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Latest & greatest articles for traumatic brain injury
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Interventions provided in the acute phase for mild traumaticbraininjury: a systematic review Interventions provided in the acute phase for mild traumaticbraininjury: a systematic review Interventions provided in the acute phase for mild traumaticbraininjury: a systematic review Gravel J, D'Angelo A, Carriere B, Crevier L, Beauchamp MH, Chauny JM, Wassef M, Chaillet N CRD summary This review concluded that there was a paucity of well-designed clinical trials for patients who sustain mild (...) traumaticbraininjury. The large variability in outcomes measured in the included trials limited comparison between them. This was a well-conducted review and the authors' conclusion seems appropriate and reliable. Authors' objectives To evaluate interventions that could be initiated in an acute setting for patients who sustain a mild traumaticbraininjury. Searching PubMed, EMBASE, PsycINFO, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL), EBM Reviews, and ACP Journal Club were
A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumaticbraininjury 23510092 2013 06 03 2013 09 25 2015 11 19 1933-0693 118 6 2013 Jun Journal of neurosurgery J. Neurosurg. A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism (...) , intracranial pressure, oxygen toxicity, and clinical outcome in severe traumaticbraininjury. 1317-28 10.3171/2013.2.JNS121468 Preclinical and clinical investigations indicate that the positive effect of hyperbaric oxygen (HBO2) for severe traumaticbraininjury (TBI) occurs after rather than during treatment. The brain appears better able to use baseline O2 levels following HBO2 treatments. In this study, the authors evaluate the combination of HBO2 and normobaric hyperoxia (NBH) as a single treatment
Comparison of hypothermia and normothermia after severe traumaticbraininjury in children (Cool Kids): a phase 3, randomised controlled trial 23664370 2013 05 20 2013 07 22 2016 06 29 1474-4465 12 6 2013 Jun The Lancet. Neurology Lancet Neurol Comparison of hypothermia and normothermia after severe traumaticbraininjury in children (Cool Kids): a phase 3, randomised controlled trial. 546-53 10.1016/S1474-4422(13)70077-2 S1474-4422(13)70077-2 On the basis of mixed results from previous trials (...) , we assessed whether therapeutic hypothermia for 48-72 h with slow rewarming improved mortality in children after braininjury. In this phase 3, multicenter, multinational, randomised controlled trial, we included patients with severe traumaticbraininjury who were younger than 18 years and could be enrolled within 6 h of injury. We used a computer-generated randomisation sequence to randomly allocate patients (1:1; stratified by site and age [<6 years, 6-15 years, 16-17 years]) to either
Mannitol for acute traumaticbraininjury. BACKGROUND: Mannitol is sometimes effective in reversing acute brain swelling, but its effectiveness in the ongoing management of severe head injury remains unclear. There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure. OBJECTIVES: To assess the effects of different mannitol therapy regimens, of mannitol compared to other intracranial pressure (ICP) lowering (...) agents, and to quantify the effectiveness of mannitol administration given at other stages following acute traumaticbraininjury. SEARCH METHODS: We searched the Cochrane Injuries Group Specialised Register, CENTRAL (The Cochrane Library), MEDLINE (OvidSP), EMBASE (OvidSP), ISI Web of Science (SCI-EXPANDED & CPCI-S) and PubMed. We checked reference lists of trials and review articles, and contacted authors of trials. The search was updated on the 20th April 2009. SELECTION CRITERIA: Randomised
Disparities in Disability After TraumaticBrainInjury Among Hispanic Children and Adolescents 23650302 2013 06 04 2013 08 16 2017 02 20 1098-4275 131 6 2013 Jun Pediatrics Pediatrics Disparities in disability after traumaticbraininjury among Hispanic children and adolescents. e1850-6 10.1542/peds.2012-3354 To compare the extent of disability in multiple areas of functioning after mild, moderate, and severe traumaticbraininjury (TBI) between Hispanic and non-Hispanic white (NHW) children (...) Disability Evaluation Ethnic Groups Female Follow-Up Studies Health Status Disparities Hispanic Americans Humans Infant Infant, Newborn Male Prospective Studies Quality of Life Surveys and Questionnaires PMC3666112 Hispanic children disability disparities traumaticbraininjury 2013 5 8 6 0 2013 5 8 6 0 2013 8 21 6 0 ppublish 23650302 peds.2012-3354 10.1542/peds.2012-3354 PMC3666112
Complications of Mild TraumaticBrainInjury in Veterans and Military Personnel Management Briefs Search the HSR&D website Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs Health Services Research & Development Management Briefs Management Briefs: Provide VA senior managers with results from VA Health Services Research in a concise and timely manner. , February 2017, Issue 122 , February 2017, Issue 122
Cognitive function and other risk factors for mild traumaticbraininjury in young men: nationwide cohort study. OBJECTIVE: To investigate cognitive function and other risk factors for mild traumaticbraininjury in young men. DESIGN: Nationwide prospective cohort study. SETTING: Sweden. PARTICIPANTS: 305 885 men conscripted for military service from 1989 to 1994. MAIN OUTCOME MEASURE: mild traumaticbraininjuries in relation to cognitive function and other potential risk factors assessed (...) at conscription and follow-up. RESULTS: Men with one mild traumaticbraininjury within two years before (n=1988) or after cognitive testing (n=2214) had about 5.5% lower overall cognitive function scores than did men with no mild traumaticbraininjury during follow up (P<0.001 for both). Moreover, men with at least two mild traumaticbraininjuries after cognitive testing (n=795) had 15% lower overall cognitive function scores compared with those with no such injury (P<0.001). Independent strong risk
Postconcussive Complaints, Anxiety, and Depression Related to Vocational Outcome in Minor to Severe TraumaticBrainInjury 23220341 2013 04 26 2013 06 24 2015 11 19 1532-821X 94 5 2013 May Archives of physical medicine and rehabilitation Arch Phys Med Rehabil Postconcussive complaints, anxiety, and depression related to vocational outcome in minor to severe traumaticbraininjury. 867-74 10.1016/j.apmr.2012.11.039 S0003-9993(12)01203-8 To investigate the relation of postconcussive complaints (...) , anxiety, and depression with vocational outcome in patients with traumaticbraininjury (TBI) of various severities and to assess sex differences. A prospective cross-sectional cohort study. Level I trauma center. Adults (N=242) with TBI of various severity. Not applicable. Extended Glasgow Outcome Scale, return to work (RTW), Head Injury Symptom Checklist, and Hospital Anxiety and Depression Scale. In 67% of the patients, complaints were present; 22% were anxious, and 18% were depressed
A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumaticbraininjury A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumaticbraininjury A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumaticbraininjury Pieracci FM, Moore EE, Beauchamp K, Tebockhorst S, Barnett CC, Bensard DD, Burlew CC, Biffl WL, Stoval RT (...) , Johnson JL Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the clinical and economic impact of levetiracetam, compared with phenytoin, to prevent early seizures after traumaticbraininjury. The authors concluded
Reliable Change in Postconcussive Symptoms and Its Functional Consequences Among Children With Mild TraumaticBrainInjury 22393171 2013 02 11 2013 02 12 2017 02 20 1538-3628 166 7 2012 Jul 01 Archives of pediatrics & adolescent medicine Arch Pediatr Adolesc Med Reliable change in postconcussive symptoms and its functional consequences among children with mild traumaticbraininjury. 615-22 10.1001/archpediatrics.2011.1082 OBJECTIVE To examine reliable change in postconcussive symptoms and its (...) functional consequences among children with mild traumaticbraininjury (TBI) over the first year postinjury as compared with children with orthopedic injuries. DESIGN Prospective, longitudinal cohort. SETTING Emergency departments at 2 children's hospitals. PARTICIPANTS Eight- to 15-year-old children with mild TBI (n = 186) or orthopedic injuries (n = 99). MAIN EXPOSURE Closed-head or orthopedic trauma. MAIN OUTCOME MEASURES Parents rated preinjury symptoms retrospectively shortly after injury
Protocol management of severe traumaticbraininjury in intensive care units: a systematic review Protocol management of severe traumaticbraininjury in intensive care units: a systematic review Protocol management of severe traumaticbraininjury in intensive care units: a systematic review English SW, Turgeon AF, Owen E, Doucette S, Pagliarello G, McIntyre L CRD summary The review concluded that management protocols (or care pathways) for severe traumaticbraininjury were associated (...) with reductions in death rate and improved neurologic outcome, although no definitive conclusions about efficacy can be made due to limitations of the included studies. These conclusions were suitably cautious in reflecting the limited evidence available, and the recommendations for further research were appropriate. Authors' objectives To compare the use of management protocols (or care pathways) versus usual care for adult intensive care unit patients with acute severe traumaticbraininjury. Searching Ten
BHR-100 for severe traumaticbraininjury ? first line BHR-100 for severe traumaticbraininjury – first line BHR-100 for severe traumaticbraininjury – first line NIHR HSC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSC. BHR-100 for severe traumaticbraininjury – first line. Birmingham: NIHR Horizon Scanning Centre (NIHR HSC (...) ). Horizon Scanning Review. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH BrainInjuries; Progesterones Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health&Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP. United Kingdom
Systematic review of head cooling in adults after traumaticbraininjury and stroke Systematic review of head cooling in adults after traumaticbraininjury and stroke Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you
A prospective study on employment outcome 3 years after moderate to severe traumaticbraininjury 22502806 2012 05 28 2012 08 02 2012 05 28 1532-821X 93 6 2012 Jun Archives of physical medicine and rehabilitation Arch Phys Med Rehabil A prospective study on employment outcome 3 years after moderate to severe traumaticbraininjury. 993-9 10.1016/j.apmr.2012.01.018 To evaluate the employment outcome in patients with moderate to severe traumaticbraininjury (TBI) and to identify which patients (...) Ian K IK Ribbers Gerard M GM eng Comparative Study Journal Article 2012 04 12 United States Arch Phys Med Rehabil 2985158R 0003-9993 AIM IM Adolescent Adult Aged Analysis of Variance BrainInjuries diagnosis rehabilitation Cognition Disorders diagnosis rehabilitation Cohort Studies Depression diagnosis rehabilitation Employment statistics & numerical data Female Follow-Up Studies Glasgow Coma Scale Humans Injury Severity Score Logistic Models Male Middle Aged Multivariate Analysis Netherlands
Specialized neurocritical care units for traumaticbraininjury Specialized neurocritical care units for traumaticbraininjury Specialized neurocritical care units for traumaticbraininjury Mitchell MD, Williams K Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Williams K. Specialized neurocritical care units for traumaticbraininjury (...) . Philadelphia: Center for Evidence-based Practice (CEP). 2012 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH BrainInjuries; Critical Cares; Intensive Care Units; Outcome and Process Assessment (Health Care) Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104