Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for traumatic brain injury
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on traumatic brain injury or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on traumatic brain injury and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via firstname.lastname@example.org
A systematic review of factors contributing to outcomes in patients with traumaticbraininjury To review, systematically, factors contributing to outcomes in patients with traumaticbrain injury.Traumatic braininjury is a leading cause of death and disability. Several studies have determined the significant predictors of outcomes after traumaticbraininjury. The comprehensive identification of these reliable factors for traumaticbraininjury is critical to both clinical practice (...) and research.Systematic literature review.Eligible studies that combined at least two variables to predict outcomes in patient with traumaticbraininjury were identified via electronic database searches, footnote chasing and contact with clinical experts. Quality of selected studies was assessed in terms of internal and external validity using 15 questions. Two reviewers independently examined titles, abstracts and whether each met the predefined inclusion criteria.A total of 46 studies which met review criteria
Detection of blast-related traumaticbraininjury in U.S. military personnel. Blast-related traumaticbraininjuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered.We tested the hypothesis that blast-related traumaticbraininjury causes traumatic axonal injury, using diffusion tensor imaging (DTI), an advanced form of magnetic resonance imaging that is sensitive to axonal injury. The subjects were 63 U.S (...) . military personnel who had a clinical diagnosis of mild, uncomplicated traumaticbraininjury. They were evacuated from the field to the Landstuhl Regional Medical Center in Landstuhl, Germany, where they underwent DTI scanning within 90 days after the injury. All the subjects had primary blast exposure plus another, blast-related mechanism of injury (e.g., being struck by a blunt object or injured in a fall or motor vehicle crash). Controls consisted of 21 military personnel who had blast exposure
Traumaticbraininjury and depression. Traumaticbraininjury and depression. Traumaticbraininjury and depression. Guillamondegui OD, Montgomery SA, Phibbs FT, McPheeters ML, Alexander PT, Jerome RN, McKoy JN, Seroogy JJ, Eicken JJ, Krishnaswami S, Salomon RM, Hartmann KE. Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Guillamondegui (...) OD, Montgomery SA, Phibbs FT, McPheeters ML, Alexander PT, Jerome RN, McKoy JN, Seroogy JJ, Eicken JJ, Krishnaswami S, Salomon RM, Hartmann KE.. Traumaticbraininjury and depression. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 25. 2011 Authors' objectives The Vanderbilt Evidence-based Practice Center systematically reviewed evidence addressing key questions on depression after traumaticbraininjury, including prevalence, optimizing timing
Hypertonic sodium solutions vs mannitol in reducing ICP in traumaticbraininjury BestBets: Hypertonic sodium solutions vs mannitol in reducing ICP in traumaticbraininjury Hypertonic sodium solutions vs mannitol in reducing ICP in traumaticbraininjury Report By: Annette Rickard - SpR Emergency Medicine Search checked by Tony Kehoe - Consultant Emergency Medicine Institution: Derriford Hospital, Plymouth, UK Date Submitted: 30th April 2010 Date Completed: 20th January 2011 Last Modified (...) : 20th January 2011 Status: Green (complete) Three Part Question In [patients with traumaticbraininjury (TBI) and signs of raised intracranial pressure (ICP)] are [hypertonic sodium solutions better than mannitol] at [reducing morbidity and mortality]? Clinical Scenario A 54 year old female pedestrian has been hit by a bus. She is brought into the ED by ambulance. Her GCS is 13 on arrival and examination reveals an isolated head injury with a haematoma over the left occiput. CT confirms a right
Prehospital rapid sequence intubation improves functional outcome for patients with severe traumaticbraininjury: a randomized controlled trial To determine whether paramedic rapid sequence intubation in patients with severe traumaticbraininjury (TBI) improves neurologic outcomes at 6 months compared with intubation in the hospital.Severe TBI is associated with a high rate of mortality and long-term morbidity. Comatose patients with TBI routinely undergo endo-tracheal intubation to protect
Progesterone for acute traumaticbraininjury. Traumaticbraininjury is a leading cause of death and disability. Progesterone is a potential neuroprotective drug to treat patients with traumaticbrain injury.To assess the effectiveness and safety of progesterone in people with acute traumaticbraininjury (TBI).We searched: the Cochrane Injuries Group's Specialised Register (to April 2010), Cochrane Central Register of Controlled Trials 2010, Issue 1 (The Cochrane Library), MEDLINE (Ovid
Is Progesterone Therapy Beneficial for Acute TraumaticBrainInjury? SystematicReviewSnapshot TAKE-HOME MESSAGE Progesterone therapy may improve mortality and neurologic disability in patients with traumaticbraininjury, but the current evidence is insuf?cient. A multicenter phase III trial sponsored by the National Institutes of Health will enhance the existing evidence. METHODS DATA SOURCES Data sources were Cochrane In- juries Group’s Specialized Regis- ter, MEDLINE, EMBASE, LILACS (...) measures assess- ing progesterone versus no pro- gesterone (or placebo) for the treatment of acute traumaticbraininjury were included. Only natural progesterone administered within 24 hours of the head injury in any dose, by any route, and for any duration was considered as a treatment. Is Progesterone Therapy Bene?cial for Acute TraumaticBrainInjury? EBEM Commentators John Pettey Sandifer, MD Alan E. Jones, MD Department of Emergency Medicine University of Mississippi Medical Center Jackson, MS
GFAP and S100B are biomarkers of traumaticbraininjury: an observational cohort study Biomarker levels in blood after traumaticbraininjury (TBI) may offer diagnostic and prognostic tools in addition to clinical indices. This study aims to validate glial fibrillary acidic protein (GFAP) and S100B concentrations in blood as outcome predictors of TBI using cutoff levels of 1.5 μg/L for GFAP and 1.13 μg/L for S100B from a previous study.In 79 patients with TBI (Glasgow Coma Scale score [GCS] ≤12 (...) ), serum, taken at hospital admission, was analyzed for GFAP and S100B. Data collected included injury mechanism, age, gender, mass lesion on CT, GCS, pupillary reactions, Injury Severity Score (ISS), presence of hypoxia, and hypotension. Outcome was assessed, using the Glasgow Outcome Scale Extended (dichotomized in death vs alive and unfavorable vs favorable), 6 months post injury.In patients who died compared to alive patients, median serum levels were increased: GFAP 33.4-fold and S100B 2.1-fold
Guidelines for the prescription of a seated wheelchair or mobility scooter for people with a traumaticbraininjury or spinal cord injury Guidelines for the prescription of a seated wheelchair or mobility scooter for people with a traumaticbraininjury or spinal cord injury Guidelines for the prescription of a seated wheelchair or mobility scooter for people with a traumaticbraininjury or spinal cord injury 2 Guidelines for the prescription of a seated wheelchair or mobility scooter (...) for people with a traumaticbraininjury or spinal cord injury This publication is endorsed by Occupational Therapy (OT) Australia – NSW Division You may copy, distribute, display and otherwise freely deal with this work for any purpose, provided that you attribute the LTCSA and EnableNSW as the owners. However, you must obtain permission if you wish to (1) charge others for access to the work (other than at cost), (2) include the work in advertising or a product for sale, or (3) modify the work. ISBN
Decompressive craniectomy in diffuse traumaticbraininjury. It is unclear whether decompressive craniectomy improves the functional outcome in patients with severe traumaticbraininjury and refractory raised intracranial pressure.From December 2002 through April 2010, we randomly assigned 155 adults with severe diffuse traumaticbraininjury and intracranial hypertension that was refractory to first-tier therapies to undergo either bifrontotemporoparietal decompressive craniectomy or standard (...) group (19%) and the standard-care group (18%).In adults with severe diffuse traumaticbraininjury and refractory intracranial hypertension, early bifrontotemporoparietal decompressive craniectomy decreased intracranial pressure and the length of stay in the ICU but was associated with more unfavorable outcomes. (Funded by the National Health and Medical Research Council of Australia and others; DECRA Australian Clinical Trials Registry number, ACTRN012605000009617.).
Effect of tranexamic acid in traumaticbraininjury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumaticbrain injury.A nested, randomised, placebo controlled trial. All investigators were masked to treatment allocation. All analyses were by intention to treat (...) . Patients 270 adult trauma patients with, or at risk of, significant extracranial bleeding within 8 hours of injury, who also had traumaticbrain injury.Patients randomly allocated to tranexamic acid (loading dose 1 g over 10 minutes, then infusion of 1 g over 8 hours) or matching placebo.Intracranial haemorrhage growth (measured by computed tomography) between hospital admission and then 24-48 hours later, with adjustment for Glasgow coma score, age, time from injury to the scans, and initial
Predictors of extended rehabilitation length of stay after traumaticbraininjury To develop a prediction rule for acutely identifying patients at risk for extended rehabilitation length of stay (LOS) after traumaticbraininjury (TBI) by using demographic and injury characteristics.Retrospective cohort study.Traumatic BrainInjury Model Systems.Sample of TBI survivors (N=7284) with injuries occurring between 1999 and 2009.Not applicable.Extended rehabilitation LOS defined as 67 days (...) or longer.A multivariable model was built containing FIM motor and cognitive scores at admission, preinjury level of education, cause of injury, punctate/petechial hemorrhage, acute-care LOS, and primary payor source. The model had good calibration, excellent discrimination (area under the receiver operating characteristic curve = .875), and validated well. Based on this model, a formula for determining the probability of extended rehabilitation LOS and a prediction rule that classifies patients
Therapeutic hypothermia for paediatric traumaticbraininjury BestBets: Therapeutic hypothermia for paediatric traumaticbraininjury within 8 hr Therapeutic hypothermia for paediatric traumaticbraininjury within 8 hr Report By: Gabriel Cade - Emergency Medicine Physician Search checked by Venkatesh Gattu - Senior Emergency Medicine Trainee Institution: Baystate Medical Center aSpringfield, MA 01199, USA nd Manchester Royal Infirmary, Manchester, UK Date Submitted: 12th December 2009 Date (...) Completed: 9th July 2010 Last Modified: 9th July 2010 Status: Green (complete) Three Part Question In [paediatric patients presenting within 8 h of traumaticbraininjury (TBI)] are [therapeutic hypothermia regimens better than normothermic care] in [improving patient survival]? Clinical Scenario An 8-year old child presents to the Emergency Department within six hours of an unclear incident at home which left nonspecific bruising and acute change in mental status. Fundoscopic exam reveals retinal
Intensive insulin therapy in severe traumaticbraininjury: a randomized trial Intensive insulin therapy (IIT) has been shown to reduce morbidity and mortality in critically ill patients. Little investigation has been done to find out whether it improves the prognosis of patients with severe traumaticbraininjury (STBI).We conducted a prospective controlled study where adult patients with blunt STBI, with Glasgow Coma Scale
Rates of major depressive disorder and clinical outcomes following traumaticbraininjury. Uncertainties exist about the rates, predictors, and outcomes of major depressive disorder (MDD) among individuals with traumaticbraininjury (TBI).To describe MDD-related rates, predictors, outcomes, and treatment during the first year after TBI.Cohort from June 2001 through March 2005 followed up by structured telephone interviews at months 1 through 6, 8, 10, and 12 (data collection ending February (...) and 21% at 6 months. In a multivariate model, risk of MDD after TBI was associated with MDD at the time of injury (risk ratio [RR], 1.62; 95% confidence interval [CI], 1.37-1.91), history of MDD prior to injury (but not at the time of injury) (RR, 1.54; 95% CI, 1.31-1.82), age (RR, 0.61; 95% CI, 0.44-0.83 for > or = 60 years vs 18-29 years), and lifetime alcohol dependence (RR, 1.34; 95% CI, 1.14-1.57). Those with MDD were more likely to report comorbid anxiety disorders after TBI than those without
Haemostatic drugs for traumaticbraininjury. Traumaticbraininjury (TBI) is a leading cause of death and disability. Intracranial bleeding is a common complication of TBI, and intracranial bleeding can develop or worsen after hospital admission. Haemostatic drugs may reduce the occurrence or size of intracranial bleeds and consequently lower the morbidity and mortality associated with TBI.To assess the effects of haemostatic drugs on mortality, disability and thrombotic complications (...) in patients with traumaticbrain injury.We searched the electronic databases: Cochrane Injuries Group Specialised Register (3 February 2009), CENTRAL (The Cochrane Library 2009, Issue 1), MEDLINE (1950 to Week 3 2009), PubMed (searched 3 February 2009 (last 180 days)), EMBASE (1980 to Week 4 2009), CINAHL (1982 to January 2009), ISI Web of Science: Science Citation Index Expanded (SCI-EXPANDED) (1970 to January 2009), ISI Web of Science: Conference Proceedings Citation Index - Science (CPCI-S) (1990
The Cognitive Effects of Mild TraumaticBrainInjury and Resulting Postconcussion Syndrome in High Risk Patients "The Cognitive Effects of Mild TraumaticBrainInjury and Resulting Pos" by Terrance Hartmann < > > > > > Title Author Date of Graduation 8-14-2010 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Dr. Mark Pedemonte, MD Second Advisor Annjanette Sommers MS, PAC Third Advisor Rob Rosenow PharmD, OD Rights . Abstract Background (...) : Mild traumaticbraininjury with postconcussion syndromes may be correlated with long term cognitive deficits. While 1.7 million traumaticbraininjuries are reported each year, this number does not account for the many mild traumaticbraininjuries that are not reported each year. Methods: Exhaustive search of available medical literature using the search engines: OVID, CINAHL, Entrez, and UpToDate. Keywords used were Mild TraumaticBrainInjury, Cognitive Disorders, Psychological Disorders