Latest & greatest articles for side effects

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Top results for side effects

1. Side effects

Side effects Top results for side effects - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for side effects The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

2. Are side effects reduced if practice nurses administer the intramuscular (IM) contraceptive injection via the ventrogluteal site compared to the dorsogluteal site?

Are side effects reduced if practice nurses administer the intramuscular (IM) contraceptive injection via the ventrogluteal site compared to the dorsogluteal site? Getting Evidence in Clinical Practice: General Practice Nurse Evidence Based Practice (CAT group) Date: May 2017 CAT Lead: Gwenllian Wynne-Jones and Katherine Gatensbury Date CAT completed: May 2017 Email: g.wynne-jones@keele.ac.uk Date CAT to be reviewed: May 2018 Clinical bottom line There is no evidence regarding side effects (...) ? The use of intramuscular injections is very common in nursing practice, and is the standard method for the administration of the contraceptive injection. However, there is little guidance relating to the most appropriate intramuscular injection site and debate on whether the dorsogluteal or ventrogluteal site is associated with fewer side effects. Search timeframe From each databases inception to March 2017. Inclusion criteria Description Search terms Population and setting Adult women wanting to use

2017 Home Modification Information Clearinghouse

3. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects

Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports (...) of disabling and potentially long-lasting or irreversible side effects Disabling, long-lasting or potentially irreversible adverse reactions affecting musculoskeletal and nervous systems have been reported very rarely with fluoroquinolone antibiotics. Fluoroquinolone treatment should be discontinued at the first signs of a serious adverse reaction, including tendon pain or inflammation. Published 21 March 2019 From: Therapeutic area: , , , , , , , , , , , , , Contents Advice for healthcare professionals

2019 MHRA Drug Safety Update

4. Systematic review with meta-analysis: Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Full Text available with Trip Pro

Systematic review with meta-analysis: Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie (...) relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Article Text Therapeutics Systematic review with meta-analysis Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Andrew Östör , Pippa A Watson Statistics from Altmetric.com Commentary on: Derry S , Moore RA , Rabbie R . Topical NSAIDs for chronic musculoskeletal pain in adults

2013 Evidence-Based Medicine

5. Domperidone: risks of cardiac side effects

Domperidone: risks of cardiac side effects Domperidone: risks of cardiac side effects - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Domperidone: risks of cardiac side effects Indication restricted to nausea and vomiting, new contraindications, and reduced dose and duration of use. Published 11 December 2014 From: Therapeutic area: , Article date: May 2014 Domperidone is a dopamine antagonist with antiemetic properties. A European review assessed the benefits and risks (...) of domperidone following continued reports of cardiac side effects. The review confirmed a small increased risk of serious cardiac side effects. A higher risk was observed particularly in people older than 60 years, people taking daily oral domperidone doses of more than 30 mg, and those taking QT-prolonging medicines or CYP3A4 inhibitors at the same time as domperidone. For indications other than nausea and vomiting, the benefits were not considered to outweigh the cardiac risk. Based on the results

2014 MHRA Drug Safety Update

6. Statins have no side effects? What our study really found, its fixable flaws, and why trials transparency matters (again).

Statins have no side effects? What our study really found, its fixable flaws, and why trials transparency matters (again). Statins have no side effects? What our study really found, its fixable flaws, and why trials transparency matters (again). – Bad Science Search TED Talk Collected Journalism This Nerdy Book This Great Book T-shirts Categories (3) (4) (6) (45) (28) (6) (16) (190) (5) (20) (52) (88) (2) (1) (2) (1) (677) (4) (14) (2) (37) (4) (9) (3) (11) (6) (3) (16) (13) (1) (6) (8) (6) (6 (...) ) (12) (1) (59) (2) (6) (34) (26) (1) (1) (1) (2) (2) (1) (52) (7) (2) (1) (2) (3) (1) (1) (1) (4) (2) (82) (1) (10) (6) (3) (2) (1) (5) (1) (10) (1) (2) (1) (1) (6) (4) (3) (2) (52) (3) (18) (10) (1) March 13th, 2014 by Ben Goldacre in , , | Hi there, sorry to be absent (dayjob!). I was surprised to see a study I’m a co-author on getting some today, under the headline “Statins ‘have no side effects'”. That’s not what found. But it was an interesting piece of work, with an odd result, looking

2014 Bad Science

7. Effect of Nurse-led Education on Parent's Anxiety and Depression on Managing Side Effects of Chemotherapy

Effect of Nurse-led Education on Parent's Anxiety and Depression on Managing Side Effects of Chemotherapy Effect of Nurse-led Education on Parent's Anxiety and Depression on Managing Side Effects of Chemotherapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Effect of Nurse-led Education on Parent's Anxiety and Depression on Managing Side Effects of Chemotherapy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03753542 Recruitment Status : Active, not recruiting First Posted : November 27, 2018 Last

2018 Clinical Trials

8. Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression. Full Text available with Trip Pro

Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression. It has been suggested that the superiority of antidepressants over placebo in controlled trials is merely a consequence of side effects enhancing the expectation of improvement by making the patient realize that he/she is not on placebo. We explored this hypothesis in a patient-level post hoc-analysis including all industry-sponsored, Food (...) , were all in line with the primary analyses. The finding that both paroxetine and citalopram are clearly superior to placebo also when not producing adverse events, as well as the lack of association between adverse event severity and response, argue against the theory that antidepressants outperform placebo solely or largely because of their side effects.

2018 Molecular psychiatry

9. What are the beneficial and side effects of cannabis and cannabinoids compared to other active agent or placebo for the treatment of cancer pain in adults. A systematic review of randomised controlled trials

What are the beneficial and side effects of cannabis and cannabinoids compared to other active agent or placebo for the treatment of cancer pain in adults. A systematic review of randomised controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening

2018 PROSPERO

10. e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns

e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns - GOV.UK GOV.UK uses cookies to make the site simpler. Search e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns Use the Yellow Card Reporting Scheme to support the safety of e-cigarettes and refill containers (e-liquids). Published 21 June 2017 From (...) : Contents What and how to report Members of the public and healthcare professionals can use the to report any suspected side effects or safety concerns with e-cigarettes and the e-liquids used for vaping. These issues could include: • suspected side-effects that occurred after the use of e-cigarettes and e-liquids • harm to children or non-users, including accidental poisoning • safety issues or defects with e-cigarette devices Your information will aid us in identifying previously unrecognised side

2017 MHRA Drug Safety Update

11. Efficacy and side effects of risperidone use in autism spectrum disorder: a systematic review and meta-analysis

Efficacy and side effects of risperidone use in autism spectrum disorder: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening

2019 PROSPERO

12. Is there Evidence to Support the use of Enteric Coated (EC) Aspirin to Reduce Gastrointestinal Side Effects in Patients with Cardiovascular Disease?

Is there Evidence to Support the use of Enteric Coated (EC) Aspirin to Reduce Gastrointestinal Side Effects in Patients with Cardiovascular Disease? Is there Evidence to Support the use of Enteric Coated (EC) Aspirin to Reduce Gastrointestinal Side Effects in Patients with Cardiovascular Disease? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · 10th January 2020 · London and South East Regional Medicines Information The enteric coated (EC (...) ) formulation of aspirin was developed and marketed in an effort to reduce GI adverse effects associated with aspirin therapy. There are reports however, that EC does not significantly reduce the risk of GI bleeding when compared to standard formulations of aspirin. There is also speculation that enteric coating may reduce the anti-platelet effect of aspirin due to a reduction in bioavailability, thereby reducing its clinical efficacy in prevention of cardiovascular events. This Q&A reviews the evidence

2020 Specialist Pharmacy Services

13. Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance. Full Text available with Trip Pro

Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance. To evaluate the effect of probiotics administered as an adjuvant to sequential Helicobacter pylori (H. pylori) eradication therapy on treatment outcome and patient compliance.In total, 159 patients with H. pylori infection receiving sequential H. pylori eradication therapy were included in this randomized placebo (...) ] received no additional treatments. Eradication rates, patient compliance, and side effects of eradication therapy were recorded in each treatment group.Significantly higher eradication rates were noted in the ERA+probiotic group (86.8% vs. 70.8%, p=0.025) than in the combined ERA (ERA-only and ERA-placebo) group. Non-compliance with anti-H. pylori treatment was noted in 24 (15.1%) of 159 patients. Lower rates of first week treatment non-compliance due to diarrhea (1.88% vs. 12.26%, p=0.036) were noted

2016 The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology Controlled trial quality: uncertain

14. Evolution of Pharmacological Obesity Treatments: Focus on Adverse Side-Effect Profiles. (Abstract)

Evolution of Pharmacological Obesity Treatments: Focus on Adverse Side-Effect Profiles. Pharmacotherapy directed toward reducing body weight may provide benefits for both curbing obesity and lowering the risk of obesity-associated comorbidities; however, many weight loss medications have been withdrawn from the market because of serious adverse effects. Examples include pulmonary hypertension (aminorex), cardiovascular toxicity, e.g. flenfluramine-induced valvopathy, stroke [phenylpropanolamine (...) programmes; (ii) stipulating post-marketing safety trials; (iii) considering responder rates and limiting cumulative exposure by discontinuation if weight loss is not attained within a reasonable timeframe; and (iv) requiring large cardiovascular outcome trials before or after approval. We chronicle the adverse effects of anti-obesity pharmacotherapy and consider how the history of high-profile toxicity issues has shaped the current regulatory landscape for new and future weight-reducing drugs.© 2016

2016 obesity & metabolism

15. Richard Smith: Who is most likely to have side effects to flu vaccination?

Richard Smith: Who is most likely to have side effects to flu vaccination? Richard Smith: Who is most likely to have side effects to flu vaccination? - The BMJ ---> A simple question that seems to be unanswered but should be answered, says Richard Smith I don’t think that I’ve ever had the flu, certainly nothing that affected me for more than a day, but last year I had the influenza vaccine for the first time. Three factors influenced me: two tough friends who had each for the first time spent (...) a week in bed with the flu; the doctor telling my wife that she should have the vaccine “for the sake of others”; and an Australian critical care doctor telling me on Twitter that they had in their winter that precedes ours seen more severe cases of flu than usual. Unfortunately I developed flu-like symptoms within a few hours of my vaccination, leaving me wondering who is most likely to have side effects from the vaccine. Could it be that I was having it for the first time? Will I be likely to get

2019 The BMJ Blog

16. The Influence of Side Effect Information Framing on Nocebo Effects. Full Text available with Trip Pro

The Influence of Side Effect Information Framing on Nocebo Effects. One contributing factor to the development of nocebo effects is information provided about possible side effects. However, nondisclosure of information can be problematic.We assessed whether positively framed side effect information (highlighting likelihood of not experiencing side effects) can reduce nocebo effects compared to negatively framed information (highlighting likelihood of experiencing side effects).One hundred (...) twelve participants took part in research ostensibly assessing the influence of benzodiazepines (actually sham capsules) on anxiety. Participants were randomized to receive a sham capsule with positively or negatively framed information about four side effects, or a no-treatment control condition. Side effect expectations were assessed after information provision. Framed side effects and other unmentioned symptoms were assessed during the session and 24-hr follow-up.Nocebo effects occurred

2018 Annals of behavioral medicine : a publication of the Society of Behavioral Medicine Controlled trial quality: uncertain

17. Reducing the oral isotretinoin skin side effects: efficacy of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide cream compound in acne patients. (Abstract)

Reducing the oral isotretinoin skin side effects: efficacy of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide cream compound in acne patients. Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless (...) muco-cutaneous side effects, particularly dryness, itching, bruising are commonly seen in patients under treatment with isotretinoin reducing the compliance to the treatment. We conducted a randomized controlled trial to evaluate the efficacy of a cream compound formulated in order to reduce the oral isotretinoin side effects (redness, dryness, itching) in patients affected by severe acne of the face.Twenty-seven patients undergoing treatment with 0.5-1 mg/kg/day for papulo-pustular or nodulo

2018 Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia Controlled trial quality: uncertain

18. Patient preferences concerning the efficacy and side-effect profile of schizophrenia medications: a survey of patients living with schizophrenia. Full Text available with Trip Pro

Patient preferences concerning the efficacy and side-effect profile of schizophrenia medications: a survey of patients living with schizophrenia. Despite the availability of numerous antipsychotic medications, many patients with schizophrenia continue to experience side effects that contribute to the overall burden of the illness. The present survey of patients with schizophrenia and schizoaffective disorder aimed to assess patient attitudes toward antipsychotic treatment, and understand key (...) factors about willingness to try a new medication.A cross-sectional survey was administered to 250 patients with a primary clinical diagnosis of a schizophrenia spectrum disorder across five outpatient clinics in the United States. The survey included self-reported gender, age, weight, and height, and questions about the importance of efficacy and side effects on the decision to take a prescribed antipsychotic medication.Patients rated efficacy and side effects as important attributes of antipsychotic

2018 BMC Psychiatry

19. Second-generation antipsychotics and metabolic side-effects: Canadian population-based study Full Text available with Trip Pro

Second-generation antipsychotics and metabolic side-effects: Canadian population-based study Use of second-generation antipsychotics (SGA) has increased in recent years; however, their use and effect on metabolic outcomes has been poorly characterised in population-level studies.AimsThis study aimed to determine the associations between SGA use and metabolic indicators in a general population.We used data from the Canadian Health Measures Survey, a cross-sectional survey of Canadian households

2018 BJPsych open

20. Self‐evaluation of duration of adjuvant chemotherapy side effects in breast cancer patients: A prospective study Full Text available with Trip Pro

Self‐evaluation of duration of adjuvant chemotherapy side effects in breast cancer patients: A prospective study We recently reported that self-evaluation of the incidence and severity of treatment-related side effects (TSEs) using a National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v4.0-based questionnaire was feasible and more informative than doctor reports in patients undergoing standard adjuvant chemotherapy for operable breast cancer. Here, we (...) charts and compared to patient questionnaires.A total of 594 and 573 paired patient and doctor questionnaires were collected after cycles one and three, respectively. TSE duration was significantly longer when reported by patients compared to doctors for six and seven of ten items after cycles one and three, respectively. Due to the combined effect of doctor underreporting of TSE incidence and duration, the mean percentages of cycle days with TSEs were significantly higher for all ten items when

2018 Cancer medicine