Latest & greatest articles for thyroid

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Top results for thyroid

161. Lenvima (lenvatinib) - To treat patients with progressive, differentiated thyroid cancer (DTC) whose disease progressed despite receiving radioactive iodine therapy (radioactive iodine refractory disease)

Lenvima (lenvatinib) - To treat patients with progressive, differentiated thyroid cancer (DTC) whose disease progressed despite receiving radioactive iodine therapy (radioactive iodine refractory disease) Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Enter Search terms Drug Approval Package - LENVIMA (lenvatinib) Capsules Company: Eisai, Inc. Application No.: 206947 Approval Date: 2/13/2015 Persons with disabilities having problems

FDA - Drug Approval Package2015

162. Vandetanib (Caprelsa) for locally advanced or metastatic differentiated thyroid cancer - second line

Vandetanib (Caprelsa) for locally advanced or metastatic differentiated thyroid cancer - second line Vandetanib (Caprelsa) for locally advanced or metastatic differentiated thyroid cancer – second line Vandetanib (Caprelsa) for locally advanced or metastatic differentiated thyroid cancer – second line NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation (...) NIHR HSRIC. Vandetanib (Caprelsa) for locally advanced or metastatic differentiated thyroid cancer – second line. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2015 Authors' objectives Vandetanib is a potent inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), epidermal growth factor receptor (EGFR) and RET tyrosine kinases. Vandetanib inhibits VEGF stimulated endothelial cell migration, proliferation, survival and new blood vessel

Health Technology Assessment (HTA) Database.2015

163. Thyroid Disease in Pregnancy

Thyroid Disease in Pregnancy Sign In (ACOG) Sign in to your ACOG account Email is required. Please enter valid Email. was not found in our system. Would you like to associated with your account? Forgot your email address? JSOG Member? © 2018 - American College of Obstetricians and Gynecologists

American College of Obstetricians and Gynecologists2015

164. Thyroid Dysfunction: Screening

Thyroid Dysfunction: Screening Final Update Summary: Thyroid Dysfunction: Screening - US Preventive Services Task Force Search USPSTF Website Text size: Assembly version: 1.0.0.308 Last Build: 3/6/2018 4:20:40 PM You are here: Final Summary Thyroid Dysfunction: Screening Release Date: March 2015 Recommendation Summary Population Recommendation Grade Nonpregnant, asymptomatic adults The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms (...) of screening for thyroid dysfunction in nonpregnant, asymptomatic adults. See the for suggestions for practice regarding the I statement. ( ) Related Information for Consumers Related Information for Health Professionals There is no related information for health professionals. Supporting Documents ( ) ( ) Clinical Summary Clinical summaries are one-page documents that provide guidance to primary care clinicians for using recommendations in practice. This summary is intended for use by primary

U.S. Preventive Services Task Force2015

165. Application of Texture Analysis Method for Classification of Benign and Malignant Thyroid Nodules in Ultrasound Images

Application of Texture Analysis Method for Classification of Benign and Malignant Thyroid Nodules in Ultrasound Images 25960851 2015 05 11 2015 05 11 2017 02 20 2008-2398 8 2 2015 Mar-Apr Iranian journal of cancer prevention Iran J Cancer Prev Application of texture analysis method for classification of benign and malignant thyroid nodules in ultrasound images. 116-24 The aim of this study was to evaluate computer aided diagnosis (CAD) system with texture analysis (TA) to improve radiologists (...) ' accuracy in identification of thyroid nodules as malignant or benign. A total of 70 cases (26 benign and 44 malignant) were analyzed in this study. We extracted up to 270 statistical texture features as a descriptor for each selected region of interests (ROIs) in three normalization schemes (default, 3s and 1%-99%). Then features by the lowest probability of classification error and average correlation coefficients (POE+ACC), and Fisher coefficient (Fisher) eliminated to 10 best and most effective

Iranian journal of cancer prevention2015 Full Text: Link to full Text with Trip Pro

166. Response and acquired resistance to everolimus in anaplastic thyroid cancer.

Response and acquired resistance to everolimus in anaplastic thyroid cancer. Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is effective in treating tumors harboring alterations in the mTOR pathway. Mechanisms of resistance to everolimus remain undefined. Resistance developed in a patient with metastatic anaplastic thyroid carcinoma after an extraordinary 18-month response. Whole-exome sequencing of pretreatment and drug-resistant tumors revealed a nonsense mutation

NEJM2014 Full Text: Link to full Text with Trip Pro

167. Management of Thyroid Cancer

Management of Thyroid Cancer CLINICAL ENDOCRINOLOGY VOLUME 81 SUPPLEMENT 1 JULY 2014 THE CLINICAL JOURNAL OF THE SOCIETY FOR ENDOCRINOLOGY AND THE ENDOCRINE SOCIETY OF AUSTRALIA British Thyroid Association Guidelines for the Management of Thyroid CancerGuidelines for the management of thyroid cancer Third edition British Thyroid Association July 2014 Perros P, Colley S, Boelaert K, Evans C, Evans RM, Gerrard GE, Gilbert JA, Harrison B, Johnson SJ, Giles TE, Moss L, Lewington V , Newbold KL (...) , Taylor J, Thakker RV , Watkinson J, Williams GR cen_frontmatter.indd i cen_frontmatter.indd i 6/27/2014 3:52:19 PM 6/27/2014 3:52:19 PMii Acknowledgements Grateful thanks are expressed to the many reviewers of these guidelines. These included leading international experts in thyroid cancer, hospital specialists, and general practitioners. They devoted much time and care to considering the document and their recommendations and suggestions for improvements were most valuable. Special thanks to Dr

British Association of Endocrine and Thyroid Surgeons2014

168. miRInform Thyroid

miRInform Thyroid miRInform Thyroid miRInform Thyroid Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation miRInform Thyroid. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2014 Authors' objectives Thyroid nodules are discrete masses present in the thyroid gland that are a common clinical finding among adults in the general population. Approximately (...) 5% of women and 1% of men have a palpable thyroid nodule on physical examination. The evaluation of thyroid nodules, which may represent benign lesions or malignant thyroid tumors, typically includes a cytopathologic examination of a biopsy specimen obtained by fine-needle aspiration (FNA). Thyroid nodules are subsequently classified based on cytology, with 70% to 75% of nodules being benign and approximately 5% being malignant. Approximately 20% to 25% of thyroid nodules are classified

Health Technology Assessment (HTA) Database.2014

169. A thyroid mass that moves with tongue protrusion: An ectopic thyroid gland

A thyroid mass that moves with tongue protrusion: An ectopic thyroid gland 25883768 2015 04 17 2015 04 17 2017 02 20 1985-207X 9 2 2014 Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia Malays Fam Physician A thyroid mass that moves with tongue protrusion: An ectopic thyroid gland. 61-3 Thyroglossal duct cyst (TDC) is a developmental anomaly that usually appears in early childhood. The common presentation is midline swelling of the neck, which (...) moves with both tongue protrusion and deglutition. Diagnosis is usually clinical and radiological. Fine needle aspiration cytology (FNAC) can be used as a tool for the exclusion of malignancy in adult patients. In some cases thyroid scan is done to rule out the presence or absence of the normal thyroid gland. A complete work-up is mandatory before cyst removal given that it contains only thyroid tissue. We report the case of a 32-year-old woman with only thyroid tissue in thyroglossal duct cyst

Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia2014 Full Text: Link to full Text with Trip Pro

170. Management of Thyroid Cancer

Management of Thyroid Cancer Guidelines for the management of thyroid cancer - Perros - 2014 - Clinical Endocrinology - Wiley Online Library You have free access to this content , Version of Record online: 3 JUL 2014

British Thyroid Association2014

171. Low risk papillary thyroid cancer.

Low risk papillary thyroid cancer. Thyroid cancer is one of the fastest growing diagnoses; more cases of thyroid cancer are found every year than all leukemias and cancers of the liver, pancreas, and stomach. Most of these incident cases are papillary in origin and are both small and localized. Patients with these small localized papillary thyroid cancers have a 99% survival rate at 20 years. In view of the excellent prognosis of these tumors, they have been denoted as low risk. The incidence (...) of these low risk thyroid cancers is growing, probably because of the use of imaging technologies capable of exposing a large reservoir of subclinical disease. Despite their excellent prognosis, these subclinical low risk cancers are often treated aggressively. Although surgery is traditionally viewed as the cornerstone treatment for these tumors, there is less agreement about the extent of surgery (lobectomy v near total thyroidectomy) and whether prophylactic central neck dissection for removal of lymph

BMJ2014

172. Afirma thyroid FNA analysis

Afirma thyroid FNA analysis Afirma thyroid FNA analysis Afirma thyroid FNA analysis Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Afirma thyroid FNA analysis. Lansdale: HAYES, Inc.. Genetic Testing Publication. 2014 Authors' conclusions Thyroid nodules are discrete masses present in the thyroid gland that are a common clinical finding among adults (...) in the general population. Approximately 5% of women and 1% of men have a palpable thyroid nodule on physical examination. The evaluation of thyroid nodules, which may represent benign lesions or malignant thyroid tumors, typically includes a cytopathologic examination of a biopsy specimen obtained by fine-needle aspiration (FNA). Thyroid nodules are subsequently classified based on cytology, with 70% to 75% of nodules being benign and approximately 5% being malignant. Approximately 20% to 25% of thyroid

Health Technology Assessment (HTA) Database.2014

173. Systematic review and meta-analysis of wound drains after thyroid surgery

Systematic review and meta-analysis of wound drains after thyroid surgery Systematic review and meta-analysis of wound drains after thyroid surgery Systematic review and meta-analysis of wound drains after thyroid surgery Woods RS, Woods JF, Duignan ES, Timon C CRD summary The authors stated that wound drains following routine thyroid surgery had no effect on reoperation rates, but could increase infection rates, length of stay and postoperative pain, with no effect on other complications (...) . Despite some concerns about trial quality, this conclusion generally reflects the evidence presented and seems reliable. Authors' objectives To evaluate the effectiveness of wound drains for thyroid and parathyroid surgery. Searching MEDLINE, EMBASE, The Cochrane Library, CINAHL, and trial registries were searched up to April 2013 for published or unpublished studies. Reference lists were screened to identify other relevant studies. Some search terms were reported. No language restrictions were

DARE.2014

174. Thyroid hormone inactivation in gastrointestinal stromal tumors.

Thyroid hormone inactivation in gastrointestinal stromal tumors. Gastrointestinal stromal tumors (GISTs) are resistant to traditional chemotherapy but are responsive to the tyrosine kinase inhibitors imatinib and sunitinib. The use of these agents has improved the outcome for patients but is associated with adverse effects, including hypothyroidism. Multiple mechanisms of this effect have been proposed, including decreased iodine organification and glandular capillary regression. Here we report (...) the finding of consumptive hypothyroidism caused by marked overexpression of the thyroid hormone-inactivating enzyme type 3 iodothyronine deiodinase (D3) within the tumor. Affected patients warrant increased monitoring and may require supernormal thyroid hormone supplementation.

NEJM2014 Full Text: Link to full Text with Trip Pro

175. Technologies scoping report 22: In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies?

Technologies scoping report 22: In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies? In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies? In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies? Thompson L Record Status (...) This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Thompson L. In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies? Glasgow: Healthcare Improvement Scotland. 2014 Authors' conclusions An American non-systematic literature review reported that serum T3 measurement has little specificity

Health Technology Assessment (HTA) Database.2014

176. Chinese herbal medicines for benign thyroid nodules in adults.

Chinese herbal medicines for benign thyroid nodules in adults. BACKGROUND: A thyroid nodule is a discrete lesion within the thyroid gland that might be palpable and is ultrasonographically distinct from the surrounding thyroid parenchyma. Thyroid nodules are more common as age increases and occur more frequently in women. Benign thyroid nodules often cause pressure symptoms and cosmetic complaints. In China and many other countries, doctors use Chinese herbal medicines (CHM) to treat thyroid (...) nodules. OBJECTIVES: To assess the effects of Chinese herbal medicines in the treatment of benign thyroid nodules in adults. SEARCH METHODS: Review authors searched the following electronic databases: The Cochrane Library, MEDLINE, EMBASE, the Chinese Biomedical Literature Database (CBM), the China National Knowledge Infrastructure (CNKI), VIP information (a Chinese database), WANFANG Data (a Chinese database), the Chinese Conference Papers Database and the Chinese Dissertation Database (all searched

Cochrane2014

177. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial.

Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. 24768112 2014 07 28 2014 08 19 2016 12 15 1474-547X 384 9940 2014 Jul 26 Lancet (London, England) Lancet Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. 319-28 10.1016/S0140-6736(14)60421-9 S0140-6736(14)60421-9 Patients with radioactive iodine (...) ((131)I)-refractory locally advanced or metastatic differentiated thyroid cancer have a poor prognosis because of the absence of effective treatment options. In this study, we assessed the efficacy and safety of orally administered sorafenib in the treatment of patients with this type of cancer. In this multicentre, randomised, double-blind, placebo-controlled, phase 3 trial (DECISION), we investigated sorafenib (400 mg orally twice daily) in patients with radioactive iodine-refractory locally

Lancet2014 Full Text: Link to full Text with Trip Pro

178. Investigation and Management of Primary Thyroid Dysfunction

Investigation and Management of Primary Thyroid Dysfunction INVESTIGATION AND MANAGEMENT OF PRIMARY THYROID DYSFUNCTION Clinical Practice Guideline | April 2014 These recommendations are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. They should be used as an adjunct to sound clinical decision making. OBJECTIVE Alberta clinicians optimize laboratory testing for the investigation and management (...) of primary thyroid dysfunction TARGET POPULATION Adults and children with suspected or confirmed primary thyroid dysfunction EXCLUSIONS Neonatal patients Asymptomatic, seemingly healthy individuals having a periodic exam RECOMMENDATIONS PRACTICE POINT Thyroid stimulating hormone (TSH) is the most sensitive and specific test for the investigation and management of primary thyroid dysfunction ? Order TSH as the single best initial test to diagnose primary hyperthyroidism and hypothyroidism when symptoms

Toward Optimized Practice2014

179. Case-control study: Population-based study provides a step towards evidence-based management of thyroid nodules detected on ultrasound

Case-control study: Population-based study provides a step towards evidence-based management of thyroid nodules detected on ultrasound Population-based study provides a step towards evidence-based management of thyroid nodules detected on ultrasound | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your (...) user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Population-based study provides a step towards evidence-based management of thyroid nodules detected on ultrasound Article Text Diagnosis Case-control study Population-based study provides a step towards evidence-based management of thyroid nodules detected

Evidence-Based Medicine (Requires free registration)2014

180. Selenium supplementation for Hashimoto's thyroiditis.

Selenium supplementation for Hashimoto's thyroiditis. BACKGROUND: Hashimoto's thyroiditis is a common auto-immune disorder. The most common presenting symptoms may include anxiety, negative mood, depression, dry skin, cold intolerance, puffy eyes, muscle cramps and fatigue, deep voice, constipation, slow thinking and poor memory. Clinical manifestations of the disease are defined primarily by low levels of thyroid hormones; therefore it is treated by hormone replacement therapy, which usually (...) consists of levothyroxine (LT4). Selenium might reduce antibody levels and result in a decreased dosage of LT4 and may provide other beneficial effects (e.g. on mood and health-related quality of life). OBJECTIVES: To assess the effects of selenium supplementation on Hashimoto's thyroiditis. SEARCH METHODS: We searched the following databases up to 2 October 2012: CENTRAL in The Cochrane Library (2012, Issue 10), MEDLINE, EMBASE, and Web of Science; we also screened reference lists of included studies

Cochrane2013