent studies indicated that ISG15 can function via conjugation-independent mechanisms to suppress the type I IFN response. These data raised the question

Microbes and infection2017 Full Text: Link to full Text with Trip Pro

59. Choroidal neovascularization secondary to tuberculosis: Presentation and management

Choroidal neovascularization secondary to tuberculosis: Presentation and management 29503964 2018 11 14 2451-9936 5 2017 Apr American journal of ophthalmology case reports Am J Ophthalmol Case Rep Choroidal neovascularization secondary to tuberculosis: Presentation and management. 124-129 10.1016/j.ajoc.2016.12.025 While there are many known etiologies of choroidal neovascularization (CNV), tuberculosis is not a well-known causative agent. In this case series, we highlight CNV occurring (...) -tuberculosis medications and oral corticosteroids, and they also received intravitreal anti-vascular endothelial growth factor (VEGF) injections as needed for the CNV. There was a significant improvement in the clinical course of all three patients with active disease-the intraocular inflammation subsided, and CNV recurrences were mitigated. Upon completion of systemic treatment, all patients have remained quiescent. Our findings demonstrate that CNV may occur in the course of tuberculous chorioretinitis

American journal of ophthalmology case reports2017 Full Text: Link to full Text with Trip Pro

60. Report of the guideline development group meeting on the use of bedaquiline in the treatment of multidrug-resistant tuberculosis: a review of available evidence (2016), 28 - 29 June 2016, Geneva, Switzerland

Report of the guideline development group meeting on the use of bedaquiline in the treatment of multidrug-resistant tuberculosis: a review of available evidence (2016), 28 - 29 June 2016, Geneva, Switzerland WHO IRIS: Report of the guideline development group meeting on the use of bedaquiline in the treatment of multidrug-resistant tuberculosis: a review of available evidence (2016), 28 - 29 June 2016, Geneva, Switzerland Browse Related links Files in This Item: File Description Size Format (...) 1.85 MB Adobe PDF Title: Report of the guideline development group meeting on the use of bedaquiline in the treatment of multidrug-resistant tuberculosis: a review of available evidence (2016), 28 - 29 June 2016, Geneva, Switzerland Authors: Issue Date: 2017 Publisher: World Health Organization Place of publication: Geneva Language: English Subject: Context: administration and dosage drug therapy Gov't Doc #: WHO/HTM/TB/2017.01 URI: License: CC BY IGO 3.0 License URL: Appears in Collections: Items

WHO2017