Latest & greatest articles for statin

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Top results for statin

161. Review: Statins reduce pancreatitis in adults with normal or mildly elevated triglyceride levels.

Review: Statins reduce pancreatitis in adults with normal or mildly elevated triglyceride levels. ACP Journal Club. Review: statins reduce pancreatitis in adults with normal or mildly elevated triglyceride levels. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography (...) Citation manager Format Create File 1 selected item: 23247957 Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2012 Dec 18;157(12):JC6-8. doi: 10.7326/0003-4819-157-12-201212180-02008. ACP Journal Club. Review: statins reduce pancreatitis in adults with normal or mildly elevated triglyceride levels. 1 . 1 Minneapolis VA Health Care

Annals of Internal Medicine2012

162. Efficacy of statins in combination with interferon therapy in multiple sclerosis: a meta-analysis

Efficacy of statins in combination with interferon therapy in multiple sclerosis: a meta-analysis Efficacy of statins in combination with interferon therapy in multiple sclerosis: a meta-analysis Efficacy of statins in combination with interferon therapy in multiple sclerosis: a meta-analysis Bhardwaj S, Coleman CI, Sobieraj DM CRD summary The authors concluded that the addition of statins to interferon therapy did not significantly influence disease progression, the relapse risk (...) , or the Expanded Disability Status Scale scores of patients with relapse-remitting multiple sclerosis. This appears to have been a well-conducted review, but methodological and clinical differences between the trials mean that the reliability of the conclusions is uncertain. Authors' objectives To evaluate the efficacy of combined statin and interferon therapy for patients with multiple sclerosis. Searching MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science were searched

DARE.2012

163. Effect of statins on ventricular tachyarrhythmia, cardiac arrest, and sudden cardiac death: a meta-analysis of published and unpublished evidence from randomized trials

Effect of statins on ventricular tachyarrhythmia, cardiac arrest, and sudden cardiac death: a meta-analysis of published and unpublished evidence from randomized trials Effect of statins on ventricular tachyarrhythmia, cardiac arrest, and sudden cardiac death: a meta-analysis of published and unpublished evidence from randomized trials Effect of statins on ventricular tachyarrhythmia, cardiac arrest, and sudden cardiac death: a meta-analysis of published and unpublished evidence from randomized (...) trials Rahimi K, Majoni W, Merhi A, Emberson J CRD summary This review concluded that statins had a modest beneficial effect on the risk of sudden cardiac death and that there was no evidence of a reduction in ventricular arrhythmias. The authors' conclusions generally reflect evidence presented but the rarity of outcome events makes it probably not possible to rule out any beneficial or harmful effect of statins on ventricular arrhythmias. Authors' objectives To assess the effects of statins on

DARE.2012

164. Review: Statins decrease mortality and major CV events in adults with CKD not receiving dialysis.

Review: Statins decrease mortality and major CV events in adults with CKD not receiving dialysis. ACP Journal Club. Review: statins decrease mortality and major CV events in adults with CKD not receiving dialysis. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography (...) Citation manager Format Create File 1 selected item: 23165680 Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2012 Nov 20;157(10):JC5-4. doi: 10.7326/0003-4819-157-10-201211200-02004. ACP Journal Club. Review: statins decrease mortality and major CV events in adults with CKD not receiving dialysis. 1 . 1 University of Toronto Toronto

Annals of Internal Medicine2012

165. Statin use and reduced cancer-related mortality.

Statin use and reduced cancer-related mortality. BACKGROUND: A reduction in the availability of cholesterol may limit the cellular proliferation required for cancer growth and metastasis. We tested the hypothesis that statin use begun before a cancer diagnosis is associated with reduced cancer-related mortality. METHODS: We assessed mortality among patients from the entire Danish population who had received a diagnosis of cancer between 1995 and 2007, with follow-up until December 31, 2009 (...) . Among patients 40 years of age or older, 18,721 had used statins regularly before the cancer diagnosis and 277,204 had never used statins. RESULTS: Multivariable-adjusted hazard ratios for statin users, as compared with patients who had never used statins, were 0.85 (95% confidence interval [CI], 0.83 to 0.87) for death from any cause and 0.85 (95% CI, 0.82 to 0.87) for death from cancer. Adjusted hazard ratios for death from any cause according to the defined daily statin dose (the assumed average

NEJM2012

166. Meta-analysis of statin effects in women versus men

Meta-analysis of statin effects in women versus men Meta-analysis of statin effects in women versus men Meta-analysis of statin effects in women versus men Kostis WJ, Cheng JQ, Dobrzynski JM, Cabrera J, Kostis JB CRD summary The authors concluded that statins decreased cardiovascular events and all-cause mortality in both women and men and this was present in primary and secondary prevention trials. The authors’ conclusions reflect the evidence presented. Potential issues with the review (...) process and power of the analysis which suggest that the authors’ cautions regarding interpretation of the findings should be heeded. Authors' objectives To assess the effects of statin therapy on cardiovascular events in women compared to men. Searching MEDLINE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science and ClinicalTrials.gov were searched up to June 2010. The search strategy was reported. Study selection Double-blind randomised controlled trials

DARE.2012

167. Statins for primary prevention of cardiovascular and cerebrovascular events in diabetic patients without established cardiovascular diseases: a meta-analysis

Statins for primary prevention of cardiovascular and cerebrovascular events in diabetic patients without established cardiovascular diseases: a meta-analysis Statins for primary prevention of cardiovascular and cerebrovascular events in diabetic patients without established cardiovascular diseases: a meta-analysis Statins for primary prevention of cardiovascular and cerebrovascular events in diabetic patients without established cardiovascular diseases: a meta-analysis Chen YH, Feng B, Chen ZW (...) CRD summary This review concluded that in people with diabetes without established cardiovascular disease, statins could reduce cardiovascular and cerebrovascular events but not all-cause mortality. Uncertainties about the quality of included data and the methods of the review mean that the conclusions should be treated with caution. Authors' objectives To assess the effects of statins in the primary prevention of cardiovascular and cerebrovascular events in people with diabetes. Searching PubMed

DARE.2012

168. Effect of perioperative statins on death, myocardial infarction, atrial fibrillation, and length of stay: a systematic review and meta-analysis

Effect of perioperative statins on death, myocardial infarction, atrial fibrillation, and length of stay: a systematic review and meta-analysis Effect of perioperative statins on death, myocardial infarction, atrial fibrillation, and length of stay: a systematic review and meta-analysis Effect of perioperative statins on death, myocardial infarction, atrial fibrillation, and length of stay: a systematic review and meta-analysis Chopra V, Wesorick DH, Sussman JB, Greene T, Rogers M, Froehlich JB (...) , Eagle KA, Saint S CRD summary This review concluded that perioperative statin treatment decreased atrial fibrillation, myocardial infarction and duration of hospital stay in statin-naive patients who underwent cardiac or non-cardiac surgery. The authors' conclusions reflect the evidence presented. A degree of caution might be required in interpreting the conclusions given the uncertain quality of some of the included studies. Authors' objectives To evaluate the influence of perioperative statin

DARE.2012

169. Very early initiation of statin therapy and mortality in patients with acute coronary syndrome

Very early initiation of statin therapy and mortality in patients with acute coronary syndrome Very early initiation of statin therapy and mortality in patients with acute coronary syndrome Very early initiation of statin therapy and mortality in patients with acute coronary syndrome Angeli F, Reboldi G, Garofoli M, Ramundo E, Verdecchia P CRD summary The review found that statins may reduce one-month mortality following acute coronary syndrome if treatment is initiated on the first day (...) of hospitalisation. These conclusions require cautious interpretation due to limitations in the review that included potential publication bias, failure to assess study quality and poor reporting. Authors' objectives To evaluate the effect of early treatment with statins on one-month mortality in patients with acute coronary syndrome. Searching MEDLINE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for articles published in peer-reviewed journals up to December 2010. Reference lists

DARE.2012

170. Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis

Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis Palmer SC, Craig JC, Navaneethan S, Tonelli M, Pellegrini F, Strippoli GF CRD summary This well-conducted review concluded that statins decreased (...) mortality and cardiovascular events in persons with early stages of chronic kidney disease, had little or no effect in people who received dialysis and had uncertain effects in kidney transplant recipients. The authors' conclusions reflect the evidence available and appear likely to be reliable. Authors' objectives To assess the benefits and harms of statin therapy for adults with chronic kidney disease and examine whether effects varied by stage of disease. Searching Studies were identified from

DARE.2012

171. Adjunctive Statin Therapy Improves Clinical Parameters in Initial Phase Treatment of Chronic Periodontitis

Adjunctive Statin Therapy Improves Clinical Parameters in Initial Phase Treatment of Chronic Periodontitis UTCAT2306, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Adjunctive Statin Therapy Improves Clinical Parameters in Initial Phase Treatment of Chronic Periodontitis Clinical Question Is adjunctive use of statins with scaling and root planing more effective than scaling and root planing alone in the treatment (...) of chronic periodontitis? Clinical Bottom Line Statin therapy (systemic or local delivery) may positively enhance the effect of non-surgical initial phase scaling and root planing therapy in the treatment of chronic periodontitis. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Pradeep/2009 Chronic Periodontitis (n=60) Randomized Controlled Trial Key results The simvastatin treatment group resulted

UTHSCSA Dental School CAT Library2012

172. The effect of statin therapy on ventricular tachyarrhythmias: a meta-analysis

The effect of statin therapy on ventricular tachyarrhythmias: a meta-analysis The effect of statin therapy on ventricular tachyarrhythmias: a meta-analysis The effect of statin therapy on ventricular tachyarrhythmias: a meta-analysis Wanahita N, Chen J, Bangalore S, Shah K, Rachko M, Coleman CI, Schweitzer P CRD summary The authors concluded that available evidence suggested statins may have been associated with reduced risk of ventricular tachyarrhythmias in patients with coronary (...) artery disease. Further large-scale randomised trials were needed. Given the limited search, unclear quality of included studies and possible limitations in the analysis, the authors' caution is warranted. Authors' objectives To investigate the association between statin therapy and the risk of ventricular tachycardia/ventricular fibrillation in patients with coronary artery disease or non-ischaemic cardiomyopathy. Searching MEDLINE and unspecified Cochrane databases were searched for articles published in English

DARE.2012

173. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials Cholesterol (...) Treatment Trialists' (CTT) Collaborators CRD summary This meta-analysis of individual patient data concluded that in individuals with five-year risk of major vascular events lower than 10%, each 1mmol/L reduction in low-density lipoprotein cholesterol produced an absolute reduction in major vascular events of about 11 per 1,000 over five years. The authors' conclusions are likely to be reliable. Authors' objectives To assess the effects of lowering low-density lipoprotein (LDL) cholesterol with statins

DARE.2012

174. Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis

Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis Alberton M, Wu P, Druyts E, Briel M, Mills EJ CRD summary The use of statin therapy for cardiovascular disease (...) was associated with a relatively low risk of adverse events. High risk of bias within the studies, high clinical and methodological heterogeneity between the studies, and a discrepancy between the initial outcomes stated and those actually reported suggest that the authors' conclusions and recommendations may not be reliable. Authors' objectives To assess adverse events associated with the use of individual statin treatments for cardiovascular disease. Searching Twelve databases were searched

DARE.2012

175. Review: Perioperative statins reduce perioperative MI and AF in statin-naïve patients.

Review: Perioperative statins reduce perioperative MI and AF in statin-naïve patients. ACP Journal Club. Review: Perioperative statins reduce perioperative MI and AF in statin-naïve patients. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format (...) Create File 1 selected item: 22711103 Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2012 Jun 19;156(12):JC6-2. doi: 10.7326/0003-4819-156-12-201206190-02002. ACP Journal Club. Review: Perioperative statins reduce perioperative MI and AF in statin-naïve patients. 1 , . 1 McMaster University, Hamilton, Ontario, Canada. Comment

Annals of Internal Medicine2012

176. Effect of Coenzyme Q10 Supplementation on Statin-Induced Myalgias

Effect of Coenzyme Q10 Supplementation on Statin-Induced Myalgias 22608359 2012 07 30 2012 12 04 2014 11 20 1879-1913 110 4 2012 Aug 15 The American journal of cardiology Am. J. Cardiol. Effect of coenzyme Q10 supplementation on statin-induced myalgias. 526-9 10.1016/j.amjcard.2012.04.026 Coenzyme Q10 (CoQ10) deficiency has been proposed to be causal in 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor (statin)-induced myopathies. However, the clinical benefit of supplementation (...) is unproved. The purpose of the present study was to assess the effect of CoQ10 supplementation on myalgias presumed to be caused by statins. Patients currently receiving a statin who developed new-onset myalgias in ≥ 2 extremities within 60 days of initiation or a dosage increase were eligible. Patients continued statin therapy and were randomized using a matched design to either CoQ10 60 mg twice daily or matching placebo. Double-blind treatment continued for 3 months, and patients completed a 10-cm

EvidenceUpdates2012

177. Statins: Is It Really Time to Reassess Benefits and Risks?

Statins: Is It Really Time to Reassess Benefits and Risks? Statins: is it really time to reassess benefits and risks? - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 22533536 Format MeSH and Other Data E-mail (...) Subject Additional text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2012 May 10;366(19):1752-5. doi: 10.1056/NEJMp1203020. Epub 2012 Apr 25. Statins: is it really time to reassess benefits and risks? 1 . 1 Harvard Medical School and the Section of Clinical, Behavioral, and Outcomes Research, Joslin Diabetes Center, Boston, USA. Comment in [N Engl J Med. 2012] PMID: 22533536 DOI

NEJM2012

178. Effect of statin therapy on contrast-induced nephropathy after coronary angiography: a meta-analysis

Effect of statin therapy on contrast-induced nephropathy after coronary angiography: a meta-analysis Effect of statin therapy on contrast-induced nephropathy after coronary angiography: a meta-analysis Effect of statin therapy on contrast-induced nephropathy after coronary angiography: a meta-analysis Pappy R, Stavrakis S, Hennebry TA, Abu-Fadel MS CRD summary The authors concluded that statin use may be associated with a significant reduction in contrast-induced nephropathy, but acknowledged (...) a need for further research to confirm the conclusion. Concerns about the quality of included studies and the synthesis of non-randomised studies suggest that the cautious interpretation of findings recommended by the authors is justified. Authors' objectives To conduct a meta-analysis evaluating the impact of statin use on the incidence of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography. Searching MEDLINE, EMBASE and The Cochrane Library were searched from inception

DARE.2012

179. Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials

Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials Mills EJ, Wu P, Chong G, Ghement I, Singh S, Akl EA, Eyawo O, Guyatt G, Berwanger O (...) , Briel M CRD summary This review concluded that statin therapies offered clear benefits in reducing cardiovascular outcomes across broad populations. The review appeared generally well conducted. The authors conclusions appear likely to be reliable, although it should be borne in mind that subgroup analysis by population type was conducted only for the primary outcome of cardiovascular disease mortality. Authors' objectives To assess the effects of statin therapy on cardiovascular mortality and other

DARE.2012

180. Meta-analysis of the cardiovascular benefits of intensive lipid lowering with statins

Meta-analysis of the cardiovascular benefits of intensive lipid lowering with statins Meta-analysis of the cardiovascular benefits of intensive lipid lowering with statins Meta-analysis of the cardiovascular benefits of intensive lipid lowering with statins Chan DK, O'Rourke F, Shen Q, Mak JC, Hung WT CRD summary The authors stated that intensive lipid lowering therapy with statins significantly reduced risk of stroke, major coronary events and cardiovascular or coronary heart disease deaths (...) in individuals at high risk of cardiovascular events. The review was largely well conducted, but the unknown methodological quality of included trials limits conclusive evidence of the review's reliability. Authors' objectives To evaluate the effects of lipid lowering therapy using higher-dose statins. Searching PubMed, EMBASE and The Cochrane Library were searched from 1966 to 2009. Search terms were reported. Reference lists and related links of relevant papers were reviewed for further studies. Study

DARE.2012