Latest & greatest articles for stroke

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on stroke or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on stroke and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for stroke

21. Association of General Anesthesia vs Procedural Sedation With Functional Outcome Among Patients With Acute Ischemic Stroke Undergoing Thrombectomy: A Systematic Review and Meta-analysis. (PubMed)

Association of General Anesthesia vs Procedural Sedation With Functional Outcome Among Patients With Acute Ischemic Stroke Undergoing Thrombectomy: A Systematic Review and Meta-analysis. General anesthesia during thrombectomy for acute ischemic stroke has been associated with poor neurological outcome in nonrandomized studies. Three single-center randomized trials reported no significantly different or improved outcomes for patients who received general anesthesia compared with procedural (...) sedation.To detect differences in functional outcome at 3 months between patients who received general anesthesia vs procedural sedation during thrombectomy for anterior circulation acute ischemic stroke.MEDLINE search for English-language articles published from January 1, 1980, to July 31, 2019.Randomized clinical trials of adults with a National Institutes of Health Stroke Scale score of at least 10 and anterior circulation acute ischemic stroke assigned to receive general anesthesia or procedural

2019 JAMA

22. Stroke, Diagnosis and Initial Treatment of Ischemic Stroke

Stroke, Diagnosis and Initial Treatment of Ischemic Stroke Health Care Guideline: Diagnosis and Initial Treatment of Ischemic Stroke www.icsi.org Acute Ischemic Stroke Algorithm Copyright © 2019 by Institute for Clinical Systems Improvement 1 Twelfth Edition June 2019 Is patient a candidate for endovascular thrombectomy? Initial assessment includes: Exam, vitals, O 2 (oxygen), record weight, assess severity using NIHSS Monitor Labs: 1) Glucose 2) INR/Cr/CBC – if there is no suspicion (...) that these are abnormal, do not delay head CT or IV Alteplase Unless emergently indicated, do not delay imaging/IV Alteplase to obtain EKG, CXR or place foley Patient presents with signs and symptoms of an acute stroke Manage hemorrhagic stroke Positive for hemorrhage Evaluate for TIA Negative for hemorrhage (resolved neurological de?cits) Symptom onset? Negative for hemorrhage (continuing neurological de?cits) Neurology consultation Within 4.5 hours > 4.5 hours or time of onset is unknown IV Alteplase

2019 Institute for Clinical Systems Improvement

23. Sex Differences in Long-Term Quality of Life Among Survivors After Stroke in the INSTRUCT

Sex Differences in Long-Term Quality of Life Among Survivors After Stroke in the INSTRUCT Background and Purpose- Women are reported to have poorer health-related quality of life (HRQoL) after stroke than men, but the underlying reasons are uncertain. We investigated factors contributing to the sex differences. Methods- Individual participant data on 4288 first-ever strokes (1996-2013) were obtained from 4 high-quality population-based incidence studies from Australasia and Europe. HRQoL (...) utility scores among survivors after stroke (range from negative scores=worse than death to 1=perfect health) were calculated from 3 scales including European Quality of Life-5 Dimensions, Short-Form 6-Dimension, and Assessment of Quality of Life at 1 year (3 studies; n=1210) and 5 years (3 studies; n=1057). Quantile regression was used to estimate the median differences in HRQoL for women compared to men with adjustment for covariates. Study factors included sociodemographics, prestroke dependency

2019 EvidenceUpdates

24. Does Sex Modify the Effect of Endovascular Treatment for Ischemic Stroke?

Does Sex Modify the Effect of Endovascular Treatment for Ischemic Stroke? Background and Purpose- Previous studies have reported less favorable outcome and less effect of endovascular treatment (EVT) after ischemic stroke in women than in men. Our aim was to study the influence of sex on outcome and on the effect of EVT for ischemic stroke in recent randomized trials on EVT. Methods- We used data from 7 randomized controlled trials on EVT within the HERMES collaboration. The primary outcome

2019 EvidenceUpdates

25. Clinical Guidelines for Stroke Management

Clinical Guidelines for Stroke Management InformMe - Clinical Guidelines for Stroke Management Our websites {{ user.firstName }} {{ user.lastName }} Go back {{ user.firstName }} {{ user.lastName }} Where am I? Clinical Guidelines for Stroke Management The Clinical Guidelines for Stroke Management are evolving into , updated as new evidence emerges in accordance with the 2011 NHMRC Standard for clinical practice guidelines. They supersede the Clinical Guidelines for Stroke Management 2017 (...) of stroke care, across 8 chapters: Imaging Cardiac investigations Thrombolysis Neurointervention Medical interventions Surgical interventions Smoking Diet Physical activity Obesity Alcohol Weakness Loss of sensation Vision Amount of rehabilitation Cardiorespiratory fitness Sitting Standing up Standing balance Walking Upper limb activity Assessment of communication deficits Aphasia Dysarthria Apraxia of speech Cognitive communication disorder in right hemisphere stroke Assessment of cognition Executive

2019 Stroke Foundation - Australia

26. Portable Stroke Detection Devices for Patients with Stroke Symptoms: A Review of Diagnostic Accuracy and Cost-Effectiveness

Portable Stroke Detection Devices for Patients with Stroke Symptoms: A Review of Diagnostic Accuracy and Cost-Effectiveness Portable Stroke Detection Devices for Patients with Stroke Symptoms: A Review of Diagnostic Accuracy and Cost-Effectiveness | CADTH.ca Find the information you need Portable Stroke Detection Devices for Patients with Stroke Symptoms: A Review of Diagnostic Accuracy and Cost-Effectiveness Portable Stroke Detection Devices for Patients with Stroke Symptoms: A Review (...) of Diagnostic Accuracy and Cost-Effectiveness Last updated: August 7, 2019 Project Number: RC1167-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the diagnostic accuracy of portable stroke detection devices for patients with stroke symptoms? What is the cost-effectiveness of portable stroke diagnostic devices for patients with stroke symptoms? Key Message No relevant literature was identified regarding the diagnostic

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

27. Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT

Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue

2019 NIHR HTA programme

28. Do Calcium Antagonists Decrease Mortality or Dependency in Acute Ischemic Stroke?

Do Calcium Antagonists Decrease Mortality or Dependency in Acute Ischemic Stroke? Do Calcium Antagonists Decrease Mortality or Dependency in Acute Ischemic Stroke? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 74, Issue 4, Pages 575–577 Do Calcium Antagonists Decrease Mortality or Dependency in Acute Ischemic Stroke? x Rachel E. Bridwell , MD (EBEM Commentator) , x Brit Long , MD (EBEM Commentator (...) ) , x Michael D. April , MD, DPhil (EBEM Commentator) Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, Fort Sam Houston, TX DOI: | Publication History Published online: May 09, 2019 Expand all Collapse all Article Outline Take-Home Message The use of calcium antagonists in acute ischemic stroke does not reduce mortality or dependency in activities of daily living. Methods Data Sources An information specialist searched the Cochrane Stroke Group Trials

2019 Annals of Emergency Medicine Systematic Review Snapshots

29. Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. (PubMed)

Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. In non-surgical settings, covert stroke is more common than overt stroke and is associated with cognitive decline. Although overt stroke occurs in less than 1% of adults after non-cardiac surgery and is associated with substantial morbidity, we know little about perioperative covert stroke. Therefore, our primary aim was to investigate the relationship between perioperative covert (...) stroke (ie, an acute brain infarct detected on an MRI after non-cardiac surgery in a patient with no clinical stroke symptoms) and cognitive decline 1 year after surgery.NeuroVISION was a prospective cohort study done in 12 academic centres in nine countries, in which we assessed patients aged 65 years or older who underwent inpatient, elective, non-cardiac surgery and had brain MRI after surgery. Two independent neuroradiology experts, masked to clinical data, assessed each MRI for acute brain

2019 Lancet

30. Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): multicentre, randomised controlled, endpoint blinded trial. (PubMed)

Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): multicentre, randomised controlled, endpoint blinded trial. To determine the safety and efficacy of aerobic exercise on activities of daily living in the subacute phase after stroke.Multicentre, randomised controlled, endpoint blinded trial.Seven inpatient rehabilitation sites in Germany (2013-17).200 adults with subacute stroke (days 5-45 after stroke) with a median National Institutes of Health stroke scale (NIHSS (...) , range 0-42 points, higher values indicating more severe strokes) score of 8 (interquartile range 5-12) were randomly assigned (1:1) to aerobic physical fitness training (n=105) or relaxation sessions (n=95, control group) in addition to standard care.Participants received either aerobic, bodyweight supported, treadmill based physical fitness training or relaxation sessions, each for 25 minutes, five times weekly for four weeks, in addition to standard rehabilitation therapy. Investigators

2019 BMJ

31. A newly designed intensive caregiver education program reduces cognitive impairment, anxiety, and depression in patients with acute ischemic stroke. (PubMed)

A newly designed intensive caregiver education program reduces cognitive impairment, anxiety, and depression in patients with acute ischemic stroke. This study aimed to evaluate the effect of a newly designed intensive caregiver education program (ICEP) on reducing cognitive impairment, anxiety, and depression in acute ischemic stroke (AIS) patients. One hundred and ninety-six AIS patients were divided into ICEP group and Control group in a 1:1 ratio using blocked randomization method

2019 Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas Controlled trial quality: uncertain

32. Risks of ischaemic heart disease and stroke in meat eaters, fish eaters, and vegetarians over 18 years of follow-up: results from the prospective EPIC-Oxford study. (PubMed)

Risks of ischaemic heart disease and stroke in meat eaters, fish eaters, and vegetarians over 18 years of follow-up: results from the prospective EPIC-Oxford study. To examine the associations of vegetarianism with risks of ischaemic heart disease and stroke.Prospective cohort study.The EPIC-Oxford study, a cohort in the United Kingdom with a large proportion of non-meat eaters, recruited across the country between 1993 and 2001.48 188 participants with no history of ischaemic heart disease (...) , stroke, or angina (or cardiovascular disease) were classified into three distinct diet groups: meat eaters (participants who consumed meat, regardless of whether they consumed fish, dairy, or eggs; n=24 428), fish eaters (consumed fish but no meat; n=7506), and vegetarians including vegans (n=16 254), based on dietary information collected at baseline, and subsequently around 2010 (n=28 364).Incident cases of ischaemic heart disease and stroke (including ischaemic and haemorrhagic types) identified

2019 BMJ

33. Society of Interventional Radiology Training Guidelines for Endovascular Stroke Treatment

Society of Interventional Radiology Training Guidelines for Endovascular Stroke Treatment Society of Interventional Radiology Training Guidelines for Endovascular Stroke Treatment - Journal of Vascular and Interventional Radiology Email/Username: Password: Remember me Available now: Use your SIR login to access JVIR. Search Terms Search within Search Share this page Access provided by Volume 30, Issue 10, Pages 1523–1531 Society of Interventional Radiology Training Guidelines for Endovascular (...) Stroke Treatment x David Sacks Affiliations Department of Interventional Radiology, The Reading Hospital and Medical Center, West Reading, Pennsylvania Correspondence Address correspondence to D.S., c/o Elizabeth Himes, 3975 Fair Ridge Dr., Suite 400 N., Fairfax, VA 22033 , MD a , ∗ , x David Sacks Affiliations Department of Interventional Radiology, The Reading Hospital and Medical Center, West Reading, Pennsylvania Correspondence Address correspondence to D.S., c/o Elizabeth Himes, 3975 Fair Ridge

Full Text available with Trip Pro

2019 Society of Interventional Radiology

34. Organisation of the early management of acute ischaemic stroke using mechanical thrombectomy

Organisation of the early management of acute ischaemic stroke using mechanical thrombectomy Organisation of the early management of acute ischaemic stroke using mechanical thrombectomy - Technological assessment report

2019 Haute Autorite de sante

35. Vertebral artery stenting to prevent recurrent stroke in symptomatic vertebral artery stenosis: the VIST RCT

Vertebral artery stenting to prevent recurrent stroke in symptomatic vertebral artery stenosis: the VIST RCT Vertebral artery stenting to prevent recurrent stroke in symptomatic vertebral artery stenosis: the VIST RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you (...) need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This trial did not recruit the planned number of patients or show that vertebral stenting reduced the risk of stroke. {{author}} {{($index , , , , , , & . Hugh S Markus 1, * , Susanna C Larsson 1 , John Dennis 2 , Wilhelm Kuker 3 , Ursula G Schulz 3 , Ian Ford 4 , Andrew Clifton 5, † , Peter M Rothwell 3, † 1 Stroke Research Group, Department of Clinical Neurosciences, University

2019 NIHR HTA programme

36. Meta-Regression to Identify Patients Deriving the Greatest Benefit from Dual Antiplatelet Therapy after Stroke or Transient Ischemic Attack Without Thrombolytic or Thrombectomy Treatment

Meta-Regression to Identify Patients Deriving the Greatest Benefit from Dual Antiplatelet Therapy after Stroke or Transient Ischemic Attack Without Thrombolytic or Thrombectomy Treatment The patient's profile drawing the greatest benefit from dual antiplatelet therapy (DAPT) after a noncardioembolic, ischemic cerebrovascular event is not well characterized. Aim of this metaregression analysis was to compare DAPT versus single antiplatelet therapy (SAPT) in patients with stroke or transient (...) ischemic attack (TIA). We searched randomized trials evaluating clinical outcome with aspirin plus a P2Y12 inhibitor versus SAPT in patients with noncardioembolic stroke or TIA. Primary end point was the incidence of recurrent stroke; safety outcome measure was major bleeding. Eleven trials were included in the analysis, enrolling 24,175 patients treated with DAPT (aspirin plus clopidogrel, n = 12,074) or SAPT (n = 12,101) after a stroke or TIA event. In the DAPT group the rates of recurrent stroke

2019 EvidenceUpdates

37. Antiplatelet Therapy After Noncardioembolic Stroke

Antiplatelet Therapy After Noncardioembolic Stroke Background and Purpose- We assessed the efficacy and safety of antiplatelet agents after noncardioembolic stroke or transient ischemic attack and examined how these vary according to patients' demographic and clinical characteristics. Methods- We did a network meta-analysis (NMA) of data from 6 randomized trials of the effects of commonly prescribed antiplatelet agents in the long-term (≥3 months) secondary prevention of noncardioembolic stroke (...) or transient ischemic attack. Individual patient data from 43 112 patients were pooled and reanalyzed. Main outcomes were serious vascular events (nonfatal stroke, nonfatal myocardial infarction, or vascular death), major bleeding, and net clinical benefit (serious vascular event or major bleeding). Subgroup analyses were done according to age, sex, ethnicity, hypertension, qualifying diagnosis, type of vessel involved (large versus small vessel disease), and time from qualifying event to randomization

2019 EvidenceUpdates

38. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral (...) . For this prespecified subgroup analysis, consultant neuroradiologists masked to treatment allocation reviewed brain CT or MRI scans performed before randomisation to confirm participant eligibility and rate features of the intracerebral haemorrhage and surrounding brain. We followed participants for primary (recurrent symptomatic intracerebral haemorrhage) and secondary (ischaemic stroke) outcomes for up to 5 years (reported elsewhere). For this report, we analysed eligible participants with intracerebral

Full Text available with Trip Pro

2019 EvidenceUpdates

39. Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial. (PubMed)

Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial. Hyperglycemia during acute ischemic stroke is common and is associated with worse outcomes. The efficacy of intensive treatment of hyperglycemia in this setting remains unknown.To determine the efficacy of intensive treatment of hyperglycemia during acute ischemic stroke.The Stroke Hyperglycemia Insulin Network Effort (SHINE) randomized clinical (...) trial included adult patients with hyperglycemia (glucose concentration of >110 mg/dL if had diabetes or ≥150 mg/dL if did not have diabetes) and acute ischemic stroke who were enrolled within 12 hours from stroke onset at 63 US sites between April 2012 and August 2018; follow-up ended in November 2018. The trial included 1151 patients who met eligibility criteria.Patients were randomized to receive continuous intravenous insulin using a computerized decision support tool (target blood glucose

2019 JAMA Controlled trial quality: predicted high

40. Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice. (PubMed)

Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice. Randomized clinical trials suggest benefit of endovascular-reperfusion therapy for large vessel occlusion in acute ischemic stroke (AIS) is time dependent, but the extent to which it influences outcome and generalizability to routine clinical practice remains uncertain.To characterize the association of speed of treatment with outcome (...) among patients with AIS undergoing endovascular-reperfusion therapy.Retrospective cohort study using data prospectively collected from January 2015 to December 2016 in the Get With The Guidelines-Stroke nationwide US quality registry, with final follow-up through April 15, 2017. Participants were 6756 patients with anterior circulation large vessel occlusion AIS treated with endovascular-reperfusion therapy with onset-to-puncture time of 8 hours or less.Onset (last-known well time) to arterial

2019 JAMA