Latest & greatest articles for tiotropium

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Top results for tiotropium

1. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. (PubMed)

Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. In many patients with mild, persistent asthma, the percentage of eosinophils in sputum is less than 2% (low eosinophil level). The appropriate treatment for these patients is unknown.In this 42-week, double-blind, crossover trial, we assigned 295 patients who were at least 12 years of age and who had mild, persistent asthma to receive mometasone (an inhaled glucocorticoid), tiotropium (a long-acting muscarinic (...) antagonist), or placebo. The patients were categorized according to the sputum eosinophil level (<2% or ≥2%). The primary outcome was the response to mometasone as compared with placebo and to tiotropium as compared with placebo among patients with a low sputum eosinophil level who had a prespecified differential response to one of the trial agents. The response was determined according to a hierarchical composite outcome that incorporated treatment failure, asthma control days, and the forced expiratory

2019 NEJM Controlled trial quality: predicted high

2. Dual bronchodilation with tiotropium/olodaterol further reduces activity-related breathlessness versus tiotropium alone in COPD

Dual bronchodilation with tiotropium/olodaterol further reduces activity-related breathlessness versus tiotropium alone in COPD The 3-min constant speed shuttle test (CSST) was used to examine the effect of tiotropium/olodaterol compared with tiotropium at reducing activity-related breathlessness in patients with chronic obstructive pulmonary disease (COPD).This was a randomised, double-blind, two-period crossover study including COPD patients with moderate to severe pulmonary impairment, lung (...) hyperinflation at rest and a Mahler Baseline Dyspnoea Index <8. Patients received 6 weeks of tiotropium/olodaterol 5/5 µg and tiotropium 5 µg in a randomised order with a 3-week washout period. The speed for the 3-min CSST was determined for each patient such that an intensity of breathing discomfort ≥4 ("somewhat severe") on the modified Borg scale was reached at the end of a completed 3-min CSST.After 6 weeks, there was a decrease in the intensity of breathlessness (Borg dyspnoea score) at the end of the 3

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2019 EvidenceUpdates

3. Tiotropium (Spiriva Respimat) - as add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma who experienced one or more severe asthma exacerbations in the preceding year

Tiotropium (Spiriva Respimat) - as add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma who experienced one or more severe asthma exacerbations in the preceding year Published 14 January 2019 www.scottishmedicines.org.uk Product update SMC2118 tiotropium 2.5 microgram solution for inhalation (Spiriva® Respimat®) Boehringer Ingelheim Limited 7 December 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product (...) and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated submission tiotropium (Spiriva® Respimat®) is accepted for use within NHSScotland. Indication under review: as add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma who experienced one or more severe asthma exacerbations in the preceding year. Tiotropium has previously been accepted for use

2019 Scottish Medicines Consortium

4. Effect and safety of tiotropium in early-stage chronic obstructive pulmonary disease: systematic review and meta-analysis

Effect and safety of tiotropium in early-stage chronic obstructive pulmonary disease: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

5. The efficacy of tiotropium bromide and formoterol (TBF) for the treatment of patients with chronic obstructive pulmonary disease (COPD): a systematic review protocol

The efficacy of tiotropium bromide and formoterol (TBF) for the treatment of patients with chronic obstructive pulmonary disease (COPD): a systematic review protocol Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

6. Tiotropium (Spiriva Respimat) add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma

Tiotropium (Spiriva Respimat) add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma Tiotropium (Spiriva ® Respimat ® ). Reference number 1882. Page 1 of 3 AWMSG Secretariat Assessment Report – Limited submission Tiotropium (Spiriva ® Respimat ® ) 2.5 microgram, inhalation solution Company: Boehringer Ingelheim Ltd Licensed indication under consideration: add-on maintenance bronchodilator treatment in patients aged 6 years to < 18 years with severe (...) asthma who experienced one or more severe asthma exacerbations in the preceding year Date of licence extension: 12 April 2018 Comparator(s) The company stated that there is no comparator and that tiotropium (Spiriva ® Respimat ® ) is an add-on treatment. Limited submission details ? The limited submission criteria were met based on a minor licence extension. Clinical effectiveness ? Tiotropium (Spiriva ® Respimat ® ) was recommended by the All Wales Medicines Strategy Group in 2017 as an add

2018 All Wales Medicines Strategy Group

7. Tiotropium

Tiotropium Top results for tiotropium - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for tiotropium The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you

2018 Trip Latest and Greatest

8. Braltus (tiotropium): risk of inhalation of capsule if placed in the mouthpiece of the inhaler

Braltus (tiotropium): risk of inhalation of capsule if placed in the mouthpiece of the inhaler Braltus (tiotropium): risk of inhalation of capsule if placed in the mouthpiece of the inhaler - GOV.UK GOV.UK uses cookies to make the site simpler. Search Braltus (tiotropium): risk of inhalation of capsule if placed in the mouthpiece of the inhaler Train patients to place the Braltus capsule in the correct chamber of the Zonda inhaler. We have received reports of patients who have inhaled a Braltus (...) in the inhaler) and to always check the mouthpiece is clear before inhaling pharmacists dispensing Braltus capsules should remind patients to always read the in the package leaflet and that they must never place a capsule directly into the mouthpiece please continue to report adverse incidents during use of the inhaler as well as suspected adverse reactions to the medicine on a Background Braltus tiotropium 10 µg per delivered dose inhalation powder is a once-a-day maintenance bronchodilator treatment

2018 MHRA Drug Safety Update

9. General medicine: Tiotropium could provide benefits in the early stage of COPD, but further studies are needed

General medicine: Tiotropium could provide benefits in the early stage of COPD, but further studies are needed Tiotropium could provide benefits in the early stage of COPD, but further studies are needed | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Tiotropium could provide benefits in the early stage of COPD, but further studies are needed Article Text Commentary General medicine Tiotropium could provide benefits in the early stage

2018 Evidence-Based Medicine (Requires free registration)

10. Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease. (PubMed)

Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease. Patients with mild or moderate chronic obstructive pulmonary disease (COPD) rarely receive medications, because they have few symptoms. We hypothesized that long-term use of tiotropium would improve lung function and ameliorate the decline in lung function in patients with mild or moderate COPD.In a multicenter, randomized, double-blind, placebo-controlled trial that was conducted in China, we randomly assigned 841 patients (...) with COPD of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1 (mild) or 2 (moderate) severity to receive a once-daily inhaled dose (18 μg) of tiotropium (419 patients) or matching placebo (422) for 2 years. The primary end point was the between-group difference in the change from baseline to 24 months in the forced expiratory volume in 1 second (FEV1) before bronchodilator use. Secondary end points included the between-group difference in the change from baseline to 24 months

2017 NEJM Controlled trial quality: predicted high

11. Spiolto Respimat (tiotropium/olodaterol) - chronic obstructive pulmonary disease (COPD)

Spiolto Respimat (tiotropium/olodaterol) - chronic obstructive pulmonary disease (COPD) Spiolto Respimat® (tiotropium/olodaterol) × Insert searchphrase to search the website Insert searchphrase to search the website > > > Spiolto Respimat® (tiotropium/olodaterol) Conclusion Spiolto Respimat® (tiotropium/olodaterol) combines a long-acting muscarinic antagonist (LAMA) with a long-acting beta agonist (LABA) and is approved for maintenance bronchodilator treatment to relieve symptoms in adult (...) patients with chronic obstructive pulmonary disease (COPD). The LAMA component, tiotropium (Spiriva®), and the LABA component, olodaterol (Striverdi®), each have the same indication as Spiolto Respimat®. Despite statistically significant differences in several patient-specific measures of effectiveness (e.g. quality of life) favouring Spiolto Respimat® over the individual components, the efficacy is assessed to have limited clinical relevance in patients not yet started on relevant symptom-alleviating

2017 Danish Pharmacotherapy Reviews

12. Effects of combined tiotropium/olodaterol on inspiratory capacity and exercise endurance in COPD

Effects of combined tiotropium/olodaterol on inspiratory capacity and exercise endurance in COPD Two replicate, double-blind, 6-week, incomplete-crossover studies (MORACTO 1 and 2) assessed the effects of tiotropium/olodaterol on inspiratory capacity and exercise endurance time in patients with moderate to severe chronic obstructive pulmonary disease.For each patient, four of five treatments were administered once daily for 6 weeks, with a 21-day washout between treatments: tiotropium (...) /olodaterol 2.5/5 µg or 5/5 µg, tiotropium 5 µg, olodaterol 5 µg or placebo, all via the Respimat inhaler. Primary outcomes were inspiratory capacity prior to exercise and exercise endurance time during constant work-rate cycle ergometry to symptom limitation at 75% of peak incremental work rate after 6 weeks (2 h post-dose).295 and 291 patients were treated in MORACTO 1 and 2, respectively. Tiotropium/olodaterol 2.5/5 and 5/5 µg provided significant improvements in inspiratory capacity versus placebo

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2017 EvidenceUpdates

13. A randomised controlled trial of tiotropium in adolescents with severe symptomatic asthma

A randomised controlled trial of tiotropium in adolescents with severe symptomatic asthma We present results from the first phase III trial of once-daily tiotropium add-on to inhaled corticosteroids (ICS) plus one or more controller therapies in adolescents with severe symptomatic asthma.In this double-blind, parallel-group trial (NCT01277523), 392 patients aged 12-17 years were randomised to receive once-daily tiotropium 5 µg or 2.5 µg, or placebo, as an add-on to ICS plus other controller (...) therapies over 12 weeks. The primary and key secondary end-points were change from baseline (response) in peak forced expiratory volume in 1 s (FEV1) within 3 h post-dosing (FEV1(0-3h)) and trough FEV1, respectively, after 12 weeks of treatment.Tiotropium 5 µg provided numerical improvements in peak FEV1(0-3h) response, compared with placebo (90 mL; p=0.104), and significant improvements were observed with tiotropium 2.5 µg (111 mL; p=0.046). Numerical improvements in trough FEV1 response and asthma

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2017 EvidenceUpdates

14. Tiotropium/olodaterol - Addendum

Tiotropium/olodaterol - Addendum 1 Translation of addendum A15-57 Tiotropium/Olodaterol – Addendum zum Auftrag A15-31 (Version 1.0; Status: 14 January 2016). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Addendum 14 January 2016 1.0 Commission: A15-57 Version: Status: IQWiG Reports – Commission No. A15-57 Tiotropium/olodaterol – Addendum to Commission A15-31 1 (...) Addendum A15-57 Version 1.0 Tiotropium/olodaterol – Addendum to Commission A15-31 14 January 2016 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Tiotropium/olodaterol – Addendum to Commission A15-31 Commissioning agency: Federal Joint Committee Commission awarded on: 22 December 2015 Internal Commission No.: A15-57 Address of publisher: Institut für Qualität und Wirtschaftlichkeit im

2016 Institute for Quality and Efficiency in Healthcare (IQWiG)

15. Combination inhaled steroid and long-acting beta₂-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease. (PubMed)

Combination inhaled steroid and long-acting beta₂-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease. The long-acting bronchodilator tiotropium and single-inhaler combination therapy of inhaled corticosteroids and long-acting beta2-agonists (ICS/LABA) are commonly used for maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). Combining these treatments, which have different mechanisms of action, may (...) be more effective than administering the individual components.To assess relative effects of the following treatments on markers of exacerbations, symptoms, quality of life and lung function in patients with COPD.• Tiotropium plus LABA/ICS versus tiotropium.• Tiotropium plus LABA/ICS versus LABA/ICS.We searched the Cochrane Airways Group Specialised Register of Trials (April 2015), ClinicalTrials.gov (www.ClinicalTrials.gov), the World Health Organization (WHO) trials portal and reference lists

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2016 Cochrane

16. [Tiotropium/olodaterol - addendum to commission A15-31]

[Tiotropium/olodaterol - addendum to commission A15-31] Tiotropium/olodaterol: addendum zum auftrag A15-31; auftrag A15-57 [Tiotropium/olodaterol - addendum to commission A15-31] Tiotropium/olodaterol: addendum zum auftrag A15-31; auftrag A15-57 [Tiotropium/olodaterol - addendum to commission A15-31] Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. Tiotropium/olodaterol: addendum zum auftrag A15-31; auftrag A15-57. [Tiotropium/olodaterol - addendum to commission A15-31] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 358. 2016 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Benzoxazines; Bronchodilator Agents; Humans; Scopolamine

2016 Health Technology Assessment (HTA) Database.

17. Chronic obstructive pulmonary disease: tiotropium/olodaterol (Spiolto Respimat)

Chronic obstructive pulmonary disease: tiotropium/olodaterol (Spiolto Respimat) Chronic obstructiv Chronic obstructive pulmonary disease: e pulmonary disease: tiotropium/olodaterol (Spiolto Respimat) tiotropium/olodaterol (Spiolto Respimat) Evidence summary Published: 10 May 2016 nice.org.uk/guidance/esnm72 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in May 2016. See summaries of product characteristics (SPCs (...) ), British national formulary (BNF) or the MHRA or NICE websites for up- to-date information. Summary Compared with its individual mono-components, a combination of tiotropium/olodaterol (Spiolto Respimat) has shown statistically significant improvements in lung function and health-related quality of life outcomes, although the clinical relevance of these improvements is unclear. There are no published studies which directly compare the efficacy and safety of tiotropium/olodaterol with other long-acting

2016 National Institute for Health and Clinical Excellence - Advice

18. Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial (PubMed)

Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial Results from phase III clinical trials in adults and phase II clinical trials in children and adolescents demonstrate that tiotropium is an effective treatment when added to inhaled corticosteroid (ICS) maintenance therapy.We sought to assess the efficacy and safety of once-daily tiotropium Respimat added to ICSs with or without a leukotriene receptor antagonist in a phase III trial in adolescent (...) patients with moderate symptomatic asthma.In this 48-week, double-blind, placebo-controlled, parallel-group study, 398 patients aged 12 to 17 years were randomized to receive 5 μg (2 puffs of 2.5 μg) or 2.5 μg (2 puffs of 1.25 μg) of once-daily tiotropium or placebo (2 puffs) administered through the Respimat device every evening, each as add-on treatment to ICS background therapy, with or without a leukotriene receptor antagonist; long-acting β2-agonist therapy was not permitted during

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2016 EvidenceUpdates Controlled trial quality: predicted high

19. [Tiotropium/olodaterol: benefit assessment according to §35a Social Code Book V (dossier assessment)]

[Tiotropium/olodaterol: benefit assessment according to §35a Social Code Book V (dossier assessment)] Tiotropium/olodaterol – nutzenbewertung gemäß § 35a SGB V [Tiotropium/olodaterol: benefit assessment according to §35a Social Code Book V (dossier assessment)] Tiotropium/olodaterol – nutzenbewertung gemäß § 35a SGB V [Tiotropium/olodaterol: benefit assessment according to §35a Social Code Book V (dossier assessment)] IQWiG Record Status This is a bibliographic record of a published health (...) technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Tiotropium/olodaterol – nutzenbewertung gemäß § 35a SGB V. [Tiotropium/olodaterol: benefit assessment according to §35a Social Code Book V (dossier assessment)] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 337. 2015 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Benzoxazines

2016 Health Technology Assessment (HTA) Database.

20. Long-acting beta2-agonist in addition to tiotropium versus either tiotropium or long-acting beta2-agonist alone for chronic obstructive pulmonary disease. (PubMed)

Long-acting beta2-agonist in addition to tiotropium versus either tiotropium or long-acting beta2-agonist alone for chronic obstructive pulmonary disease. Long-acting bronchodilators, comprising long-acting beta2-agonists (LABA) and long-acting anti-muscarinic agents (LAMA, principally tiotropium), are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease (COPD). Combining these treatments, which have different mechanisms of action, may be more effective than (...) the individual components. However, the benefits and risks of combining tiotropium and LABAs for the treatment of COPD are unclear.To compare the relative effects on markers of quality of life, exacerbations, symptoms, lung function and serious adverse events in people with COPD randomised to LABA plus tiotropium versus tiotropium alone; or LABA plus tiotropium versus LABA alone.We searched the Cochrane Airways Group Specialised Register of trials and ClinicalTrials.gov up to July 2015.We included parallel

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2015 Cochrane