Latest & greatest articles for thyroid

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Top results for thyroid

181. Revised ATA guidelines for the management of medullary thyroid carcinoma

Revised ATA guidelines for the management of medullary thyroid carcinoma SPECIAL ARTICLE Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma The American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma Samuel A. Wells, Jr., 1, * Sylvia L. Asa, 2 Henning Dralle, 3 Rossella Elisei, 4 Douglas B. Evans, 5 Robert F. Gagel, 6 Nancy Lee, 7 Andreas Machens, 3 Jeffrey F. Moley, 8 Furio Pacini, 9 Friedhelm Raue, 10 Karin Frank-Raue (...) , 10 Bruce Robinson, 11 M. Sara Rosenthal, 12 Massimo Santoro, 13 Martin Schlumberger, 14 Manisha Shah, 15 and Steven G. Waguespack 6 Introduction: The American Thyroid Association appointed a Task Force of experts to revise the original Medullary Thyroid Carcinoma: Management Guidelines of the American Thyroid Association. Methods: The Task Force identi?ed relevant articles using a systematic PubMed search, supplemented with additionalpublishedmaterials,andthencreatedevidence-basedrecommendations

2015 Pediatric Endocrine Society

182. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer SPECIAL ARTICLES Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Pediatric Thyroid Cancer Gary L. Francis, 1, * Steven G. Waguespack, 2, * Andrew J. Bauer, 3,4, * Peter Angelos, 5 Salvatore Benvenga, 6 Janete M. Cerutti, 7 Catherine A. Dinauer, 8 Jill Hamilton, 9 Ian D. Hay, 10 Markus Luster, 11,12 (...) Marguerite T. Parisi, 13 Marianna Rachmiel, 14,15 Geoffrey B. Thompson, 16 and Shunichi Yamashita 17 Background: Previous guidelines for the management of thyroid nodules and cancers were geared toward adults. Compared with thyroid neoplasms in adults, however, those in the pediatric population exhibit differ- ences in pathophysiology, clinical presentation, and long-term outcomes. Furthermore, therapy that may be recommended for an adult may not be appropriate for a child who is at low risk for death

2015 Pediatric Endocrine Society

183. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer

2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer SPECIAL ARTICLE 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer Bryan R. Haugen, 1, * Erik K. Alexander, 2 Keith C. Bible, 3 Gerard M. Doherty, 4 Susan J. Mandel, 5 Yuri E (...) . Nikiforov, 6 Furio Pacini, 7 Gregory W. Randolph, 8 Anna M. Sawka, 9 Martin Schlumberger, 10 Kathryn G. Schuff, 11 Steven I. Sherman, 12 Julie Ann Sosa, 13 David L. Steward, 14 R. Michael Tuttle, 15 and Leonard Wartofsky 16 Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the American Thyroid Association’s (ATA’s) guidelines for the management of these disorders were revised in 2009, signi?cant scienti?c advances have

2015 Pediatric Endocrine Society

184. Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee

Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee REQUESTED REVIEW Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee Onyebuchi Okosieme*, Jackie Gilbert†, Prakash Abraham‡, Kristien Boelaert§, Colin Dayan¶, Mark Gurnell**, Graham Leese††, Christopher McCabe‡‡, Petros Perros§§, Vicki Smith‡‡, Graham Williams¶¶ and Mark Vanderpump*** *Medicine, Prince Charles Hospital, Merthyr Tyd?l (...) of such individuals has been the subject of controversy and of con- siderable public interest. The American Thyroid Association (ATA) and the European Thyroid Association (ETA) have recently published guidelines on the diagnosis and management of hypothyroidism. These guidelines have been based on exten- sive reviews of the medical literature and include sections on the role of combination therapy with L-T4 and liothyronine (L-T3) in individuals who are persistently dissatis?ed with L-T4 ther- apy. This position

2015 British Thyroid Association

185. Application of Texture Analysis Method for Classification of Benign and Malignant Thyroid Nodules in Ultrasound Images Full Text available with Trip Pro

Application of Texture Analysis Method for Classification of Benign and Malignant Thyroid Nodules in Ultrasound Images The aim of this study was to evaluate computer aided diagnosis (CAD) system with texture analysis (TA) to improve radiologists' accuracy in identification of thyroid nodules as malignant or benign.A total of 70 cases (26 benign and 44 malignant) were analyzed in this study. We extracted up to 270 statistical texture features as a descriptor for each selected region of interests (...) (ROIs) in three normalization schemes (default, 3s and 1%-99%). Then features by the lowest probability of classification error and average correlation coefficients (POE+ACC), and Fisher coefficient (Fisher) eliminated to 10 best and most effective features. These features were analyzed under standard and nonstandard states. For TA of the thyroid nodules, Principle Component Analysis (PCA), Linear Discriminant Analysis (LDA) and Non-Linear Discriminant Analysis (NDA) were applied. First Nearest

2015 Iranian journal of cancer prevention

186. Thyroid Dysfunction: Screening

Thyroid Dysfunction: Screening Recommendation | United States Preventive Services Taskforce Toggle navigation Main navigation Main navigation Recommendation Nonpregnant, asymptomatic adults The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for thyroid dysfunction in nonpregnant, asymptomatic adults. I View the Clinical Summary in Population Nonpregnant, asymptomatic adults Recommendation No recommendation. Grade: I statement (...) (insufficient evidence) Risk Assessment Risk factors for an elevated thyroid-stimulating hormone (TSH) level include female sex, advancing age, white race, type 1 diabetes, Down syndrome, family history of thyroid disease, goiter, previous hyperthyroidism, and external-beam radiation in the head and neck area. Risk factors for a low TSH level include female sex; advancing age; black race; low iodine intake; personal or family history of thyroid disease; and ingestion of iodine-containing drugs

2015 U.S. Preventive Services Task Force

187. Response and acquired resistance to everolimus in anaplastic thyroid cancer. Full Text available with Trip Pro

Response and acquired resistance to everolimus in anaplastic thyroid cancer. Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is effective in treating tumors harboring alterations in the mTOR pathway. Mechanisms of resistance to everolimus remain undefined. Resistance developed in a patient with metastatic anaplastic thyroid carcinoma after an extraordinary 18-month response. Whole-exome sequencing of pretreatment and drug-resistant tumors revealed a nonsense mutation

2014 NEJM

188. Management of Thyroid Cancer

Management of Thyroid Cancer CLINICAL ENDOCRINOLOGY VOLUME 81 SUPPLEMENT 1 JULY 2014 THE CLINICAL JOURNAL OF THE SOCIETY FOR ENDOCRINOLOGY AND THE ENDOCRINE SOCIETY OF AUSTRALIA British Thyroid Association Guidelines for the Management of Thyroid CancerGuidelines for the management of thyroid cancer Third edition British Thyroid Association July 2014 Perros P, Colley S, Boelaert K, Evans C, Evans RM, Gerrard GE, Gilbert JA, Harrison B, Johnson SJ, Giles TE, Moss L, Lewington V , Newbold KL (...) , Taylor J, Thakker RV , Watkinson J, Williams GR cen_frontmatter.indd i cen_frontmatter.indd i 6/27/2014 3:52:19 PM 6/27/2014 3:52:19 PMii Acknowledgements Grateful thanks are expressed to the many reviewers of these guidelines. These included leading international experts in thyroid cancer, hospital specialists, and general practitioners. They devoted much time and care to considering the document and their recommendations and suggestions for improvements were most valuable. Special thanks to Dr

2014 British Association of Endocrine and Thyroid Surgeons

189. miRInform Thyroid

miRInform Thyroid miRInform Thyroid miRInform Thyroid Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation miRInform Thyroid. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2014 Authors' objectives Thyroid nodules are discrete masses present in the thyroid gland that are a common clinical finding among adults in the general population. Approximately (...) 5% of women and 1% of men have a palpable thyroid nodule on physical examination. The evaluation of thyroid nodules, which may represent benign lesions or malignant thyroid tumors, typically includes a cytopathologic examination of a biopsy specimen obtained by fine-needle aspiration (FNA). Thyroid nodules are subsequently classified based on cytology, with 70% to 75% of nodules being benign and approximately 5% being malignant. Approximately 20% to 25% of thyroid nodules are classified

2014 Health Technology Assessment (HTA) Database.

190. A thyroid mass that moves with tongue protrusion: An ectopic thyroid gland Full Text available with Trip Pro

A thyroid mass that moves with tongue protrusion: An ectopic thyroid gland Thyroglossal duct cyst (TDC) is a developmental anomaly that usually appears in early childhood. The common presentation is midline swelling of the neck, which moves with both tongue protrusion and deglutition. Diagnosis is usually clinical and radiological. Fine needle aspiration cytology (FNAC) can be used as a tool for the exclusion of malignancy in adult patients. In some cases thyroid scan is done to rule out (...) the presence or absence of the normal thyroid gland. A complete work-up is mandatory before cyst removal given that it contains only thyroid tissue. We report the case of a 32-year-old woman with only thyroid tissue in thyroglossal duct cyst.

2014 Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia

191. Management of Thyroid Cancer

Management of Thyroid Cancer CLINICAL ENDOCRINOLOGY VOLUME 81 SUPPLEMENT 1 JULY 2014 THE CLINICAL JOURNAL OF THE SOCIETY FOR ENDOCRINOLOGY AND THE ENDOCRINE SOCIETY OF AUSTRALIA British Thyroid Association Guidelines for the Management of Thyroid CancerGuidelines for the management of thyroid cancer Third edition British Thyroid Association July 2014 Perros P, Colley S, Boelaert K, Evans C, Evans RM, Gerrard GE, Gilbert JA, Harrison B, Johnson SJ, Giles TE, Moss L, Lewington V , Newbold KL (...) , Taylor J, Thakker RV , Watkinson J, Williams GR cen_frontmatter.indd i cen_frontmatter.indd i 6/27/2014 3:52:19 PM 6/27/2014 3:52:19 PMii Acknowledgements Grateful thanks are expressed to the many reviewers of these guidelines. These included leading international experts in thyroid cancer, hospital specialists, and general practitioners. They devoted much time and care to considering the document and their recommendations and suggestions for improvements were most valuable. Special thanks to Dr

2014 British Thyroid Association

192. Low risk papillary thyroid cancer. (Abstract)

Low risk papillary thyroid cancer. Thyroid cancer is one of the fastest growing diagnoses; more cases of thyroid cancer are found every year than all leukemias and cancers of the liver, pancreas, and stomach. Most of these incident cases are papillary in origin and are both small and localized. Patients with these small localized papillary thyroid cancers have a 99% survival rate at 20 years. In view of the excellent prognosis of these tumors, they have been denoted as low risk. The incidence (...) of these low risk thyroid cancers is growing, probably because of the use of imaging technologies capable of exposing a large reservoir of subclinical disease. Despite their excellent prognosis, these subclinical low risk cancers are often treated aggressively. Although surgery is traditionally viewed as the cornerstone treatment for these tumors, there is less agreement about the extent of surgery (lobectomy v near total thyroidectomy) and whether prophylactic central neck dissection for removal of lymph

2014 BMJ

193. Acetazolamide and Thyroid-Associated Ophthalmopathy; a Preliminary Tested Hypothesis in a TertiaryReferral Center. (Abstract)

Acetazolamide and Thyroid-Associated Ophthalmopathy; a Preliminary Tested Hypothesis in a TertiaryReferral Center. This study evaluated the effect of acetazolamide on thyroid-associated ophthalmopathy (TAO). Patients with a VISA classification index equal to or more than four were enrolled in the study and were randomly assigned into two groups. In both groups, treatment was initiated using prednisolone. Patients in the case group received acetazolamide tablets 250 mg daily in addition

2014 Medical hypothesis, discovery & innovation ophthalmology journal Controlled trial quality: uncertain

194. Afirma thyroid FNA analysis

Afirma thyroid FNA analysis Afirma thyroid FNA analysis Afirma thyroid FNA analysis Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Afirma thyroid FNA analysis. Lansdale: HAYES, Inc.. Genetic Testing Publication. 2014 Authors' conclusions Thyroid nodules are discrete masses present in the thyroid gland that are a common clinical finding among adults (...) in the general population. Approximately 5% of women and 1% of men have a palpable thyroid nodule on physical examination. The evaluation of thyroid nodules, which may represent benign lesions or malignant thyroid tumors, typically includes a cytopathologic examination of a biopsy specimen obtained by fine-needle aspiration (FNA). Thyroid nodules are subsequently classified based on cytology, with 70% to 75% of nodules being benign and approximately 5% being malignant. Approximately 20% to 25% of thyroid

2014 Health Technology Assessment (HTA) Database.

195. Thyroid hormone inactivation in gastrointestinal stromal tumors. Full Text available with Trip Pro

Thyroid hormone inactivation in gastrointestinal stromal tumors. Gastrointestinal stromal tumors (GISTs) are resistant to traditional chemotherapy but are responsive to the tyrosine kinase inhibitors imatinib and sunitinib. The use of these agents has improved the outcome for patients but is associated with adverse effects, including hypothyroidism. Multiple mechanisms of this effect have been proposed, including decreased iodine organification and glandular capillary regression. Here we report (...) the finding of consumptive hypothyroidism caused by marked overexpression of the thyroid hormone-inactivating enzyme type 3 iodothyronine deiodinase (D3) within the tumor. Affected patients warrant increased monitoring and may require supernormal thyroid hormone supplementation.

2014 NEJM

196. Technologies scoping report 22: In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies?

Technologies scoping report 22: In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies? In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies? In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies? Thompson L Record Status (...) This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Thompson L. In the context of hypothyroidism, what is the evidence for the effectiveness of diagnostic tests and thyroid hormone replacement therapies? Glasgow: Healthcare Improvement Scotland. 2014 Authors' conclusions An American non-systematic literature review reported that serum T3 measurement has little specificity

2014 Health Technology Assessment (HTA) Database.

197. Chinese herbal medicines for benign thyroid nodules in adults. (Abstract)

Chinese herbal medicines for benign thyroid nodules in adults. A thyroid nodule is a discrete lesion within the thyroid gland that might be palpable and is ultrasonographically distinct from the surrounding thyroid parenchyma. Thyroid nodules are more common as age increases and occur more frequently in women. Benign thyroid nodules often cause pressure symptoms and cosmetic complaints. In China and many other countries, doctors use Chinese herbal medicines (CHM) to treat thyroid nodules.To (...) assess the effects of Chinese herbal medicines in the treatment of benign thyroid nodules in adults.Review authors searched the following electronic databases: The Cochrane Library, MEDLINE, EMBASE, the Chinese Biomedical Literature Database (CBM), the China National Knowledge Infrastructure (CNKI), VIP information (a Chinese database), WANFANG Data (a Chinese database), the Chinese Conference Papers Database and the Chinese Dissertation Database (all searched up to April 2013).Randomised controlled

2014 Cochrane

198. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Full Text available with Trip Pro

Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Patients with radioactive iodine ((131)I)-refractory locally advanced or metastatic differentiated thyroid cancer have a poor prognosis because of the absence of effective treatment options. In this study, we assessed the efficacy and safety of orally administered sorafenib in the treatment of patients with this type of cancer.In this multicentre (...) , randomised, double-blind, placebo-controlled, phase 3 trial (DECISION), we investigated sorafenib (400 mg orally twice daily) in patients with radioactive iodine-refractory locally advanced or metastatic differentiated thyroid cancer that had progressed within the past 14 months. Adult patients (≥18 years of age) with this type of cancer were enrolled from 77 centres in 18 countries. To be eligible for inclusion, participants had to have at least one measurable lesion by CT or MRI according to Response

2014 Lancet Controlled trial quality: predicted high

199. Case-control study: Population-based study provides a step towards evidence-based management of thyroid nodules detected on ultrasound

Case-control study: Population-based study provides a step towards evidence-based management of thyroid nodules detected on ultrasound Population-based study provides a step towards evidence-based management of thyroid nodules detected on ultrasound | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Population-based study provides a step towards evidence-based management of thyroid nodules detected on ultrasound Article Text Diagnosis

2014 Evidence-Based Medicine

200. Selenium supplementation for Hashimoto's thyroiditis. Full Text available with Trip Pro

Selenium supplementation for Hashimoto's thyroiditis. Hashimoto's thyroiditis is a common auto-immune disorder. The most common presenting symptoms may include anxiety, negative mood, depression, dry skin, cold intolerance, puffy eyes, muscle cramps and fatigue, deep voice, constipation, slow thinking and poor memory. Clinical manifestations of the disease are defined primarily by low levels of thyroid hormones; therefore it is treated by hormone replacement therapy, which usually consists (...) with sodium selenite 200 μg plus titrated LT4 compared with placebo plus titrated LT4 (relative risk (RR) 4.67, 95% confidence interval (CI) 1.61 to 13.50; P = 0.004; 36 participants; number needed to treat (NNT) = 2 (95% CI 2 to 3)).Selenomethionine 200 μg reduced the serum levels of anti-thyroid peroxidase antibodies compared with placebo in two studies (mean difference (MD) -917 U/mL, 95% CI -1056 to -778; P < 0.001; 85 participants) and (MD -345 IU/mL, 95% CI -359 to -331; P < 0.001; 169 participants

2013 Cochrane