Latest & greatest articles for tramadol

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on tramadol or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on tramadol and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for tramadol

1. Tramadol

Tramadol Top results for tramadol - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for tramadol The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

2. Single fixed-dose oral dexketoprofen plus tramadol for acute postoperative pain in adults. (PubMed)

Single fixed-dose oral dexketoprofen plus tramadol for acute postoperative pain in adults. Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and migraine headache. A new combination of dexketoprofen (a nonsteroidal anti-inflammatory drug) plus tramadol (an opioid) has been tested in acute postoperative pain (...) conditions. It is not yet licensed for use. This review is one of a series on oral analgesics for acute postoperative pain. Individual reviews have been brought together in two overviews to provide information about the relative efficacy and harm of the different interventions.To assess the analgesic efficacy and adverse effects of a single fixed-dose of oral dexketoprofen plus tramadol, compared with placebo, for moderate to severe postoperative pain in adults, using methods that permit comparison

Full Text available with Trip Pro

2016 Cochrane

3. Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy

Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02428777 Recruitment Status : Unknown Verified January 2017 by AbdelGany Hassan, Cairo University. Recruitment status was: Recruiting First Posted

2015 Clinical Trials

4. A comparative study of oral tramadol and ibuprofen in postoperative pain in operations of lower abdomen. (PubMed)

A comparative study of oral tramadol and ibuprofen in postoperative pain in operations of lower abdomen. The objective of this study was to assess efficacy and safety of oral tramadol in postoperative pain in operations of lower abdomen as compared to oral ibuprofen. Eighty patients undergoing operations in the lower abdomen under spinal anaesthesia were randomly assigned to two parallel groups--ibuprofen 400 mg thrice daily and tramadol 100 mg thrice daily, both orally after food. Treatment (...) was given single-blind for 5 days in the postoperative period. Patient's perception of pain scored byvisual analogue scale (VAS) and wound tenderness assessed by a 3-point ordinal scale were the primary efficacy parameters. A steady decline in VAS pain score from baseline to study end (99.7 +/- 2.75 to 54.4 +/- 9.71 in the ibuprofen group and 97.3 +/- 3.14 to 52.5 +/- 9.95 in tramadol group) indicated good analgesic efficacy in both groups. Within groups, comparisons showed highly significant difference

2011 Journal of the Indian Medical Association

6. Tramadol? Think of it more as ‘Tramadont’

Tramadol? Think of it more as ‘Tramadont’ Tramadol? Think of it more as 'Tramadont' - CanadiEM Tramadol? Think of it more as ‘Tramadont’ In , by Shahbaz Syed December 13, 2017 Ok, I’ll concede that title is pretty bad, but I felt my usual name for Tramadol (Tramacrap), just didn’t seem as appropriate for a headline. Dad jokes aside, Tramadol is a synthetic opioid that entered the Canadian market in 2005, and has seen widespread uptake and use. Unfortunately, Tramadol has not been the miracle (...) drug that we anticipated it would be, as is fraught with harms. Alarmingly, despite a host of problems associated with this medication (as we will get in to), the Canadian government has yet to reclassify Tramadol as an opioid, and this has some concerning ramifications. What is Tramadol? Tramadol is a synthetic analgesic that is converted to M1 (an opioid) by the liver, as well as enhancing serotonin and norepinephrine neurotransmission – resulting in its dual action analgesic properties 1

2017 CandiEM

7. A Comparative Study of the Efficacy of IV Dexketoprofen, Lornoxicam, and Diclophenac Sodium on Postoperative Analgesia and Tramadol Consumption in Patients Receiving Patient-Controlled Tramadol. (PubMed)

A Comparative Study of the Efficacy of IV Dexketoprofen, Lornoxicam, and Diclophenac Sodium on Postoperative Analgesia and Tramadol Consumption in Patients Receiving Patient-Controlled Tramadol. This study was designed to compare the effects of dexketoprofen, lornoxicam, and diclophenac sodium on postoperative analgesia and tramadol consumption in patients receiving postoperative patient-controlled tramadol after a major abdominal surgery.Eighty patients were randomized to receive one (...) of the four study drugs. Patients in group dexketoprofen (DT) received IV 50 mg dexketoprofen, group lornoxicam (LR) received IV 8 mg lornoxicam, group diclophenac sodium (DS) received 75 mg IV diclophenac sodium and group saline (S) received 0.9% saline in 2 mL syringes, 20 min before the end of anaesthesia. A standardized (1 mg kg(-1)) dose of tramadol was routinely administered to all patients as the loading dose at the end of surgery. Postoperatively, whenever patients requested, they were allowed

Full Text available with Trip Pro

2016 Turkish journal of anaesthesiology and reanimation

8. Comparative pharmacology and toxicology of tramadol and tapentadol. (PubMed)

Comparative pharmacology and toxicology of tramadol and tapentadol. Moderate-to-severe pain represents a heavy burden in patients' quality of life, and ultimately in the society and in healthcare costs. The aim of this review was to summarize data on tramadol and tapentadol adverse effects, toxicity, potential advantages and limitations according to the context of clinical use. We compared data on the pharmacological and toxicological profiles of tramadol and tapentadol, after an extensive (...) literature search in the US National Library of Medicine (PubMed). Tramadol is a prodrug that acts through noradrenaline and serotonin reuptake inhibition, with a weak opioid component added by its metabolite O-desmethyltramadol. Tapentadol does not require metabolic activation and acts mainly through noradrenaline reuptake inhibition and has a strong opioid activity. Such features confer tapentadol potential advantages, namely lower serotonergic, dependence and abuse potential, more linear

2018 European Journal of Pain

9. Tramadol for the Management of Pain in Adult Patients

Tramadol for the Management of Pain in Adult Patients TITLE: Tramadol for the Management of Pain in Adult Patients: Clinical Effectiveness and Guidelines DATE: 24 October 2014 RESEARCH QUESTIONS 1. What is the clinical effectiveness of tramadol for the management of pain in adult patients? 2. What are the evidence-based guidelines regarding the use of tramadol for pain in adult patients? KEY FINDINGS Four systematic reviews, 17 randomized controlled trials, seven non-randomized studies (...) , and five evidence-based guidelines were identified regarding the use of tramadol for the management of pain in adult patients. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 10), University of York Centre for Reviews and Dissemination (CRD), Pubmed, Medline (OVID) and Embase (OVID) databases, Canadian and major international health technology agencies, as well as a focused Internet search. Methodological filters were applied

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

10. "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine

"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Prescrire IN ENGLISH - Spotlight ''"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine'', 1 February 2016 {1} {1} {1} | | > > > "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |    (...) |   |   |   |   |  Spotlight "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine FEATURED REVIEW When opioid therapy is needed, there is no evidence that codeine, dihydrocodeine or tramadol is less risky than morphine at its lowest effective dose. The efficacy of these drugs varies more from one patient to another, and their multiple pharmacokinetic interactions can be difficult to manage. Weak opioids require at least

2016 Prescrire

11. Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness

Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness | CADTH.ca Find the information you need Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Published on: November 3, 2015 Project Number: RB0927-000 Product Line (...) : Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients? Key Message Two randomized controlled trials and four non-randomized studies were identified regarding the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients. Tags acetaminophen, anesthesia, paracetamol, tramadol, Tramacet Files Rapid Response Summary of Abstracts

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

12. Comparison of lornoxicam and low-dose tramadol for management of post-thyroidectomy pain. (PubMed)

Comparison of lornoxicam and low-dose tramadol for management of post-thyroidectomy pain. The present study sought to compare the analgesic efficacy and adverse effects of intravenous (IV) lornoxicam and tramadol to investigate if lornoxicam is a reasonable alternative to a weak opioid for post-thyroidectomy pain.Fifty patients of American Society of Anesthesiologists class I or II, 18 to 65 years of age, and who underwent thyroidectomy were assigned to 2 groups in a randomized manner. Group L (...) received 8 mg of lornoxicam IV and Group T received 1 mg/kg of tramadol IV at conclusion of the operation. Pain intensity of patients was recorded at 15 and 30 minutes, and at 1, 2, 3, 4, 6, 12, and 24 hours after the initial dose with Numerical Rating Scale (NRS) and Ramsey Sedation Scale. Electrocardiogram, heart rate, systolic/diastolic and average artery pressure and peripheral oxygen saturations were monitored continuously during this period. Patients completed satisfaction questionnaires at 24th

Full Text available with Trip Pro

2017 Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology

13. Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. (PubMed)

Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis.15 client-owned adult horses with chronic laminitis.Each horse received tramadol alone or tramadol and ketamine in a randomized, crossover study (≥ 2 months between (...) treatments). Tramadol (5 mg/kg) was administered orally every 12 hours for 1 week. When appropriate, ketamine (0.6 mg/kg/h) was administered IV for 6 hours on each of the first 3 days of tramadol administration. Noninvasive systemic blood pressure values, heart and respiratory rates, intestinal sounds, forelimb load and off-loading frequency (determined via force plate system), and plasma tumor necrosis factor-α and thromboxane B(2) concentrations were assessed before (baseline) during (7 days) and after

2012 American journal of veterinary research

14. Tramadol with or without paracetamol (acetaminophen) for cancer pain. (PubMed)

Tramadol with or without paracetamol (acetaminophen) for cancer pain. Tramadol is an opioid analgesic licensed for use in moderate to severe pain. It is considered as a low risk for abuse, so control regulations are not as stringent as for 'strong' opioids such as morphine. It has a potential role as a step 2 option of the World Health Organization (WHO) analgesic ladder.To assess the benefits and adverse effects of tramadol with or without paracetamol (acetaminophen) for cancer-related pain.We (...) participants. All the studies enrolled participants with chronic malignant tumour-related pain who were experiencing pain intensities described as moderate to severe, with most experiencing at least 4/10 with current treatment. The mean ages were 59 to 70 years, with participants aged between 24 and 87 years. Study length ranged from one day to six months. Five studies used a cross-over design. Tramadol doses ranged from 50 mg as single dose to 600 mg per day; doses of 300 mg per day to 400 mg per day were

Full Text available with Trip Pro

2017 Cochrane

15. Effectiveness and safety of tramadol in the treatment of patients with fibromyalgia: systematic review

Effectiveness and safety of tramadol in the treatment of patients with fibromyalgia: systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web

2017 PROSPERO

16. Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery

Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery UTCAT2725, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Tramadol/Acetaminophen Tablets Provide Rapid, Effective, and Dose-Dependent Analgesia Following Dental Surgery Clinical Question Following dental surgery, does Tramadol provide adequate analgesia when compared to hydrocodone/APAP or codeine/APAP (...) combination drug preparations? Clinical Bottom Line Tramadol/Acetaminophen 75/650mg tablets provide effective, rapid ( Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Jung/2004 128 healthy adults undergoing extraction of > or = 1 impacted 3rd molars Randomized Controlled Trial Key results Tr/APAP 75/650mg and Co/APAP/Ibuprofen 20/500/400mg mean total pain relief and the sum of pain intensity difference were

2014 UTHSCSA Dental School CAT Library

17. Tramadol compared with opioids for pain: a review of addiction potential

Tramadol compared with opioids for pain: a review of addiction potential Tramadol compared with opioids for pain: a review of addiction potential Tramadol compared with opioids for pain: a review of addiction potential Pohar R, Cunningham J Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pohar R, Cunningham J. Tramadol compared (...) with opioids for pain: a review of addiction potential. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2010 Authors' conclusions Two RCTs were identified in which the abuse potential of tramadol was compared to another opioid analgesic. The results of one RCT were inconclusive given that no instances of abuse were identified. The other RCT suggested the abuse potential of tramadol was lower than hydrocodone-containing analgesics in patients with NCP and similar to that of NSAIDs

2010 Health Technology Assessment (HTA) Database.

18. Tramadol for neuropathic pain in adults. (PubMed)

Tramadol for neuropathic pain in adults. This review is an update of a review of tramadol for neuropathic pain, published in 2006; updating was to bring the review in line with current standards. Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Peripheral neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity (...) to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the peripheral nervous system.To assess the analgesic efficacy of tramadol compared with placebo or other active interventions for chronic neuropathic pain in adults, and the adverse events associated with its use in clinical trials.We searched CENTRAL, MEDLINE, and Embase for randomised controlled trials from inception to January 2017. We also searched the reference lists of retrieved studies and reviews, and online

2017 Cochrane

19. Tramadol for the management of pain in adult patients: clinical effectiveness and guidelines

Tramadol for the management of pain in adult patients: clinical effectiveness and guidelines Tramadol for the management of pain in adult patients: clinical effectiveness and guidelines Tramadol for the management of pain in adult patients: clinical effectiveness and guidelines CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH (...) . Tramadol for the management of pain in adult patients: clinical effectiveness and guidelines. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response: reference list. 2014 Authors' conclusions Four systematic reviews, 17 randomized controlled trials, seven non-randomized studies, and five evidence-based guidelines were identified regarding the use of tramadol for the management of pain in adult patients. Final publication URL Indexing Status Subject indexing assigned by CRD

2014 Health Technology Assessment (HTA) Database.

20. Tramadol

Tramadol USE OF TRAMADOL IN PREGNANCY 0344 892 0909 USE OF TRAMADOL IN PREGNANCY (Date of issue: January 2016 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Tramadol is an opioid receptor agonist with serotonergic and noradrenergic (...) activity used in the management of moderate to severe pain. The available published data concerning gestational tramadol exposure describe the outcomes of approximately 1900 exposed infants, with the majority of the data considering the risk of congenital malformation alone. Data considering the risk of other adverse pregnancy outcomes are highly limited. Data regarding malformation risk are conflicting. A large prospective population-based study identified possible associations between first trimester

2014 UK Teratology Information Service