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Latest & greatest articles for spironolactone
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[Cost-effectiveness of the use of spironolactone in the treatment of chronic heart failure] Analisis coste-efectividad del uso de espironolactona en el tratamiento de la insuficiencia cardiaca cronica [Cost-effectiveness of the use of spironolactone in the treatment of chronic heart failure] Analisis coste-efectividad del uso de espironolactona en el tratamiento de la insuficiencia cardiaca cronica [Cost-effectiveness of the use of spironolactone in the treatment of chronic heart failure] Soto (...) Alvarez J, Gonzalez Vilchez F Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The health intervention under examination was spironolactone 25 mg daily as adjunct therapy for the treatment of patients with chronic heart failure (CHF
Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. BACKGROUND: Hirsutism is the presence of excessive hair growth in women and is an important cosmetic condition often resulting in severe distress. Hirsutism is most often caused by increased production of male sex hormones also known as androgens. It is also affected by increased sensitivity to androgens in the hair follicles, and the secretory glands around the hair follicles, called sebaceous glands (...) . Spironolactone is an antiandrogen and aldosterone antagonist used to treat hirsutism. Since 1978, many studies have been conducted to determine its effectiveness. OBJECTIVES: The objective of this review was to investigate the effectiveness of spironolactone and/or in combination with steroids (oral contraceptive pill included) in reducing excess hair growth and/or acne in women. SEARCH STRATEGY: All publications of randomised controlled trials of spironolactone versus placebo and/or in combination
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. 10471456 1999 09 02 1999 09 02 2013 11 21 0028-4793 341 10 1999 Sep 02 The New England journal of medicine N. Engl. J. Med. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. 709-17 Aldosterone is important in the pathophysiology of heart failure. In (...) a doubleblind study, we enrolled 1663 patients who had severe heart failure and a left ventricular ejection fraction of no more than 35 percent and who were being treated with an angiotensin-converting-enzyme inhibitor, a loop diuretic, and in most cases digoxin. A total of 822 patients were randomly assigned to receive 25 mg of spironolactone daily, and 841 to receive placebo. The primary end point was death from all causes. The trial was discontinued early, after a mean follow-up period of 24 months