Latest & greatest articles for traumatic brain injury

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on traumatic brain injury or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on traumatic brain injury and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for traumatic brain injury

61. Visual Dysfunction in Patients with Traumatic Brain Injury

Visual Dysfunction in Patients with Traumatic Brain Injury Management Briefs Search the HSR&D website Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs Health Services Research & Development Management Brief no. 96 » Issue 96 April 2015 Visual Dysfunction in Patients with Traumatic Brain Injury: A Systematic Review Given that visual function depends on complex brain interactions, it's reasonable (...) to consider when and whether traumatic brain injury (TBI) is related to visual dysfunction. Such questions are particularly pertinent to the VA since an estimated 15% of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) Service Members (390,000 of 2.6 million) have incurred TBI during deployment. By comparison, just more than 1% of the U.S. population sought treatment for TBI in 2009. In an attempt to discover the frequency and type of visual problems among those with TBI

Veterans Affairs - R&D2015

62. A Clinical Trial of Progesterone for Severe Traumatic Brain Injury

A Clinical Trial of Progesterone for Severe Traumatic Brain Injury PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2015

63. Standing with electrical stimulation and splinting is no better than standing alone for management of ankle plantarflexion contractures in people with traumatic brain injury: a randomised trial

Standing with electrical stimulation and splinting is no better than standing alone for management of ankle plantarflexion contractures in people with traumatic brain injury: a randomised trial 25443650 2014 12 02 2015 11 03 2014 12 02 1836-9561 60 4 2014 Dec Journal of physiotherapy J Physiother Standing with electrical stimulation and splinting is no better than standing alone for management of ankle plantarflexion contractures in people with traumatic brain injury: a randomised trial. 201-8 (...) 10.1016/j.jphys.2014.09.007 S1836-9553(14)00132-5 Is a combination of standing, electrical stimulation and splinting more effective than standing alone for the management of ankle contractures after severe brain injury? A multi-centre randomised trial with concealed allocation, assessor blinding and intention-to-treat analysis. Thirty-six adults with severe traumatic brain injury and ankle plantarflexion contractures. All participants underwent a 6-week program. The experimental group received tilt

EvidenceUpdates2015 Full Text: Link to full Text with Trip Pro

64. Prediction rule: Physician practice and PECARN rule outperform CATCH and CHALICE rules based on the detection of traumatic brain injury as defined by PECARN

Prediction rule: Physician practice and PECARN rule outperform CATCH and CHALICE rules based on the detection of traumatic brain injury as defined by PECARN Physician practice and PECARN rule outperform CATCH and CHALICE rules based on the detection of traumatic brain injury as defined by PECARN | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Physician practice and PECARN rule outperform CATCH and CHALICE rules based on the detection of traumatic brain injury as defined by PECARN Article Text Diagnosis Prediction rule Physician practice and PECARN rule

Evidence-Based Medicine (Requires free registration)2015 Full Text: Link to full Text with Trip Pro

65. Management of Traumatic Brain Injury

Management of Traumatic Brain Injury ACS TQIP BEST PRACTICES IN THE MANAGEMENT OF TRAUMATIC BRAIN INJURYTable of Contents Introduction 3 Using the Glasgow Coma Scale 3 Triage and Transport 5 Goals of Treatment 5 Intracranial Pressure Monitoring 6 Management of Intracranial Hypertension 9 Advanced Neuromonitoring 12 Surgical Management 13 Nutritional Support 14 Tracheostomy 15 Timing of Secondary Procedures 15 Timing of Pharmacologic Venous Thromboembolism Prophylaxis 17 Management (...) Considerations for Pediatric Patients with TBI 18 Management Considerations for Elderly Patients with TBI 19 Prognostic Decision-Making and Withdrawal of Medical Support 20 Outcome Assessment and Quality Improvement in TBI 22 Bibliography 24 Expert Panel 28 Acknowledgements 29 Disclaimer 29 2INTRODUCTION Traumatic brain injury (TBI) is a disease process that carries major public health and socioeconomic consequences. In the United States alone, an estimated 2.5 million emergency department visits

American College of Surgeons2015

66. Very early administration of progesterone for acute traumatic brain injury.

Very early administration of progesterone for acute traumatic brain injury. 25493974 2014 12 25 2015 01 09 2017 01 09 1533-4406 371 26 2014 Dec 25 The New England journal of medicine N. Engl. J. Med. Very early administration of progesterone for acute traumatic brain injury. 2457-66 10.1056/NEJMoa1404304 Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase (...) N Engl J Med. 2015 Apr 30;372(18):1766-7 25923558 Accidents, Traffic Adolescent Adult Aged Aged, 80 and over Brain Injuries drug therapy Double-Blind Method Drug Administration Schedule Female Glasgow Outcome Scale Humans Infusions, Intravenous Injury Severity Score Male Middle Aged Phlebitis chemically induced Progesterone administration & dosage adverse effects Treatment Failure Young Adult NIHMS653108 PMC4303469 Wright David W DW Frankel Michael M Merck Lisa H LH Espinoza Tamara R TR Salomone

NEJM2014 Full Text: Link to full Text with Trip Pro

67. A clinical trial of progesterone for severe traumatic brain injury.

A clinical trial of progesterone for severe traumatic brain injury. 25493978 2014 12 25 2015 01 09 2015 04 30 1533-4406 371 26 2014 Dec 25 The New England journal of medicine N. Engl. J. Med. A clinical trial of progesterone for severe traumatic brain injury. 2467-76 10.1056/NEJMoa1411090 Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated (...) Apr 30;372(18):1765 25923559 N Engl J Med. 2014 Dec 25;371(26):2522-3 25493975 N Engl J Med. 2015 Apr 30;372(18):1767 25932489 N Engl J Med. 2015 Apr 30;372(18):1765-6 25923560 Adolescent Adult Aged Brain Injuries drug therapy Double-Blind Method Drug Administration Schedule Female Glasgow Coma Scale Glasgow Outcome Scale Humans Infusions, Intravenous Intention to Treat Analysis Male Middle Aged Odds Ratio Progesterone administration & dosage adverse effects Treatment Failure Young Adult Marmarou

NEJM2014

68. Very early administration of progesterone for acute traumatic brain injury.

Very early administration of progesterone for acute traumatic brain injury. BACKGROUND: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase trials involving patients with TBI. METHODS: We conducted a double-blind, multicenter clinical trial in which patients with severe, moderate-to-severe, or moderate acute TBI (Glasgow Coma Scale score of 4 to 12 (...) , on a scale from 3 to 15, with lower scores indicating a lower level of consciousness) were randomly assigned to intravenous progesterone or placebo, with the study treatment initiated within 4 hours after injury and administered for a total of 96 hours. Efficacy was defined as an increase of 10 percentage points in the proportion of patients with a favorable outcome, as determined with the use of the stratified dichotomy of the Extended Glasgow Outcome Scale score at 6 months after injury. Secondary

NEJM2014

69. A clinical trial of progesterone for severe traumatic brain injury.

A clinical trial of progesterone for severe traumatic brain injury. BACKGROUND: Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase 3 randomized clinical trial. METHODS: We conducted a multinational placebo-controlled trial, in which 1195 patients, 16 to 70 years of age (...) , with severe TBI (Glasgow Coma Scale score, ≤8 [on a scale of 3 to 15, with lower scores indicating a reduced level of consciousness] and at least one reactive pupil) were randomly assigned to receive progesterone or placebo. Dosing began within 8 hours after injury and continued for 120 hours. The primary efficacy end point was the Glasgow Outcome Scale score at 6 months after the injury. RESULTS: Proportional-odds analysis with covariate adjustment showed no treatment effect of progesterone as compared

NEJM2014

70. Progesterone for Traumatic Brain Injury - Resisting the Sirens' Song.

Progesterone for Traumatic Brain Injury - Resisting the Sirens' Song. Progesterone for traumatic brain injury--resisting the sirens' song. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 25493975 Format MeSH (...) and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2014 Dec 25;371(26):2522-3. doi: 10.1056/NEJMe1412951. Epub 2014 Dec 10. Progesterone for traumatic brain injury--resisting the sirens' song. 1 . 1 From the Department of Neurology, TeleStroke and Acute Stroke Services, and Institute for Heart, Vascular, and Stroke Care, Massachusetts General

NEJM2014

71. Screening Tools to Identify Adults with Cognitive Impairment Associated with a Cerebrovascular Accident or Traumatic Brain Injury

Screening Tools to Identify Adults with Cognitive Impairment Associated with a Cerebrovascular Accident or Traumatic Brain Injury TITLE: Screening Tools to Identify Adults with Cognitive Impairment Associated with a Cerebrovascular Accident or Traumatic Brain Injury: Diagnostic Accuracy DATE: 13 November 2014 RESEARCH QUESTION What is the diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a cerebrovascular accident (CVA) or traumatic brain injury (...) (TBI)? KEY FINDINGS One systematic review and 30 non-randomized studies were identified regarding diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with cerebrovascular accident or traumatic brain injury. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 10), University of York Centre for Reviews and Dissemination (CRD) databases, Canadian and major international health technology

Canadian Agency for Drugs and Technologies in Health - Rapid Review2014

72. Modest cooling therapies (35ºC to 37.5ºC) for traumatic brain injury.

Modest cooling therapies (35ºC to 37.5ºC) for traumatic brain injury. BACKGROUND: Animal models of traumatic brain injury suggest that induced normothermia (36.5 or 37 ºC), compared to induced hyperthermia (39 ºC), improves histopathological and neurobehavioural outcomes. Observational clinical studies of patients with TBI suggest an association between raised body temperature and unfavourable outcome, although this relationship is inconsistent. OBJECTIVES: To assess the effects of modest (...) cooling therapies (defined as any drug or physical therapy aimed at maintaining body temperature between 35 ºC and 37.5 ºC) when applied to patients in the first week after traumatic brain injury. SEARCH METHODS: The most recent search was run on 23(rd) September 2013. We searched the Cochrane Injuries Group's Specialised Register, The Cochrane Library (CENTRAL), MEDLINE (OvidSP), Embase (OvidSP), ISI WOS: SCI-EXPANDED (1970) & CPCI-S (1990), PubMed and trials registries together with reference

Cochrane2014

73. Health-related quality of life 3 years after moderate to severe traumatic brain injury: a prospective cohort study

Health-related quality of life 3 years after moderate to severe traumatic brain injury: a prospective cohort study 24561059 2014 06 24 2014 08 19 2014 06 24 1532-821X 95 7 2014 Jul Archives of physical medicine and rehabilitation Arch Phys Med Rehabil Health-related quality of life 3 years after moderate to severe traumatic brain injury: a prospective cohort study. 1268-76 10.1016/j.apmr.2014.02.002 S0003-9993(14)00124-5 To evaluate the time course of health-related quality of life (HRQoL (...) ) after moderate to severe traumatic brain injury (TBI) and to identify its predictors. Prospective cohort study with follow-up measurements at 3, 6, 12, 18, 24, and 36 months after TBI. Patients with moderate to severe TBI discharged from 3 level-1 trauma centers. Patients (N=97, 72% men) with a mean age ± SD of 32.8±13.0 years (range, 18-65y), hospitalized with moderate (23%) or severe (77%) TBI. Not applicable. HRQoL was measured with the Medical Outcomes Study 36-Item Short-Form Health Survey (SF

EvidenceUpdates2014

74. Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial.

Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. 25058216 2014 07 25 2014 08 11 2017 02 20 1538-3598 312 1 2014 Jul 02 JAMA JAMA Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. 36-47 10.1001/jama.2014.6490 There is limited information about the effect of erythropoietin or a high hemoglobin transfusion threshold after (...) a traumatic brain injury. To compare the effects of erythropoietin and 2 hemoglobin transfusion thresholds (7 and 10 g/dL) on neurological recovery after traumatic brain injury. Randomized clinical trial of 200 patients (erythropoietin, n = 102; placebo, n = 98) with closed head injury who were unable to follow commands and were enrolled within 6 hours of injury at neurosurgical intensive care units in 2 US level I trauma centers between May 2006 and August 2012. The study used a factorial design to test

JAMA2014 Full Text: Link to full Text with Trip Pro

75. Screening tools to identify adults with cognitive impairment associated with a cerebrovascular accident or traumatic brain injury: diagnostic accuracy

Screening tools to identify adults with cognitive impairment associated with a cerebrovascular accident or traumatic brain injury: diagnostic accuracy Screening tools to identify adults with cognitive impairment associated with a cerebrovascular accident or traumatic brain injury: diagnostic accuracy Screening tools to identify adults with cognitive impairment associated with a cerebrovascular accident or traumatic brain injury: diagnostic accuracy CADTH Record Status This is a bibliographic (...) record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Screening tools to identify adults with cognitive impairment associated with a cerebrovascular accident or traumatic brain injury: diagnostic accuracy. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response: summary of abstracts. 2014 Authors' conclusions Nine systematic reviews and meta-analyses

Health Technology Assessment (HTA) Database.2014

76. Optimal oxygen saturation range for adults suffering from traumatic brain injury: a review of patient benefit, harms, and guidelines

Optimal oxygen saturation range for adults suffering from traumatic brain injury: a review of patient benefit, harms, and guidelines Optimal oxygen saturation range for adults suffering from traumatic brain injury: a review of patient benefit, harms, and guidelines Optimal oxygen saturation range for adults suffering from traumatic brain injury: a review of patient benefit, harms, and guidelines CADTH Record Status This is a bibliographic record of a published health technology assessment from (...) a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Optimal oxygen saturation range for adults suffering from traumatic brain injury: a review of patient benefit, harms, and guidelines. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response. 2014 Authors' conclusions According to retrospective studies, hyperoxia appears to be associated with a lower likelihood of in-hospital survival compared to normoxia

Health Technology Assessment (HTA) Database.2014

77. The Lund concept for severe traumatic brain injury.

The Lund concept for severe traumatic brain injury. BACKGROUND: Severe traumatic brain injury is a significant cause of morbidity and mortality. Treatment strategies in management of such injuries are directed to the prevention of secondary brain ischaemia, as a consequence of disturbed post-traumatic cerebral blood flow. They are usually concerned with avoiding high intracranial pressure (ICP) or adequate cerebral perfusion pressure (CPP). An alternative to this conventional treatment (...) is the Lund concept, which emphasises a reduction in microvascular pressures. OBJECTIVES: To assess the role of the Lund concept versus other treatment modalities such as ICP-targeted therapy, CPP-targeted therapy or other possible treatment strategies in the management of severe traumatic brain injury. SEARCH METHODS: We searched the Cochrane Injuries Group's Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL; Issue 10, 2013), MEDLINE (OvidSP), EMBASE (OvidSP), CINAHL Plus

Cochrane2013

79. Paediatric Traumatic Brain Injury Consortium. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial

Paediatric Traumatic Brain Injury Consortium. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2013

80. Meta-analysis of Glasgow Coma Scale and Simplified Motor Score in predicting traumatic brain injury outcomes

Meta-analysis of Glasgow Coma Scale and Simplified Motor Score in predicting traumatic brain injury outcomes Meta-analysis of Glasgow Coma Scale and Simplified Motor Score in predicting traumatic brain injury outcomes Meta-analysis of Glasgow Coma Scale and Simplified Motor Score in predicting traumatic brain injury outcomes Singh B, Murad MH, Prokop LJ, Erwin PJ, Wang Z, Mommer SK, Mascarenhas SS, Parsaik AK CRD summary The authors concluded that the Simplified Motor Score and Glasgow (...) Coma Scale performed similarly in predicting three traumatic brain injury outcomes. Mortality was better predicted by the Glasgow Coma Scale but the clinical significance was undetermined. This was a generally well-conducted review in terms of methodology; the authors' recommendation for prospective evidence to confirm the findings seems appropriate. Authors' objectives To compare the accuracy of the Glasgow Coma Scale with the Simplified Motor Score in predicting outcomes in patients with traumatic brain injury

DARE.2013