Latest & greatest articles for tramadol

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Top results for tramadol

1. Tramadol

Tramadol Top results for tramadol - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for tramadol The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

2. Tramadol for osteoarthritis. (Abstract)

Tramadol for osteoarthritis. Tramadol is often prescribed to treat pain and is associated physical disability in osteoarthritis (OA). Due to the pharmacologic mechanism of tramadol, it may lead to fewer associated adverse effects (i.e. gastrointestinal bleeding or renal problems) compared to non-steroidal anti-inflammatory drugs (NSAIDs). This is an update of a Cochrane Review originally published in 2006.To determine the benefits and harms of oral tramadol or tramadol combined (...) with acetaminophen or NSAIDs in people with osteoarthritis.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and Embase databases, as well as the US National Institutes of Health and World Health Organization trial registries up to February 2018. We searched the LILACS database up to August 2015.We included randomized controlled trials (RCTs) that evaluated the effect of tramadol, or tramadol in combination with acetaminophen (paracetamol) or NSAIDs versus placebo or any

2019 Cochrane

4. Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis. Full Text available with Trip Pro

Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis. An American Academy of Orthopaedic Surgeons guideline recommends tramadol for patients with knee osteoarthritis, and an American College of Rheumatology guideline conditionally recommends tramadol as first-line therapy for patients with knee osteoarthritis, along with nonsteroidal anti-inflammatory drugs.To examine the association of tramadol prescription with all-cause mortality among patients (...) with osteoarthritis.Sequential, propensity score-matched cohort study at a general practice in the United Kingdom. Individuals aged at least 50 years with a diagnosis of osteoarthritis in the Health Improvement Network database from January 2000 to December 2015, with follow-up to December 2016.Initial prescription of tramadol (n = 44 451), naproxen (n = 12 397), diclofenac (n = 6512), celecoxib (n = 5674), etoricoxib (n = 2946), or codeine (n = 16 922).All-cause mortality within 1 year after initial tramadol prescription

2019 JAMA

5. "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine

"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Prescrire IN ENGLISH - Spotlight ''"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine'', 1 February 2016 {1} {1} {1} | | > > > "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |    (...) |   |   |   |   |  Spotlight "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine FEATURED REVIEW When opioid therapy is needed, there is no evidence that codeine, dihydrocodeine or tramadol is less risky than morphine at its lowest effective dose. The efficacy of these drugs varies more from one patient to another, and their multiple pharmacokinetic interactions can be difficult to manage. Weak opioids require at least

2016 Prescrire

6. Comparative pharmacology and toxicology of tramadol and tapentadol. (Abstract)

Comparative pharmacology and toxicology of tramadol and tapentadol. Moderate-to-severe pain represents a heavy burden in patients' quality of life, and ultimately in the society and in healthcare costs. The aim of this review was to summarize data on tramadol and tapentadol adverse effects, toxicity, potential advantages and limitations according to the context of clinical use. We compared data on the pharmacological and toxicological profiles of tramadol and tapentadol, after an extensive (...) literature search in the US National Library of Medicine (PubMed). Tramadol is a prodrug that acts through noradrenaline and serotonin reuptake inhibition, with a weak opioid component added by its metabolite O-desmethyltramadol. Tapentadol does not require metabolic activation and acts mainly through noradrenaline reuptake inhibition and has a strong opioid activity. Such features confer tapentadol potential advantages, namely lower serotonergic, dependence and abuse potential, more linear

2018 European Journal of Pain

7. Safety and efficacy of on-demand tramadol in patients with premature ejaculation: an updated meta-analysis

Safety and efficacy of on-demand tramadol in patients with premature ejaculation: an updated meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

8. Tramadol for the Management of Pain in Adult Patients

Tramadol for the Management of Pain in Adult Patients TITLE: Tramadol for the Management of Pain in Adult Patients: Clinical Effectiveness and Guidelines DATE: 24 October 2014 RESEARCH QUESTIONS 1. What is the clinical effectiveness of tramadol for the management of pain in adult patients? 2. What are the evidence-based guidelines regarding the use of tramadol for pain in adult patients? KEY FINDINGS Four systematic reviews, 17 randomized controlled trials, seven non-randomized studies (...) , and five evidence-based guidelines were identified regarding the use of tramadol for the management of pain in adult patients. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 10), University of York Centre for Reviews and Dissemination (CRD), Pubmed, Medline (OVID) and Embase (OVID) databases, Canadian and major international health technology agencies, as well as a focused Internet search. Methodological filters were applied

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

9. Tramadol? Think of it more as ‘Tramadont’

Tramadol? Think of it more as ‘Tramadont’ Tramadol? Think of it more as 'Tramadont' - CanadiEM Tramadol? Think of it more as ‘Tramadont’ In , by Shahbaz Syed December 13, 2017 Ok, I’ll concede that title is pretty bad, but I felt my usual name for Tramadol (Tramacrap), just didn’t seem as appropriate for a headline. Dad jokes aside, Tramadol is a synthetic opioid that entered the Canadian market in 2005, and has seen widespread uptake and use. Unfortunately, Tramadol has not been the miracle (...) drug that we anticipated it would be, as is fraught with harms. Alarmingly, despite a host of problems associated with this medication (as we will get in to), the Canadian government has yet to reclassify Tramadol as an opioid, and this has some concerning ramifications. What is Tramadol? Tramadol is a synthetic analgesic that is converted to M1 (an opioid) by the liver, as well as enhancing serotonin and norepinephrine neurotransmission – resulting in its dual action analgesic properties 1

2017 CandiEM

10. Single fixed-dose oral dexketoprofen plus tramadol for acute postoperative pain in adults. Full Text available with Trip Pro

Single fixed-dose oral dexketoprofen plus tramadol for acute postoperative pain in adults. Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and migraine headache. A new combination of dexketoprofen (a nonsteroidal anti-inflammatory drug) plus tramadol (an opioid) has been tested in acute postoperative pain (...) conditions. It is not yet licensed for use. This review is one of a series on oral analgesics for acute postoperative pain. Individual reviews have been brought together in two overviews to provide information about the relative efficacy and harm of the different interventions.To assess the analgesic efficacy and adverse effects of a single fixed-dose of oral dexketoprofen plus tramadol, compared with placebo, for moderate to severe postoperative pain in adults, using methods that permit comparison

2016 Cochrane

11. On-demand use of tramadol, sildenafil, paroxetine and local anaesthetics for the management of premature ejaculation: A randomised placebo-controlled clinical trial. Full Text available with Trip Pro

On-demand use of tramadol, sildenafil, paroxetine and local anaesthetics for the management of premature ejaculation: A randomised placebo-controlled clinical trial. To compare the clinical efficacy of the on-demand use of four drugs in the management of patients with premature ejaculation (PE), as the off-label use of selective serotonin-reuptake inhibitors and topical penile anaesthetics is frequently indicated for the management of patients with PE, and tramadol HCl and sildenafil citrate (...) were also tried for managing this disorder, but with recommendations based on weak evidence.This was a single-centre, single-blind, placebo-controlled clinical trial conducted on 150 patients who had PE for >1 year. Patients were randomised equally into five groups. On-demand tramadol, sildenafil, paroxetine, local lidocaine gel or placebo was given for patients in groups 1-5, respectively. During the month before treatment, the intravaginal ejaculation latency time (IELT) and sexual satisfaction

2015 Arab journal of urology Controlled trial quality: uncertain

12. Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update

Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update | CADTH.ca Find the information you need Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update Last updated: November 16, 2018 Project Number (...) : RC1039-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of tramadol for the management of pain in adult patients? Key Message Results of six systematic reviews (including one conventional meta-analysis and three network meta-analyses) and three individual RCTs suggest greater pain reduction and more adverse events with tramadol and tramadol combination products compared with placebo. The differences

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

14. A comparative study of oral tramadol and ibuprofen in postoperative pain in operations of lower abdomen. (Abstract)

A comparative study of oral tramadol and ibuprofen in postoperative pain in operations of lower abdomen. The objective of this study was to assess efficacy and safety of oral tramadol in postoperative pain in operations of lower abdomen as compared to oral ibuprofen. Eighty patients undergoing operations in the lower abdomen under spinal anaesthesia were randomly assigned to two parallel groups--ibuprofen 400 mg thrice daily and tramadol 100 mg thrice daily, both orally after food. Treatment (...) was given single-blind for 5 days in the postoperative period. Patient's perception of pain scored byvisual analogue scale (VAS) and wound tenderness assessed by a 3-point ordinal scale were the primary efficacy parameters. A steady decline in VAS pain score from baseline to study end (99.7 +/- 2.75 to 54.4 +/- 9.71 in the ibuprofen group and 97.3 +/- 3.14 to 52.5 +/- 9.95 in tramadol group) indicated good analgesic efficacy in both groups. Within groups, comparisons showed highly significant difference

2011 Journal of the Indian Medical Association Controlled trial quality: uncertain

15. Comparison of Intravenous Infusion of Tramadol Alone with Combination of Tramadol and Paracetamol for Postoperative Pain after Major Abdominal Surgery in Children. Full Text available with Trip Pro

Comparison of Intravenous Infusion of Tramadol Alone with Combination of Tramadol and Paracetamol for Postoperative Pain after Major Abdominal Surgery in Children. Pain is a common complaint after surgery and seems to be difficult to manage in children because of fear of complications of pain treatment or misconception that infants and small children do not feel pain at all or feel less pain. A survey reported that 40% of pediatric surgical patients experienced moderate or severe postoperative (...) pain and that more than 75% had insufficient analgesia. Our study was carried to provide continuous infusion of intravenous (i.v.) tramadol alone using a dedicated infusion device Graseby 2100 syringe pump and compared it to a combination of i.v. tramadol infusion and per rectal paracetamol.A total of 124 children aged 1-8 years selected for the study were randomized into two groups using a table of random numbers. Power calculation had suggested a sample size of 62 in each group with a power of 80

2019 Anesthesia, essays and researches Controlled trial quality: uncertain

16. From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care. (Abstract)

From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care. More than 15,000 children die annually in the United States due to an underlying life-limiting disease and the majority of those children experience distressing symptoms, which are not adequately relieved, such as pain and dyspnea. Multimodal analgesia, that is multiple agents, interventions, rehabilitation, psychological modalities, and integrative (nonpharmacologic) therapies, act (...) opioids: tramadol and methadone.Methadone, due to its multimechanistic action profile, is possibly among the most effective and most underutilized opioid analgesics in children with severe unrelieved pain at end of life. However, methadone should not be prescribed by those unfamiliar with its use: Its effects should be closely monitored for several days, particularly when it is first started and after any dose changes.Tramadol appears to play a key role in treating episodes of inconsolability

2019 Clinical Journal of Pain

17. Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness

Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness | CADTH.ca Find the information you need Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Published on: November 3, 2015 Project Number: RB0927-000 Product Line (...) : Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients? Key Message Two randomized controlled trials and four non-randomized studies were identified regarding the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients. Tags acetaminophen, anesthesia, paracetamol, tramadol, Tramacet Files Rapid Response Summary of Abstracts

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

18. A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers. (Abstract)

A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers. Combination therapy of pregabalin and tramadol is used to treat chronic neuropathic pain; however, the pharmacokinetic (PK) interactions of these drugs has not been studied. This study aimed to evaluate PK interactions between pregabalin and tramadol and the safety of combination therapy.A randomized, open-label, multiple-dose, three-treatment, three-period, six-sequence cross-over study (...) was conducted in healthy subjects. All subjects received the following three treatments for 4 days in each period: pregabalin 150 mg twice daily; tramadol extended-release (ER) 200 mg in the morning, and 100 mg in the evening; and co-administration of pregabalin 150 mg and tramadol ER 200 mg in the morning, and pregabalin 150 mg and tramadol ER 100 mg in the evening.A total of 21 subjects completed the study with no clinically significant safety issues. For pregabalin, the geometric mean ratio (GMR) (90% CI

2018 European journal of clinical pharmacology Controlled trial quality: uncertain

19. Postoperative analgesia using bupivacaine wound infiltration with intravenous tramadol or dexamethasone following obstetric spinal anaesthesia. (Abstract)

Postoperative analgesia using bupivacaine wound infiltration with intravenous tramadol or dexamethasone following obstetric spinal anaesthesia. Effective management of postcesarean section (CS) pain is important for the well-being of mother and child; even in limited-resource areas, there are drug options which can be explored to achieve this.This study aimed to compare the analgesic effects of a combination of bupivacaine wound infiltration with either intravenous (IV) dexamethasone (...) or tramadol after CS.This study was a randomized, double-blind, comparative study in a tertiary hospital. Clearance obtained from the Institution's Ethics and Research Committee.One hundred and twenty American Society of Anesthesiologists I or II pregnant women scheduled for CS under spinal anesthesia were recruited after giving consent. At the end of skin closure, all the patients received 20 ml of 0.1% plain bupivacaine for wound infiltration and IV dexamethasone 8 mg (Group BD) or tramadol 100 mg

2018 Nigerian journal of clinical practice Controlled trial quality: uncertain

20. Effectiveness and safety of tramadol in the treatment of patients with fibromyalgia: systematic review

Effectiveness and safety of tramadol in the treatment of patients with fibromyalgia: systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web

2017 PROSPERO