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Toxic thyroid adenoma Toxic thyroid adenoma - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Toxic thyroid adenoma Last reviewed: August 2018 Last updated: June 2017 Summary Typically a single large thyroid nodule accompanied by clinical and biochemical hyperthyroidism. Diagnosis confirmed by thyroid scan demonstrating a hot area and suppression of extranodular thyroid tissue. Hyperthyroidism caused by toxic adenomas (...) generally does not remit. Definitive treatment, such as radioactive iodine therapy, is usually required. Complications of untreated toxic adenomas may include sequelae of hyperthyroidism such as cardiac dysfunction or bone loss, or tracheal compression by large nodules. Definition A toxic adenoma is an autonomously functioning thyroid nodule that causes hyperthyroidism. Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism
Thyroid cancer Thyroid cancer - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Thyroid cancer Last reviewed: August 2018 Last updated: November 2017 Summary Most commonly presents as an asymptomatic thyroid nodule detected by palpation or ultrasound in a woman in her 30s or 40s. The most important diagnostic test is fine-needle aspiration. Treatment is usually total thyroidectomy followed by radioactive iodine (...) ablation and TSH suppression (papillary or follicular). Treatment differs and must be tailored for uncommon types of thyroid cancer such as medullary, lymphoma, or anaplastic. Prognosis depends on risk-group stratification. Definition Four types account for more than 98% of thyroid malignancies: papillary, follicular, anaplastic, and medullary. Gimm O. Thyroid cancer. Cancer Lett. 2001;163:143-156. http://www.ncbi.nlm.nih.gov/pubmed/11165748?tool=bestpractice.com History and exam presence of risk
Risk of Hematologic Malignancies After Radioiodine Treatment of Well-Differentiated Thyroid Cancer 29252123 2017 12 18 1527-7755 2017 Dec 18 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Risk of Hematologic Malignancies After Radioiodine Treatment of Well-Differentiated Thyroid Cancer. JCO2017750232 10.1200/JCO.2017.75.0232 Purpose To investigate the risk and outcomes of second hematologic malignancies (SHMs) in a population-based (...) cohort of patients with well-differentiated thyroid cancer (WDTC) treated or not with radioactive iodine (RAI). Methods Patients with WDTC were identified from SEER registries. Competing risk regression analysis was performed to calculate the risks of SHMs that occurred after WDTC treatment and outcomes after SHM development were assessed. Results Of 148,215 patients with WDTC, 53% received surgery alone and 47% received RAI. In total, 783 patients developed an SHM after a median interval of 6.5
Afirma thyroid FNA analysis (Veracyte) Afirma thyroid FNA analysis (Veracyte) Afirma thyroid FNA analysis (Veracyte) HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Afirma thyroid FNA analysis (Veracyte) Lansdale: HAYES, Inc. Genetic Testing Publication. 2017 Authors' conclusions In recent years, significant advances in understanding (...) the genetic mechanisms of thyroid cancer have changed the way thyroid nodules are treated clinically. Several molecular targets have been associated with malignancy, including microRNA (miRNA), a noncoding endogenous form of RNA that helps regulate gene expression. Previous investigations have detected the dysregulation of miRNAs in malignant thyroid nodules, identifying the potential role of miRNAs in differentiating benign thyroid nodules from malignant ones. The Afirma Thyroid FNA Analysis
Activated charcoal for preoperative localization of thyroid cancer recurrence Activated charcoal for preoperative localization of thyroid cancer recurrence Activated charcoal for preoperative localization of thyroid cancer recurrence Klappenbach R, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation Klappenbach R, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A, López A, Rey-Ares L. Activated charcoal for preoperative localization of thyroid cancer recurrence. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No. 501. 2016 Authors' conclusions Very low-quality evidence does not allow drawing conclusions on activated charcoal for preoperative localization
Association between screening and the thyroid cancer "epidemic" in South Korea: evidence from a nationwide study. OBJECTIVE: To investigate whether screening for thyroid cancer led to the current "epidemic" in South Korea. DESIGN: Review of the medical records of nationally representative samples of patients with a diagnosis of thyroid cancer in 1999, 2005, and 2008. SETTING: Sample cases were randomly selected from South Korea's nationwide cancer registry, using a systematic sampling method (...) after stratification by region. PARTICIPANTS: 5796 patients with thyroid cancer were included (891 in 1999, 2355 in 2005, and 2550 in 2008). MAIN OUTCOME MEASURES: The primary outcome was age standardised incidence of thyroid cancer and the changes in incidence between 1999 and 2008 according to the methods used to detect tumours (screen detection versus clinical detection versus unspecified). RESULTS: Between 1999 and 2008, the incidence of thyroid cancer increased 6.4-fold (95% confidence interval
Minimally invasive and remoteâ€access thyroid surgery in the era of the 2015 American Thyroid Association guidelines 28894814 2018 11 13 2378-8038 1 6 2016 12 Laryngoscope investigative otolaryngology Laryngoscope Investig Otolaryngol Minimally invasive and remote-access thyroid surgery in the era of the 2015 American Thyroid Association guidelines. 175-179 10.1002/lio2.36 Thyroid surgery has evolved throughout the years from being one of the most dangerous surgeries to becoming one (...) of the safest surgical procedures performed today. Recent technologic innovations have allowed surgeons to remove the thyroid gland from a remote site while avoiding visible neck scars. There are many endoscopic approaches for thyroidectomy. The most common cervical approach is the minimally invasive video-assisted technique developed by Miccoli et al. The robotic transaxillary and axillary breast approaches avoid a neck scar and have been demonstrated to be safe and effective in international populations
Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia 28670190 2018 11 13 1452-8258 35 4 2016 Oct Journal of medical biochemistry J Med Biochem Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia. 385-389 10.1515/jomb-2016-0023 Iodine deficiency is associated with goiter and impaired brain function leading to cretinism. An increased frequency (...) of thyroid-stimulating hormone (TSH) measurements above 5 mlU/L on newborn screening points toward an impaired iodine status of the population. A 13-year retrospective analysis was performed in 228,266 newborns participating in the national thyroid newborn screening program. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 48 hours after birth, using fluoroimmunometric DELFIA method. Out of 236,378 live-born infants, 228,266 (96.6%) have been screened for TSH
Thyroid Stimulating Hormone (TSH) in the Evaluation of Subclinical Hypothyroidism 27755618 2016 11 07 2018 11 13 1538-3598 316 15 2016 Oct 18 JAMA JAMA Thyroid-Stimulating Hormone in the Evaluation of Subclinical Hypothyroidism. 1592-1593 10.1001/jama.2016.9534 Papaleontiou Maria M Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor. Cappola Anne R AR Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University
Lacrimal gland enlargement as an early clinical or radiological sign in thyroid orbitopathy 29503935 2018 11 14 2451-9936 5 2017 Apr American journal of ophthalmology case reports Am J Ophthalmol Case Rep Lacrimal gland enlargement as an early clinical or radiological sign in thyroid orbitopathy. 1-3 10.1016/j.ajoc.2016.10.005 Characteristic ophthalmic signs of Thyroid Orbitopathy (TO) include exophthalmos, eyelid retraction, eyelid edema, restrictive extraocular myopathy, and optic neuropathy (...) and demonstrated isolated LG enlargement. This case represents, to our knowledge, the first report of LG enlargement as an initial presenting sign of TO. Further clinical and radiological studies looking at the natural history of TO would be useful to better understand the timing of LG involvement. In patients presenting with lacrimal gland enlargement, thyroid orbitopathy should be strongly considered in the differential diagnosis together with other causes of dacryoadenitis and LG tumors. This may save
Lenvima for Differentiated Thyroid Cancer – Details Lenvima for Differentiated Thyroid Cancer – Details | CADTH.ca Find the information you need Lenvima for Differentiated Thyroid Cancer – Details Lenvima for Differentiated Thyroid Cancer – Details Project Number pCODR 10080 Brand Name Lenvima Generic Name Lenvatinib Strength 4mg and 10mg Capsules Tumour Type Endocrine Indication Differentiated Thyroid Cancer Funding Request For the treatment of patients with locally recurrent or metastatic
Use of imaging tests after primary treatment of thyroid cancer in the United States: population based retrospective cohort study evaluating death and recurrence. OBJECTIVE: To determine whether the use of imaging tests after primary treatment of differentiated thyroid cancer is associated with more treatment for recurrence and fewer deaths from the disease. DESIGN: Population based retrospective cohort study. SETTING: Surveillance Epidemiology and End Results-Medicare database in the United (...) States. PARTICIPANTS: 28 220 patients diagnosed with differentiated thyroid cancer between 1998 and 2011. The study cohort was followed up to 2013, with a median follow-up of 69 months. MAIN OUTCOME MEASURES: Treatment for recurrence of differentiated thyroid cancer (additional neck surgery, additional radioactive iodine treatment, or radiotherapy), and deaths due to differentiated thyroid cancer. We conducted propensity score analyses to assess the relation between imaging (neck ultrasound