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Latest & greatest articles for testosterone
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Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men: A Systematic Review and Meta-analysis 30427999 2018 11 14 2168-6238 2018 Nov 14 JAMA psychiatry JAMA Psychiatry Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men: A Systematic Review and Meta-analysis. 10.1001/jamapsychiatry.2018.2734 Countering depressive disorders is a public health priority. Currently, antidepressants are the first-line treatment, although they show modest (...) effects. In men, testosterone treatment is a controversial alternative or adjunct treatment option. To examine the association of testosterone treatment with alleviation of depressive symptoms in men and to clarify moderating effects of testosterone status, depression status, age, treatment duration, and dosage. English-language studies published in peer-reviewed journals identified from PubMed/Medline, Embase, Scopus, PsychINFO, and the Cochrane Controlled Trials Register from database inception
Multi-year patterns in testosterone, cortisol and corticosterone in baleen from adult males of three whale species 30254748 2018 11 14 2051-1434 6 1 2018 Conservation physiology Conserv Physiol Multi-year patterns in testosterone, cortisol and corticosterone in baleen from adult males of three whale species. coy049 10.1093/conphys/coy049 Male baleen whales have long been suspected to have annual cycles in testosterone, but due to difficulty in collecting endocrine samples, little direct (...) evidence exists to confirm this hypothesis. Potential influences of stress or adrenal stress hormones (cortisol, corticosterone) on male reproduction have also been difficult to study. Baleen has recently been shown to accumulate steroid hormones during growth, such that a single baleen plate contains a continuous, multi-year retrospective record of the whale's endocrine history. As a preliminary investigation into potential testosterone cyclicity in male whales and influences of stress, we determined
Testosterone Top results for testosterone - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for testosterone The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines
Estradiol Does Not Influence Lipid Measures and Inflammatory Markers in Testosterone-Clamped Healthy Men 30057969 2018 11 14 2472-1972 2 8 2018 Aug 01 Journal of the Endocrine Society J Endocr Soc Estradiol Does Not Influence Lipid Measures and Inflammatory Markers in Testosterone-Clamped Healthy Men. 882-892 10.1210/js.2018-00141 Experimentally controlled studies of estrogenic regulation of lipid measures and inflammatory cytokines in men are rare. To delineate the effect of estradiol (E 2 (...) ) on lipids and inflammatory markers. This was a placebo-controlled, single-masked, prospectively randomized study comprising experimentally degarelix-downregulated healthy men [n = 74; age 65 years (range, 57 to 77)] assigned to four treatment groups: (1) IM saline and oral placebo; (2) IM testosterone and oral placebo; (3) IM testosterone and oral anastrozole (aromatase inhibitor); and (4) IM testosterone, oral anastrozole, and transdermal E 2 for 22 (±1) days. Mean mass spectrometry-quantified serum E
Evaluation and Management of Testosterone Deficiency 1 Executive Summary Testosterone testing and prescriptions have nearly tripled in recent years; however, it is clear from clinical practice that there are many men using testosterone without a clear indication. 1-3 Some studies estimate that up to 25% of men who receive testosterone therapy do not have their testosterone tested prior to initiation of treatment. 2, 3 Of men who are treated with testosterone, nearly half do not have (...) their testosterone levels checked after therapy commences. 2, 3 While up to a third of men who are placed on testosterone therapy do not meet the criteria to be diagnosed as testosterone deficient, 2, 3 there are a large percentage of men in need of testosterone therapy who fail to receive it due to clinician concerns, mainly surrounding prostate cancer development and cardiovascular events, although current evidence fails to definitively support these concerns. Given the clinical and commercial testosterone
Suspected Testosterone-Producing Tumor in a Patient Taking Biotin Supplements 29942920 2018 11 14 2472-1972 2 6 2018 Jun 01 Journal of the Endocrine Society J Endocr Soc Suspected Testosterone-Producing Tumor in a Patient Taking Biotin Supplements. 563-569 10.1210/js.2018-00069 A perimenopausal woman presented with palpitations, hirsutism, and inability to lose weight. Laboratory tests revealed an unusual endocrine hormonal profile including pituitary hormones (TSH, ACTH, and prolactin) below (...) reference intervals and gonadal (testosterone) and adrenal (cortisol) hormones above reference intervals. Ultimately, after a comprehensive workup including a scheduled surgical procedure, abnormal laboratories were determined due to biotin interference. Biotin (vitamin B7) is a water-soluble vitamin and essential cofactor for the metabolism of fatty acids, glucose, and amino acids. The recommended daily intake of biotin for adults is 30 µg/d. Many over-the-counter products, particularly those marketed
Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study 29765575 2018 11 14 2008-5842 10 3 2018 Mar Electronic physician Electron Physician Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study. 6500-6505 10.19082/6500 It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs (...) ) levels decrease in body fluids of patients with RA. The aim of this study was to determine the association of serum testosterone and DHEAs with RA. This case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014. Serum free testosterone and DHEAs levels were measured and compared between two groups. Serum testosterone levels lower than 0.029 ng/ml in females and 2.49 ng/ml in males were
Testosterone and All-Cause Mortality in Older Men: The Role of Metabolic Syndrome 29577108 2018 11 14 2472-1972 2 4 2018 Apr 01 Journal of the Endocrine Society J Endocr Soc Testosterone and All-Cause Mortality in Older Men: The Role of Metabolic Syndrome. 322-335 10.1210/js.2018-00005 Previous studies have shown controversial results about the role of testosterone in all-cause mortality in elderly men. We hypothesized that metabolic syndrome (MetS) could partly explain this discrepancy. We (...) therefore examined the association of all-cause mortality with total and bioavailable testosterone, taking into account the MetS. We used data from the Three-City Cohort (3C) study with 12-year follow-up. The 3C study included 3650 men aged >65 years in three French cities. Hormone was measured in a random subsample of 444 men, and MetS was determined as stated by the International Diabetes Federation criteria. We used inverse-probability-weighted Cox regression to estimate hazard ratios (HRs) and 95
Serum testosterone changes in patients treated with radiation therapy alone for prostate cancer on NRG oncology RTOG 9408 29204528 2018 11 13 2452-1094 2 4 2017 Oct-Dec Advances in radiation oncology Adv Radiat Oncol Serum testosterone changes in patients treated with radiation therapy alone for prostate cancer on NRG oncology RTOG 9408. 608-614 10.1016/j.adro.2017.07.004 We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408 (...) . Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 months after RT. The Wilcoxon signed rank test was used to compare pre- and post-treatment ST levels in patients who were randomized to the RT-alone arm. Of 2028 patients enrolled, 992 patients were randomized to receive RT alone and 917 (92.4%) had baseline ST values
Serum Testosterone Concentrations Remain Stable Between Injections in Patients Receiving Subcutaneous Testosterone 29264562 2018 11 13 2472-1972 1 8 2017 Aug 01 Journal of the Endocrine Society J Endocr Soc Serum Testosterone Concentrations Remain Stable Between Injections in Patients Receiving Subcutaneous Testosterone. 1095-1103 10.1210/js.2017-00148 Intramuscular (IM) testosterone is the most common modality for testosterone therapy of both male hypogonadism and female-to-male (FTM) gender (...) transition. However, IM injections can be painful and often are not self-administered by the patient. The objective of this study was to further characterize subcutaneous (SC) administration of testosterone as an effective and safe alternative to IM injections by evaluating the pharmacodynamics of serum total and free testosterone concentrations between weekly testosterone injections. Eleven FTM transgender patients already receiving weekly SC testosterone cypionate with documented therapeutic levels
Testosterone Replacement Therapy and Risk of Favorable and Aggressive Prostate Cancer 28447913 2017 04 27 2017 06 10 1527-7755 35 13 2017 May 01 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Testosterone Replacement Therapy and Risk of Favorable and Aggressive Prostate Cancer. 1430-1436 10.1200/JCO.2016.69.5304 Purpose The association between exposure to testosterone replacement therapy (TRT) and prostate cancer risk
Genetics of Sex Hormone-Binding Globulin and Testosterone Levels in Fertile and Infertile Men of Reproductive Age 29264510 2018 11 13 2472-1972 1 6 2017 Jun 01 Journal of the Endocrine Society J Endocr Soc Genetics of Sex Hormone-Binding Globulin and Testosterone Levels in Fertile and Infertile Men of Reproductive Age. 560-576 10.1210/js.2017-00050 Testosterone (T) is a central androgenic hormone, and sex hormone-binding globulin (SHBG) is the major determinant of its bioactivity
Association Between Direct-to-Consumer Advertising and Testosterone Testing and Initiation in the United States, 2009-2013. Importance: Testosterone initiation increased substantially in the United States from 2000 to 2013, especially among men without clear indications. Direct-to-consumer advertising (DTCA) also increased during this time. Objective: To investigate associations between televised DTCA and testosterone testing and initiation in the United States. Design, Setting, and Population (...) : Ecologic study conducted in designated market areas (DMAs) in the United States. Monthly testosterone advertising ratings were linked to DMA-level testosterone use data from 2009-2013 derived from commercial insurance claims. Associations between DTCA and testosterone testing, initiation, and initiation without recent baseline tests were estimated using Poisson generalized estimating equations. Exposures: Monthly Nielsen ratings for testosterone DTCA in the 75 largest DMAs. Main Outcomes and Measures
Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet 29264488 2018 11 13 2472-1972 1 4 2017 Apr 01 Journal of the Endocrine Society J Endocr Soc Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet. 302-312 10.1210/js.2017-00062 In obese men with lowered testosterone levels, testosterone treatment augments diet-associated loss of body fat. We hypothesized that testosterone treatment modulates circulating (...) concentrations of hormonal mediators of fat mass and energy homeostasis in obese men undergoing a weight loss program. Prespecified secondary analysis of a randomized, double-blind, placebo-controlled trial. Tertiary referral center. Obese men (body mass index ≥30 kg/m 2 ) with a repeated total testosterone level ≤12 nmol/L. One hundred participants mean age 53 years (interquartile range 47 to 60 years) receiving 10 weeks of a very low-energy diet followed by 46 weeks of weight maintenance were randomly
Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone. Importance: Recent studies have yielded conflicting results as to whether testosterone treatment increases cardiovascular risk. Objective: To test the hypothesis that testosterone treatment of older men with low testosterone slows progression of noncalcified coronary artery plaque volume. Design, Setting, and Participants: Double-blinded, placebo-controlled trial at 9 academic medical centers (...) in the United States. The participants were 170 of 788 men aged 65 years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism who were enrolled in the Testosterone Trials between June 24, 2010, and June 9, 2014. Intervention: Testosterone gel, with the dose adjusted to maintain the testosterone level in the normal range for young men, or placebo gel for 12 months. Main Outcomes and Measures