Latest & greatest articles for thyroid

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on thyroid or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on thyroid and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for thyroid

21. Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine

Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine L Len envatinib and sor vatinib and sorafenib for treating afenib for treating differentiated th differentiated thyroid cancer after yroid cancer after r radioactiv adioactive iodine e iodine T echnology appraisal guidance Published: 8 August 2018 nice.org.uk/guidance/ta535 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y (...) to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine (TA535) © NICE 2018. All rights reserved. Subject to Notice of rights (https

National Institute for Health and Clinical Excellence - Technology Appraisals2018

22. Lenvatinib (LENVIMA) - locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer

Lenvatinib (LENVIMA) - locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Summary Basis of Decision (SBD) for Contact: Summary basis of decision (SBD) documents provide information related to the original authorization of a product. The for is located below

Health Canada - Drug and Health Product Register2018

23. Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals

Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals 30034809 2018 11 14 2051-1434 6 1 2018 Conservation physiology Conserv Physiol Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals. coy040 10.1093/conphys/coy040 Understanding the physiological response of marine mammals to anthropogenic stressors can inform marine ecosystem conservation strategies. Stress (...) were decreased on Day 4 relative to Day 1, while reverse triiodothyronine (rT3) concentrations increased relative to baseline on Days 1 and 4 in response to ACTH, indicating a suppression of thyroid hormone production. There was no effect of ACTH on the sex steroid dehydroepiandrosterone. These data suggest that elephant seals are able to mount adrenal responses to multiple ACTH administrations. However, repeated ACTH administration resulted in facilitation of aldosterone secretion and suppression

Conservation physiology2018 Full Text: Link to full Text with Trip Pro

24. Update on Multiple Endocrine Neoplasia Type 2: Focus on Medullary Thyroid Carcinoma

Update on Multiple Endocrine Neoplasia Type 2: Focus on Medullary Thyroid Carcinoma 30087948 2018 11 14 2472-1972 2 8 2018 Aug 01 Journal of the Endocrine Society J Endocr Soc Update on Multiple Endocrine Neoplasia Type 2: Focus on Medullary Thyroid Carcinoma. 933-943 10.1210/js.2018-00178 Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant hereditary cancer syndrome caused by missense gain-of-function mutations in the RET proto-oncogene on chromosome 10. Specific RET mutations (...) can predispose toward a particular phenotype and clinical course, with strong genotype-phenotype correlations. MEN2 is highly penetrant in medullary thyroid carcinoma (MTC), and it can be associated with bilateral pheochromocytoma and primary hyperparathyroidism. Two different clinical variants of MEN2 are known: MEN2A, which includes the familial subtype, and MEN2B. Treatment includes early thyroidectomy. Recommendations on the timing and extent of surgery are based on the RET mutation risk

Journal of the Endocrine Society2018 Full Text: Link to full Text with Trip Pro

25. Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations

Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations 30087949 2018 11 14 2472-1972 2 8 2018 Aug 01 Journal of the Endocrine Society J Endocr Soc Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. 944-948 10.1210/js.2018-00132 Struma ovarii is a rare ovarian teratoma predominantly composed of thyroid tissue. The simultaneous presence of thyroid carcinoma (...) in the struma ovarii and the thyroid gland is extremely rare. It remains unclear if these carcinomas represent independent primary tumors and whether the molecular mechanisms of the tumors developing in the thyroid and ovarian tissues are similar. We present the case of a patient with two independent papillary thyroid carcinomas (PTCs) in struma ovarii and the thyroid gland that are driven by different RAS mutations. A 62-year-old woman with a history of chronic lymphocytic leukemia/small lymphocytic

Journal of the Endocrine Society2018 Full Text: Link to full Text with Trip Pro

26. Can Ultrasound Alone Predict Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis? A Retrospective Analysis of 13 Cases, Focusing on the Stromal Area

Can Ultrasound Alone Predict Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis? A Retrospective Analysis of 13 Cases, Focusing on the Stromal Area 30250939 2018 11 14 2509-596X 4 2 2018 Apr Ultrasound international open Ultrasound Int Open Can Ultrasound Alone Predict Papillary Thyroid Carcinoma with Desmoid-Type Fibromatosis? A Retrospective Analysis of 13 Cases, Focusing on the Stromal Area. E39-E44 10.1055/a-0591-6163 Papillary thyroid carcinoma with desmoid-type fibromatosis (PTC (...) were generally heterogeneous (62.5%) and more hypoechoic (71.4%) than PTC areas. Microcalcification was not observed in the DTF areas. All of the DTF areas revealed no or mild flow signal. On ultrasound elastography, the DTF areas were not stiff, and they were more elastic than the PTC areas. It is difficult to predict PTC-DTF using ultrasound alone, and B-mode ultrasonography is more reliable than ultrasound elastography in the ultrasound diagnosis of malignant thyroid nodules. Tajiri Kumiko K

Ultrasound international open2018 Full Text: Link to full Text with Trip Pro

27. Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type

Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type 30250940 2018 11 14 2509-596X 4 2 2018 Apr Ultrasound international open Ultrasound Int Open Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type. E45-E51 10.1055/a-0591-6070 The purpose of the study is to clarify the prevalence of calcifications within thyroid tumors on ultrasonography as well as the relationship (...) between the calcification and histopathological types. Calcifications were classified into 6 (or 8) types according to their shape, size, and region. The prevalence of calcifications and types were investigated in new outpatients and patients who underwent thyroid surgery. Among 2,902 nodules in 2,678 new outpatients, 747 nodules (26%) had calcifications. The types showed a wide distribution. Among 941 patients with papillary carcinoma (PC), 725 patients (77%) had calcifications, and the types showed

Ultrasound international open2018 Full Text: Link to full Text with Trip Pro

28. An oncogenic role for microRNA-146b in the thyroid

An oncogenic role for microRNA-146b in the thyroid 30035174 2018 11 14 2331-4737 5 5-6 2018 May Oncoscience Oncoscience An oncogenic role for microRNA-146b in the thyroid. 155-156 10.18632/oncoscience.432 Ramírez-Moya Julia J Instituto de Investigaciones Biomédicas, CSIC-UAM, Ciberonc, Madrid, Spain. Santisteban Pilar P Instituto de Investigaciones Biomédicas, CSIC-UAM, Ciberonc, Madrid, Spain. eng Editorial 2018 06 27 United States Oncoscience 101636666 2331-4737 PTEN microRNA146b thyroid

Oncoscience2018 Full Text: Link to full Text with Trip Pro

29. Sonographic Presentation of Metastases to the Thyroid Gland: A Case Series

Sonographic Presentation of Metastases to the Thyroid Gland: A Case Series 30019024 2018 11 14 2472-1972 2 8 2018 Aug 01 Journal of the Endocrine Society J Endocr Soc Sonographic Presentation of Metastases to the Thyroid Gland: A Case Series. 855-859 10.1210/js.2018-00124 Incidental sonographic discovery of thyroid nodules is an increasingly common event. The vast majority is benign, and those that are malignant, are generally associated with an indolent course and low mortality. Sonographic (...) scoring systems have been developed to help clinicians identify nodules that warrant prompt fine-needle aspiration cytology (FNAC), but they are based largely on experience with papillary thyroid cancers. We analyzed the performance of four scoring systems widely used for this purpose (American Thyroid Association Guidelines, American Association of Clinical Endocrinologists/American College of Endocrinology/Associazione Medici Endocrinologi Guidelines, European Thyroid Imaging Reporting and Data

Journal of the Endocrine Society2018 Full Text: Link to full Text with Trip Pro

30. Educational Case: Endocrine Neoplasm: Medullary Thyroid Carcinoma

Educational Case: Endocrine Neoplasm: Medullary Thyroid Carcinoma 29978018 2018 11 14 2374-2895 5 2018 Jan-Dec Academic pathology Acad Pathol Educational Case: Endocrine Neoplasm: Medullary Thyroid Carcinoma. 2374289518775722 10.1177/2374289518775722 Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary (...) tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance. This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma. Segura Sheila

Academic pathology2018 Full Text: Link to full Text with Trip Pro

31. Educational Case: Medullary Thyroid Carcinoma

Educational Case: Medullary Thyroid Carcinoma 29978015 2018 11 14 2374-2895 5 2018 Jan-Dec Academic pathology Acad Pathol Educational Case: Medullary Thyroid Carcinoma. 2374289518770173 10.1177/2374289518770173 The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology (...) cytology medullary thyroid carcinoma organ system pathology pathology competencies 2017 11 20 2018 02 08 2018 02 16 2018 7 7 6 0 2018 7 7 6 0 2018 7 7 6 1 epublish 29978015 10.1177/2374289518770173 10.1177_2374289518770173 PMC6024339 Arch Pathol Lab Med. 1995 Jun;119(6):514-7 7605166 Hum Pathol. 2003 Nov;34(11):1092-100 14652809 Acta Cytol. 2016;60(3):185-97 27318895 Am J Clin Pathol. 2009 Nov;132(5):658-65 19846805 Acad Pathol. 2016 Jul 25;3:2374289516659079 28725774

Academic pathology2018 Full Text: Link to full Text with Trip Pro

32. Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery

Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery 29579320 2018 04 13 1365-2168 105 6 2018 May The British journal of surgery Br J Surg Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery. 645-649 10.1002/bjs.10829 Suturing the platysma muscle during wound closure after thyroid surgery is frequently described in the literature. There is no prospective evidence to support its use (...) or benefit. The aim of this study was to evaluate how a platysma muscle suture influences initial postoperative pain following thyroid surgery. Patients were assigned randomly to receive a platysma suture or no platysma suture in this prospective, patient-blinded trial. The duration of follow-up was 6 months. The primary endpoint was wound-specific pain 24 h after thyroid resection. Secondary endpoints were intraoperative and perioperative analgesia requirement, postoperative pain and complications until

EvidenceUpdates2018

33. Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery

Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery 29405252 2018 02 28 1365-2168 105 4 2018 Mar The British journal of surgery Br J Surg Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery. 350-357 10.1002/bjs.10783 Hypoparathyroidism, the most common complication after (...) thyroid surgery, leads to hypocalcaemia and significant medical problems. An RCT was undertaken to determine whether intraoperative parathyroid gland angiography with indocyanine green (ICG) could predict postoperative hypoparathyroidism, and obviate the need for systematic blood tests and oral calcium supplementation. Between September 2014 and February 2016, patients who had at least one well perfused parathyroid gland on ICG angiography were randomized to receive standard follow-up (measurement

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

34. Management of recurrent or metastatic thyroid cancer

Management of recurrent or metastatic thyroid cancer 29713501 2018 11 14 2059-7029 3 Suppl 1 2018 ESMO open ESMO Open Management of recurrent or metastatic thyroid cancer. e000359 10.1136/esmoopen-2018-000359 Recently, vascular endothelial growth factor receptor (VEGFR)-targeted tyrosine kinase inhibitors (TKIs) have become available for the treatment of recurrent or metastatic thyroid cancer. However, a number of clinical challenges that impact the use of VEGFR-targeted TKI in daily clinical (...) or with follicular thyroid cancer and increased risk of brain metastasis or bleeding. Thus, optimal timing for the start of VEGFR-targeted TKI requires careful consideration. Moreover, management of VEGFR-targeted TKI toxicities requires appropriate supportive care, well-organised infrastructure in the outpatient clinic and patient education. Future treatment will progress to precision medicine based on molecular testing. Promotion of precision medicine requires the establishment of a system of easy access

ESMO open2018 Full Text: Link to full Text with Trip Pro

35. Treating subclinical thyroid dysfunction in pregnancy probably has no benefit

Treating subclinical thyroid dysfunction in pregnancy probably has no benefit NIHR DC | Signal - Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Published on 8 August 2017 Testing for and then treating pregnant women with mild or “subclinical” underactive thyroid did not improve pregnancy outcomes, newborn baby outcomes (...) , or the child’s IQ at three to five years. A clearly underactive thyroid (clinical hypothyroidism) in pregnancy has been linked with various adverse outcomes for the mother and baby, including pre-eclampsia, preterm birth, congenital defects and neurodevelopmental delay. This needs treatment. However, there has been debate around the harms and benefits from treating only mildly abnormal blood test results in women who do not show signs of thyroid problems, subclinical hypothyroidism. These two linked trials

NIHR Dissemination Centre2018

36. Retrospective Analysis of Patients with Synchronous Primary Breast and Thyroid Carcinoma

Retrospective Analysis of Patients with Synchronous Primary Breast and Thyroid Carcinoma 29774315 2018 11 14 14 2 2018 Apr European journal of breast health Eur J Breast Health Retrospective Analysis of Patients with Synchronous Primary Breast and Thyroid Carcinoma. 80-84 10.5152/ejbh.2018.3853 Breast and thyroid cancers are commonly encountered malignancies. Increased risk of breast cancer in follow-up period of thyroid cancer or vice versa has been reported. However, they have some (...) associations, synchronous presentation of these tumors is rare. We presented 12 patients diagnosed as breast and thyroid cancer and treated at the same time. Mastectomy and thyroidectomy were performed in 19 patients at the same time. 7 patients were excluded because of benign thyroid pathology. Therefore 12 patients who had diagnosis of synchronous breast and thyroid cancer were included. Data regarding clinical, pathological, treatment and prognostic factors was retrospectively analyzed. Total

European journal of breast health2018 Full Text: Link to full Text with Trip Pro

37. Cabozantinib for treating medullary thyroid cancer

Cabozantinib for treating medullary thyroid cancer Cabozantinib for treating medullary Cabozantinib for treating medullary th thyroid cancer yroid cancer T echnology appraisal guidance Published: 28 March 2018 nice.org.uk/guidance/ta516 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent the view of NICE, arrived at after careful (...) a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Cabozantinib for treating medullary thyroid cancer (TA516) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 15Contents Contents 1 Recommendations 4 2 Information about cabozantinib 5 3 Committee discussion 6 The condition and current

National Institute for Health and Clinical Excellence - Technology Appraisals2018

38. Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma

Uptake of 99mTc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma 29644341 2018 11 14 2472-1972 2 4 2018 Apr 01 Journal of the Endocrine Society J Endocr Soc Uptake of 99m Tc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma. 386-390 10.1210/js.2018-00014 Technetium-99m methoxy isobutyl isonitrile ( 99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed (...) tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized

Journal of the Endocrine Society2018 Full Text: Link to full Text with Trip Pro

39. The Diagnosis and Management of Thyroid Nodules: A Review.

The Diagnosis and Management of Thyroid Nodules: A Review. Importance: Thyroid nodules are common, being detected in up to 65% of the general population. This is likely due to the increased use of diagnostic imaging for purposes unrelated to the thyroid. Most thyroid nodules are benign, clinically insignificant, and safely managed with a surveillance program. The main goal of initial and long-term follow-up is identification of the small subgroup of nodules that harbor a clinically significant (...) cancer (≈10%), cause compressive symptoms (≈5%), or progress to functional disease (≈5%). Observations: Thyroid function testing and ultrasonographic characteristics guide the initial management of thyroid nodules. Certain ultrasound features, such as a cystic or spongiform appearance, suggest a benign process that does not require additional testing. Suspicious sonographic patterns including solid composition, hypoechogenicity, irregular margins, and microcalcifications should prompt cytological

JAMA2018

40. Cutting‐edge endonasal surgical approaches to thyroid ophthalmopathy

Cutting‐edge endonasal surgical approaches to thyroid ophthalmopathy Cutting‐edge endonasal surgical approaches to thyroid ophthalmopathy - Tyler - 2018 - Laryngoscope Investigative Otolaryngology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search term Search Search term Search The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Allergy, Rhinology, and Immunology Open Access Cutting (...) ‐edge endonasal surgical approaches to thyroid ophthalmopathy Department of Otorhinolaryngology–Head & Neck Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, U.S.A. Department of Otorhinolaryngology–Head & Neck Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, U.S.A. Department of Otorhinolaryngology–Head & Neck Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, U.S.A

Laryngoscope investigative otolaryngology2018 Full Text: Link to full Text with Trip Pro