Latest & greatest articles for thyroid

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Top results for thyroid

181. EANM Dosimetry Committee Series on Standard Operational Procedures for Pre-Therapeutic Dosimetry II. Dosimetry prior to Radioiodine Therapy of Benign Thyroid Diseases (Supplement)

EANM Dosimetry Committee Series on Standard Operational Procedures for Pre-Therapeutic Dosimetry II. Dosimetry prior to Radioiodine Therapy of Benign Thyroid Diseases (Supplement)

European Association of Nuclear Medicine2013

182. EANM Dosimetry Committee Series on Standard Operational Procedures for Pre-Therapeutic Dosimetry II. Dosimetry prior to Radioiodine Therapy of Benign Thyroid Diseases

EANM Dosimetry Committee Series on Standard Operational Procedures for Pre-Therapeutic Dosimetry II. Dosimetry prior to Radioiodine Therapy of Benign Thyroid Diseases

European Association of Nuclear Medicine2013

183. Rituximab for thyroid-associated ophthalmopathy.

Rituximab for thyroid-associated ophthalmopathy. BACKGROUND: Thyroid associated ophthalmopathy (TAO) is the most frequent extrathyroidal manifestation of Graves' disease, affecting up to 50% of patients, and has a great impact on quality of life. Rituximab is a human/murine chimeric monoclonal antibody that targets CD20, a transmembrane protein expressed on the surface of pre-B and mature B lymphocytes, but not on stem cells, pro-B lymphocytes or plasma cells. Preliminary work has shown

Cochrane2013

184. BRAF p.Val600Glu testing in papillary thyroid carcinoma

BRAF p.Val600Glu testing in papillary thyroid carcinoma BRAF p.Val600Glu testing in papillary thyroid carcinoma BRAF p.Val600Glu testing in papillary thyroid carcinoma Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation BRAF p.Val600Glu testing in papillary thyroid carcinoma. Lansdale: HAYES, Inc.. Genetic Testing Publication. 2013 Authors' conclusions The incidence (...) of thyroid carcinoma is rising steadily; in the United States, approximately 48,000 new cases were diagnosed and 1700 deaths were attributed to the disease in 2011. While thyroid cancer occurs more in women, it is more often fatal in men, and it is more common in whites than in blacks. Thyroid carcinoma is categorized into 3 histological types: differentiated, medullary, and anaplastic. A subtype of differentiated thyroid carcinoma, papillary thyroid carcinoma (PTC), comprised 80% of all treated thyroid

Health Technology Assessment (HTA) Database.2013

185. Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer.

Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. IMPORTANCE: BRAF V600E is a prominent oncogene in papillary thyroid cancer (PTC), but its role in PTC-related patient mortality has not been established. OBJECTIVE: To investigate the relationship between BRAF V600E mutation and PTC-related mortality. DESIGN, SETTING, AND PARTICIPANTS: Retrospective study of 1849 patients (1411 women and 438 men) with a median age of 46 years (interquartile range

JAMA2013 Full Text: Link to full Text with Trip Pro

186. Progress in molecular-based management of differentiated thyroid cancer.

Progress in molecular-based management of differentiated thyroid cancer. Substantial developments have occurred in the past 5-10 years in clinical translational research of thyroid cancer. Diagnostic molecular markers, such as RET-PTC, RAS, and BRAF(V600E) mutations; galectin 3; and a new gene expression classifier, are outstanding examples that have improved diagnosis of thyroid nodules. BRAF mutation is a prognostic genetic marker that has improved risk stratification and hence tailored (...) management of patients with thyroid cancer, including those with conventionally low risks. Novel molecular-targeted treatments hold great promise for radioiodine-refractory and surgically inoperable thyroid cancers as shown in clinical trials; such treatments are likely to become a component of the standard treatment regimen for patients with thyroid cancer in the near future. These novel molecular-based management strategies for thyroid nodules and thyroid cancer are the most exciting developments

Lancet2013 Full Text: Link to full Text with Trip Pro

187. Afirma® thyroid FNA analysis

Afirma® thyroid FNA analysis Afirma® thyroid FNA analysis Afirma® thyroid FNA analysis Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Afirma® thyroid FNA analysis. Lansdale: HAYES, Inc.. Genetic Testing Publication. 2012 Authors' conclusions Thyroid nodules are discrete masses present in the thyroid gland that are a common clinical finding among adults (...) in the general population. Approximately 5% of women and 1% of men have a palpable thyroid nodule on physical examination, while up to 67% of adults may have thyroid nodules detected with a high-resolution ultrasound. The evaluation of thyroid nodules, which may represent benign lesions or malignant thyroid tumors, typically includes a cytopathological examination of a biopsy specimen obtained by fine-needle aspiration (FNA). Thyroid nodules are subsequently classified based on cytology, with 70% to 75

Health Technology Assessment (HTA) Database.2013

188. Thyroid hormone receptor beta (THRB) gene testing in resistance to thyroid hormone (RTH)

Thyroid hormone receptor beta (THRB) gene testing in resistance to thyroid hormone (RTH) Thyroid hormone receptor beta (THRB) gene testing in resistance to thyroid hormone (RTH) Thyroid hormone receptor beta (THRB) gene testing in resistance to thyroid hormone (RTH) Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Thyroid hormone receptor beta (THRB) gene testing (...) in resistance to thyroid hormone (RTH) Lansdale: HAYES, Inc.. Genetic Testing Publication. 2012 Authors' conclusions Resistance to thyroid hormone (RTH) is an endocrine disorder characterized by reduced tissue responsiveness to circulating thyroid hormone. The condition, which is estimated to occur in approximately 1 in 40,000 individuals, may be diagnosed in patients with elevated levels of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), along with normal to high levels of thyroid

Health Technology Assessment (HTA) Database.2013

189. The accuracy of ultrasonography in the preoperative diagnosis of cervical lymph node metastasis in patients with papillary thyroid carcinoma: a meta-analysis

The accuracy of ultrasonography in the preoperative diagnosis of cervical lymph node metastasis in patients with papillary thyroid carcinoma: a meta-analysis The accuracy of ultrasonography in the preoperative diagnosis of cervical lymph node metastasis in patients with papillary thyroid carcinoma: a meta-analysis The accuracy of ultrasonography in the preoperative diagnosis of cervical lymph node metastasis in patients with papillary thyroid carcinoma: a meta-analysis Wu LM, Gu HY, Qu XH (...) , Zheng J, Zhang W, Yin Y, Xu JR CRD summary This review concluded that real-time ultrasonography was a good technique for preoperative lymph node staging of papillary thyroid carcinoma. Relevant studies may have been missed and there were limitations in the meta-analysis. The conclusions appear optimistic; summary estimates seemed to indicate that ultrasonography may be useful to confirm cervical lymph node metastases but not adequate for rule-out. Authors' objectives To assess the diagnostic

DARE.2013

190. Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer.

Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. BACKGROUND: Metastatic thyroid cancers that are refractory to radioiodine (iodine-131) are associated with a poor prognosis. In mouse models of thyroid cancer, selective mitogen-activated protein kinase (MAPK) pathway antagonists increase the expression of the sodium-iodide symporter and uptake of iodine. Their effects in humans are not known. METHODS: We conducted a study to determine whether the MAPK kinase (MEK) 1 and MEK2 (...) inhibitor selumetinib (AZD6244, ARRY-142886) could reverse refractoriness to radioiodine in patients with metastatic thyroid cancer. After stimulation with thyrotropin alfa, dosimetry with iodine-124 positron-emission tomography (PET) was performed before and 4 weeks after treatment with selumetinib (75 mg twice daily). If the second iodine-124 PET study indicated that a dose of iodine-131 of 2000 cGy or more could be delivered to the metastatic lesion or lesions, therapeutic radioiodine

NEJM2013 Full Text: Link to full Text with Trip Pro

191. Population-Based Study Evaluating and Predicting the Probability of Death Resulting From Thyroid Cancer and Other Causes Among Patients With Thyroid Cancer

Population-Based Study Evaluating and Predicting the Probability of Death Resulting From Thyroid Cancer and Other Causes Among Patients With Thyroid Cancer 23270002 2013 01 28 2013 03 11 2013 01 28 1527-7755 31 4 2013 Feb 01 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Population-based study evaluating and predicting the probability of death resulting from thyroid cancer and other causes among patients with thyroid cancer. 468-74 (...) 10.1200/JCO.2012.42.4457 The purpose of this study was to evaluate the probability of death for patients with thyroid cancer and construct a comprehensive nomogram based on a competing risks model to predict cumulative incidence of death resulting from thyroid cancer, other cancers, and non-cancer-related causes. Patients diagnosed with thyroid cancer between 1988 and 2003 were selected for the study from the Surveillance, Epidemiology, and End Results program. We estimated probabilities of death

EvidenceUpdates2013

192. Thyroid hormones for acute kidney injury.

Thyroid hormones for acute kidney injury. BACKGROUND: Acute kidney injury (AKI), which is common in hospitalised patients, is associated with significant morbidity and mortality. Despite recent advances in treatment, AKI outcomes have not changed substantially during the past four decades, and incidence is increasing. There is an urgent need to explore novel therapeutic agents and revisit some older drugs to review their roles in the management of AKI. Although thyroid hormone therapy has shown (...) promise in experimental animal studies, clinical efficacy and safety have not been systematically assessed for the management of people with AKI. OBJECTIVES: To evaluate the benefits and harms of thyroid hormones for the treatment of hospitalised adults with AKI of any aetiology. SEARCH METHODS: We searched the Cochrane Renal Group's Specialised Register, CENTRAL, MEDLINE, and EMBASE. We also checked the reference lists of retrieved studies and articles.Date of search: November 2012 SELECTION CRITERIA

Cochrane2013

193. Improving Voice Outcomes After Thyroid Surgery

Improving Voice Outcomes After Thyroid Surgery SAGE Journals: Your gateway to world-class journal research MENU My Profile Institution Society Access Options You can be signed in via any or all of the methods shown below at the same time. My Profile Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions Email (required) Password (required) Remember me I don't have a profile I am signed in as: With my free profile I can: Set up and register for List

American Academy of Otolaryngology - Head and Neck Surgery2013

194. Thyroid Carcinoma

Thyroid Carcinoma Date of origin: 2013 ACR Appropriateness Criteria ® 1 Thyroid Carcinoma American College of Radiology ACR Appropriateness Criteria ® THYROID CARCINOMA Expert Panel on Radiation Oncology–Head & Neck Cancer: Joseph K. Salama, MD 1 ; Daniel W. Golden, MD 2 ; Jonathan J. Beitler, MD, MBA 3 ; Sue S. Yom, MD, PhD 4 ; Madhur Kumar Garg, MD 5 ; Joshua Lawson, MD 6 ; Mark W. McDonald, MD 7 ; Harry Quon, MD, MS 8 ; John A. Ridge, MD, PhD 9 ; Nabil Saba, MD 10 ; Richard V. Smith, MD 11 (...) ; Francis Worden, MD 12 ; Anamaria Reyna Yeung, MD. 13 Summary of Literature Review Introduction/Background Thyroid cancer is the most common endocrine malignancy in the United States, where the annual incidence is approximately 37,000 and increasing due to the more frequent diagnosis of early well-differentiated thyroid carcinoma (WDTC) [1]. Annually, approximately 1,600 people die from thyroid malignancies [2]. Women represent approximately 75% of newly diagnosed thyroid carcinoma cases. Risk factors

American College of Radiology2013

195. AIUM Practice Parameter for the Performance of a Thyroid and Parathyroid Ultrasound Examination

AIUM Practice Parameter for the Performance of a Thyroid and Parathyroid Ultrasound Examination AIUM Practice Parameter for the Performance of a Thyroid and Parathyroid Ultrasound Examination © 2013 by the American Institute of Ultrasound in Medicine Parameter developed in conjunction with the American College of Radiology (ACR), the Society for Pediatric Radiology (SPR), and the Society of Radiologists in Ultrasound (SRU). thyroid.qxp_1115 12/1/15 3:41 PM Page 1The American Institute (...) for the Performance of a Thyroid and Parathyroid Ultrasound Examination. We are indebted to the many volunteers who contributed their time, knowledge, and energy to bringing this document to completion. The AIUM represents the entire range of clinical and basic science interests in medical diagnostic ultrasound, and, with hundreds of volunteers, the AIUM has promoted the safe and effective use of ultrasound in clinical medicine for more than 50 years. This document and others like it will continue to advance

American Institute of Ultrasound in Medicine2013

196. Absolute Risk Prediction of Second Primary Thyroid Cancer Among 5-Year Survivors of Childhood Cancer

Absolute Risk Prediction of Second Primary Thyroid Cancer Among 5-Year Survivors of Childhood Cancer 23169509 2012 12 31 2013 02 21 2016 10 19 1527-7755 31 1 2013 Jan 01 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Absolute risk prediction of second primary thyroid cancer among 5-year survivors of childhood cancer. 119-27 10.1200/JCO.2012.41.8996 We developed three absolute risk models for second primary thyroid cancer to assist (...) with long-term clinical monitoring of childhood cancer survivors. We used data from the Childhood Cancer Survivor Study (CCSS) and two nested case-control studies (Nordic CCSS; Late Effects Study Group). Model M1 included self-reported risk factors, model M2 added basic radiation and chemotherapy treatment information abstracted from medical records, and model M3 refined M2 by incorporating reconstructed radiation absorbed dose to the thyroid. All models were validated in an independent cohort of French

EvidenceUpdates2012 Full Text: Link to full Text with Trip Pro

197. The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study.

The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study. OBJECTIVES: To examine the risk of atrial fibrillation in relation to the whole spectrum of thyroid function in a large cohort of patients. DESIGN: Population based cohort study of general practice patients identified by linkage of nationwide registries at the individual level. SETTING: Primary care patients in the city of Copenhagen. SUBJECTS: Registry data for 586,460 adults who had (...) their thyroid function evaluated for the first time by their general practitioner during 2000-10 and who were without previously recorded thyroid disease or atrial fibrillation. MAIN OUTCOME MEASURE: Poisson regression models used to estimate risk of atrial fibrillation by thyroid function. RESULTS: Of the 586,460 individuals in the study population (mean (SD) age 50.2 (16.9) years, 39% men), 562,461 (96.0%) were euthyroid, 1670 (0.3%) had overt hypothyroidism, 12,087 (2.0%) had subclinical hypothyroidism

BMJ2012 Full Text: Link to full Text with Trip Pro

199. Thyroid nodules with indeterminate cytology.

Thyroid nodules with indeterminate cytology. Thyroid nodules with indeterminate cytology. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 23150966 Format MeSH and Other Data E-mail Subject Additional text E (...) -mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2012 Nov 15;367(20):1957; author reply 1958-9. doi: 10.1056/NEJMc1211421#SA1. Thyroid nodules with indeterminate cytology. , . Comment on [N Engl J Med. 2012] PMID: 23150966 DOI: [Indexed for MEDLINE] Publication types MeSH terms Full Text Sources PubMed Commons 0 comments How to cite this comment: Supplemental Content Full text links You

NEJM2012 Full Text: Link to full Text with Trip Pro

200. Thyroid nodules with indeterminate cytology.

Thyroid nodules with indeterminate cytology. Thyroid nodules with indeterminate cytology. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 23150967 Format MeSH and Other Data E-mail Subject Additional text E (...) -mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2012 Nov 15;367(20):1957-8; author reply 1958-9. doi: 10.1056/NEJMc1211421#SA2. Thyroid nodules with indeterminate cytology. . Comment on [N Engl J Med. 2012] [N Engl J Med. 2012] PMID: 23150967 DOI: [Indexed for MEDLINE] Publication types MeSH terms Full Text Sources PubMed Commons 0 comments How to cite this comment: Supplemental Content

NEJM2012 Full Text: Link to full Text with Trip Pro