Latest & greatest articles for tuberculosis

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Top results for tuberculosis

181. Comparison of levofloxacin versus moxifloxacin for multidrug-resistant tuberculosis

Comparison of levofloxacin versus moxifloxacin for multidrug-resistant tuberculosis 23927582 2013 10 02 2013 11 26 2014 11 20 1535-4970 188 7 2013 Oct 01 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. Comparison of levofloxacin versus moxifloxacin for multidrug-resistant tuberculosis. 858-64 10.1164/rccm.201303-0604OC Levofloxacin (LFX) and moxifloxacin (MXF) are the two most frequently recommended fluoroquinolones for treatment of patients (...) with multidrug-resistant tuberculosis (MDR-TB). However, studies comparing the effectiveness of LFX and MXF among patients with MDR-TB are lacking. To compare the effectiveness of LFX and MXF in terms of culture conversion after 3 months of treatment for MDR-TB. In this prospective multicenter randomized open label trial, we randomly assigned 182 patients with MDR-TB (sensitive to LFX and MXF) to receive either LFX (750 mg/day; 90 patients) or MXF (400 mg/day; 92 patients) with a background drug regimen

EvidenceUpdates2014

183. Community-based evaluation of immigrant tuberculosis screening using interferon release assays and tuberculin skin testing: observational study and economic analysis

Community-based evaluation of immigrant tuberculosis screening using interferon release assays and tuberculin skin testing: observational study and economic analysis Community-based evaluation of immigrant tuberculosis screening using interferon release assays and tuberculin skin testing: observational study and economic analysis Community-based evaluation of immigrant tuberculosis screening using interferon release assays and tuberculin skin testing: observational study and economic analysis (...) of latent tuberculosis infection in immigrants aged 16 and above. The authors concluded that use of a single-step interferon gamma release assay at intermediate screening thresholds was safe and cost-effective without the need for port-of-arrival chest x-ray. Reporting and methodology were generally good. The conclusions made are appropriate but uncertainty remains around many of the key assumptions/parameters. Type of economic evaluation Cost-effectiveness analysis Study objective The objective

NHS Economic Evaluation Database.2013

184. Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper

Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper 23349445 2013 08 01 2014 03 20 2017 02 20 1399-3003 42 2 2013 Aug The European respiratory journal Eur. Respir. J. Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper. 495-503 10.1183/09031936.00129412 Interferon (IFN)-γ release assays (IGRAs) are probably the most accurate tests for the detection of latent Mycobacterium tuberculosis infection, but IGRAs are labour (...) on a training cohort comprising 60 tuberculosis (TB) patients and 59 healthy controls. Diagnostic accuracy was assessed in a validation cohort comprising 78 TB patients and 98 healthy controls. Plasma was measured in Spain and DPS samples were sent to Denmark using the conventional postal service for analysis. IP-10 was readily detectable in both plasma and DPS, and correlation was excellent (r(2) = 0.95). QuantiFERON-TB Gold In-Tube (QFT-TB) and IP-10 in DPS and plasma rendered comparable sensitivity (78

EvidenceUpdates2013 Full Text: Link to full Text with Trip Pro

185. Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial.

Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial. BACKGROUND: The Xpert MTB/RIF test for tuberculosis is being rolled out in many countries, but evidence is lacking regarding its implementation outside laboratories, ability to inform same-day treatment decisions at the point of care, and clinical effect on tuberculosis-related morbidity. We aimed to assess (...) the feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing at primary-care health-care facilities in southern Africa. METHODS: In this pragmatic, randomised, parallel-group, multicentre trial, we recruited adults with symptoms suggestive of active tuberculosis from five primary-care health-care facilities in South Africa, Zimbabwe, Zambia, and Tanzania. Eligible patients were randomly assigned using pregenerated tables to nurse-performed Xpert MTB/RIF at the clinic or sputum smear

Lancet2013

186. Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guérin vaccination against tuberculosis

Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guérin vaccination against tuberculosis Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guérin vaccination against tuberculosis Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry

NIHR HTA programme2013

188. Should all inpatients be screened for tuberculosis?

Should all inpatients be screened for tuberculosis? Should all inpatients be screened for tuberculosis? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Should all inpatients be screened for tuberculosis? View/ Open Date 2013-04 Format Metadata Abstract Current guidelines do not recommend routine screening of all (...) hospital inpatients. Household contacts over 5 years of age and other close contacts in workplace or school of a patient with active tuberculosis (TB) should be screened. Patients with a prolonged cough in highly endemic areas should be screened (SOR: C, consensus guideline). URI Part of Part of Citation Evidence Based Practice 16(4): 05. Collections hosted by hosted by

Evidence Based Practice 2013

189. Effect of household and community interventions on the burden of tuberculosis in southern Africa: the ZAMSTAR community-randomised trial.

Effect of household and community interventions on the burden of tuberculosis in southern Africa: the ZAMSTAR community-randomised trial. BACKGROUND: Southern Africa has had an unprecedented increase in the burden of tuberculosis, driven by the HIV epidemic. The Zambia, South Africa Tuberculosis and AIDS Reduction (ZAMSTAR) trial examined two public health interventions that aimed to reduce the burden of tuberculosis by facilitating either rapid sputum diagnosis or integrating tuberculosis (...) and HIV services within the community. METHODS: ZAMSTAR was a community-randomised trial done in Zambia and the Western Cape province of South Africa. Two interventions, community-level enhanced tuberculosis case-finding (ECF) and household level tuberculosis-HIV care, were implemented between Aug 1, 2006, and July 31, 2009, and assessed in a 2×2 factorial design between Jan 9, 2010, and Dec 6, 2010. All communities had a strengthened tuberculosis-HIV programme implemented in participating health-care

Lancet2013

190. The Global Drug Facility and its role in the market for tuberculosis drugs.

The Global Drug Facility and its role in the market for tuberculosis drugs. Universal access to high-quality treatment is central to the Global Plan to Stop TB. The Global Drug Facility (GDF) was launched in 2001 to help to achieve this goal, through services including the supply of affordable, quality-assured drugs to countries in need. We assess the scale of GDF drug supplies worldwide and find that the GDF commands a substantial proportion of the market for drugs for first-line and second

Lancet2013

191. Action to Stop Smoking in Suspected Tuberculosis (ASSIST) in Pakistan: A Cluster Randomized, Controlled Trial.

Action to Stop Smoking in Suspected Tuberculosis (ASSIST) in Pakistan: A Cluster Randomized, Controlled Trial. BACKGROUND: Tobacco use is responsible for a large proportion of the total disease burden from tuberculosis. Pakistan is one of the 10 high-burden countries for both tuberculosis and tobacco use. OBJECTIVE: To assess the effectiveness of a behavioral support intervention and bupropion in achieving 6-month continuous abstinence in adult smokers with suspected pulmonary tuberculosis (...) . DESIGN: Cluster randomized, controlled trial. (Current Controlled Trials: ISRCTN08829879) SETTING: Health centers in the Jhang and Sargodha districts in Pakistan. PATIENTS: 1955 adult smokers with suspected tuberculosis. INTERVENTION: Health centers were randomly assigned to provide 2 brief behavioral support sessions (BSS), BSS plus 7 weeks of bupropion therapy (BSS+), or usual care. MEASUREMENTS: The primary end point was continuous abstinence at 6 months after the quit date and was determined

Annals of Internal Medicine2013

192. Rifampicin, isoniazid, pyrazinamide, ethambutol hydrochloride (Voractiv) - initial treatment of tuberculosis

Rifampicin, isoniazid, pyrazinamide, ethambutol hydrochloride (Voractiv) - initial treatment of tuberculosis Published 13 May 2013 Statement of Advice: rifampicin, isoniazid, pyrazinamide, ethambutol hydrochloride (Voractiv®) Film-coated Tablets (No: 876/13) Genus Pharmaceuticals 05 April 2013 ADVICE: in the absence of a submission from the holder of the marketing authorisation rifampicin, isoniazid, pyrazinamide, ethambutol hydrochloride (Voractiv®) is not recommended for use within NHS (...) Scotland. Indication under review: initial treatment of tuberculosis according to World Health Organisation (WHO) guidelines. The holder of the marketing authorisation has not made a submission to SMC regarding this product in this indication. As a result we cannot recommend its use within NHSScotland. Advice context: No part of this advice may be used without the whole of the advice being quoted in full. This advice represents the view of the Scottish Medicines Consortium. It is provided to inform

Scottish Medicines Consortium2013

193. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial.

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. BACKGROUND: BCG vaccination provides incomplete protection against tuberculosis in infants. A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was designed to enhance the protective efficacy of BCG. We aimed to assess safety, immunogenicity, and efficacy of MVA85A against tuberculosis and Mycobacterium tuberculosis (...) followed up infants every 3 months for up to 37 months. The primary study outcome was safety (incidence of adverse and serious adverse events) in all vaccinated participants, but we also assessed efficacy in a protocol-defined group of participants who received at least one dose of allocated vaccine. The primary efficacy endpoint was incident tuberculosis incorporating microbiological, radiological, and clinical criteria, and the secondary efficacy endpoint was M tuberculosis infection according

Lancet2013

194. Cost-effectiveness of various tuberculosis control strategies in Thailand

Cost-effectiveness of various tuberculosis control strategies in Thailand Cost-effectiveness of various tuberculosis control strategies in Thailand Cost-effectiveness of various tuberculosis control strategies in Thailand Hunchangsith P, Barendregt JJ, Vos T, Bertram M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed (...) critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to estimate the cost-effectiveness of different tuberculosis control strategies in Thailand. The authors concluded that due to the large uncertainty it was not possible to determine whether directly observed treatment was cost-effective when compared to self-administered treatment. Study methodology was of adequate quality. Methods and results were well reported. Given the limitations

NHS Economic Evaluation Database.2013

195. Annals of Internal Medicine Article Time to Sputum Culture Conversion in Multidrug-Resistant Tuberculosis : Predictors and Relationship to Treatment Outcome

Annals of Internal Medicine Article Time to Sputum Culture Conversion in Multidrug-Resistant Tuberculosis : Predictors and Relationship to Treatment Outcome Annals of Internal Medicine Artic... preview & related info | Mendeley E-mail address Password ( ) Remember me …or sign in with Search Main Navigation › Short URL Annals of Internal Medicine ( 2000 ) Volume: 144 , Issue: 3 , Publisher: Am Coll Physicians , Pages: 650-659 ISSN: 15393704 PubMed: Available from or Find this paper at: Abstract (...) . Related papers Timothy H Holtz , Maya Sternberg , Steve Kammerer , Kayla F Laserson , Vija Riekstina , Evija Zarovska , et al. in Annals of Internal Medicine (2006) 10 readers A U S Population-based Survey , Philip L Graham III , Susan X Lin , Elaine L Larson in Annals of Internal Medicine (2006) 114 readers F Qazi , U Khan , S Khowaja , M Javaid , A Ahmed , N Salahuddin , et al. in The international journal of tuberculosis and lung disease the official journal of the International Union against

Annals of Internal Medicine2013

196. Systematic screening for active tuberculosis: principles and recommendations

Systematic screening for active tuberculosis: principles and recommendations WHO | Systematic screening for active tuberculosis: principles and recommendations Access Search Search the Navigation Language Tuberculosis (TB) Menu Systematic screening for active tuberculosis: principles and recommendations WHO has developed guidelines on systematic screening for active tuberculosis (TB) based on a thorough review of available evidence. Early detection of TB is essential to further improve health

World Health Organisation Guidelines2013

197. Nutritional care and support for patients with tuberculosis

Nutritional care and support for patients with tuberculosis WHO | Nutritional care and support for patients with tuberculosis Access Search Search the Navigation Language Nutrition Menu Nutritional care and support for patients with tuberculosis Guideline Authors : World Health Organization Publication details Number of pages : 54 Publication date : 2013 Languages : English ISBN : 978 92 4 150641 0 Downloads pdf, 596kb pdf, 334kb Overview This guideline provides guidance on the principles (...) and evidence-informed recommendations on the nutritional care and support for patients with tuberculosis. Undernutrition increases the risk of tuberculosis and in turn tuberculosis can lead to malnutrition. Undernutrition is therefore highly prevalent among people with tuberculosis. It has been demonstrated that undernutrition is a risk factor for progression from tuberculosis infection to active tuberculosis disease and that undernutrition at the time of diagnosis of active tuberculosis is a predictor

World Health Organisation Guidelines2013

198. Tuberculosis patients in South Africa have a high prevalence of psychological distress

Tuberculosis patients in South Africa have a high prevalence of psychological distress Tuberculosis patients in South Africa have a high prevalence of psychological distress | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword (...) Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Tuberculosis patients in South Africa have a high prevalence of psychological distress Article Text Therapeutics Tuberculosis patients in South Africa have a high prevalence of psychological distress Statistics from Altmetric.com No Altmetric data available for this article. Question Question : What are the prevalence

Evidence-Based Mental Health2013

200. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial.

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. 23391465 2013 06 17 2013 06 27 2016 11 22 1474-547X 381 9871 2013 Mar 23 Lancet (London, England) Lancet Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. 1021-8 BCG vaccination provides incomplete protection against tuberculosis in infants. A new (...) vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was designed to enhance the protective efficacy of BCG. We aimed to assess safety, immunogenicity, and efficacy of MVA85A against tuberculosis and Mycobacterium tuberculosis infection in infants. In our double-blind, randomised, placebo-controlled phase 2b trial, we enrolled healthy infants (aged 4–6 months) without HIV infection who had previously received BCG vaccination. We randomly allocated infants (1:1), according

Lancet2013