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Increased ethanolâ€inducible cytochrome P450â€2E1 and cytochrome P450 isoforms in exosomes of alcoholâ€exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress 29404485 2018 11 13 2471-254X 1 7 2017 09 Hepatology communications Hepatol Commun Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress. 675-690 10.1002 (...) reduced in the corresponding Cyp2e1 -null mice. EV CYP2E1 amounts depended on increased oxidative and endoplasmic reticulum (ER) stress because their levels were decreased by cotreatment with the antioxidant N -acetylcysteine or the CYP2E1 inhibitor chlormethiazole but increased by ER stress-inducer thapsigargin, which was blocked by 4-phenylbutyric acid. Furthermore, cell death rates were elevated when primary hepatocytes or human hepatoma cells were exposed to EVs from alcohol-exposed rodents
Ablation of Oxytocin Neurons Causes a Deficit in Cold Stress Response 29264556 2018 11 13 2472-1972 1 8 2017 Aug 01 Journal of the Endocrine Society J Endocr Soc Ablation of Oxytocin Neurons Causes a Deficit in Cold Stress Response. 1041-1055 10.1210/js.2017-00136 The paraventricular nucleus (PVN) is a critical locus of energy balance control. Three sets of neurons in the PVN are involved in regulating energy balance: oxytocin-expressing neurons (OXT-neurons), thyrotropin-releasing hormone (...) ablation did not alter food intake, weight, or energy expenditure at room temperature on either chow or a high-fat diet. To further characterize OXT-neuron-ablated mice, we examined their response to 1) intraperitoneal cholecystokinin (CCK) injection and 2) thermogenic stress. OXT-neuron-ablated mice had a blunted decrease in feeding response to CCK. When exposed to the extreme cold (4°C) for 3 hours, OXT-neuron-ablated mice had significant decreases in both rectal and brown adipose tissue temperature
Stress at work: Factors associated with cognitive disorganisation among private sector professionals 28748104 2018 11 13 2055-1029 4 3 2017 Jul-Sep Health psychology open Health Psychol Open Stress at work: Factors associated with cognitive disorganisation among private sector professionals. 2055102917718376 10.1177/2055102917718376 This study explores psychological and psychological variables associated with perceived stress at work. A total of 100 international participants consented (...) to donating a hair sample and completing a work-related stress survey. Logistic regression was used to investigate associations with low/high cognitive disorganisation using data collected from hair cortisol analysis and self-report questionnaires. High cognitive disorganisation scores were associated with high cardiopulmonary and anger scores. Low perceived self-efficacy was associated with high cognitive disorganisation. An association was found between low cortisol and low perceived self-efficacy
Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress 28685097 2018 11 13 2055-5008 3 2017 NPJ biofilms and microbiomes NPJ Biofilms Microbiomes Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress. 15 10.1038/s41522-017-0023-4 Bacterial biofilms are intrinsically resistant to antimicrobial treatment, which contributes to microbial persistence in clinical infections. Enterococcus faecalis (...) that are monolayers in the absence of antibiotics. Remarkably, upon exposure to antibiotics parent biofilm cells restructure into complex three-dimensional biofilms resembling those of the Δ epaOX mutant without antibiotics. All biofilms exhibiting complex cellular architectures were less structurally stable than monolayer biofilms, with the biofilm cells exhibiting increased detachment. Our results indicate that E. faecalis biofilms restructure in response to cellular stress whether induced by antibiotics
Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary Incontinence: A Randomized Clinical Trial. Importance: Electroacupuncture involving the lumbosacral region may be effective for women with stress urinary incontinence (SUI), but evidence is limited. Objective: To assess the effect of electroacupuncture vs sham electroacupuncture for women with SUI. Design, Setting, and Participants: Multicenter, randomized clinical trial conducted at 12 hospitals in China (...) episodes in weeks 27 to 30 (95% CI, 1.3-2.8; P < .001). The incidence of treatment-related adverse events was 1.6% in the electroacupuncture group and 2.0% in the sham electroacupuncture group, and all events were classified as mild. Conclusions and Relevance: Among women with stress urinary incontinence, treatment with electroacupuncture involving the lumbosacral region, compared with sham electroacupuncture, resulted in less urine leakage after 6 weeks. Further research is needed to understand
The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood 29170760 2018 11 13 2451-9030 2 7 2017 Oct Biological psychiatry. Cognitive neuroscience and neuroimaging Biol Psychiatry Cogn Neurosci Neuroimaging The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood. 582-590 10.1016/j.bpsc.2017.06.005 Early life adversities including harsh parenting, maternal depression, neighborhood (...) deprivation, and low family economic resources are more prevalent in low-income urban environments and are potent predictors of psychopathology, including, for boys, antisocial behavior (AB). However, little research has examined how these stressful experiences alter later neural function. Moreover, identifying genetic markers of greater susceptibility to adversity is critical to understanding biopsychosocial pathways from early adversity to later psychopathology. Within a sample of 310 low-income boys
Predictors of post-traumatic stress disorder following critical illness: A mixed methods study 29123558 2018 11 13 1751-1437 18 4 2017 Nov Journal of the Intensive Care Society J Intensive Care Soc Predictors of post-traumatic stress disorder following critical illness: A mixed methods study. 289-293 10.1177/1751143717713853 Post-traumatic stress disorder has been reported in survivors of critical illness. The aim of this study was to investigate the predictors of post-traumatic stress (...) disorder in survivors of critical illness. Patients attending the intensive care unit (ICU) follow-up clinic completed the UK-Post-Traumatic Stress Syndrome 14-Questions Inventory and data was collected from their medical records. Predictors investigated included age, gender, Apache II score, ICU length of stay, pre-illness psychopathology; delirium and benzodiazepine administration during ICU stay and delusional memories of the ICU stay following discharge. A total of 198 patients participated, with 54 (27
Relationship between hysterectomy and severity of female stress urinary incontinence 28848647 2018 11 13 2008-5842 9 6 2017 Jun Electronic physician Electron Physician Relationship between hysterectomy and severity of female stress urinary incontinence. 4678-4682 10.19082/4678 Stress Urinary Incontinence (SUI) is one of the most reported health dilemmas of women suffering from lower urinary tract symptoms. To determine the relation between hysterectomy and severity of female SUI using Valsalva
Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study 29034365 2018 11 13 2473-9529 1 15 2017 Jun 27 Blood advances Blood Adv Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study. 1132-1141 10.1182/bloodadvances.2017004820 Genetic polymorphisms in blood donors may contribute to donor-specific differences in the survival of red blood cells (RBCs
Psychological stress has a higher rate of developing addictive behaviors compared to physical stress in rat offspring 28900372 2018 11 13 1611-2156 16 2017 EXCLI journal EXCLI J Psychological stress has a higher rate of developing addictive behaviors compared to physical stress in rat offspring. 903-913 10.17179/excli2016-685 Prenatal stress could have great influence on development of offspring and might alter cognitive function and other physiological processes of children. The current study (...) was conducted to study the effect of physical or psychological prenatal stress on addictive and anxiety-like behavior of male and female offspring during their adolescence period (postnatal day (PND) 40). Adult female rats were exposed to physical (swimming) or psychological (observing another female rat swimming) stress from day six of gestation for 10 days. Male and female offspring were assayed for anxiety-like behavior, motor and balance function and morphine conditioned place preference using the open
Group Cognitive Processing Therapy for Adults with Post-Traumatic Stress Disorder, Anxiety, or Mood Disorders: A Review of Clinical Effectiveness and Guidelines Group Cognitive Processing Therapy for Adults with Post-Traumatic Stress Disorder, Anxiety, or Mood Disorders: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Group Cognitive Processing Therapy for Adults with Post-Traumatic Stress Disorder, Anxiety, or Mood Disorders: A Review of Clinical (...) Effectiveness and Guidelines Group Cognitive Processing Therapy for Adults with Post-Traumatic Stress Disorder, Anxiety, or Mood Disorders: A Review of Clinical Effectiveness and Guidelines Published on: June 12, 2017 Project Number: RC0891-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of group cognitive processing therapy for adults with post-traumatic stress disorder, anxiety disorders
Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial 28434547 2017 04 24 2017 04 24 1552-6259 2017 Apr 20 The Annals of thoracic surgery Ann. Thorac. Surg. Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial. S0003-4975(17)30248-5 10.1016/j.athoracsur.2017.01.111 Corticosteroids can improve the hemodynamic status of neonates with postoperative low cardiac output syndrome after cardiac (...) operations. This study compared a prophylactically administered stress-dose corticosteroid (SDC) regimen against placebo on inflammation, adrenocortical function, and hemodynamic outcome. Forty neonates undergoing elective open heart operations were randomized into two groups. The SDC group received perioperatively 2 mg/kg methylprednisolone, and 6 hours after the operation, a hydrocortisone infusion (0.2 mg/kg/h) was started with tapering doses for 5 days. Placebo was administered in a similar fashion
Cellular fluid shear stress on implant surfacesâ€”establishment of a novel experimental set up 28567712 2018 11 13 2198-4034 3 1 2017 Dec International journal of implant dentistry Int J Implant Dent Cellular fluid shear stress on implant surfaces-establishment of a novel experimental set up. 22 10.1186/s40729-017-0085-3 Mechanostimuli of different cells can affect a wide array of cellular and inter-cellular biological processes responsible for dental implant healing. The purpose (...) of this in vitro study was to establish a new test model to create a reproducible flow-induced fluid shear stress (FSS) of osteoblast cells on implant surfaces. As FSS effects on osteoblasts are detectable at 10 dyn/cm 2 , a custom-made flow chamber was created. Computer-aided verification of circulation processes was performed. In order to verify FSS effects, cells were analysed via light and fluorescence microscopy. Utilising computer-aided simulations, the underside of the upper plate was considered to have
Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease 28553639 2018 11 13 2297-055X 4 2017 Frontiers in cardiovascular medicine Front Cardiovasc Med Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease. 29 10.3389/fcvm.2017.00029 Cardiovascular diseases are a class of heart or blood vessels diseases, which are now considered to be the leading cause of death globally. A number of recent studies have reported key roles (...) for inflammation in the progression of diseased vessels and systematic heart failure. In particular, endoplasmic reticulum (ER) stress, which is mechanistically implicated in inflammation and autophagy, has now been associated with pathophysiological states in the cardiovascular system. Autophagy has also been identified as an important process in the progression of multiple cardiovascular diseases such as in atherosclerosis plaque progression and ischemia and/or reperfusion. In light of the above, it has been
Stress, self-regulation, and context: Evidence from the health and retirement survey 29130063 2018 11 13 2352-8273 3 2017 Dec SSM - population health SSM Popul Health Stress, self-regulation, and context: Evidence from the Health and Retirement Survey. 455-463 10.1016/j.ssmph.2017.05.004 Health-related behaviors, such as smoking, alcohol use, exercise, and diet, are major determinants of physical health and health disparities. However, a growing body of experimental research in humans (...) and animals also suggests these behaviors can impact the ways our bodies respond to stress, such that they modulate (that is, serve as a means to self-regulate or cope with) the deleterious impact of stressful experiences on mental health. A handful of epidemiologic studies have investigated the intersection between stress and health behaviors on health disparities (both mental and physical), with mixed results. In this study we use a novel instrument designed to explicitly measure the self-regulatory
The perceived stress and approach to learning effects on academic performance among Sudanese medical students 28607637 2018 11 13 2008-5842 9 4 2017 Apr Electronic physician Electron Physician The perceived stress and approach to learning effects on academic performance among Sudanese medical students. 4072-4076 10.19082/4072 There is an increasing awareness of the perceived stress and approach to learning effects on academic achievement. This study aimed to assess the educational environment (...) and approach to learning in clinical phase medical students. This comparative cross-sectional study was conducted among fifty-nine clinical stage medical students at Omdurman Islamic University (Khartoum, Sudan) during the period from June to August 2016. All the participants signed a written informed consent, then responded to a structured questionnaire to collect demographic data, the two process study questionnaires and the perceived stress questionnaire. The ethical committee of Omdurman Islamic
Secondary traumatic stress, dissociative and somatization symptoms in spouses of veterans with PTSD in Zahedan, Iran 28607656 2018 11 13 2008-5842 9 4 2017 Apr Electronic physician Electron Physician Secondary traumatic stress, dissociative and somatization symptoms in spouses of veterans with PTSD in Zahedan, Iran. 4202-4206 10.19082/4202 Secondary traumatic stress is a disorder which occurs in spouses and people with close relation to someone with posttraumatic stress disorder. Like PTSD, it (...) seems that STS also occurs with other psychiatric problems like somatization and dissociation. This study aimed to determine the relationship between STS and somatization and dissociation symptoms. This cross-sectional study was done in 2015 and lasted for one year. Self-report questionnaires assessing secondary traumatic stress symptoms, dissociation symptoms and somatization symptoms were distributed among spouses of veterans with PTSD in Zahedan, Iran. The relationship between STS symptoms
Investigation of marital satisfaction and its relationship with job stress and general health of nurses in Qazvin, Iran 28607660 2018 11 13 2008-5842 9 4 2017 Apr Electronic physician Electron Physician Investigation of marital satisfaction and its relationship with job stress and general health of nurses in Qazvin, Iran. 4231-4237 10.19082/4231 Pressures in nursing can affect family life and marital problems, disrupt common social problems, increase work-family conflicts and endanger people's (...) general health. To determine marital satisfaction and its relationship with job stress and general health of nurses. This descriptive and cross-sectional study was done in 2015 in medical educational centers of Qazvin by using an ENRICH marital satisfaction scale and General Health and Job Stress questionnaires completed by 123 nurses. Analysis was done by SPSS version 19 using descriptive and analytical statistics (Pearson correlation, t-test, ANOVA, Chi-square, regression line, multiple regression
Oxidative Stress Markers in GnRH Agonist and Antagonist Protocols in IVF 28680360 2018 11 13 1452-8258 36 2 2017 Apr Journal of medical biochemistry J Med Biochem Oxidative Stress Markers in GnRH Agonist and Antagonist Protocols in IVF. 163-170 10.1515/jomb-2017-0001 Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. This (...) , miscarriage and live-birth rate in both groups. Mean serum SOD was significantly lower, while mean serum MDA and SH groups were significantly higher after ovarian stimulation. Delivery rate was higher in patients without OS while miscarriage rate was higher in patients with OS. Our study confirmed that there is a difference in the concentration of oxidative stress parameters before and after ovarian stimulation. IVF outcome is better in patients without OS after ovarian stimulation. However, the protocol