Latest & greatest articles for trazodone

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Top results for trazodone

1. Evaluation of Trazodone and Quetiapine for Insomnia: An Observational Study in Psychiatric Inpatients Full Text available with Trip Pro

Evaluation of Trazodone and Quetiapine for Insomnia: An Observational Study in Psychiatric Inpatients Insomnia is symptomatic of most psychiatric disorders. Non-habit-forming agents such as trazodone and quetiapine are commonly used off-label to treat patients with insomnia. The safety and efficacy of trazodone and quetiapine as medications for treatment of insomnia have never been directly contrasted. The objective of this study was to compare the effectiveness of trazodone to quetiapine among (...) inpatient psychiatric patients by measuring the traditional sleep parameters of total sleep time, number of nighttime awakenings, sleep efficiency, sleep latency, length of hospitalization, and patient-reported side effects.Participants were recruited from St Helena Hospital Center for Behavioral Health, Vallejo, California. Patient inclusion criteria were age 18 to 65 years, admitted between September 2011 and February 2012, and a physician order for trazodone or quetiapine for insomnia. Exclusion

2013 The Primary Care Companion for CNS Disorders

2. Trazodone

Trazodone Top results for trazodone - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for trazodone The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

3. Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study Full Text available with Trip Pro

Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study Trazodone is increasingly prescribed for behavioural and psychological symptoms of dementia, but little is known about its risk of harm. Our objective was to describe the comparative risk of falls and fractures among older adults with dementia dispensed trazodone or atypical antipsychotics.The study cohort included adults with dementia (excluding patients (...) with chronic psychotic illnesses) living in long-term care and aged 66 years and older. Data were obtained from routinely collected, linked health administrative databases in Ontario, Canada. We compared new users of trazodone with new users of atypical antipsychotics (quetiapine, olanzapine or risperidone) between Dec. 1, 2009, and Dec. 31, 2015. The primary outcome was a composite of fall or major osteoporotic fracture within 90 days of first prescription. Secondary outcomes were falls, major

2019 EvidenceUpdates

4. The Effects of Trazodone on Sleep Apnea Severity

The Effects of Trazodone on Sleep Apnea Severity The Effects of Trazodone on Sleep Apnea Severity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects of Trazodone on Sleep Apnea Severity The safety (...) pressure [CPAP] treatment). While CPAP treatment stops the upper airway from closing in most people, many people have difficulty sleeping with the mask in place and therefore do not use the CPAP treatment. This research study is being conducted to learn whether using a sedative will improve OSA severity by altering some of the traits that are responsible for the disorder. Condition or disease Intervention/treatment Phase Sleep Apnea, Obstructive Drug: Placebo pill Drug: Trazodone Not Applicable

2012 Clinical Trials

5. Trazodone for Insomnia: A Systematic Review. Full Text available with Trip Pro

Trazodone for Insomnia: A Systematic Review. OBJECTIVE: While trazodone is approved for the treatment of depression, the off-label use of this medication for insomnia has surpassed its usage as an antidepressant. In this systematic review, we examined the evidence for the efficacy and safety of trazodone for insomnia. METHODS: A literature search was conducted using MEDLINE/PubMed databases from the past 33 years (1983-2016) and the keywords insomnia, trazodone, sedative, treatment (...) , and hypnotics. The results were restricted to English language and human subjects. All randomized clinical trials, meta-analyses, observational studies, and placebo-controlled trials regarding trazodone for the treatment of primary or secondary insomnia were reported, per PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The study selection process yielded a total of 45 studies. RESULTS: Evidence for the efficacy of trazodone has been repeatedly demonstrated for primary

2018 Innovations in clinical neuroscience

6. Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy

Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03749642 Recruitment Status : Recruiting First Posted : November 21, 2018

2018 Clinical Trials

7. Low-Dose Trazodone, Benzodiazepines, and Fall-Related Injuries in Nursing Homes: A Matched-Cohort Study (Abstract)

Low-Dose Trazodone, Benzodiazepines, and Fall-Related Injuries in Nursing Homes: A Matched-Cohort Study To evaluate whether risk of fall-related injuries differs between nursing home (NH) residents newly dispensed low-dose trazodone and those newly dispensed benzodiazepines.Retrospective, matched cohort study in linked, population-based administrative data. Matching was based on propensity score ( ± 0.2 standard deviations of the score as a caliper), age ( ± 1 year), sex, frailty status (...) functions accounted for competing risk of death. Sensitivity analyses were used to examine falls resulting in hip or wrist fracture only, as well as different lengths of follow-up at 30, 60, and 180 days.Cumulative incidence of a fall-related injury in the 90 days after index was 5.7% for low-dose trazodone users and 6.0% for benzodiazepine users (between-group change=-0.29, 95% confidence interval (CI)=-1.02-0.44]; hazard ratio=0.94, 95% CI=0.83-1.08). Findings were consistent across sensitivity

2018 EvidenceUpdates

8. Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium

Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02118688 Recruitment Status

2014 Clinical Trials

9. Trazodone use and risk of dementia: A population-based cohort study. Full Text available with Trip Pro

Trazodone use and risk of dementia: A population-based cohort study. In vitro and animal studies have suggested that trazodone, a licensed antidepressant, may protect against dementia. However, no studies have been conducted to assess the effect of trazodone on dementia in humans. This electronic health records study assessed the association between trazodone use and the risk of developing dementia in clinical practice.The Health Improvement Network (THIN), an archive of anonymised medical (...) and prescribing records from primary care practices in the United Kingdom, contains records of over 15 million patients. We assessed patients from THIN aged ≥50 years who received at least two consecutive prescriptions for an antidepressant between January 2000 and January 2017. We compared the risk of dementia among patients who were prescribed trazodone to that of patients with similar baseline characteristics prescribed other antidepressants, using a Cox regression model with 1:5 propensity score matching

2019 PLoS medicine

10. Trazodone Once a Day in Major Depression Disorder

Trazodone Once a Day in Major Depression Disorder Trazodone Once a Day in Major Depression Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trazodone Once a Day in Major Depression Disorder (...) S.p.A Study Details Study Description Go to Brief Summary: The study objective is to evaluate the efficacy and safety of trazodone OAD vs venlafaxine extended release (venlafaxine XR) after an 8-week treatment period in patients with major depressive disorder. Condition or disease Intervention/treatment Phase Major Depressive Disorder Drug: Trazodone Drug: Venlafaxine Phase 3 Detailed Description: This randomized, venlafaxine-controlled, double-blind, parallel design study consists of a Pre

2014 Clinical Trials

11. Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01662297 Recruitment Status : Terminated (it became clear that recruitment was infeasible) First Posted : August 10, 2012 Results First

2012 Clinical Trials

12. Trazodone for Sleep Disorders in Alzheimer's Disease

Trazodone for Sleep Disorders in Alzheimer's Disease Trazodone for Sleep Disorders in Alzheimer's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trazodone for Sleep Disorders in Alzheimer's Disease (...) Camargos, Brasilia University Hospital Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether trazodone is effective in the treatment of sleep disorders in Alzheimer's disease (AD). Condition or disease Intervention/treatment Phase Sleep Sleep Disorders Insomnia Alzheimer's Disease Drug: Trazodone Drug: Placebo Phase 3 Detailed Description: Sleep disorders (SD) affects 35 to 50 percent of patients with AD. These disorders often make caring for patients

2010 Clinical Trials

13. Trazodone Improves Sleep Parameters in Alzheimer Disease Patients: A Randomized, Double-Blind, and Placebo-Controlled Study. (Abstract)

Trazodone Improves Sleep Parameters in Alzheimer Disease Patients: A Randomized, Double-Blind, and Placebo-Controlled Study. There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy and safety of trazodone to treat SD in patients with AD.We conducted a double-blind, randomized and controlled trial during periods of 7-9 days at baseline and 2 weeks of treatment.Geriatric (...) medical center of the university's general hospital.Individuals with probable AD and SD. The complete analysis comprised 30 patients assigned to either the active treatment group (N = 15) or the placebo group (N = 15).Patients received 50 mg of trazodone once daily at 10:00 P.M. or placebo in a 1:1 ratio for 2 weeks.Patients were evaluated using actigraphy and structured scales before and after intervention.Compared with the placebo group, trazodone users slept 42.5 more minutes per night and had

2014 The American Journal of Geriatric Psychiatry Controlled trial quality: predicted high

14. Survey on the usefulness of trazodone in patients with PTSD with insomnia or nightmares. (Abstract)

Survey on the usefulness of trazodone in patients with PTSD with insomnia or nightmares. Trazodone is commonly used in the treatment of insonmia and nightmares in patients with PTSD. There is little evidence in the literature for this practice.Seventy-four patients from the Palo Alto Veterans Affairs Health Care System in California who were admitted to a specialized 8 week inpatient treatment program for PTSD were surveyed regarding their use of trazodone in the treatment of insomnia (...) or nightmares. Patients were asked to complete a questionnaire regarding trazodone's effectiveness, side effects, and optimal doses.Of 74 patients surveyed, 60 patients were able to maintain an effective dose of trazodone. The other 14 patients were unable to tolerate the medication. Seventy-two percent of the 60 patients assessed found trazodone helpful in decreasing nightmares, from an average of 3.3 to 1.3 nights per week (p<.005). Ninety-two percent found it helped with sleep onset, and 78% reported

2001 Pharmacopsychiatry Controlled trial quality: uncertain

15. The efficacy and tolerability of once-daily controlled-release trazodone for depressed mood, anxiety, insomnia, and suicidality in major depressive disorder. (Abstract)

The efficacy and tolerability of once-daily controlled-release trazodone for depressed mood, anxiety, insomnia, and suicidality in major depressive disorder. Trazodone Contramid(R) once-a-day (TzCOAD) is a reformulation of trazodone hydrochloride that controls the release of trazodone over 24 hours. A standard effect size analysis (Cohen's d) determined which items of the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Montgomery-Asberg Depression Rating Scale (MADRS) showed

2009 Psychopharmacology bulletin Controlled trial quality: uncertain

16. Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial. Full Text available with Trip Pro

Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial. To test whether trazodone, one of the most commonly prescribed medications for treatment of insomnia, improves subjective and/or objective sleep among methadone-maintained persons with sleep complaints, we performed a randomized, double-blind, placebo-controlled trial with 6-month follow-up.From eight methadone maintenance programs in the northeastern United States, we recruited 137 persons (...) on 10 PSG-derived objective sleep measures and 11 self-reported measures. Over 88% (n=121) of participants completed the PSG at 1-month. Without adjusting p-values for multiple comparisons, only 1 of 21 sleep measure comparisons was statistically significant (p<.05). The effect of trazodone on mean PSQI scores during the 6-month follow-up was not statistically significant (p=.10). Trazodone neither significantly increased nor decreased illicit drug use relative to placebo.Trazodone did not improve

2012 Drug and alcohol dependence Controlled trial quality: predicted high

17. Cognitive, psychomotor and polysomnographic effects of trazodone in primary insomniacs. Full Text available with Trip Pro

Cognitive, psychomotor and polysomnographic effects of trazodone in primary insomniacs. Trazodone is prescribed widely as a sleep aid, although it is indicated for depression, not insomnia. Its daytime cognitive and psychomotor effects have not been investigated systematically in insomniacs. The primary goal of this study was to quantify, in primary insomniacs, the hypnotic efficacy of trazodone and subsequent daytime impairments. Sixteen primary insomniacs (mean age 44 years) participated (...) , with insomnia confirmed by overnight polysomnography (sleep efficiency ≤ 85%). Trazodone 50 mg was administered to participants 30 min before bedtime for 7 days in a 3-week, within-subjects, randomized, double-blind, placebo-controlled design. Subjective effects, equilibrium (anterior/posterior body sway), short-term memory, verbal learning, simulated driving and muscle endurance were assessed the morning after days 1 and 7 of drug administration. Sleep was evaluated with overnight polysomnography

2011 Journal of sleep research Controlled trial quality: uncertain

18. Trazodone for agitation in dementia. Full Text available with Trip Pro

Trazodone for agitation in dementia. Behavioural and psychiatric disturbances affect at least 50% of people with Alzheimer's disease and other dementias. Neuroleptic drugs are extensively prescribed to treat behavioural manifestations of dementia in spite of only modest efficacy and a high frequency of adverse effects. There is clearly a need for safer and more effective remedies. Trazodone is a psychoactive compound with sedative and antidepressant properties, and with mixed serotonin agonist (...) and antagonist effects. Functional serotonergic deficits may be related to the genesis of behavioural disturbances in dementia.To determine the clinical efficacy and safety of trazodone, for any type of behavioural or psychological cognition in people with dementia without an additional diagnosis of depression.Trials were identified from a search of the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group on 1 June 2004 using the terms trazodon*, beneficat, desirel, sideril, trazodil

2004 Cochrane

19. [Combination of buprenorphine and trazodone in preanesthetic medication]. (Abstract)

[Combination of buprenorphine and trazodone in preanesthetic medication]. 3614688 1987 08 28 2013 11 21 0375-9393 53 1-2 1987 Jan-Feb Minerva anestesiologica Minerva Anestesiol [Combination of buprenorphine and trazodone in preanesthetic medication]. 1-8 Santamaria L B LB Sinardi A U AU Sutera T T Latella S S De Pasquale M M De Leo S S Mandolfino T T ita Clinical Trial Comparative Study English Abstract Journal Article Randomized Controlled Trial Associazione buprenorfina-trazodone (...) in preanestesia. Italy Minerva Anestesiol 0375272 0375-9393 40D3SCR4GZ Buprenorphine YBK48BXK30 Trazodone IM Abdomen surgery Adult Aged Buprenorphine Female Humans Male Middle Aged Preanesthetic Medication Trazodone 1987 1 1 1987 1 1 0 1 1987 1 1 0 0 ppublish 3614688

1987 Minerva anestesiologica Controlled trial quality: uncertain

20. A review of the evidence for the efficacy and safety of trazodone in insomnia. (Abstract)

A review of the evidence for the efficacy and safety of trazodone in insomnia. Trazodone, a triazolopyridine antidepressant, is currently the second most commonly prescribed agent for the treatment of insomnia due to its sedating qualities. Given trazodone's widespread use, a careful review of the literature was conducted to assess its efficacy and side effects when given for treatment of insomnia.In April 2003, a MEDLINE search was conducted using the search terms trazodone and insomnia (...) and trazodone and sleep and restricted to 1980-2003, human subjects, and English language. As trazodone has been implicated in cardiac disorders, a further search was conducted using the term cardiac and trazodone.All clinical trials that measured any endpoint for insomnia efficacy were included in the assessment. A total of 18 studies were identified from the literature search. In addition, commonly used texts were consulted for information regarding adverse effects related to trazodone.Because so few

2005 Journal of Clinical Psychiatry