Latest & greatest articles for thyroid

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on thyroid or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on thyroid and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for thyroid

301. Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer

Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer McGriff N J, Csako G, Gourgiotis L, Guthrie L C, Pucino F, Sarlis N J Authors' objectives To evaluate the effect of thyroid hormone suppression therapy (THST) on the clinical outcomes of papillary and/or follicular (...) well-differentiated thyroid cancer (ThyrCa). Searching MEDLINE and EMBASE were searched using the search terms listed in the report. Manual searches of literature (1937 to 2000) were also performed. There were no language restrictions, but only published studies were eligible for inclusion. Study selection Study designs of evaluations included in the review The review did not state a priori inclusion criteria for study design. The included studies were described as case series, registry

DARE.2002

302. Role of fine-needle aspiration biopsy and frozen-section evaluation in the surgical management of thyroid nodules

Role of fine-needle aspiration biopsy and frozen-section evaluation in the surgical management of thyroid nodules Role of fine-needle aspiration biopsy and frozen-section evaluation in the surgical management of thyroid nodules Role of fine-needle aspiration biopsy and frozen-section evaluation in the surgical management of thyroid nodules Caraci P, Aversa S, Mussa A, Pancani G, Ondolo C, Conticello S Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of intraoperative frozen section (FS) and fine-needle aspiration biopsy (FNAB) for the evaluation of thyroid nodules that require surgical treatment. Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis. Study population The study population

NHS Economic Evaluation Database.2002

303. The value of frozen section examinations in determining the extent of thyroid surgery in patients with indeterminate fine-needle aspiration cytology

The value of frozen section examinations in determining the extent of thyroid surgery in patients with indeterminate fine-needle aspiration cytology The value of frozen section examinations in determining the extent of thyroid surgery in patients with indeterminate fine-needle aspiration cytology The value of frozen section examinations in determining the extent of thyroid surgery in patients with indeterminate fine-needle aspiration cytology Roach J C, Heller K S, Dubner S, Sznyter L A Record (...) Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of intraoperative frozen section examination (FSE) to establish a diagnosis of thyroid cancer in patients undergoing thyroidectomy for nodules with indeterminate cytological results

NHS Economic Evaluation Database.2002

304. Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study.

Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study. BACKGROUND: Some so-called autoimmune diseases in women might be alloimmune and represent a chronic graft-versus-host response attributable to transplacentally acquired fetal cells. Thyroid disease is more common in women than men, and post partum exacerbation of thyroiditis is common. Our aim was to investigate whether there is an association between fetal cell microchimerism and thyroid disease (...) in women. METHODS: Surgical specimens were obtained from 29 women who underwent thyroidectomy for various thyroid disorders. Control specimens were taken from clinically and histologically normal thyroids obtained at necropsy from eight women who died from unrelated conditions. Medical records and pregnancy histories were reviewed. Fluorescence in-situ hybridisation analysis was done with probes specific for X and Y chromosomes. Slides were examined with a fluorescence microscope to detect the presence

Lancet2001

305. 15 years after Chernobyl: new evidence of thyroid cancer.

15 years after Chernobyl: new evidence of thyroid cancer. The Chernobyl nuclear power plant accident happened on April 26, 1986. We investigated the cause of the striking increase in frequency of thyroid cancer in children who lived within a 150 km radius of Chernobyl and who were born before and after the accident. No thyroid cancer was seen in 9472 children born in 1987-89, whereas one and 31 thyroid cancers were recorded in 2409 children born April 27, 1986, to Dec 31, 1986, and 9720 born (...) Jan 1, 1983, to April 26, 1986, respectively. Short-lived radioactive fallout caused by the Chernobyl accident probably induced thyroid cancer in children living near Chernobyl.

Lancet2001

306. Diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography in the follow-up of papillary or follicular thyroid cancer

Diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography in the follow-up of papillary or follicular thyroid cancer Diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography in the follow-up of papillary or follicular thyroid cancer Diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography in the follow-up of papillary or follicular thyroid cancer Hooft L, Hoekstra O S, Deville W, Lips P, Teule G J, Boers M, van Tulder M W Authors' objectives (...) To determine the diagnostic accuracy of positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) in patients suspected of recurrent papillary or follicular thyroid carcinoma. Searching MEDLINE, EMBASE and Cancerlit were searched up to October 2000 for studies reported in any language. A specifically designed search strategy for diagnostic accuracy studies was combined with a specific search for PET, FDG and thyroid cancer. Further details of the searches were provided in the review

DARE.2001

307. Does thyroid supplementation accelerate tricyclic antidepressant response: a review and meta-analysis of the literature

Does thyroid supplementation accelerate tricyclic antidepressant response: a review and meta-analysis of the literature Does thyroid supplementation accelerate tricyclic antidepressant response: a review and meta-analysis of the literature Does thyroid supplementation accelerate tricyclic antidepressant response: a review and meta-analysis of the literature Altshuler L L, Bauer M, Frye M A, Gitlin M J, Mintz J, Szuba M P, Leight K L, Whybrow P C Authors' objectives To determine whether adding (...) thyroid hormone to antidepressants increases the speed of response in patients with nonrefractory depression. Searching MEDLINE was searched from 1966 to March 2000; the key terms were stated. In addition, the reference lists of identified studies and reviews were checked. Studies published in any language were eligible for inclusion. Study selection Study designs of evaluations included in the review Double-blind placebo-controlled trials (RCTs) were eligible for inclusion. Studies with less than

DARE.2001

308. Cost-effectiveness of prenatal screening for postpartum thyroiditis

Cost-effectiveness of prenatal screening for postpartum thyroiditis Cost-effectiveness of prenatal screening for postpartum thyroiditis Cost-effectiveness of prenatal screening for postpartum thyroiditis Bonds D E, Freedberg K A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability (...) of the study and the conclusions drawn. Health technology Screening pregnant women for the thyroid peroxidase (TPO) antibody. This was compared with the current strategy of no screening, or an alternative strategy of a thyroid-stimulating hormone (TSH) test 6 weeks' postpartum. Type of intervention Screening. Economic study type Cost-utility analysis. Study population The study population comprised hypothetical cohorts of 1,000 pregnant women with uncomplicated pregnancies and 1,000 pregnant women

NHS Economic Evaluation Database.2001

309. Randomized prospective evaluation of frozen-section analysis for follicular neoplasms of the thyroid

Randomized prospective evaluation of frozen-section analysis for follicular neoplasms of the thyroid Randomized prospective evaluation of frozen-section analysis for follicular neoplasms of the thyroid Randomized prospective evaluation of frozen-section analysis for follicular neoplasms of the thyroid Udelsman R, Westra W H, Donovan P I, Sohn T A, Cameron J L Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of frozen-section analysis to establish a precise diagnosis of malignancy on patients with a dominant thyroid nodule, which was demonstrated by fine-needle aspiration (FNA) to be a follicular or Hurthle cell neoplasm of the thyroid. Patients had thyroid lobectomy and isthmusectomy. A surgeon and a pathologist

NHS Economic Evaluation Database.2001

310. Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial.

Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial. 11668132 2001 10 22 2001 12 04 2015 11 19 0959-8138 323 7318 2001 Oct 20 BMJ (Clinical research ed.) BMJ Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial. 891-5 To determine whether thyroxine (...) treatment is effective in patients with symptoms of hypothyroidism but with thyroid function tests within the reference range, and to investigate the effect of thyroxine treatment on psychological and physical wellbeing in healthy participants. Randomised double blind placebo controlled crossover trial. Outpatient clinic in a general hospital. 25 patients with symptoms of hypothyroidism who had thyroid function tests within the reference range, and 19 controls. PARTICIPANTS were given thyroxine 100

BMJ2001 Full Text: Link to full Text with Trip Pro

311. Thyroid hormones for preventing neurodevelopmental impairment in preterm infants.

Thyroid hormones for preventing neurodevelopmental impairment in preterm infants. BACKGROUND: Observational studies have shown an association between transiently low thyroid hormone levels in preterm infants in the first weeks of life (transient hypothyroxinemia) and abnormal neurodevelopmental outcome. Thyroid hormone therapy might prevent this morbidity. OBJECTIVES: To assess whether thyroid hormone therapy in preterm infants without congenital hypothyroidism results in clinically important (...) allocation, in which thyroid hormone therapy (either treatment or prophylaxis) was compared to control in premature infants. DATA COLLECTION AND ANALYSIS: Primary clinical outcomes included measures of neurodevelopmental outcome and mortality. Assessment of trial quality, data extraction and synthesis of data, using relative risk (RR) and weighted mean difference (WMD), were performed using standard methods of the Cochrane Collaboration and its Neonatal Review Group. MAIN RESULTS: Nine studies were

Cochrane2001

312. Ablation of the thyroid remnant and I-131 dose in differentiated thyroid cancer

Ablation of the thyroid remnant and I-131 dose in differentiated thyroid cancer Ablation of the thyroid remnant and I-131 dose in differentiated thyroid cancer Ablation of the thyroid remnant and I-131 dose in differentiated thyroid cancer Doi S A, Woodhouse N J Authors' objectives To compare the efficacy of remnant ablation following a single low dose versus a single high dose of iodine-131 (I-131) in patients with differentiated thyroid cancer, and to determine whether or not the extent (...) in the review Studies of patients who had received surgery for differentiated thyroid cancer were eligible for inclusion in the review. Patients not eligible for inclusion were: patients with medullary, anaplastic or poorly differentiated carcinomas who were not given radioiodine; patients who presented with distant metastases; and patients who received their first dose of I-131 more than 12 months after surgery. The studies included patients who had received total, near-total and sub-total thyroidectomy

DARE.2000

313. Assessing the effects of thyroid suppression on benign solitary thyroid nodules: a model for using quantitative research synthesis

Assessing the effects of thyroid suppression on benign solitary thyroid nodules: a model for using quantitative research synthesis Assessing the effects of thyroid suppression on benign solitary thyroid nodules: a model for using quantitative research synthesis Assessing the effects of thyroid suppression on benign solitary thyroid nodules: a model for using quantitative research synthesis Csako G, Byrd D, Wesley R A, Sarlis N J, Skarulis M C, Nieman L K, Pucino F Authors' objectives (...) To evaluate and develop standards of care for levothyroxine (L-T4) suppression therapy in patients with benign solitary thyroid nodules. Searching A search of MEDLINE, and a manual search of the literature, were performed from 1950 to 1998 using the MeSH 'levothyroxine' and 'thyroid nodule'. English and non-English language articles were reviewed. Study selection Study designs of evaluations included in the review All study designs were eligible for inclusion in the review. Case reports, open-label cohort

DARE.2000

314. Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature

Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature Danese M D, Ladenson P W, Meinert C L, Powe N R Authors' objectives To estimate the expected change in serum (...) lipoprotein concentrations after treatment with hydroxine therapy (T4) in patients with mild thyroid failure, i.e. subclinical hypothyroidism. Searching The authors searched MEDLINE from 1966 to May 1999 using the textwords 'thyroid disease' and 'cholesterol'. Additional published and unpublished material was located by examining the reference lists of retrieved articles, and contacting their authors. Study selection Study designs of evaluations included in the review RCTs and prospective evaluations

DARE.2000

315. [Evaluation of the Ultracision ultrasonic dissector in thyroid surgery: a prospective randomized study]

[Evaluation of the Ultracision ultrasonic dissector in thyroid surgery: a prospective randomized study] Evaluation de l'utilisation du dissecteur ultrasonique Ultracision en chirurgie thyroidienne: etude prospective randomisee [Evaluation of the Ultracision ultrasonic dissector in thyroid surgery: a prospective randomized study] Evaluation de l'utilisation du dissecteur ultrasonique Ultracision en chirurgie thyroidienne: etude prospective randomisee [Evaluation of the Ultracision ultrasonic (...) dissector in thyroid surgery: a prospective randomized study] Meurisse M, Defechereux T, Maweja S, Degauque C, Vandelaer M, Hamoir E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of an ultrasonic hook (HS 002, Ultracision

NHS Economic Evaluation Database.2000

316. Thyroid hormone for preventing of neurodevelopmental impairment in preterm infants.

Thyroid hormone for preventing of neurodevelopmental impairment in preterm infants. BACKGROUND: Observational studies have shown an association between transiently low thyroid hormone levels in preterm infants in the first weeks of life (transient hypothyroxemia) and an abnormal neurodevelopmental outcome. Thyroid hormone therapy might prevent this morbidity. OBJECTIVES: To assess whether thyroid hormone therapy in preterm infants without congenital hypothyroidism results in clinically (...) patient allocation, in which thyroid hormone therapy (either treatment or prophylaxis) was compared to a control in premature infants. DATA COLLECTION AND ANALYSIS: Primary clinical outcomes included measures of neurodevelopmental outcome and mortality. Assessment of trial quality, data extraction and synthesis of data, using relative risk (RR) and weighted mean difference (WMD), were performed using standard methods of the Cochrane Collaboration and its Neonatal Review Group. MAIN RESULTS: Eight

Cochrane2000

317. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. 10568572 1999 11 30 1999 11 30 2015 06 16 0140-6736 354 9191 1999 Nov 13 Lancet (London, England) Lancet Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. 1691-5 Multiple sclerosis results from T-cell-dependent inflammatory demyelination of the central nervous system. Our objective was long-term suppression of inflammation with short-term monoclonal antibody (...) of patients developed antibodies against the thyrotropin receptor and carbimazole-responsive autoimmune hyperthyroidism. The depleted peripheral lymphocyte pool was reconstituted with cells that had decreased mitogen-induced proliferation and interferon gamma secretion in vitro. Campath-1H causes the immune response to change from the Th1 phenotype, suppressing multiple sclerosis disease activity, but permitting the generation of antibody-mediated thyroid autoimmunity. Coles A J AJ University of Cambridge

Lancet1999

318. Clinical guideline - part 2. Screening for thyroid disease: an update

Clinical guideline - part 2. Screening for thyroid disease: an update Clinical guideline - part 2. Screening for thyroid disease: an update Clinical guideline - part 2. Screening for thyroid disease: an update Helfand M, Redfern C C Authors' objectives To review information on the benefits of screening with a thyroid-stimulating hormone (TSH) test for thyroid dysfunction in asymptomatic patients seeking primary care for other reasons. A subsidiary aim was to evaluate the efficacy of treatment (...) for subclinical thyroid dysfunction. Searching The authors reviewed the original literature from 1989 to 1996 to identify articles that were not included in the original College background paper (Helfand & Crapo, 1990; see Other Publications of Related Interest). In a MEDLINE search, the MeSH terms "thyroid function tests" and "thyroid diseases" were combined with the term "mass screening" and the textwords "screening" or "case finding". A separate MEDLINE search (1970 to 1996) was conducted for controlled

DARE.1998

319. Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses

Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses Zelmanovitz F, Genro S, Gross J L Authors' objectives To assess the effect (...) of suppressive doses of levothyroxine (T4) on the volume of benign solitary thyroid nodules (STN) and bone mineral density (BMD). Searching The authors searched the MEDLINE electronic database (January 1985 to December 1997). No further search details are reported. Study selection Study designs of evaluations included in the review Prospective controlled clinical trials with a sufficient dose of T4 for TSH suppression. Additional study inclusion criteria were: 1. A minimum study period of 6 months. 2. STN

DARE.1998

320. Evaluation of solitary thyroid nodules in a community practice: a managed care approach

Evaluation of solitary thyroid nodules in a community practice: a managed care approach Evaluation of solitary thyroid nodules in a community practice: a managed care approach Evaluation of solitary thyroid nodules in a community practice: a managed care approach Gossain V V, Charnas J, Carella M J, Rovner D R, Calaca W D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Fine-needle aspiration biopsy or radioisotope and ultrasound scan in the initial evaluation of solitary thyroid nodules. Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis. Study population Patients assigned to thyroid aspiration. Setting Hospital. The economic study was carried out in the USA. Dates to which data relate

NHS Economic Evaluation Database.1998