Latest & greatest articles for trazodone

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Top results for trazodone

1. Evaluation of Trazodone and Quetiapine for Insomnia: An Observational Study in Psychiatric Inpatients (PubMed)

Evaluation of Trazodone and Quetiapine for Insomnia: An Observational Study in Psychiatric Inpatients Insomnia is symptomatic of most psychiatric disorders. Non-habit-forming agents such as trazodone and quetiapine are commonly used off-label to treat patients with insomnia. The safety and efficacy of trazodone and quetiapine as medications for treatment of insomnia have never been directly contrasted. The objective of this study was to compare the effectiveness of trazodone to quetiapine among (...) inpatient psychiatric patients by measuring the traditional sleep parameters of total sleep time, number of nighttime awakenings, sleep efficiency, sleep latency, length of hospitalization, and patient-reported side effects.Participants were recruited from St Helena Hospital Center for Behavioral Health, Vallejo, California. Patient inclusion criteria were age 18 to 65 years, admitted between September 2011 and February 2012, and a physician order for trazodone or quetiapine for insomnia. Exclusion

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2013 The Primary Care Companion for CNS Disorders

2. Trazodone

Trazodone USE OF TRAZODONE IN PREGNANCY 0344 892 0909 USE OF TRAZODONE IN PREGNANCY (Date of issue: March 2018 , Version: 3 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Trazodone is a triazolopyridine antidepressant drug used in the treatment (...) of anxiety and depressive disorders, particularly where sedation is required. Data are limited to a very small number of trazodone-exposed pregnant women and providing an estimate on the likelihood of adverse outcomes following exposure during pregnancy is not currently possible. However, there is currently no evidence to suggest that exposure to trazodone is associated with an increased risk of congenital malformation, spontaneous abortion or stillbirth/intrauterine death, preterm delivery or low infant

2014 UK Teratology Information Service

3. The Effects of Trazodone on Sleep Apnea Severity

The Effects of Trazodone on Sleep Apnea Severity The Effects of Trazodone on Sleep Apnea Severity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects of Trazodone on Sleep Apnea Severity The safety (...) pressure [CPAP] treatment). While CPAP treatment stops the upper airway from closing in most people, many people have difficulty sleeping with the mask in place and therefore do not use the CPAP treatment. This research study is being conducted to learn whether using a sedative will improve OSA severity by altering some of the traits that are responsible for the disorder. Condition or disease Intervention/treatment Phase Sleep Apnea, Obstructive Drug: Placebo pill Drug: Trazodone Not Applicable

2012 Clinical Trials

4. Circadian rhythm in Alzheimer disease after trazodone use. (PubMed)

Circadian rhythm in Alzheimer disease after trazodone use. A circadian rhythm is a cycle of approximately 24 h, responsible for many physiological adjustments, and ageing of the circadian clock contributes to cognitive decline. Rhythmicity is severely impaired in Alzheimer disease (AD) and few therapeutic attempts succeeded in improving sleep disorders in such context. This study evaluated sleep parameters by actigraphy in 30 AD patients before and after trazodone use for 2 weeks, and we show (...) a significant improvement in relative rhythm amplitude (RRA), compatible with a more stable daytime behavioral pattern. So, trazodone appears to produce a stabilization of the circadian rhythms in individuals with AD.

2015 Chronobiology international

5. Trazodone

Trazodone Top results for trazodone - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for trazodone The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

6. Trazodone for agitation in dementia. (PubMed)

Trazodone for agitation in dementia. Behavioural and psychiatric disturbances affect at least 50% of people with Alzheimer's disease and other dementias. Neuroleptic drugs are extensively prescribed to treat behavioural manifestations of dementia in spite of only modest efficacy and a high frequency of adverse effects. There is clearly a need for safer and more effective remedies. Trazodone is a psychoactive compound with sedative and antidepressant properties, and with mixed serotonin agonist (...) and antagonist effects. Functional serotonergic deficits may be related to the genesis of behavioural disturbances in dementia.To determine the clinical efficacy and safety of trazodone, for any type of behavioural or psychological cognition in people with dementia without an additional diagnosis of depression.Trials were identified from a search of the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group on 1 June 2004 using the terms trazodon*, beneficat, desirel, sideril, trazodil

2004 Cochrane

7. Trazodone for Insomnia: A Systematic Review. (PubMed)

Trazodone for Insomnia: A Systematic Review. OBJECTIVE: While trazodone is approved for the treatment of depression, the off-label use of this medication for insomnia has surpassed its usage as an antidepressant. In this systematic review, we examined the evidence for the efficacy and safety of trazodone for insomnia. METHODS: A literature search was conducted using MEDLINE/PubMed databases from the past 33 years (1983-2016) and the keywords insomnia, trazodone, sedative, treatment (...) , and hypnotics. The results were restricted to English language and human subjects. All randomized clinical trials, meta-analyses, observational studies, and placebo-controlled trials regarding trazodone for the treatment of primary or secondary insomnia were reported, per PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The study selection process yielded a total of 45 studies. RESULTS: Evidence for the efficacy of trazodone has been repeatedly demonstrated for primary

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2018 Innovations in clinical neuroscience

8. Trazodone Improves Sleep Parameters in Alzheimer Disease Patients: A Randomized, Double-Blind, and Placebo-Controlled Study. (PubMed)

Trazodone Improves Sleep Parameters in Alzheimer Disease Patients: A Randomized, Double-Blind, and Placebo-Controlled Study. There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy and safety of trazodone to treat SD in patients with AD.We conducted a double-blind, randomized and controlled trial during periods of 7-9 days at baseline and 2 weeks of treatment.Geriatric (...) medical center of the university's general hospital.Individuals with probable AD and SD. The complete analysis comprised 30 patients assigned to either the active treatment group (N = 15) or the placebo group (N = 15).Patients received 50 mg of trazodone once daily at 10:00 P.M. or placebo in a 1:1 ratio for 2 weeks.Patients were evaluated using actigraphy and structured scales before and after intervention.Compared with the placebo group, trazodone users slept 42.5 more minutes per night and had

2014 The American Journal of Geriatric Psychiatry

9. The efficacy and tolerability of once-daily controlled-release trazodone for depressed mood, anxiety, insomnia, and suicidality in major depressive disorder. (PubMed)

The efficacy and tolerability of once-daily controlled-release trazodone for depressed mood, anxiety, insomnia, and suicidality in major depressive disorder. Trazodone Contramid(R) once-a-day (TzCOAD) is a reformulation of trazodone hydrochloride that controls the release of trazodone over 24 hours. A standard effect size analysis (Cohen's d) determined which items of the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Montgomery-Asberg Depression Rating Scale (MADRS) showed

2009 Psychopharmacology bulletin

10. Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial. (PubMed)

Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial. To test whether trazodone, one of the most commonly prescribed medications for treatment of insomnia, improves subjective and/or objective sleep among methadone-maintained persons with sleep complaints, we performed a randomized, double-blind, placebo-controlled trial with 6-month follow-up.From eight methadone maintenance programs in the northeastern United States, we recruited 137 persons (...) on 10 PSG-derived objective sleep measures and 11 self-reported measures. Over 88% (n=121) of participants completed the PSG at 1-month. Without adjusting p-values for multiple comparisons, only 1 of 21 sleep measure comparisons was statistically significant (p<.05). The effect of trazodone on mean PSQI scores during the 6-month follow-up was not statistically significant (p=.10). Trazodone neither significantly increased nor decreased illicit drug use relative to placebo.Trazodone did not improve

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2012 Drug and alcohol dependence

11. Cognitive, psychomotor and polysomnographic effects of trazodone in primary insomniacs. (PubMed)

Cognitive, psychomotor and polysomnographic effects of trazodone in primary insomniacs. Trazodone is prescribed widely as a sleep aid, although it is indicated for depression, not insomnia. Its daytime cognitive and psychomotor effects have not been investigated systematically in insomniacs. The primary goal of this study was to quantify, in primary insomniacs, the hypnotic efficacy of trazodone and subsequent daytime impairments. Sixteen primary insomniacs (mean age 44 years) participated (...) , with insomnia confirmed by overnight polysomnography (sleep efficiency ≤ 85%). Trazodone 50 mg was administered to participants 30 min before bedtime for 7 days in a 3-week, within-subjects, randomized, double-blind, placebo-controlled design. Subjective effects, equilibrium (anterior/posterior body sway), short-term memory, verbal learning, simulated driving and muscle endurance were assessed the morning after days 1 and 7 of drug administration. Sleep was evaluated with overnight polysomnography

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2011 Journal of sleep research

12. Trazodone Once a Day in Major Depression Disorder

Trazodone Once a Day in Major Depression Disorder Trazodone Once a Day in Major Depression Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trazodone Once a Day in Major Depression Disorder (...) S.p.A Study Details Study Description Go to Brief Summary: The study objective is to evaluate the efficacy and safety of trazodone OAD vs venlafaxine extended release (venlafaxine XR) after an 8-week treatment period in patients with major depressive disorder. Condition or disease Intervention/treatment Phase Major Depressive Disorder Drug: Trazodone Drug: Venlafaxine Phase 3 Detailed Description: This randomized, venlafaxine-controlled, double-blind, parallel design study consists of a Pre

2014 Clinical Trials

13. Trazodone for Sleep Disorders in Alzheimer's Disease

Trazodone for Sleep Disorders in Alzheimer's Disease Trazodone for Sleep Disorders in Alzheimer's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trazodone for Sleep Disorders in Alzheimer's Disease (...) Camargos, Brasilia University Hospital Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether trazodone is effective in the treatment of sleep disorders in Alzheimer's disease (AD). Condition or disease Intervention/treatment Phase Sleep Sleep Disorders Insomnia Alzheimer's Disease Drug: Trazodone Drug: Placebo Phase 3 Detailed Description: Sleep disorders (SD) affects 35 to 50 percent of patients with AD. These disorders often make caring for patients

2010 Clinical Trials

14. Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01662297 Recruitment Status : Terminated (it became clear that recruitment was infeasible) First Posted : August 10, 2012 Results First

2012 Clinical Trials

15. Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study. (PubMed)

Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study. There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy and safety of trazodone to treat SD in patients with AD.We conducted a double-blind, randomized and controlled trial during periods of 7-9 days at baseline and 2 weeks of treatment.Geriatric (...) medical center of the university's general hospital.Individuals with probable AD and SD. The complete analysis comprised 30 patients assigned to either the active treatment group (N = 15) or the placebo group (N = 15).Patients received 50 mg of trazodone once daily at 10:00 P.M. or placebo in a 1:1 ratio for 2 weeks.Patients were evaluated using actigraphy and structured scales before and after intervention.Compared with the placebo group, trazodone users slept 42.5 more minutes per night and had

2014 The American Journal of Geriatric Psychiatry

16. The Sedating Antidepressant Trazodone Impairs Sleep-Dependent Cortical Plasticity (PubMed)

The Sedating Antidepressant Trazodone Impairs Sleep-Dependent Cortical Plasticity Recent findings indicate that certain classes of hypnotics that target GABA(A) receptors impair sleep-dependent brain plasticity. However, the effects of hypnotics acting at monoamine receptors (e.g., the antidepressant trazodone) on this process are unknown. We therefore assessed the effects of commonly-prescribed medications for the treatment of insomnia (trazodone and the non-benzodiazepine GABA(A) receptor (...) agonists zaleplon and eszopiclone) in a canonical model of sleep-dependent, in vivo synaptic plasticity in the primary visual cortex (V1) known as ocular dominance plasticity.After a 6-h baseline period of sleep/wake polysomnographic recording, cats underwent 6 h of continuous waking combined with monocular deprivation (MD) to trigger synaptic remodeling. Cats subsequently received an i.p. injection of either vehicle, trazodone (10 mg/kg), zaleplon (10 mg/kg), or eszopiclone (1-10 mg/kg), and were

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2009 PloS one

17. Serotonin syndrome associated with sertraline, trazodone and tramadol abuse (PubMed)

Serotonin syndrome associated with sertraline, trazodone and tramadol abuse 19742207 2011 07 14 2009 09 10 0019-5545 51 1 2009 Jan Indian journal of psychiatry Indian J Psychiatry Serotonin syndrome associated with sertraline, trazodone and tramadol abuse. 68 10.4103/0019-5545.44913 Nayyar Neha N 3323 Circle Brook Dr Apt F Roanoke USA. E-mail: nnayyar@carilion.com. eng Journal Article India Indian J Psychiatry 0013255 0019-5545 2009 9 11 6 0 2009 9 11 6 0 2009 9 11 6 1 ppublish 19742207 10.4103

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2009 Indian journal of psychiatry

18. Efficacy of a single dose of trazodone hydrochloride given to cats prior to veterinary visits to reduce signs of transport- and examination-related anxiety. (PubMed)

Efficacy of a single dose of trazodone hydrochloride given to cats prior to veterinary visits to reduce signs of transport- and examination-related anxiety. OBJECTIVE To evaluate the efficacy of a single dose of trazodone for reducing anxiety in cats during transport to a veterinary hospital and facilitating handling during veterinary examination. DESIGN Double-blind, placebo-controlled, randomized crossover study. ANIMALS 10 healthy client-owned cats (2 to 12 years of age) with a history (...) of anxiety during transport or veterinary examination. PROCEDURES Each cat was randomly assigned to first receive trazodone hydrochloride (50 mg) or a placebo PO. The assigned treatment was administered, and each cat was placed in a carrier and transported by car to a veterinary clinic, where it received a structured veterinary examination. Owners scored their cat's signs of anxiety before, during, and after transport and examination. The veterinarian also assessed signs of anxiety during examination

2016 Journal of the American Veterinary Medical Association

19. Sleep laboratory evaluation of the effects and efficacy of trazodone in depressed insomniac patients. (PubMed)

Sleep laboratory evaluation of the effects and efficacy of trazodone in depressed insomniac patients. Trazodone (150 mg to 400 mg) was administered to six depressed patients with significant sleep disturbances in an 8-week single-blind study design. Patients were evaluated psychologically by means of the Hamilton Rating Scales for Anxiety and Depression. Polysomnographic monitoring in the sleep laboratory was conducted at each of the time points corresponding to the psychiatric evaluations

1990 The Journal of clinical psychiatry

20. Serotonin Syndrome in a Patient on Trazodone and Duloxetine Who Received Fentanyl following a Percutaneous Liver Biopsy (PubMed)

Serotonin Syndrome in a Patient on Trazodone and Duloxetine Who Received Fentanyl following a Percutaneous Liver Biopsy Serotonin syndrome is a rare but potentially life-threatening adverse drug reaction resulting from the use or overuse of serotonergic medications alone or in combination. Mild symptoms, overlapping features with similar conditions and clinician lack of awareness are the major reasons for an often missed diagnosis. Not surprisingly, this condition is significantly underreported

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2015 Case reports in gastroenterology