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Latest & greatest articles for traumatic brain injury
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on traumatic brain injury or other clinical topics then use Trip today.
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A trial of intracranial-pressure monitoring in traumaticbraininjury. 23234472 2012 12 27 2013 01 07 2016 12 15 1533-4406 367 26 2012 Dec 27 The New England journal of medicine N. Engl. J. Med. A trial of intracranial-pressure monitoring in traumaticbraininjury. 2471-81 10.1056/NEJMoa1207363 Intracranial-pressure monitoring is considered the standard of care for severe traumaticbraininjury and is used frequently, but the efficacy of treatment based on monitoring in improving the outcome (...) has not been rigorously assessed. We conducted a multicenter, controlled trial in which 324 patients 13 years of age or older who had severe traumaticbraininjury and were being treated in intensive care units (ICUs) in Bolivia or Ecuador were randomly assigned to one of two specific protocols: guidelines-based management in which a protocol for monitoring intraparenchymal intracranial pressure was used (pressure-monitoring group) or a protocol in which treatment was based on imaging and clinical
Placebo-controlled trial of amantadine for severe traumaticbraininjury. 22375973 2012 03 01 2012 03 08 2013 11 21 1533-4406 366 9 2012 Mar 01 The New England journal of medicine N. Engl. J. Med. Placebo-controlled trial of amantadine for severe traumaticbraininjury. 819-26 10.1056/NEJMoa1102609 Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumaticbraininjury. Preliminary studies have suggested (...) that amantadine may promote functional recovery. We enrolled 184 patients who were in a vegetative or minimally conscious state 4 to 16 weeks after traumaticbraininjury and who were receiving inpatient rehabilitation. Patients were randomly assigned to receive amantadine or placebo for 4 weeks and were followed for 2 weeks after the treatment was discontinued. The rate of functional recovery on the Disability Rating Scale (DRS; range, 0 to 29, with higher scores indicating greater disability) was compared
Effect on behavior problems of teen online problem-solving for adolescent traumaticbraininjury 21890828 2011 10 03 2011 11 30 2016 12 15 1098-4275 128 4 2011 Oct Pediatrics Pediatrics Effect on behavior problems of teen online problem-solving for adolescent traumaticbraininjury. e947-53 10.1542/peds.2010-3721 To report the results of a randomized clinical trial of teen online problem-solving (TOPS) meant to improve behavioral outcomes of adolescents with traumaticbraininjury (TBI (...) Pediatr Psychol. 2006 Nov-Dec;31(10):1072-83 16150875 J Head Trauma Rehabil. 2008 Nov-Dec;23(6):369-77 19033829 J Consult Clin Psychol. 1999 Feb;67(1):116-23 10028215 Adolescent Adolescent Behavior Behavior Therapy methods BrainInjuries psychology Child Communication Family Conflict Female Humans Internet Male Mental Disorders etiology therapy Parent-Child Relations Problem Solving Self Report Social Class Social Control, Informal Treatment Outcome PMC3387908 2011 9 6 6 0 2011 9 6 6 0 2011 12 13 0 0
Detection of blast-related traumaticbraininjury in U.S. military personnel. BACKGROUND: Blast-related traumaticbraininjuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered. METHODS: We tested the hypothesis that blast-related traumaticbraininjury causes traumatic axonal injury, using diffusion tensor imaging (DTI), an advanced form of magnetic resonance imaging that is sensitive to axonal injury (...) . The subjects were 63 U.S. military personnel who had a clinical diagnosis of mild, uncomplicated traumaticbraininjury. They were evacuated from the field to the Landstuhl Regional Medical Center in Landstuhl, Germany, where they underwent DTI scanning within 90 days after the injury. All the subjects had primary blast exposure plus another, blast-related mechanism of injury (e.g., being struck by a blunt object or injured in a fall or motor vehicle crash). Controls consisted of 21 military personnel who
Traumaticbraininjury and depression. Traumaticbraininjury and depression. Traumaticbraininjury and depression. Guillamondegui OD, Montgomery SA, Phibbs FT, McPheeters ML, Alexander PT, Jerome RN, McKoy JN, Seroogy JJ, Eicken JJ, Krishnaswami S, Salomon RM, Hartmann KE. Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Guillamondegui (...) OD, Montgomery SA, Phibbs FT, McPheeters ML, Alexander PT, Jerome RN, McKoy JN, Seroogy JJ, Eicken JJ, Krishnaswami S, Salomon RM, Hartmann KE.. Traumaticbraininjury and depression. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 25. 2011 Authors' objectives The Vanderbilt Evidence-based Practice Center systematically reviewed evidence addressing key questions on depression after traumaticbraininjury, including prevalence, optimizing timing
Hypertonic sodium solutions vs mannitol in reducing ICP in traumaticbraininjury BestBets: Hypertonic sodium solutions vs mannitol in reducing ICP in traumaticbraininjury Hypertonic sodium solutions vs mannitol in reducing ICP in traumaticbraininjury Report By: Annette Rickard - SpR Emergency Medicine Search checked by Tony Kehoe - Consultant Emergency Medicine Institution: Derriford Hospital, Plymouth, UK Date Submitted: 30th April 2010 Date Completed: 20th January 2011 Last Modified (...) : 20th January 2011 Status: Green (complete) Three Part Question In [patients with traumaticbraininjury (TBI) and signs of raised intracranial pressure (ICP)] are [hypertonic sodium solutions better than mannitol] at [reducing morbidity and mortality]? Clinical Scenario A 54 year old female pedestrian has been hit by a bus. She is brought into the ED by ambulance. Her GCS is 13 on arrival and examination reveals an isolated head injury with a haematoma over the left occiput. CT confirms a right
Prehospital rapid sequence intubation improves functional outcome for patients with severe traumaticbraininjury: a randomized controlled trial 21107105 2010 11 25 2010 12 31 2014 05 16 1528-1140 252 6 2010 Dec Annals of surgery Ann. Surg. Prehospital rapid sequence intubation improves functional outcome for patients with severe traumaticbraininjury: a randomized controlled trial. 959-65 10.1097/SLA.0b013e3181efc15f To determine whether paramedic rapid sequence intubation in patients (...) with severe traumaticbraininjury (TBI) improves neurologic outcomes at 6 months compared with intubation in the hospital. Severe TBI is associated with a high rate of mortality and long-term morbidity. Comatose patients with TBI routinely undergo endo-tracheal intubation to protect the airway, prevent hypoxia, and control ventilation. In many places, paramedics perform intubation prior to hospital arrival. However, it is unknown whether this approach improves outcomes. In a prospective, randomized
Is Progesterone Therapy Beneficial for Acute TraumaticBrainInjury? DEFINE_ME_WA This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.
Decompressive craniectomy in diffuse traumaticbraininjury. 21434843 2011 04 21 2011 04 28 2014 01 17 1533-4406 364 16 2011 Apr 21 The New England journal of medicine N. Engl. J. Med. Decompressive craniectomy in diffuse traumaticbraininjury. 1493-502 10.1056/NEJMoa1102077 It is unclear whether decompressive craniectomy improves the functional outcome in patients with severe traumaticbraininjury and refractory raised intracranial pressure. From December 2002 through April 2010, we randomly (...) assigned 155 adults with severe diffuse traumaticbraininjury and intracranial hypertension that was refractory to first-tier therapies to undergo either bifrontotemporoparietal decompressive craniectomy or standard care. The original primary outcome was an unfavorable outcome (a composite of death, vegetative state, or severe disability), as evaluated on the Extended Glasgow Outcome Scale 6 months after the injury. The final primary outcome was the score on the Extended Glasgow Outcome Scale at 6
Effect of tranexamic acid in traumaticbraininjury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). 21724564 2011 07 04 2012 02 27 2016 11 25 1756-1833 343 2011 Jul 01 BMJ (Clinical research ed.) BMJ Effect of tranexamic acid in traumaticbraininjury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). d3795 10.1136/bmj.d3795 bmj.d3795 To assess the effect of tranexamic acid (which reduces bleeding in surgical patients (...) and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumaticbraininjury. A nested, randomised, placebo controlled trial. All investigators were masked to treatment allocation. All analyses were by intention to treat. Patients 270 adult trauma patients with, or at risk of, significant extracranial bleeding within 8 hours of injury, who also had traumaticbraininjury. Patients randomly allocated to tranexamic acid (loading dose 1 g over 10 minutes
GFAP and S100B are biomarkers of traumaticbraininjury: an observational cohort study 21079180 2010 11 16 2010 12 14 2015 11 19 1526-632X 75 20 2010 Nov 16 Neurology Neurology GFAP and S100B are biomarkers of traumaticbraininjury: an observational cohort study. 1786-93 10.1212/WNL.0b013e3181fd62d2 Biomarker levels in blood after traumaticbraininjury (TBI) may offer diagnostic and prognostic tools in addition to clinical indices. This study aims to validate glial fibrillary acidic protein (...) , Nijmegen, the Netherlands. email@example.com Jacobs B B Andriessen T M J C TM Lamers K J B KJ Borm G F GF Beems T T Edwards M M Rosmalen C F CF Vissers J L M JL eng Journal Article United States Neurology 0401060 0028-3878 0 Biomarkers 0 Glial Fibrillary Acidic Protein 0 Nerve Growth Factors 0 S100 Calcium Binding Protein beta Subunit 0 S100 Proteins 0 S100B protein, human AIM IM Nat Rev Neurol. 2011 Feb;7(2):63 21391320 Adolescent Adult Aged Aged, 80 and over Biomarkers blood BrainInjuries blood