Latest & greatest articles for thyroid

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Top results for thyroid

1. Network meta-analysis of topical haemostatic agents in thyroid surgery

Network meta-analysis of topical haemostatic agents in thyroid surgery 30199093 2018 10 12 1365-2168 105 12 2018 Nov The British journal of surgery Br J Surg Network meta-analysis of topical haemostatic agents in thyroid surgery. 1573-1582 10.1002/bjs.10975 The objective of this study was to investigate the potential benefit of local haemostatic agents for the prevention of postoperative bleeding after thyroidectomy. A systematic literature search was performed, and RCTs involving adult (...) patients who underwent thyroid surgery using either active (AHA) or passive (PHA) haemostatic agents were included in the review. The main outcome was the rate of cervical haematoma that required reoperation. A Bayesian random-effects model was used for network meta-analysis with minimally informative prior distributions. Thirteen RCTs were included. The rate of cervical haematoma requiring reoperation ranged from 0 to 9·1 per cent, and was not reduced by haemostatic agents: AHA versus control (odds

EvidenceUpdates2018

2. Treating subclinical thyroid dysfunction in pregnancy probably has no benefit

Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Signal - Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Dissemination Centre Discover Portal NIHR DC Discover Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Published on 8 August 2017 Testing for and then treating pregnant women with mild or “subclinical” underactive thyroid did not improve pregnancy outcomes, newborn baby outcomes, or the child’s IQ (...) at three to five years. A clearly underactive thyroid (clinical hypothyroidism) in pregnancy has been linked with various adverse outcomes for the mother and baby, including pre-eclampsia, preterm birth, congenital defects and neurodevelopmental delay. This needs treatment. However, there has been debate around the harms and benefits from treating only mildly abnormal blood test results in women who do not show signs of thyroid problems, subclinical hypothyroidism. These two linked trials randomised

NIHR Dissemination Centre2018

3. Overview of thyroid dysfunction

Overview of thyroid dysfunction Overview of thyroid dysfunction - Summary of relevant conditions | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Overview of thyroid dysfunction Last reviewed: September 2018 Last updated: October 2018 Introduction The thyroid gland produces, stores, and secretes thyroxine (T4) and triiodothyronine (T3) through a negative feedback process involving the hypothalamus and pituitary gland. Thyroid dysfunction can result when (...) any part of this process is affected, and is usually characterised by the presence of high or low levels of thyroid-stimulating hormone (TSH, secreted by the pituitary gland) and free thyroid hormones. Causes of thyroid disorders include autoimmunity (e.g., Graves' disease), infections (e.g., post-viral inflammation), other systemic medical conditions, medications (e.g., lithium, amiodarone), nutritional excesses or deficiencies (e.g., of iodine), tumours (thyroid, or rarely pituitary), trauma

BMJ Best Practice2018

4. Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis.

Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis. Importance: The benefit of thyroid hormone therapy for subclinical hypothyroidism is uncertain. New evidence from recent large randomized clinical trials warrants an update of previous meta-analyses. Objective: To conduct a meta-analysis of the association of thyroid hormone therapy with quality of life and thyroid-related (...) symptoms in adults with subclinical hypothyroidism. Data Sources: PubMed, EMBASE, ClinicalTrials.gov, Web of Science, Cochrane Library, CENTRAL, Emcare, and Academic Search Premier from inception until July 4, 2018. Study Selection: Randomized clinical trials that compared thyroid hormone therapy with placebo or no therapy in nonpregnant adults with subclinical hypothyroidism were eligible. Two reviewers independently evaluated eligibility based on titles and abstracts of all retrieved studies. Studies

JAMA2018

5. Intravenously Administered Lidocaine and Magnesium During Thyroid Surgery in Female Patients for Better Quality of Recovery After Anesthesia

Intravenously Administered Lidocaine and Magnesium During Thyroid Surgery in Female Patients for Better Quality of Recovery After Anesthesia 29324495 2018 08 16 1526-7598 127 3 2018 Sep Anesthesia and analgesia Anesth. Analg. Intravenously Administered Lidocaine and Magnesium During Thyroid Surgery in Female Patients for Better Quality of Recovery After Anesthesia. 635-641 10.1213/ANE.0000000000002797 Although systemic lidocaine and magnesium have been widely studied as perioperative analgesic

EvidenceUpdates2018

7. Thyroid

Thyroid Top results for thyroid - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button (...) . An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for thyroid The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical

Trip Latest and Greatest2018

8. Lenvatinib (LENVIMA) - locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer

Lenvatinib (LENVIMA) - locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Summary Basis of Decision (SBD) for Contact: Summary basis of decision (SBD) documents provide information related to the original authorization of a product. The for is located below

Health Canada - Drug and Health Product Register2018

9. Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery

Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery 29579320 2018 04 13 1365-2168 105 6 2018 May The British journal of surgery Br J Surg Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery. 645-649 10.1002/bjs.10829 Suturing the platysma muscle during wound closure after thyroid surgery is frequently described in the literature. There is no prospective evidence to support its use (...) or benefit. The aim of this study was to evaluate how a platysma muscle suture influences initial postoperative pain following thyroid surgery. Patients were assigned randomly to receive a platysma suture or no platysma suture in this prospective, patient-blinded trial. The duration of follow-up was 6 months. The primary endpoint was wound-specific pain 24 h after thyroid resection. Secondary endpoints were intraoperative and perioperative analgesia requirement, postoperative pain and complications until

EvidenceUpdates2018

10. Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery

Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery 29405252 2018 02 28 1365-2168 105 4 2018 Mar The British journal of surgery Br J Surg Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery. 350-357 10.1002/bjs.10783 Hypoparathyroidism, the most common complication after (...) thyroid surgery, leads to hypocalcaemia and significant medical problems. An RCT was undertaken to determine whether intraoperative parathyroid gland angiography with indocyanine green (ICG) could predict postoperative hypoparathyroidism, and obviate the need for systematic blood tests and oral calcium supplementation. Between September 2014 and February 2016, patients who had at least one well perfused parathyroid gland on ICG angiography were randomized to receive standard follow-up (measurement

EvidenceUpdates2018

11. Treating subclinical thyroid dysfunction in pregnancy probably has no benefit

Treating subclinical thyroid dysfunction in pregnancy probably has no benefit NIHR DC | Signal - Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Published on 8 August 2017 Testing for and then treating pregnant women with mild or “subclinical” underactive thyroid did not improve pregnancy outcomes, newborn baby outcomes (...) , or the child’s IQ at three to five years. A clearly underactive thyroid (clinical hypothyroidism) in pregnancy has been linked with various adverse outcomes for the mother and baby, including pre-eclampsia, preterm birth, congenital defects and neurodevelopmental delay. This needs treatment. However, there has been debate around the harms and benefits from treating only mildly abnormal blood test results in women who do not show signs of thyroid problems, subclinical hypothyroidism. These two linked trials

NIHR Dissemination Centre2018

13. The Diagnosis and Management of Thyroid Nodules: A Review.

The Diagnosis and Management of Thyroid Nodules: A Review. Importance: Thyroid nodules are common, being detected in up to 65% of the general population. This is likely due to the increased use of diagnostic imaging for purposes unrelated to the thyroid. Most thyroid nodules are benign, clinically insignificant, and safely managed with a surveillance program. The main goal of initial and long-term follow-up is identification of the small subgroup of nodules that harbor a clinically significant (...) cancer (≈10%), cause compressive symptoms (≈5%), or progress to functional disease (≈5%). Observations: Thyroid function testing and ultrasonographic characteristics guide the initial management of thyroid nodules. Certain ultrasound features, such as a cystic or spongiform appearance, suggest a benign process that does not require additional testing. Suspicious sonographic patterns including solid composition, hypoechogenicity, irregular margins, and microcalcifications should prompt cytological

JAMA2018

14. Cutting‐edge endonasal surgical approaches to thyroid ophthalmopathy

Cutting‐edge endonasal surgical approaches to thyroid ophthalmopathy Cutting‐edge endonasal surgical approaches to thyroid ophthalmopathy - Tyler - 2018 - Laryngoscope Investigative Otolaryngology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search term Search Search term Search The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Allergy, Rhinology, and Immunology Open Access Cutting (...) ‐edge endonasal surgical approaches to thyroid ophthalmopathy Department of Otorhinolaryngology–Head & Neck Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, U.S.A. Department of Otorhinolaryngology–Head & Neck Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, U.S.A. Department of Otorhinolaryngology–Head & Neck Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, U.S.A

Laryngoscope investigative otolaryngology2018 Full Text: Link to full Text with Trip Pro

15. Maternal thyroid function and child educational attainment: prospective cohort study.

Maternal thyroid function and child educational attainment: prospective cohort study. OBJECTIVE: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. DESIGN: Prospective cohort study. SETTING: Avon Longitudinal Study of Parents and Children cohort in the UK. PARTICIPANTS: 4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile range 8-12 (...) ). EXPOSURES: Free thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies assessed as continuous measures and the seven clinical categories of maternal thyroid function. MAIN OUTCOME MEASURES: Five age-specific national curriculum assessments in 3580 children at entry stage assessment at 54 months, increasing up to 4461 children at their final school assessment at age 15. RESULTS: No strong evidence of clinically meaningful associations of first trimester free thyroxine and thyroid

BMJ2018

16. Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study ISSN 2472-1972 Patients With Antithyroid Antibodies Are ProneToDevelopDestructiveThyroiditis by Nivolumab: A Prospective Study Tomoko Kobayashi, 1 Shintaro Iwama, 1,2 Yoshinori Yasuda, 1 Norio Okada, 1 Taku Tsunekawa, 1 Takeshi Onoue, 1 Hiroshi Takagi, 1 Daisuke Hagiwara, 1 Yoshihiro Ito, 1 Yoshiaki Morishita, 1 Motomitsu Goto, 1 Hidetaka Suga, 1 Ryoichi Banno, 1 Kenji Yokota, 3 (...) ,thyroidfunction,antithyroid antibodies (Abs), and glucose levels every 6 weeks after the initiation of nivolumab for 24 weeks. Results: Four out of 66 patients developed destructive thyroiditis, and three patients developed hypo- thyroidismrequiringlevothyroxinereplacement.Theprevalenceofpositiveanti-thyroglobulinAbs(TgAbs) and/oranti–thyroidperoxidaseAbs(TPOAbs)atbaselinewassignificantlyhigherinthegroupthatdeveloped destructivethyroiditis(3/4)comparedwiththegroupthatdidnotdevelopthyroiditis(3/62;P=0.002

Journal of the Endocrine Society2018 Full Text: Link to full Text with Trip Pro

17. From Consternation to Revelation: Discovery of a Role for IGSF1 in Pituitary Control of Thyroid Function

From Consternation to Revelation: Discovery of a Role for IGSF1 in Pituitary Control of Thyroid Function ISSN 2472-1972 From Consternation to Revelation: Discovery ofaRoleforIGSF1inPituitaryControlof Thyroid Function Daniel J. Bernard, 1,2 Emilie Brˆ ul´ e, 2 Courtney L. Smith, 1 Sjoerd D. Joustra, 3 and Jan M. Wit 3 1 Department of Pharmacology and Therapeutics, McGill University, Montr´ eal, Qu´ ebec H3G 1Y6, Canada; 2 Department of Anatomy and Cell Biology, McGill University, Montr´ eal, Qu (...) nearly ground to a halt until 2011, when next-generation sequencing identified mutationsintheX-linkedIGSF1geneinboysandmenwithcongenitalcentralhypothyroidism.IGSF1 was localized to thyrotrope cells, implicating the protein in pituitary control of the thyroid. In- vestigations in two Igsf1 knockout mouse models converged to show that IGSF1 deficiency leads to reduced expression of the receptor for thyrotropin-releasing hormone (TRH) and impaired TRH stimulation ofthyrotropin secretion

Journal of the Endocrine Society2018 Full Text: Link to full Text with Trip Pro

18. Assessment of thyroid mass

Assessment of thyroid mass Assessment of thyroid mass - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of thyroid mass Last reviewed: August 2018 Last updated: June 2018 Summary Thyroid parenchymal expansion can result from diffuse enlargement or infiltration of the thyroid gland or from the presence of one or more thyroid nodules. A thyroid nodule is a discrete lesion distinct from the surrounding thyroid (...) parenchyma. Enlargement of other nearby anatomical structures, such as the parathyroid glands or regional lymph nodes, as well as branchial cleft and thyroglossal duct cysts, may sometimes be confused with thyroid nodules. Thyroid nodules may be palpable at presentation or may be incidentally detected during an imaging procedure (40% are self-identified, 30% are physician-identified, and 30% are incidentally discovered on imaging Mevawalla N, McMullen T, Sidhu S, et al. Presentation of clinically

BMJ Best Practice2018

19. Thyroid function testing

Thyroid function testing Thyroid function testing - Medical information | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Thyroid function testing Last reviewed: August 2018 Last updated: February 2018 Summary Thyroid hormones thyroxine (T4) and tri-iodothyronine (T3) are produced, stored, and secreted by the thyroid gland. These hormones, particularly T3, play a major role in multiple biological and metabolic processes. They act by binding to thyroid (...) receptors that are distributed in almost every organ. Typically, this process regulates gene transcription and the subsequent production of various proteins that are involved in development, growth, and cellular metabolism. Kronenberg HM, Melmed S, Polonsky KS, et al, eds. Williams textbook of endocrinology. 12th ed. Philadelphia, PA: Saunders/Elsevier; 2011. Thyroid function tests (TFTs) are the most commonly used endocrine test. Details Thyroid hormone production Thyroid hormone-binding proteins

BMJ Best Practice2018

20. Overview of thyroid dysfunction

Overview of thyroid dysfunction Overview of thyroid dysfunction - Summary of relevant conditions | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Overview of thyroid dysfunction Last reviewed: August 2018 Last updated: June 2018 Introduction The thyroid gland produces, stores, and secretes thyroxine (T4) and triiodothyronine (T3) through a negative feedback process involving the hypothalamus and pituitary gland. Thyroid dysfunction can result when any (...) part of this process is affected, and is usually characterised by the presence of high or low levels of thyroid-stimulating hormone (TSH, secreted by the pituitary gland) and free thyroid hormones. Causes of thyroid disorders include autoimmunity (e.g., Graves' disease), infections (e.g., post-viral inflammation), other systemic medical conditions, medications (e.g., lithium, amiodarone), nutritional excesses or deficiencies (e.g., of iodine), tumours (thyroid, or rarely pituitary), trauma

BMJ Best Practice2018