Latest & greatest articles for thyroid

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Top results for thyroid

41. Clinical efficacy of novel elastography using acoustic radiation force impulse (ARFI) for diagnosis of malignant thyroid nodules Full Text available with Trip Pro

Clinical efficacy of novel elastography using acoustic radiation force impulse (ARFI) for diagnosis of malignant thyroid nodules Acoustic radiation force impulse (ARFI) imaging is a recent ultrasound elastography technique; consequently, its efficacy is not fully known. In this study, we compared ARFI imaging with conventional strain elastography (SE) and shear wave velocities (SWVs) to evaluate the utility of ARFI imaging for diagnosing thyroid nodules.In this study we examined 233 thyroid (...) scores 1 and 2.The diagnostic accuracy of ARFI imaging for differentiating malignant thyroid nodules was higher than that of SE. The VTI scores of the nodules accurately reflected their SWVs.4.

2018 Laryngoscope investigative otolaryngology

42. Thyroid Full Text available with Trip Pro

Thyroid Top results for thyroid - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading (...) history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for thyroid The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted

2018 Trip Latest and Greatest

43. Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine

Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine L Len envatinib and sor vatinib and sorafenib for treating afenib for treating differentiated th differentiated thyroid cancer after yroid cancer after r radioactiv adioactive iodine e iodine T echnology appraisal guidance Published: 8 August 2018 nice.org.uk/guidance/ta535 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y (...) to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine (TA535) © NICE 2018. All rights reserved. Subject to Notice of rights (https

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

44. Lenvatinib (LENVIMA) - locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer

Lenvatinib (LENVIMA) - locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product. The for is located

2018 Health Canada - Drug and Health Product Register

45. Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals Full Text available with Trip Pro

Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals Understanding the physiological response of marine mammals to anthropogenic stressors can inform marine ecosystem conservation strategies. Stress stimulates the activation of the hypothalamic-pituitary-adrenal (HPA) axis and synthesis of glucocorticoid (GC) hormones, which increase energy substrate availability while suppressing energy-intensive processes. Exposure to repeated (...) the first ACTH administration on Day 1 and the last administration on Day 4. In contrast, aldosterone levels remained elevated above baseline for at least 24 h after each ACTH injection, and responses were greater on Day 4 than Day 1. Total triiodothyronine (tT3) levels were decreased on Day 4 relative to Day 1, while reverse triiodothyronine (rT3) concentrations increased relative to baseline on Days 1 and 4 in response to ACTH, indicating a suppression of thyroid hormone production

2018 Conservation physiology

46. Update on Multiple Endocrine Neoplasia Type 2: Focus on Medullary Thyroid Carcinoma Full Text available with Trip Pro

Update on Multiple Endocrine Neoplasia Type 2: Focus on Medullary Thyroid Carcinoma Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant hereditary cancer syndrome caused by missense gain-of-function mutations in the RET proto-oncogene on chromosome 10. Specific RET mutations can predispose toward a particular phenotype and clinical course, with strong genotype-phenotype correlations. MEN2 is highly penetrant in medullary thyroid carcinoma (MTC), and it can be associated

2018 Journal of the Endocrine Society

47. Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations Full Text available with Trip Pro

Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations Struma ovarii is a rare ovarian teratoma predominantly composed of thyroid tissue. The simultaneous presence of thyroid carcinoma in the struma ovarii and the thyroid gland is extremely rare. It remains unclear if these carcinomas represent independent primary tumors and whether the molecular mechanisms of the tumors developing in the thyroid and ovarian tissues are similar (...) . We present the case of a patient with two independent papillary thyroid carcinomas (PTCs) in struma ovarii and the thyroid gland that are driven by different RAS mutations. A 62-year-old woman with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma was diagnosed with a pelvic mass during a CT scan. She had surgery that included removal of her ovaries. A 7.2-cm classical variant of PTC arising in a struma ovarii was identified in the right ovary. Two months after the pelvic

2018 Journal of the Endocrine Society

48. Can Ultrasound Alone Predict Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis? A Retrospective Analysis of 13 Cases, Focusing on the Stromal Area Full Text available with Trip Pro

Can Ultrasound Alone Predict Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis? A Retrospective Analysis of 13 Cases, Focusing on the Stromal Area Papillary thyroid carcinoma with desmoid-type fibromatosis (PTC-DTF) is extremely rare. So far, only 4 cases describing the ultrasound findings of this variant have been reported. Here, we describe the ultrasound findings of 13 cases of PTC-DTF, focusing especially on the DTF area.We retrospectively analyzed the clinical reports, ultrasound (...) the PTC areas.It is difficult to predict PTC-DTF using ultrasound alone, and B-mode ultrasonography is more reliable than ultrasound elastography in the ultrasound diagnosis of malignant thyroid nodules.

2018 Ultrasound international open

49. Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type Full Text available with Trip Pro

Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type The purpose of the study is to clarify the prevalence of calcifications within thyroid tumors on ultrasonography as well as the relationship between the calcification and histopathological types.Calcifications were classified into 6 (or 8) types according to their shape, size, and region. The prevalence of calcifications and types were investigated in new outpatients (...) and patients who underwent thyroid surgery.Among 2,902 nodules in 2,678 new outpatients, 747 nodules (26%) had calcifications. The types showed a wide distribution. Among 941 patients with papillary carcinoma (PC), 725 patients (77%) had calcifications, and the types showed a wide distribution. 18 patients with the diffuse sclerosing variant of PC only showed punctate microcalcifications in the parenchyma (100%), 32 patients with the cyst-forming type of PC mostly fragmentary and massive types (100

2018 Ultrasound international open

50. An oncogenic role for microRNA-146b in the thyroid Full Text available with Trip Pro

An oncogenic role for microRNA-146b in the thyroid 30035174 2018 11 14 2331-4737 5 5-6 2018 May Oncoscience Oncoscience An oncogenic role for microRNA-146b in the thyroid. 155-156 10.18632/oncoscience.432 Ramírez-Moya Julia J Instituto de Investigaciones Biomédicas, CSIC-UAM, Ciberonc, Madrid, Spain. Santisteban Pilar P Instituto de Investigaciones Biomédicas, CSIC-UAM, Ciberonc, Madrid, Spain. eng Editorial 2018 06 27 United States Oncoscience 101636666 2331-4737 PTEN microRNA146b thyroid

2018 Oncoscience

51. Sonographic Presentation of Metastases to the Thyroid Gland: A Case Series Full Text available with Trip Pro

Sonographic Presentation of Metastases to the Thyroid Gland: A Case Series Incidental sonographic discovery of thyroid nodules is an increasingly common event. The vast majority is benign, and those that are malignant, are generally associated with an indolent course and low mortality. Sonographic scoring systems have been developed to help clinicians identify nodules that warrant prompt fine-needle aspiration cytology (FNAC), but they are based largely on experience with papillary thyroid (...) cancers. We analyzed the performance of four scoring systems widely used for this purpose (American Thyroid Association Guidelines, American Association of Clinical Endocrinologists/American College of Endocrinology/Associazione Medici Endocrinologi Guidelines, European Thyroid Imaging Reporting and Data System, and Korean Thyroid Imaging Reporting and Data System) in patients whose nodules proved to be metastases from other solid cancers. Such nodules reportedly account for 0.2% to 3% of all thyroid

2018 Journal of the Endocrine Society

52. Educational Case: Endocrine Neoplasm: Medullary Thyroid Carcinoma Full Text available with Trip Pro

Educational Case: Endocrine Neoplasm: Medullary Thyroid Carcinoma Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect (...) in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance. This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma.

2018 Academic pathology

53. Educational Case: Medullary Thyroid Carcinoma Full Text available with Trip Pro

Educational Case: Medullary Thyroid Carcinoma The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http

2018 Academic pathology

54. Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery (Abstract)

Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery Suturing the platysma muscle during wound closure after thyroid surgery is frequently described in the literature. There is no prospective evidence to support its use or benefit. The aim of this study was to evaluate how a platysma muscle suture influences initial postoperative pain following thyroid surgery.Patients were assigned randomly to receive a platysma suture or no platysma (...) suture in this prospective, patient-blinded trial. The duration of follow-up was 6 months. The primary endpoint was wound-specific pain 24 h after thyroid resection. Secondary endpoints were intraoperative and perioperative analgesia requirement, postoperative pain and complications until postoperative day 14, and Patient and Observer Scar Assessment Score (POSAS) 6 months after surgery.Forty-one patients were randomized to each group. Visual analogue scale scores for wound-specific pain were lower

2018 EvidenceUpdates

55. Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery Full Text available with Trip Pro

Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery Hypoparathyroidism, the most common complication after thyroid surgery, leads to hypocalcaemia and significant medical problems. An RCT was undertaken to determine whether intraoperative parathyroid gland angiography with indocyanine green (ICG) could predict postoperative hypoparathyroidism, and obviate the need for systematic blood (...) after thyroidectomy. The primary endpoint was hypocalcaemia on POD 10-15.A total of 196 patients underwent ICG angiography during thyroid surgery, of whom 146 had at least one well perfused parathyroid gland on ICG angiography and were randomized. None of these patients presented with hypoparathyroidism, including those who did not receive calcium supplementation. The intervention group was statistically non-inferior to the control group (exact 95 per cent c.i. of the difference in proportion

2018 EvidenceUpdates

56. Management of recurrent or metastatic thyroid cancer Full Text available with Trip Pro

Management of recurrent or metastatic thyroid cancer Recently, vascular endothelial growth factor receptor (VEGFR)-targeted tyrosine kinase inhibitors (TKIs) have become available for the treatment of recurrent or metastatic thyroid cancer. However, a number of clinical challenges that impact the use of VEGFR-targeted TKI in daily clinical practice have arisen. Toxicity is considerable, to the extent that most physicians hesitate to start VEGFR-targeted TKI and prefer to continue a watch (...) -and-wait approach until the patient's disease markedly worsens. This delayed use of VEGFR-targeted TKI leads to a higher incidence of serious adverse events than was reported in clinical trials. Moreover, the watch-and-wait approach has several demerits, including a worsening of quality of life, worsening of outcomes in patients of older age or with follicular thyroid cancer and increased risk of brain metastasis or bleeding. Thus, optimal timing for the start of VEGFR-targeted TKI requires careful

2018 ESMO open

57. Retrospective Analysis of Patients with Synchronous Primary Breast and Thyroid Carcinoma Full Text available with Trip Pro

Retrospective Analysis of Patients with Synchronous Primary Breast and Thyroid Carcinoma Breast and thyroid cancers are commonly encountered malignancies. Increased risk of breast cancer in follow-up period of thyroid cancer or vice versa has been reported. However, they have some associations, synchronous presentation of these tumors is rare. We presented 12 patients diagnosed as breast and thyroid cancer and treated at the same time.Mastectomy and thyroidectomy were performed in 19 patients (...) at the same time. 7 patients were excluded because of benign thyroid pathology. Therefore 12 patients who had diagnosis of synchronous breast and thyroid cancer were included. Data regarding clinical, pathological, treatment and prognostic factors was retrospectively analyzed.Total thyroidectomy was performed in all patients. The mean age of patients was 54 years (min. 44-max. 70). Only one patient was male. Thyroid pathology was detected preoperatively by FDG PET-CT scan in 11 patients. Breast

2018 European journal of breast health

58. Cabozantinib for treating medullary thyroid cancer

Cabozantinib for treating medullary thyroid cancer Cabozantinib for treating medullary Cabozantinib for treating medullary th thyroid cancer yroid cancer T echnology appraisal guidance Published: 28 March 2018 nice.org.uk/guidance/ta516 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent the view of NICE, arrived at after careful (...) a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Cabozantinib for treating medullary thyroid cancer (TA516) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 15Contents Contents 1 Recommendations 4 2 Information about cabozantinib 5 3 Committee discussion 6 The condition and current

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

59. Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma Full Text available with Trip Pro

Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma Technetium-99m methoxy isobutyl isonitrile (99mTc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also (...) present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2.0 g/mL). A sestamibi SPECT/CT performed because of concomitant primary hyperparathyroidism showed increased uptake by both the MTC and the pulmonary nodule, raising suspicion of MTC metastasis

2018 Journal of the Endocrine Society

60. The Diagnosis and Management of Thyroid Nodules: A Review. (Abstract)

The Diagnosis and Management of Thyroid Nodules: A Review. Thyroid nodules are common, being detected in up to 65% of the general population. This is likely due to the increased use of diagnostic imaging for purposes unrelated to the thyroid. Most thyroid nodules are benign, clinically insignificant, and safely managed with a surveillance program. The main goal of initial and long-term follow-up is identification of the small subgroup of nodules that harbor a clinically significant cancer (≈10 (...) %), cause compressive symptoms (≈5%), or progress to functional disease (≈5%).Thyroid function testing and ultrasonographic characteristics guide the initial management of thyroid nodules. Certain ultrasound features, such as a cystic or spongiform appearance, suggest a benign process that does not require additional testing. Suspicious sonographic patterns including solid composition, hypoechogenicity, irregular margins, and microcalcifications should prompt cytological evaluation. Additional

2018 JAMA