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Latest & greatest articles for traumatic brain injury
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on traumatic brain injury or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on traumatic brain injury and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
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A systematic review of differences between brain temperature and core body temperature in adult patients with severe traumaticbraininjury. Studies have shown that temperature at the extremes of the thermoregulatory physiological range, commensurate with a clinical diagnosis of hypothermia (at the lower end) and hyperthermia or fever (at the upper end) increase the risk of a poor neurological outcome and contribute to higher mortality. The tissue most at risk is nervous tissue. That said (...) (or fall) in brain temperature beyond the 'normal' range is suspected.This systematic review focused on whether brain temperature is higher, lower, or the same as core body temperature in patients with severe traumaticbrain injury.This review considered studies that include male and female patients, aged 15 years and above, admitted to an adult Intensive Care Unit, with the diagnosis of severe traumaticbraininjury, with a Glasgow Coma Scale score of less than eight, and who require brain temperature
Cerebrospinal Fluid and Microdialysis Cytokines in Severe TraumaticBrainInjury: A Scoping Systematic Review. To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumaticbraininjury (TBI) patients.Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytokines. Both were conducted in severe TBI (sTBI) patients only.Articles from MEDLINE
Incidence, Demographics and Outcome of TraumaticBrainInjury in The Middle East: A Systematic Review. Traumaticbraininjury (TBI) is a serious global public health challenge. We aimed to assess the pattern of TBI in the Middle East, as reported in the last decade.Literature searches were conducted on PubMed, MEDLINE, and Google scholar electronic databases. The search terms used in different combinations were epidemiology, incidence, case fatality, mortality, intracranialinjury, braininjury (...) , head injury, and the country names. Additional searches were conducted using reference lists of studies and review articles for selection of relevant articles. The search yielded 1082 articles; of which 701 duplicates and 346 articles were excluded. Thirty-five original studies met the inclusion criteria. Data were extracted using standardized Excel form and pilot tested. Median with interquartile range (IQR) was used to estimate the incidence rate and mortality of TBI.In the Middle East region
A systematic review of peer mentoring interventions for people with traumaticbraininjury. This systematic review sought evidence concerning the effectiveness of peer mentoring for people with traumaticbrain injury.Fourteen electronic databases were searched, including PsycINFO, MEDLINE, CINAHL, EMBASE and the Cochrane Library, from inception to September 21 2016. Ten grey literature databases, PROSPERO, two trials registers, reference lists and author citations were also searched.Studies (...) which employed a model of one-to-one peer mentoring between traumaticbraininjury survivors were included. Two reviewers independently screened all titles and abstracts before screening full texts of shortlisted studies. A third reviewer resolved disagreements. Two reviewers independently extracted data and assessed studies for quality and risk of bias.The search returned 753 records, including one identified through hand searching. 495 records remained after removal of duplicates and 459 were
Serial Sampling of Serum Protein Biomarkers for Monitoring Human TraumaticBrainInjury Dynamics: A Systematic Review. The proteins S100B, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and neurofilament light (NF-L) have been serially sampled in serum of patients suffering from traumaticbraininjury (TBI) in order to assess injury severity and tissue fate. We review the current literature of serum level dynamics (...) frequent biomarkers that were serially sampled. For S100B in severe TBI, a majority of studies indicate a t1/2 of about 24 h, even if very early sampling in these patients reveals rapid decreases (1-2 h) though possibly of non-cerebral origin. In contrast, the t1/2 for NSE is comparably longer, ranging from 48 to 72 h in severe TBI cases. The protein GFAP (n = 18) appears to have t1/2 of about 24-48 h in severe TBI. The protein UCH-L1 (n = 9) presents a t1/2 around 7 h in mild TBI and about 10 h
Mannitol cannot reduce the mortality on acute severe traumaticbraininjury (TBI) patients: a meta-analyses and systematic review. We aimed to systematically review the efficacy of mannitol (MTL) on patients with acute severe traumaticbraininjury (TBI).Databases such as PubMed (US National Library of Medicine), CENTRAL (The Cochrane Library 2014, Issue 3), ISI (Web of Science: Science Citation Index Expanded), Chinese Biomedicine Database (CBM), and China Knowledge Resource Integrated (...) with diffuse braininjuries than mannitol did.As a conclusion, the mannitol therapy cannot reduce the mortality risk of acute severe traumaticbraininjury. Current evidence does not support the mannitol as an effective treatment of acute severe traumaticbraininjury. The well-designed randomized controlled trials are in urgent need to demonstrate the adoption of mannitol to acute severe traumaticbraininjury.
The clinical significance of isolated traumatic subarachnoid hemorrhage in mild traumaticbraininjury: A meta-analysis. The rates of clinical and radiographic progression and the need for neurosurgical intervention in patients with isolated traumatic subarachnoid hemorrhage (itSAH) after mild traumaticbraininjury (Glasgow Coma Scale score, 13-15) has not been well established.The aim of this work was to review the evidence regarding patient outcomes after mild traumaticbraininjury
Neuropsychological Predictors of Outcome Following TraumaticBrainInjury in Adults: a Meta-Analysis. Several neuropsychological dimensions are correlated with functional outcome (e.g., ability to return to family and community roles) following traumaticbraininjury (TBI). Commonly investigated neuropsychological dimensions include verbal memory, visuo-spatial construction, set-shifting, generativity, and processing speed. Unfortunately, small sample sizes across relevant studies have
Acute Alcohol Exposure and Risk of Mortality of Patients with TraumaticBrainInjury: A Systematic Review and Meta-analysis. After traumaticbraininjury (TBI), patients usually live with significant disability and socioeconomic burdens. Acute exposure to alcohol is considered a major risk factor for TBI. Numerous studies have examined whether alcohol exposure is related to the risk of mortality in patients with TBI, yet the results remain inconsistent. We performed a meta-analysis to assess
Cognitive rehabilitation for adults with traumaticbraininjury to improve occupational outcomes. Cognitive impairment in people with traumaticbraininjury (TBI) could affect multiple facets of their daily functioning. Cognitive rehabilitation brings about clinically significant improvement in certain cognitive skills. However, it is uncertain if these improved cognitive skills lead to betterments in other key aspects of daily living. We evaluated whether cognitive rehabilitation for people (...) with TBI improves return to work, independence in daily activities, community integration and quality of life.To evaluate the effects of cognitive rehabilitation on return to work, independence in daily activities, community integration (occupational outcomes) and quality of life in people with traumaticbraininjury, and to determine which cognitive rehabilitation strategy better achieves these outcomes.We searched CENTRAL (the Cochrane Library; 2017, Issue 3), MEDLINE (OvidSP), Embase (OvidSP
Detecting social-cognitive deficits after traumaticbraininjury: An ALE meta-analysis of fMRI studies. Traumaticbraininjury (TBI) can result in significant social dysfunction, which is represented by impairment to social-cognitive abilities (i.e. social cognition, social attention/executive function and communication). This study is aimed to explore brain networks mediating the social dysfunction after TBI and its underlying mechanisms.We performed a quantitative meta-analysis using
Preclinical progenitor cell therapy in traumaticbraininjury: a meta-analysis. No treatment is available to reverse injury associated with traumaticbraininjury (TBI). Progenitor cell therapies show promise in both preclinical and clinical studies. We conducted a meta-analysis of preclinical studies using progenitor cells to treat TBI.EMBASE, MEDLINE, Cochrane Review, Biosis, and Google Scholar were searched for articles using prespecified search strategies. Studies meeting inclusion criteria
Growing Literature but Limited Evidence: A Systematic Review regarding Prebiotic and Probiotic Interventions for those with TraumaticBrainInjury and/or Posttraumatic Stress Disorder. Traumaticbraininjury (TBI) is highly prevalent among a wide range of populations, including civilians, military personnel, and Veterans. TBI sequelae may be further exacerbated by symptoms associated with frequently occurring comorbid psychiatric conditions, including posttraumatic stress disorder (PTSD
Therapeutic effect of beta-blocker in patients with traumaticbraininjury: A systematic review and meta-analysis. β-Blocker exposure has been shown to reduce mortality in traumaticbraininjury (TBI); however, the efficacy of β-blockers remains inconclusive. Therefore, a meta-analysis was conducted in this paper to evaluate the safety and efficacy of β-blocker therapy on patients with TBI.The electronic databases were systemically retrieved from construction to February 2017. The odds ratio
Correlations between diffusion tensor imaging and levels of consciousness in patients with traumaticbraininjury: a systematic review and meta-analysis. Traumaticbraininjury (TBI) often leads to impaired consciousness. Recent diffusion tensor imaging studies associated consciousness with imaging metrics including fractional anisotropy (FA) and apparent diffusion coefficient (ADC). We evaluated their correlations and determined the best index in candidate regions. Six databases were searched (...) , including PubMed and Embase, and 16 studies with 701 participants were included. Data from region-of-interest and whole-brain analysis methods were meta-analysed separately. The FA-consciousness correlation was marginal in the whole-brain white matter (r = 0.63, 95% CI [0.47, 0.79], p = 0.000) and the corpus callosum (CC) (r = 0.60, 95% CI [0.48, 0.71], p = 0.000), and moderate in the internal capsule (r = 0.48, 95% CI [0.24, 0.72], p = 0.000). Correlations with ADC trended negative and lacked
Prognostic role of copeptin after traumaticbraininjury: A systematic review and meta-analysis of observational studies. Copeptin, the C-terminal portion of provasopressin, has emerged as a novel prognostic marker in neurocritical care, such as in traumaticbraininjury (TBI). The aim of this study was to quantitatively assess the prognostic significance of initial plasma copeptin levels in the neurological outcome and mortality after traumaticbrain injury.Six relevant studies with data from
Complementary and alternative interventions for fatigue management after traumaticbraininjury: a systematic review. We systematically reviewed randomized controlled trials (RCTs) of complementary and alternative interventions for fatigue after traumaticbraininjury (TBI).We searched multiple online sources including ClinicalTrials.gov, the Cochrane Library database, MEDLINE, CINAHL, Embase, the Web of Science, AMED, PsychINFO, Toxline, ProQuest Digital Dissertations, PEDro, PsycBite
Beta-Blockers and TraumaticBrainInjury: A Systematic Review, Meta-analysis, and Eastern Association for the Surgery of Trauma Guideline. To determine if beta-(β)-blockers improve outcomes after acute traumaticbraininjury (TBI).There have been no new inpatient pharmacologic therapies to improve TBI outcomes in a half-century. Treatment of TBI patients with β-blockers offers a potentially beneficial approach.Using MEDLINE, EMBASE, and CENTRAL databases, eligible articles for our systematic