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Latest & greatest articles for traumatic brain injury
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on traumatic brain injury or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on traumatic brain injury and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
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A Systematic Review of the Incidence, Prevalence, Costs, and Activity/Work Limitations of Amputation, Osteoarthritis, Rheumatoid Arthritis, Back Pain, Multiple Sclerosis, Spinal Cord Injury, Stroke, and TraumaticBrainInjury in the United States: A 2019 To present recent evidence on the prevalence, incidence, costs, activity limitations, and work limitations of common conditions requiring rehabilitation.This was a systematic review. Medline (PubMed), SCOPUS, Web of Science, and the grey (...) literature were searched for relevant articles about amputation, osteoarthritis, rheumatoid arthritis, back pain, multiple sclerosis, spinal cord injury, stroke, and traumaticbraininjury. Two investigators independently reviewed articles and selected those for inclusion. Quality grading was performed using the Methodological Evaluation of Observational Research Checklist and Newcastle-Ottawa Quality Assessment Form.110 articles were included. The prevalence of back pain in the past 3 months is 33.9
Task-related functional magnetic resonance imaging activations in patients with acute and subacute mild traumaticbraininjury: A coordinate-based meta-analysis. Task-based functional magnetic resonance imaging (fMRI) has been used to examine neuroanatomical and functional changes following mild traumaticbraininjury (mTBI). Prior studies have lacked consistency in identifying common regions of altered neural activity during cognitive tasks. This may be partly due to differences in task (...) paradigm, patient heterogeneity, and methods of fMRI analysis. We conducted a meta-analysis using an activation likelihood estimation (ALE) method to identify regions of differential brain activation in patients with mTBI compared to healthy controls. We included experiments that performed scans from acute to subacute time points post-injury. The seven included studies recruited a total sample of 174 patients with mTBIs and 139 control participants. The results of our coordinate based meta-analysis
Comparing Region of Interest versus Voxel-Wise Diffusion Tensor Imaging Analytic Methods in Mild and Moderate TraumaticBrainInjury: A Systematic Review and Meta-Analysis. Diffusion tensor imaging is a magnetic resonance imaging technique that is uniquely capable of detecting microstructural tissue damage in mild and moderate traumaticbraininjuries (TBIs). To date, it remains unknown if two common analytic techniques, region of interest (ROI) versus voxel-wise (VW) analyses, detect injury
The role of amantadine in cognitive recovery early after traumaticbraininjury: A systematic review. We conducted an updated systematic review on the safety and efficacy of amantadine in cognitive recovery after traumaticbraininjury (TBI), in order to determine if the current literature justifies its use in this clinical condition. A comprehensive search strategy was applied to three databases (PubMed, Scopus, and Cochrane). Only randomized clinical trials (RCTs) that compared the effect (...) included. All of the studies evaluated only severe TBI in adults. Amantadine was found to be well tolerated across the studies. Two RCTs reported improvement in the intermediate-term cognitive recovery (four to six weeks after end of treatment), using DRS (in both studies) and MMSE, GOS, and FIM-Cog (in one study). The effect of amantadine on the short-term (seven days to discharge) and long-term (six months from the injury) cognitive outcome was found not superior to placebo in two RCTs. The rate
Sleep disturbances after pediatric traumaticbraininjury: a systematic review of prevalence, risk factors, and association with recovery. Sleep is vital for brain development and healing after injury, placing children with sleep wake disturbances (SWD) after traumaticbraininjury (TBI) at risk for worse outcomes. We conducted a systematic review to quantify SWD after pediatric TBI including prevalence, phenotypes, and risk factors. We also evaluated interventions for SWD and the association (...) reviewed, and 24 studies were included (11 prospective, 9 cross-sectional, and 4 case studies). Marked heterogeneity was found in study populations, measures defining SWD, and time from injury to evaluation. Studies showed at least 20% of children with TBI had trouble falling or staying asleep, fatigue, daytime sleepiness, and nightmares. SWD are negatively correlated with post-traumatic cognitive, behavioral, and quality of life outcomes. No comparative intervention studies were identified. Risk
Role of Decompressive Craniectomy in TraumaticBrainInjury - A Meta-analysis of Randomized Controlled Trials. Several studies have indicated that decompressive craniectomy (DC) for traumaticbraininjury (TBI) is lifesaving. However, there is lack of level 1 evidence to define the role of DC in TBI. We performed a meta-analysis of all the randomized controlled trials (RCTs) published so far on the role of DC in adult patients with TBI.A systematic literature search was performed for articles
Indomethacin for intracranial hypertension secondary to severe traumaticbraininjury in adults. Among people who have suffered a traumaticbraininjury, increased intracranial pressure continues to be a major cause of early death; it is estimated that about 11 people per 100 with traumaticbraininjury die. Indomethacin (also known as indometacin) is a powerful cerebral vasoconstrictor that can reduce intracranial pressure and, ultimately, restore cerebral perfusion and oxygenation. Thus (...) in the field.Our search criteria included randomised controlled trials (RCTs) that compared indomethacin with any control in adults presenting with severe traumaticbraininjury associated with elevated intracranial pressure, with no previous decompressive surgery.Two review authors independently decided on the selection of the studies. We followed standard Cochrane methods.We identified no eligible studies for this review, either completed or ongoing.We found no studies, either completed or ongoing
Sensory stimulation to improve arousal in comatose patients after traumaticbraininjury: a systematic review of the literature. No standard rehabilitative treatment for coma arousal after traumaticbraininjury (TBI) exists. Based on our clinical experience, we hypothesized that sensory stimulation (SS) is a promising protocol to improve outcomes in these patients.We performed a literature review on the progress of sensory stimulation to enhance coma arousal after traumaticbraininjury. We (...) searched the databases on Medline, Embase, and Cochrane to gain access to relevant publications using the key words "traumaticbraininjury," "disorders of consciousness," "sensory stimulation," and "coma scale."We included all original studies published in English with patients presenting severe disorders of consciousness due to traumaticbraininjury who had received SS and whose behavioral/neural responses had been measured. We compared data on ten selected studies and analyzed the SS effects
Risk Factors for the Development of Post-Traumatic Headache Attributed to TraumaticBrainInjury: A Systematic Review. To systematically identify risk factors for the development of post-traumatic headache (PTH) attributed to traumaticbraininjury (TBI) as defined in the International Classification of Headache Disorders (ICHD).PTH is a common sequela of TBI and a leading cause of injury-related disability worldwide. However, little is known about risk factors for the development of PTH (...) assessed for the development of acute PTH: age, sex, type of injury, loss of consciousness, previous TBIs, history of primary headache disorders, history of chronic pain condition other than headache, current treatment for depression/anxiety, attention or learning disorders, body mass index, and other diseases (not further specified). None of the included studies assessed risk factors for the development of persistent PTH.We found that there is little evidence for any risk factors involved
Prognostic-factors for neurodegeneration in chronic moderate-to-severe traumaticbraininjury: a systematic review protocol. Traumaticbraininjury (TBI) is a leading cause of death and disability. Recently, a paradigm shift in our understanding of moderate-to-severe TBI has led to its reconceptualization as a progressive neurodegenerative disorder. Widespread progressive atrophy is observed in the months and years post-injury, long after the acute effects of the injury have resolved. Some (...) studies have begun to examine prognostic demographic, injury-related, and post-injury risk factors that contribute to these declines. A synthesis of this information, and in particular, an increased understanding of post-injury factors that may be modifiable, would improve our ability to design interventions to reduce neurodegeneration in moderate-to-severe TBI. This systematic review aims to identify prognostic factors for neural deterioration in moderate-to-severe TBI, and thereby inform future
Fluid Biomarkers of Pediatric Mild TraumaticBrainInjury: A Systematic Review. Public concern is growing about the short- and long-term effects of pediatric mild traumaticbraininjury (mTBI). This concern is amplified because pediatric mTBI has the potential to go undiagnosed in acute care settings, placing children at increased risk for reinjury prior to complete recovery. Diagnosis can be particularly challenging due to the lack of validated biomarkers that clinicians can use to objectively (...) of pediatric mTBI. Ultimately, well-designed longitudinal studies across diverse points of care are needed to truly characterize the utility of fluid biomarkers of injury and recovery for the pediatric mTBI patient.
Comorbidity in adults with traumaticbraininjury and all-cause mortality: a systematic review. Comorbidity in traumaticbraininjury (TBI) has been recognised to alter the clinical course of patients and influence short-term and long-term outcomes. We synthesised the evidence on the effects of different comorbid conditions on early and late mortality post-TBI in order to (1) examine the relationship between comorbid condition(s) and all-cause mortality in TBI and (2) determine the influence
Impact of Cervical Collars on Intracranial Pressure Values in TraumaticBrainInjury: A Systematic Review and Meta-Analysis of Prospective Studies. Spinal cord injury (SCI) is present in around 2-4% of trauma victims. More than half of this injuries are located at the cervical region. Twenty percent of victims with cervical spinal trauma and 5% of patients with severe traumaticbraininjury (TBI) will have an SCI. Cervical immobilization with rigid or semirigid collars is routinely used (...) as prophylactic or definitive treatment intervention in general trauma care. An important adverse effect of cervical collars application is the increase in intracranial pressure (ICP) values. This systematic review and meta-analysis aim to estimate the overall magnitude of ICP changes after cervical collar application.Major electronic databases (Ovid/Medline, Embase and Cochrane Library) were systematically searched for prospective studies that assessed ICP changes after cervical collar applications. Study
Incidence, Risk Factors, and Outcomes of Ventilator-Associated Pneumonia in TraumaticBrainInjury: A Meta-analysis. Ventilator-associated pneumonia (VAP) is one of the most severe complications in patients with traumaticbraininjury (TBI) and is considered a risk factor for poor outcomes. However, the incidence of VAP among patients with TBI reported in studies varies widely. What is more, the risk factors and outcomes of VAP are controversial. This study estimates the incidence, risk factors (...) -28.17), blood transfusion on admission (OR 2.54; 95% CI 1.24-5.18), barbiturate infusion (OR 3.52; 95% CI 1.68-7.40), injury severity score (OR 4.65; 95% CI 1.96-7.34), and head abbreviated injury scale (OR 2.99; 95% CI 1.66-5.37) were related to the occurrence of VAP. When patients developed VAP, mechanical ventilation time (OR 5.45; 95% CI 3.78-7.12), ICU length of stay (OR 6.85; 95% CI 4.90-8.79), and hospital length of stay (OR 10.92; 95% CI 9.12-12.72) were significantly increased. However, VAP
of different opioids as well as varying dosages in order to develop improved understanding as well as allow for tighter control of cerebral physiology.CPP: Cerebral Perfusion Pressure, GCS: Glasgow Coma Scale, ICP: Intracranial Pressure, MAP: Mean Arterial Pressure, PEDro: Physiotherapy Evidence Database, RCT: Randomized Controlled Trial, TBI: TraumaticBrainInjury. (...) Opioids and cerebral physiology in the acute management of traumaticbraininjury: a systematic review. Following traumaticbraininjury (TBI), optimization of cerebral physiology is recommended to promote more favourable patient outcomes. Accompanying pain and agitation are commonly treated with sedative and analgesic agents, such as opioids. However, the impact of opioids on certain aspects of cerebral physiology is not well established.To conduct a systematic review of the evidence
Sleep disturbance and recovery during rehabilitation after traumaticbraininjury: a systematic review. Purpose: Sleep disturbance is well recognized following traumaticbraininjury, but less is known about the potential effects of this on patients and their recovery. We review the recent literature that investigates the relationship between sleep disturbance in adult patients following a traumaticbraininjury and their functioning, disability, and health.Materials and methods: The PRISMA (...) statement was used as a guide to report the systematic review. Embase, PubMed, and the Cochrane library were searched for all research articles published (or in press) in the 10 y prior to 25 May 2018 that investigated the relationship between the development (or treatment) of sleep disturbance of adult patients with a history of traumaticbraininjury and patient outcomes, according to the domains of the International Classification of Functioning, Disability, and Health Core Sets for persons
Pharmacological and Non-Pharmacological Interventions for Depression after Moderate-to-Severe TraumaticBrainInjury: A Systematic Review and Meta-Analysis. The objective of this study was to systematically review the literature and perform a meta-analysis of randomized controlled trials (RCTs) on the effectiveness of pharmacological and non-pharmacological interventions for depression in patients with moderate-to-severe traumaticbraininjury. Databases searched were: Embase, PubMed, PsycInfo
Tranexamic acid is associated with reduced mortality, hemorrhagic expansion, and vascular occlusive events in traumaticbraininjury - meta-analysis of randomized controlled trials. This systematic review and meta-analysis aimed to synthesize the latest evidence on the efficacy and safety of tranexamic acid (TXA) on traumaticbraininjury (TBI).We performed a systematic literature search on topics that compared intravenous TXA to placebo in patients with TBI up until January 2020 from several
A Systematic Review of Sleep-Wake Disturbances in Childhood TraumaticBrainInjury: Relationship with Fatigue, Depression, and Quality of Life. To systematically appraise the literature on the prevalence, types, and predictors of sleep-wake disturbances (SWD), and on the relationship between SWD, fatigue, depression, and quality of life in children and adolescents with traumaticbraininjury (TBI).MEDLINE, PubMed, PsychInfo, Web of Science, and EMBASE databases were searched, reference lists (...) involving mild TBI participants included TBI severity, male sex, preexisting SWD, high body weight, and depression; while injury severity and internalizing problems were associated with SWD in moderate-severe TBI participants. Sleep-wake disturbances were also associated with fatigue and poor quality of life following TBI.Sleep-wake disturbances are highly prevalent in childhood TBI, regardless of injury severity. Routine assessments of SWD in survivors of childhood TBI are recommended.
Quality Appraisal of Systematic Reviews for Behavioral Treatments of Attention Disorders in TraumaticBrainInjury. This review appraised the quality of systematic reviews (SRs) and meta-analyses (MAs) to summarize research on behavioral interventions for attention disorders in persons with traumaticbrain injury.A search of 7 databases revealed 15 MAs/SRs reporting outcomes for attention treatments in traumaticbraininjury. Two examiners independently coded the quality of reviews (...) activities. Strategy training for activities and tasks requiring attentional abilities had a stronger evidence base in 1 rigorous MA.This appraisal provides valuable practice information. The conclusions of 4 rigorous reviews suggest that there is only limited positive scientific support for the effects of attention treatments for traumaticbraininjury. Future SRs/MAs would benefit from adherence to review guidelines.