Latest & greatest articles for tramadol

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Top results for tramadol

1. Tramadol for osteoarthritis. (PubMed)

Tramadol for osteoarthritis. Tramadol is often prescribed to treat pain and is associated physical disability in osteoarthritis (OA). Due to the pharmacologic mechanism of tramadol, it may lead to fewer associated adverse effects (i.e. gastrointestinal bleeding or renal problems) compared to non-steroidal anti-inflammatory drugs (NSAIDs). This is an update of a Cochrane Review originally published in 2006.To determine the benefits and harms of oral tramadol or tramadol combined (...) with acetaminophen or NSAIDs in people with osteoarthritis.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and Embase databases, as well as the US National Institutes of Health and World Health Organization trial registries up to February 2018. We searched the LILACS database up to August 2015.We included randomized controlled trials (RCTs) that evaluated the effect of tramadol, or tramadol in combination with acetaminophen (paracetamol) or NSAIDs versus placebo or any

2019 Cochrane

2. Chronic use of tramadol after acute pain episode: cohort study. (PubMed)

Chronic use of tramadol after acute pain episode: cohort study. To determine the risk of prolonged opioid use in patients receiving tramadol compared with other short acting opioids.Observational study of administrative claims data.United States commercial and Medicare Advantage insurance claims (OptumLabs Data Warehouse) January 1, 2009 through June 30, 2018.Opioid-naive patients undergoing elective surgery.Risk of persistent opioid use after discharge for patients treated with tramadol alone (...) patients who met the inclusion criteria, 357 884 filled a discharge prescription for one or more opioids associated with one of 20 included operations. The most commonly prescribed post-surgery opioid was hydrocodone (53.0% of those filling a single opioid), followed by short acting oxycodone (37.5%) and tramadol (4.0%). The unadjusted risk of prolonged opioid use after surgery was 7.1% (n=31 431) with additional opioid use, 1.0% (n=4457) with persistent opioid use, and 0.5% (n=2027) meeting

2019 BMJ

3. Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis. (PubMed)

Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis. An American Academy of Orthopaedic Surgeons guideline recommends tramadol for patients with knee osteoarthritis, and an American College of Rheumatology guideline conditionally recommends tramadol as first-line therapy for patients with knee osteoarthritis, along with nonsteroidal anti-inflammatory drugs.To examine the association of tramadol prescription with all-cause mortality among patients (...) with osteoarthritis.Sequential, propensity score-matched cohort study at a general practice in the United Kingdom. Individuals aged at least 50 years with a diagnosis of osteoarthritis in the Health Improvement Network database from January 2000 to December 2015, with follow-up to December 2016.Initial prescription of tramadol (n = 44 451), naproxen (n = 12 397), diclofenac (n = 6512), celecoxib (n = 5674), etoricoxib (n = 2946), or codeine (n = 16 922).All-cause mortality within 1 year after initial tramadol prescription

2019 JAMA

4. Patient-controlled intravenous tramadol versus patient-controlled intravenous hydromorphone for analgesia after secondary cesarean delivery: a randomized controlled trial to compare analgesic, anti-anxiety and anti-depression effects

Patient-controlled intravenous tramadol versus patient-controlled intravenous hydromorphone for analgesia after secondary cesarean delivery: a randomized controlled trial to compare analgesic, anti-anxiety and anti-depression effects This study aimed to compare the postoperative analgesic effects of tramadol and hydromorphone for secondary cesarean delivery (CD) as well as their anti-anxiety and anti-depression properties.A total of 106 patients receiving secondary CD under spinal anesthesia (...) were randomly allocated to the tramadol group (n=53) and the hydromorphone group (n=53). Each group received patient-controlled intravenous analgesia using flurbiprofen 4 mg/kg combined with tramadol (4 mg/kg) or hydromorphone (0.04 mg/kg) immediately after the surgery. Postoperative pain numerical rating scale (NRS) for incision and visceral pain, hospital anxiety and depression scale (HADS), early walking time and length of hospital stay were assessed.Patients in the tramadol and hydromorphone

2019 EvidenceUpdates

5. Tramadol in dentistry: is it effective as a local anesthetic? A systematic review

Tramadol in dentistry: is it effective as a local anesthetic? A systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

6. Safety and efficacy of on-demand tramadol in patients with premature ejaculation: an updated meta-analysis

Safety and efficacy of on-demand tramadol in patients with premature ejaculation: an updated meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

7. The efficacy and safety of analgesia by using local infiltration of tramadol, during tonsillectomy and adenotonsillectomy in children: a systematic review and meta-analysis of randomized controlled trials

The efficacy and safety of analgesia by using local infiltration of tramadol, during tonsillectomy and adenotonsillectomy in children: a systematic review and meta-analysis of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

8. Tramadol versus placebo or no intervention for pain: a systematic review with meta-analysis and trial sequential analysis

Tramadol versus placebo or no intervention for pain: a systematic review with meta-analysis and trial sequential analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

9. Tramadol

Tramadol Top results for tramadol - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for tramadol The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

12. Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update

Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update | CADTH.ca Find the information you need Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update Last updated: November 16, 2018 Project Number (...) : RC1039-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of tramadol for the management of pain in adult patients? Key Message Results of six systematic reviews (including one conventional meta-analysis and three network meta-analyses) and three individual RCTs suggest greater pain reduction and more adverse events with tramadol and tramadol combination products compared with placebo. The differences

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Tramadol? Think of it more as ‘Tramadont’

Tramadol? Think of it more as ‘Tramadont’ Tramadol? Think of it more as 'Tramadont' - CanadiEM Tramadol? Think of it more as ‘Tramadont’ In , by Shahbaz Syed December 13, 2017 Ok, I’ll concede that title is pretty bad, but I felt my usual name for Tramadol (Tramacrap), just didn’t seem as appropriate for a headline. Dad jokes aside, Tramadol is a synthetic opioid that entered the Canadian market in 2005, and has seen widespread uptake and use. Unfortunately, Tramadol has not been the miracle (...) drug that we anticipated it would be, as is fraught with harms. Alarmingly, despite a host of problems associated with this medication (as we will get in to), the Canadian government has yet to reclassify Tramadol as an opioid, and this has some concerning ramifications. What is Tramadol? Tramadol is a synthetic analgesic that is converted to M1 (an opioid) by the liver, as well as enhancing serotonin and norepinephrine neurotransmission – resulting in its dual action analgesic properties 1

2017 CandiEM

14. Tramadol for neuropathic pain in adults. (PubMed)

Tramadol for neuropathic pain in adults. This review is an update of a review of tramadol for neuropathic pain, published in 2006; updating was to bring the review in line with current standards. Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Peripheral neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity (...) to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the peripheral nervous system.To assess the analgesic efficacy of tramadol compared with placebo or other active interventions for chronic neuropathic pain in adults, and the adverse events associated with its use in clinical trials.We searched CENTRAL, MEDLINE, and Embase for randomised controlled trials from inception to January 2017. We also searched the reference lists of retrieved studies and reviews, and online

2017 Cochrane

15. Tramadol with or without paracetamol (acetaminophen) for cancer pain. (Full text)

Tramadol with or without paracetamol (acetaminophen) for cancer pain. Tramadol is an opioid analgesic licensed for use in moderate to severe pain. It is considered as a low risk for abuse, so control regulations are not as stringent as for 'strong' opioids such as morphine. It has a potential role as a step 2 option of the World Health Organization (WHO) analgesic ladder.To assess the benefits and adverse effects of tramadol with or without paracetamol (acetaminophen) for cancer-related pain.We (...) participants. All the studies enrolled participants with chronic malignant tumour-related pain who were experiencing pain intensities described as moderate to severe, with most experiencing at least 4/10 with current treatment. The mean ages were 59 to 70 years, with participants aged between 24 and 87 years. Study length ranged from one day to six months. Five studies used a cross-over design. Tramadol doses ranged from 50 mg as single dose to 600 mg per day; doses of 300 mg per day to 400 mg per day were

2017 Cochrane PubMed

16. Impact of tramadol and morphine abuse on the activities of acetylcholine esterase, Na+/K+-ATPase and related parameters in cerebral cortices of male adult rats (Full text)

Impact of tramadol and morphine abuse on the activities of acetylcholine esterase, Na+/K+-ATPase and related parameters in cerebral cortices of male adult rats To determine the effect of the most commonly abused drugs (tramadol and morphine), on acetylcholine esterase (AChE), Na+/K+-ATPase activities and related parameters, Na+ and K+ as biomarkers of neurotoxicity.Tramadol - as a weak μ opioid receptor agonist- and morphine - as opiate analgesic drugs, were chosen for the present study. Four (...) series of experimental animals were conducted for either tramadol or morphine: control series; repeated single equal doses (therapeutic dose) series; cumulative increasing doses series and delay (withdrawal) series (96 hours withdrawal period after last administration), at time period intervals 7, 14 and 21 days. Acetylcholine esterase (AChE), Na+/K+-ATPase activities and related parameters, Na+ and K+ were measured in cerebral cortices of experimental rats.Acetylcholine esterase (AChE) activity

2017 Electronic physician PubMed

18. Single fixed-dose oral dexketoprofen plus tramadol for acute postoperative pain in adults. (Full text)

Single fixed-dose oral dexketoprofen plus tramadol for acute postoperative pain in adults. Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and migraine headache. A new combination of dexketoprofen (a nonsteroidal anti-inflammatory drug) plus tramadol (an opioid) has been tested in acute postoperative pain (...) conditions. It is not yet licensed for use. This review is one of a series on oral analgesics for acute postoperative pain. Individual reviews have been brought together in two overviews to provide information about the relative efficacy and harm of the different interventions.To assess the analgesic efficacy and adverse effects of a single fixed-dose of oral dexketoprofen plus tramadol, compared with placebo, for moderate to severe postoperative pain in adults, using methods that permit comparison

2016 Cochrane PubMed

19. "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine

"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Prescrire IN ENGLISH - Spotlight ''"Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine'', 1 February 2016 {1} {1} {1} | | > > > "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |    (...) |   |   |   |   |  Spotlight "Weak" opioid analgesics: codeine, dihydrocodeine and tramadol are no less risky than morphine FEATURED REVIEW When opioid therapy is needed, there is no evidence that codeine, dihydrocodeine or tramadol is less risky than morphine at its lowest effective dose. The efficacy of these drugs varies more from one patient to another, and their multiple pharmacokinetic interactions can be difficult to manage. Weak opioids require at least

2016 Prescrire

20. Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness

Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness | CADTH.ca Find the information you need Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Published on: November 3, 2015 Project Number: RB0927-000 Product Line (...) : Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients? Key Message Two randomized controlled trials and four non-randomized studies were identified regarding the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients. Tags acetaminophen, anesthesia, paracetamol, tramadol, Tramacet Files Rapid Response Summary of Abstracts

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review