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Lenvatinib (LENVIMA) - locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Summary Basis of Decision (SBD) for Contact: Summary basis of decision (SBD) documents provide information related to the original authorization of a product. The for is located below
Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals 30034809 2018 11 14 2051-1434 6 1 2018 Conservation physiology Conserv Physiol Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals. coy040 10.1093/conphys/coy040 Understanding the physiological response of marine mammals to anthropogenic stressors can inform marine ecosystem conservation strategies. Stress (...) were decreased on Day 4 relative to Day 1, while reverse triiodothyronine (rT3) concentrations increased relative to baseline on Days 1 and 4 in response to ACTH, indicating a suppression of thyroid hormone production. There was no effect of ACTH on the sex steroid dehydroepiandrosterone. These data suggest that elephant seals are able to mount adrenal responses to multiple ACTH administrations. However, repeated ACTH administration resulted in facilitation of aldosterone secretion and suppression
Update on Multiple Endocrine Neoplasia Type 2: Focus on Medullary Thyroid Carcinoma 30087948 2018 11 14 2472-1972 2 8 2018 Aug 01 Journal of the Endocrine Society J Endocr Soc Update on Multiple Endocrine Neoplasia Type 2: Focus on Medullary Thyroid Carcinoma. 933-943 10.1210/js.2018-00178 Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant hereditary cancer syndrome caused by missense gain-of-function mutations in the RET proto-oncogene on chromosome 10. Specific RET mutations (...) can predispose toward a particular phenotype and clinical course, with strong genotype-phenotype correlations. MEN2 is highly penetrant in medullary thyroid carcinoma (MTC), and it can be associated with bilateral pheochromocytoma and primary hyperparathyroidism. Two different clinical variants of MEN2 are known: MEN2A, which includes the familial subtype, and MEN2B. Treatment includes early thyroidectomy. Recommendations on the timing and extent of surgery are based on the RET mutation risk
Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations 30087949 2018 11 14 2472-1972 2 8 2018 Aug 01 Journal of the Endocrine Society J Endocr Soc Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. 944-948 10.1210/js.2018-00132 Struma ovarii is a rare ovarian teratoma predominantly composed of thyroid tissue. The simultaneous presence of thyroid carcinoma (...) in the struma ovarii and the thyroid gland is extremely rare. It remains unclear if these carcinomas represent independent primary tumors and whether the molecular mechanisms of the tumors developing in the thyroid and ovarian tissues are similar. We present the case of a patient with two independent papillary thyroid carcinomas (PTCs) in struma ovarii and the thyroid gland that are driven by different RAS mutations. A 62-year-old woman with a history of chronic lymphocytic leukemia/small lymphocytic
Can Ultrasound Alone Predict Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis? A Retrospective Analysis of 13 Cases, Focusing on the Stromal Area 30250939 2018 11 14 2509-596X 4 2 2018 Apr Ultrasound international open Ultrasound Int Open Can Ultrasound Alone Predict Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis? A Retrospective Analysis of 13 Cases, Focusing on the Stromal Area. E39-E44 10.1055/a-0591-6163 Papillary thyroid carcinoma with desmoid-type fibromatosis (PTC (...) were generally heterogeneous (62.5%) and more hypoechoic (71.4%) than PTC areas. Microcalcification was not observed in the DTF areas. All of the DTF areas revealed no or mild flow signal. On ultrasound elastography, the DTF areas were not stiff, and they were more elastic than the PTC areas. It is difficult to predict PTC-DTF using ultrasound alone, and B-mode ultrasonography is more reliable than ultrasound elastography in the ultrasound diagnosis of malignant thyroid nodules. Tajiri Kumiko K
Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type 30250940 2018 11 14 2509-596X 4 2 2018 Apr Ultrasound international open Ultrasound Int Open Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type. E45-E51 10.1055/a-0591-6070 The purpose of the study is to clarify the prevalence of calcifications within thyroid tumors on ultrasonography as well as the relationship (...) between the calcification and histopathological types. Calcifications were classified into 6 (or 8) types according to their shape, size, and region. The prevalence of calcifications and types were investigated in new outpatients and patients who underwent thyroid surgery. Among 2,902 nodules in 2,678 new outpatients, 747 nodules (26%) had calcifications. The types showed a wide distribution. Among 941 patients with papillary carcinoma (PC), 725 patients (77%) had calcifications, and the types showed
An oncogenic role for microRNA-146b in the thyroid 30035174 2018 11 14 2331-4737 5 5-6 2018 May Oncoscience Oncoscience An oncogenic role for microRNA-146b in the thyroid. 155-156 10.18632/oncoscience.432 Ramírez-Moya Julia J Instituto de Investigaciones Biomédicas, CSIC-UAM, Ciberonc, Madrid, Spain. Santisteban Pilar P Instituto de Investigaciones Biomédicas, CSIC-UAM, Ciberonc, Madrid, Spain. eng Editorial 2018 06 27 United States Oncoscience 101636666 2331-4737 PTEN microRNA146b thyroid
Sonographic Presentation of Metastases to the Thyroid Gland: A Case Series 30019024 2018 11 14 2472-1972 2 8 2018 Aug 01 Journal of the Endocrine Society J Endocr Soc Sonographic Presentation of Metastases to the Thyroid Gland: A Case Series. 855-859 10.1210/js.2018-00124 Incidental sonographic discovery of thyroid nodules is an increasingly common event. The vast majority is benign, and those that are malignant, are generally associated with an indolent course and low mortality. Sonographic (...) scoring systems have been developed to help clinicians identify nodules that warrant prompt fine-needle aspiration cytology (FNAC), but they are based largely on experience with papillary thyroid cancers. We analyzed the performance of four scoring systems widely used for this purpose (American Thyroid Association Guidelines, American Association of Clinical Endocrinologists/American College of Endocrinology/Associazione Medici Endocrinologi Guidelines, European Thyroid Imaging Reporting and Data
Educational Case: Endocrine Neoplasm: Medullary Thyroid Carcinoma 29978018 2018 11 14 2374-2895 5 2018 Jan-Dec Academic pathology Acad Pathol Educational Case: Endocrine Neoplasm: Medullary Thyroid Carcinoma. 2374289518775722 10.1177/2374289518775722 Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary (...) tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance. This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma. Segura Sheila
Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery 29579320 2018 04 13 1365-2168 105 6 2018 May The British journal of surgery Br J Surg Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery. 645-649 10.1002/bjs.10829 Suturing the platysma muscle during wound closure after thyroid surgery is frequently described in the literature. There is no prospective evidence to support its use (...) or benefit. The aim of this study was to evaluate how a platysma muscle suture influences initial postoperative pain following thyroid surgery. Patients were assigned randomly to receive a platysma suture or no platysma suture in this prospective, patient-blinded trial. The duration of follow-up was 6 months. The primary endpoint was wound-specific pain 24 h after thyroid resection. Secondary endpoints were intraoperative and perioperative analgesia requirement, postoperative pain and complications until
Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery 29405252 2018 02 28 1365-2168 105 4 2018 Mar The British journal of surgery Br J Surg Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery. 350-357 10.1002/bjs.10783 Hypoparathyroidism, the most common complication after (...) thyroid surgery, leads to hypocalcaemia and significant medical problems. An RCT was undertaken to determine whether intraoperative parathyroid gland angiography with indocyanine green (ICG) could predict postoperative hypoparathyroidism, and obviate the need for systematic blood tests and oral calcium supplementation. Between September 2014 and February 2016, patients who had at least one well perfused parathyroid gland on ICG angiography were randomized to receive standard follow-up (measurement
Management of recurrent or metastatic thyroid cancer 29713501 2018 11 14 2059-7029 3 Suppl 1 2018 ESMO open ESMO Open Management of recurrent or metastatic thyroid cancer. e000359 10.1136/esmoopen-2018-000359 Recently, vascular endothelial growth factor receptor (VEGFR)-targeted tyrosine kinase inhibitors (TKIs) have become available for the treatment of recurrent or metastatic thyroid cancer. However, a number of clinical challenges that impact the use of VEGFR-targeted TKI in daily clinical (...) or with follicular thyroid cancer and increased risk of brain metastasis or bleeding. Thus, optimal timing for the start of VEGFR-targeted TKI requires careful consideration. Moreover, management of VEGFR-targeted TKI toxicities requires appropriate supportive care, well-organised infrastructure in the outpatient clinic and patient education. Future treatment will progress to precision medicine based on molecular testing. Promotion of precision medicine requires the establishment of a system of easy access
Treating subclinical thyroid dysfunction in pregnancy probably has no benefit NIHR DC | Signal - Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Published on 8 August 2017 Testing for and then treating pregnant women with mild or “subclinical” underactive thyroid did not improve pregnancy outcomes, newborn baby outcomes (...) , or the child’s IQ at three to five years. A clearly underactive thyroid (clinical hypothyroidism) in pregnancy has been linked with various adverse outcomes for the mother and baby, including pre-eclampsia, preterm birth, congenital defects and neurodevelopmental delay. This needs treatment. However, there has been debate around the harms and benefits from treating only mildly abnormal blood test results in women who do not show signs of thyroid problems, subclinical hypothyroidism. These two linked trials
Retrospective Analysis of Patients with Synchronous Primary Breast and Thyroid Carcinoma 29774315 2018 11 14 14 2 2018 Apr European journal of breast health Eur J Breast Health Retrospective Analysis of Patients with Synchronous Primary Breast and Thyroid Carcinoma. 80-84 10.5152/ejbh.2018.3853 Breast and thyroid cancers are commonly encountered malignancies. Increased risk of breast cancer in follow-up period of thyroid cancer or vice versa has been reported. However, they have some (...) associations, synchronous presentation of these tumors is rare. We presented 12 patients diagnosed as breast and thyroid cancer and treated at the same time. Mastectomy and thyroidectomy were performed in 19 patients at the same time. 7 patients were excluded because of benign thyroid pathology. Therefore 12 patients who had diagnosis of synchronous breast and thyroid cancer were included. Data regarding clinical, pathological, treatment and prognostic factors was retrospectively analyzed. Total
Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma 29644341 2018 11 14 2472-1972 2 4 2018 Apr 01 Journal of the Endocrine Society J Endocr Soc Uptake of 99m Tc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma. 386-390 10.1210/js.2018-00014 Technetium-99m methoxy isobutyl isonitrile ( 99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed (...) tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized
The Diagnosis and Management of Thyroid Nodules: A Review. Importance: Thyroid nodules are common, being detected in up to 65% of the general population. This is likely due to the increased use of diagnostic imaging for purposes unrelated to the thyroid. Most thyroid nodules are benign, clinically insignificant, and safely managed with a surveillance program. The main goal of initial and long-term follow-up is identification of the small subgroup of nodules that harbor a clinically significant (...) cancer (≈10%), cause compressive symptoms (≈5%), or progress to functional disease (≈5%). Observations: Thyroid function testing and ultrasonographic characteristics guide the initial management of thyroid nodules. Certain ultrasound features, such as a cystic or spongiform appearance, suggest a benign process that does not require additional testing. Suspicious sonographic patterns including solid composition, hypoechogenicity, irregular margins, and microcalcifications should prompt cytological