Latest & greatest articles for spironolactone

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Top results for spironolactone

1. Spironolactone is effective for treating resistant hypertension

Spironolactone is effective for treating resistant hypertension Signal - Spironolactone is effective for treating resistant hypertension Dissemination Centre Discover Portal NIHR DC Discover Spironolactone is effective for treating resistant hypertension Published on 1 December 2015 This trial investigated which drug is best added to high blood pressure (hypertension) treatment if blood pressure has not come down to normal levels after taking three blood pressure lowering drugs. Such “resistant (...) hypertension” accounts for around 10% of all people who have hypertension. The study found that adding spironolactone to the existing three-drug regimen was the most effective treatment and was well-tolerated by patients. Spironolactone is currently recommended by NICE at this fourth stage of treatment, but at half the dose used in this study. The higher dose will increase the cost of prescribing slightly. Potassium levels need to be monitored when using spironolactone as there is a risk they can rise

NIHR Dissemination Centre2018

2. Spironolactone

Spironolactone Top results for spironolactone - Trip Database or use your Google+ account Turning Research Into Practice My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box (...) and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for spironolactone The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical

Trip Latest and Greatest2018

3. Spironolactone is effective for treating resistant hypertension

Spironolactone is effective for treating resistant hypertension NIHR DC | Signal - Spironolactone is effective for treating resistant hypertension Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Spironolactone is effective for treating resistant hypertension Published on 1 December 2015 This trial investigated which drug is best added to high blood pressure (hypertension) treatment if blood pressure has not come down to normal levels after taking three blood pressure lowering (...) drugs. Such “resistant hypertension” accounts for around 10% of all people who have hypertension. The study found that adding spironolactone to the existing three-drug regimen was the most effective treatment and was well-tolerated by patients. Spironolactone is currently recommended by NICE at this fourth stage of treatment, but at half the dose used in this study. The higher dose will increase the cost of prescribing slightly. Potassium levels need to be monitored when using spironolactone

NIHR Dissemination Centre2018

4. Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial

Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial 28700781 2018 11 13 2380-6591 2 9 2017 Sep 01 JAMA cardiology JAMA Cardiol Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial. 950-958 10.1001/jamacardio.2017.2198 Persistent congestion is associated with worse outcomes in acute heart failure (AHF). Mineralocorticoid receptor antagonists administered at high doses may relieve congestion (...) , overcome diuretic resistance, and mitigate the effects of adverse neurohormonal activation in AHF. To assess the effect of high-dose spironolactone and usual care on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels compared with usual care alone. This double-blind and placebo (or low-dose)-controlled randomized clinical trial was conducted in 22 US acute care hospitals among patients with AHF who were previously receiving no or low-dose (12.5 mg or 25 mg daily) spironolactone and had NT

JAMA cardiology2017 Full Text: Link to full Text with Trip Pro

5. Combined low-dose spironolactone plus vitamin E vs. vitamin E monotherapy on insulin resistance, noninvasive indices of steatosis and fibrosis and adipokine levels in nonalcoholic fatty liver disease: A randomized controlled trial

Combined low-dose spironolactone plus vitamin E vs. vitamin E monotherapy on insulin resistance, noninvasive indices of steatosis and fibrosis and adipokine levels in nonalcoholic fatty liver disease: A randomized controlled trial 28452101 2017 04 28 2017 07 10 1463-1326 2017 Apr 28 Diabetes, obesity & metabolism Diabetes Obes Metab Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and fibrosis, and (...) adipokine levels in non-alcoholic fatty liver disease: a randomized controlled trial. 10.1111/dom.12989 The beneficial effects of mineralocorticoid receptor blockade by spironolactone have been shown in animal models of non-alcoholic fatty liver disease (NAFLD). The aim of the present 52-week randomized controlled trial was to compare the effects of low-dose spironolactone and vitamin E combination with those of vitamin E monotherapy on insulin resistance, non-invasive indices of hepatic steatosis

EvidenceUpdates2017

6. Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction

Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction 28542926 2017 05 25 2017 05 25 1532-5415 2017 May 19 Journal of the American Geriatrics Society J Am Geriatr Soc Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction. 10.1111/jgs.14940 To evaluate the effects of an aldosterone antagonist on exercise intolerance in older adults (...) with heart failure and preserved ejection fraction (HFpEF). Randomized, placebo-controlled, double-blind trial. Academic medical center, Winston-Salem, North Carolina. Older adults (N = 80, aged 71 ± 1; 80% female) with stable compensated HFpEF and controlled blood pressure (BP). Participants were randomized into a 9-month treatment of spironolactone 25 mg/d vs placebo. Assessments were peak exercise oxygen consumption (VO2 ), 6-minute walk test, Minnesota Living with Heart Failure Questionnaire (MLHFQ

EvidenceUpdates2017

7. Spironolactone for the treatment of acne in women, a retrospective study of 110 patients

Spironolactone for the treatment of acne in women, a retrospective study of 110 patients 28560306 2018 11 13 2352-6475 3 2 2017 Jun International journal of women's dermatology Int J Womens Dermatol Spironolactone for the treatment of acne in women, a retrospective study of 110 patients. 111-115 10.1016/j.ijwd.2016.12.002 There is limited evidence on the safety and efficacy of spironolactone in the treatment of women with acne. Thus, for many dermatologists spironolactone remains an alternative (...) rather than a mainstay treatment for female patients with acne. An electronic medical records search tool was used to select data from a group of women who received spironolactone to treat acne and were evaluated with the comprehensive acne severity scale (CASS) before treatment and at all follow-up visits. Data points were collected for CASS scores at each follow-up visit, concurrent and previous treatments, and side effects. These data points were used to draw conclusions about the safety

International journal of women's dermatology2017 Full Text: Link to full Text with Trip Pro

8. Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia?clarification

Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia?clarification Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia—clarification, December 2016 - GOV.UK GOV.UK uses cookies to make the site simpler. Search Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia—clarification, December 2016 From: Published: 13 December 2016 (...) Therapeutic area: and In light of feedback, we have clarified our article on concomitant use of these medicines in heart failure. In February 2016, we published an article about the use of spironolactone and renin-angiotensin system drugs in patients with heart failure. Following publication, we received feedback from a small number of readers and a professional organisation that the article was inconsistent with clinical guidelines. We sought advice from the , who considered that the advice outlined

MHRA Drug Safety Update2017

9. Gamechanger? Is Spironolactone the Magic Bullet for Resistant Hypertension?

Gamechanger? Is Spironolactone the Magic Bullet for Resistant Hypertension? Gamechanger? Is Spironolactone the Magic Bullet for Resistant Hypertension? | Clinical Correlations Gamechanger? Is Spironolactone the Magic Bullet for Resistant Hypertension? November 9, 2016 By Amar Parikh, MD Peer Reviewed Welcome to Gamechangers, a series that takes a critical look at the latest in medical literature to answer one important question: would the results of this article change my practice? Featuring (...) is already on maximum doses of a calcium channel blocker (CCB), angiotensin-converting enzyme inhibitor (ACEi), and a thiazide-like diuretic, and he refuses any beta blocker as he fears it will worsen his erectile dysfunction. What are your options for additional anti-hypertensives, and would you consider spironolactone? Why Does This Matter? Resistant hypertension (rHTN), defined as suboptimal blood pressure control despite treatment with at least three anti-hypertensives including a thiazide

Clinical Correlations2016

10. Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study

Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study 27036390 2016 06 02 2016 06 02 0315-162X 43 6 2016 Jun The Journal of rheumatology J. Rheumatol. Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study. 1114-20 10.3899/jrheum.151200 To evaluate the effectiveness of spironolactone as a treatment for osteoarthritis (OA)-related knee effusion (...) in comparison to ibuprofen, cold compresses, and placebo. This study was carried out on 200 patients, aged 40 years or older, attending the outpatient clinic of the Rheumatology Department of Sohag University Hospital with unilateral knee effusion related to OA based on clinical examination, musculoskeletal ultrasonography (US), and synovial fluid analysis. In group 1, 50 patients received spironolactone 25 mg daily for 2 weeks; in group 2, 50 patients took ibuprofen 1200 mg daily for 2 weeks; in group 3

EvidenceUpdates2016

11. Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia

Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia—February 2016 article - GOV.UK GOV.UK uses cookies to make the site simpler. Search Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia—February 2016 article From: Published: 17 February 2016 Last updated: 14 December 2016 (...) , Therapeutic area: and Monitoring of blood electrolytes is essential in patients coprescribed a potassium-sparing diuretic and an angiotensin converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB) for heart failure. Contents Reminder for healthcare professionals: concomitant use of spironolactone with ACEi or ARB increases the risk of severe hyperkalaemia, particularly in patients with marked renal impairment, and should be used with caution use the lowest effective doses

MHRA Drug Safety Update2016

12. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial.

Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. BACKGROUND: Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses that resistant hypertension is most often caused by excessive sodium retention, and that spironolactone would therefore be superior to non-diuretic add-on drugs at lowering blood (...) weeks of once daily treatment with each of spironolactone (25-50 mg), bisoprolol (5-10 mg), doxazosin modified release (4-8 mg), and placebo, in addition to their baseline blood pressure drugs. Random assignment was done via a central computer system. Investigators and patients were masked to the identity of drugs, and to their sequence allocation. The dose was doubled after 6 weeks of each cycle. The hierarchical primary endpoints were the difference in averaged home systolic blood pressure between

Lancet2015

13. Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone

Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone 25646289 2015 03 03 2015 06 18 2017 02 20 1488-2329 187 4 2015 Mar 03 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone. E138-43 10.1503/cmaj.140816 Trimethoprim-sulfamethoxazole increases the risk of hyperkalemia when used with spironolactone. We examined whether (...) this drug combination is associated with an increased risk of sudden death, a consequence of severe hyperkalemia. We conducted a population-based nested case-control study involving Ontario residents aged 66 years or older who received spironolactone between Apr. 1, 1994, and Dec. 31, 2011. Within this group, we identified cases as patients who died of sudden death within 14 days after receiving a prescription for trimethoprim-sulfamethoxazole or one of the other study antibiotics (amoxicillin

EvidenceUpdates2015 Full Text: Link to full Text with Trip Pro

14. Spironolactone for heart failure with preserved ejection fraction.

Spironolactone for heart failure with preserved ejection fraction. BACKGROUND: Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction. We evaluated the effects of spironolactone in patients with heart failure and a preserved left ventricular ejection fraction. METHODS: In this randomized, double-blind trial, we assigned 3445 patients with symptomatic heart failure and a left ventricular ejection fraction (...) of 45% or more to receive either spironolactone (15 to 45 mg daily) or placebo. The primary outcome was a composite of death from cardiovascular causes, aborted cardiac arrest, or hospitalization for the management of heart failure. RESULTS: With a mean follow-up of 3.3 years, the primary outcome occurred in 320 of 1722 patients in the spironolactone group (18.6%) and 351 of 1723 patients in the placebo group (20.4%) (hazard ratio, 0.89; 95% confidence interval [CI], 0.77 to 1.04; P=0.14

NEJM2014

15. Spironolactone for heart failure with preserved ejection fraction.

Spironolactone for heart failure with preserved ejection fraction. 24716680 2014 04 10 2014 04 18 2014 12 09 1533-4406 370 15 2014 Apr 10 The New England journal of medicine N. Engl. J. Med. Spironolactone for heart failure with preserved ejection fraction. 1383-92 10.1056/NEJMoa1313731 Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction. We evaluated the effects of spironolactone in patients with heart (...) failure and a preserved left ventricular ejection fraction. In this randomized, double-blind trial, we assigned 3445 patients with symptomatic heart failure and a left ventricular ejection fraction of 45% or more to receive either spironolactone (15 to 45 mg daily) or placebo. The primary outcome was a composite of death from cardiovascular causes, aborted cardiac arrest, or hospitalization for the management of heart failure. With a mean follow-up of 3.3 years, the primary outcome occurred in 320 of 1722

NEJM2014

16. Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial.

Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. 23443441 2013 02 27 2013 02 28 2016 10 17 1538-3598 309 8 2013 Feb 27 JAMA JAMA Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. 781-91 10.1001/jama.2013.905 Diastolic heart failure (ie, heart (...) failure with preserved ejection fraction) is a common condition without established therapy, and aldosterone stimulation may contribute to its progression. To assess the efficacy and safety of long-term aldosterone receptor blockade in heart failure with preserved ejection fraction. The primary objective was to determine whether spironolactone is superior to placebo in improving diastolic function and maximal exercise capacity in patients with heart failure with preserved ejection fraction. The Aldo-DHF

JAMA2013

17. Case control: Exposure to trimethoprim?sulfamethoxazole is associated with hospitalisation for hyperkalaemia in older people treated with spironolactone

Case control: Exposure to trimethoprim?sulfamethoxazole is associated with hospitalisation for hyperkalaemia in older people treated with spironolactone Exposure to trimethoprim–sulfamethoxazole is associated with hospitalisation for hyperkalaemia in older people treated with spironolactone | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Exposure to trimethoprim–sulfamethoxazole is associated with hospitalisation for hyperkalaemia in older people treated with spironolactone Article Text Harm Case control Exposure to trimethoprim–sulfamethoxazole

Evidence-Based Medicine (Requires free registration)2012

18. Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study.

Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study. OBJECTIVES: To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone. DESIGN: Population based nested case-control study. SETTING: Ontario, Canada, from 1 April 1992 to 1 March 2010. PARTICIPANTS: Cases were residents of Ontario aged 66 years or above receiving (...) chronic treatment with spironolactone and admitted to hospital with hyperkalaemia within 14 days of receiving a prescription for either trimethoprim-sulfamethoxazole, amoxicillin, norfloxacin, or nitrofurantoin. Up to four controls for each case were identified from the same cohort, matched on age, sex, and presence or absence of chronic kidney disease and diabetes, and required to have received one of the study antibiotics within 14 days before the case's index date. MAIN OUTCOME MEASURES: Odds ratio

BMJ2011 Full Text: Link to full Text with Trip Pro

19. Spironolactone and risk of upper gastrointestinal events: population based case-control study.

Spironolactone and risk of upper gastrointestinal events: population based case-control study. OBJECTIVE: To confirm and quantify any association between spironolactone and upper gastrointestinal bleeding and ulcers. DESIGN: Population based case-control study. SETTING: A primary care information database in the Netherlands. PARTICIPANTS: All people on the database who were aged 18 or more between 1 January 1996 and 30 September 2003. Patients with a history of alcoholism or gastrointestinal (...) to 5230 controls. Current use of spironolactone was associated with a 2.7-fold (95% confidence interval 1.2 to 6.0) increased risk of a gastrointestinal event. CONCLUSION: The risk of gastroduodenal ulcers or upper gastrointestinal bleeding is significantly increased in patients using spironolactone.

BMJ2006 Full Text: Link to full Text with Trip Pro

20. Cost-effectiveness of spironolactone in patients with severe heart failure

Cost-effectiveness of spironolactone in patients with severe heart failure Cost-effectiveness of spironolactone in patients with severe heart failure Cost-effectiveness of spironolactone in patients with severe heart failure Tilson L, McGowan B, Ryan M, Barry M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical (...) assessment on the reliability of the study and the conclusions drawn. Health technology The use of spironolactone (mean daily dose 25 mg) in combination with standard therapy was investigated in patients with severe heart failure. Standard therapy could include a loop diuretic, an angiotensin-converting enzyme inhibitor, digoxin, a beta-blocker, or a combination of these. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised

NHS Economic Evaluation Database.2003