Latest & greatest articles for side effects

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Top results for side effects

81. Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review

Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review McNicol E, Horowicz-Mehler N, Fisk R A, Bennett K, Gialeli-Goudas M, Chew P W, Lau J, Carr D CRD summary The authors concluded that they found limited evidence to support diverse interventions (...) for the management of opioid-related side-effects, as well as the general approach of opioid rotation, and that there is a need for higher quality research. These conclusions appear justified on the basis of the evidence reported in the review, though it is possible that relevant evidence may have been available that was not included in the review. Authors' objectives To assess the management of opioid side-effects in the context of cancer pain management or, in the event that no evidence was available

DARE.2003

82. Impact of side-effects of atypical antipsychotics on non-compliance, relapse and cost

Impact of side-effects of atypical antipsychotics on non-compliance, relapse and cost Impact of side-effects of atypical antipsychotics on non-compliance, relapse and cost Impact of side-effects of atypical antipsychotics on non-compliance, relapse and cost Mortimer A, Williams P, Meddis D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) outcomes was derived from a review of published studies and reviews. It was supplemented by a two-round Delphi study, in which a panel of 25 experts on schizophrenia assessed the impact of different side effect profiles on non-compliance. Modelling A state-transition model was used to represent the relationship between compliance and relapse over a 1-year period following recovery from an episode of schizophrenia. This technique involved identifying clinically important events and defining them

NHS Economic Evaluation Database.2003

83. Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects

Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Shekelle P, Morton S, Maglione M Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Shekelle P, Morton S, Maglione M. Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 76. 2003 Authors' objectives This report aims to assess the efficacy of herbal ephedra-containing dietary supplements and ephedrine on weight loss and athletic performance, through

Health Technology Assessment (HTA) Database.2003

84. Provision of information about drug side-effects to patients.

Provision of information about drug side-effects to patients. To make informed decisions about taking medicinal drugs, people need accurate information about side-effects. A European Union guideline now recommends use of qualitative descriptions for five bands of risk, ranging from very rare (affecting <0.01% of the population), to very common (>10%). We did four studies of more than 750 people, whom we asked to estimate the probability of having a side-effect on the basis of qualitative

Lancet2002

85. Nonspecific medication side effects and the nocebo phenomenon.

Nonspecific medication side effects and the nocebo phenomenon. Patients taking active medications frequently experience adverse, nonspecific side effects that are not a direct result of the specific pharmacological action of the drug. Although this phenomenon is common, distressing, and costly, it is rarely studied and poorly understood. The nocebo phenomenon, in which placebos produce adverse side effects, offers some insight into nonspecific side effect reporting. We performed a focused (...) review of the literature, which identified several factors that appear to be associated with the nocebo phenomenon and/or reporting of nonspecific side effects while taking active medication: the patient's expectations of adverse effects at the outset of treatment; a process of conditioning in which the patient learns from prior experiences to associate medication-taking with somatic symptoms; certain psychological characteristics such as anxiety, depression, and the tendency to somatize

JAMA2002

86. Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature

Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature Raaijmakers E, Engelen A M Authors' objectives The authors appear to study the effects (...) . Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature. Radiotherapy and Oncology 2002; 65(1): 1-7 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Hearing /radiation effects; Hearing Loss, Sensorineural /etiology; Humans; Nasopharyngeal Neoplasms /radiotherapy; Parotid Neoplasms /radiotherapy; Radiation Injuries /etiology AccessionNumber 12003000015 Date bibliographic record published 28/02/2005 Date abstract record

DARE.2002

87. Behavioral intervention for cancer treatment side effects

Behavioral intervention for cancer treatment side effects Behavioral intervention for cancer treatment side effects Behavioral intervention for cancer treatment side effects Redd W H, Montgomery G H, DuHamel K N Authors' objectives To evaluate the clinical impact of behavioural interventions in patients undergoing cancer treatment. Searching PubMed and PsycLIT were searched from 1979 to January 2000 for reports published in the English language, using the following search terms in combination (...) patients). Nausea and vomiting (23 studies, including 13 RCTs with 401 patients). Studies supported the effectiveness of behavioural interventions in controlling anticipatory nausea and vomiting. Twelve of the 13 RCTs reported a statistically-significant benefit from behavioural interventions when compared with a no treatment or attention control interventions. Modest results were found in the 4 studies that assessed behavioural interventions in post-chemotherapy side-effects. Anxiety and distress (19

DARE.2001

88. The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction

The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction HS Osman, HI Rashid, N Sathananthan, MC Parker Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study evaluated the cost-effectiveness of self-expanding metal stents to treat acute left-sided large bowel obstruction in colorectal carcinoma. The authors concluded that stenting showed reduction in hospital stay and costs, but further analysis was necessary due to small sample size

NHS Economic Evaluation Database.2000

89. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. OBJECTIVES: To assess the effects of folic acid and folinic acid in reducing the mucosal and gastrointestinal (GI) and haematologic side effects of low-dose of Methotrexate (MTX) in patients with Rheumatoid Arthritis (RA) and to determine whether or not folate supplementation alters MTX efficacy. SEARCH STRATEGY: We searched the Cochrane Controlled Clinical Trial's Register (CCTR (...) in different countries were compared. MAIN RESULTS: Of the 12 trials retrieved, 7 met the inclusion criteria. The total sample included 307 patients, of which 147 were treated with folate supplementation, 80 patients with folinic acid and 67 patients with folic acid. A 79% reduction in mucosal and GI side effects was observed for folic acid [OR = 0.21 (95% CI 0.10 to 0.44)]. For folinic acid, a clinically but non-statistically significant reduction of 43% was found [OR = 0. 57 (95% CI 0.28 to 1.15

Cochrane2000

90. Umbilical artery catheters in the newborn: effects of catheter design (end vs side hole).

Umbilical artery catheters in the newborn: effects of catheter design (end vs side hole). BACKGROUND: This section is under preparation and will be included in the next issue. OBJECTIVES: To determine whether the design of an umbilical arterial catheter influences the frequency of ischemic events, aortic thrombosis, intraventricular hemorrhage, mortality or necrotising enterocolitis in newborn infants. SEARCH STRATEGY: Randomized and quasi randomized controlled trials of umbilical (...) catheterization use were obtained from the following sources: 1. Effective Care of the Newborn Infant, edited by JC Sinclair and MB Bracken. 2. Medline Search using Melvyl Medline Plus and the keyword headings 'Umbilic#', 'Catheter#' and subject heading 'Infant, Newborn' 3. Search of personal data files SELECTION CRITERIA: Randomized trials in newborn infants of any birthweight or gestation. Comparison of end hole catheters with side hole catheters. Clinically important end points such as ischemic events

Cochrane2000

91. Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice

Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Honig A, Arts B M, Ponds R W, Riedel W J Authors' objectives To investigate whether lithium gives rise to cognitive side-effects and affects (...) with lithium who present themselves with memory problems and mental slowness in order to rule out lithium intoxication. Patients should be given psycho-education about cognitive deficits in an attempt to make them aware of implications of these deficits for their ability to drive, thereby decreasing the risk of road accidents'. Bibliographic details Honig A, Arts B M, Ponds R W, Riedel W J. Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily

DARE.1999

92. Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials

Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials Efficacy and extrapyramidal side-effects of the new (...) to assess the global improvement in schizophrenic symptoms. Where this was not available the mean change of the total score on the Positive and Negative Syndrome Scale (PANSS) was used. Further outcome measures included the mean change as measured by the Scale for the Assessment of Negative Symptoms (SANS) or the PANSS negative subscore; the number of patients requiring at least one dose of antiparkinson medication; drop-outs due to treatment failure; and drop-outs due to adverse events. How were

DARE.1999

93. Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects

Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Hindmarch I, Shamsi Z Authors' objectives The primary aim was to identify the test which are most sensitive to the effects of antihistamines, to identify a test-battery which (...) and other side-effects. Clinical and Experimental Allergy 1999; 29(Supplement 3): 133-142 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Cognition /drug effects; Histamine Antagonists /adverse effects; Humans; Hypnotics and Sedatives /adverse effects; Psychomotor Performance /drug effects AccessionNumber 11999001555 Date bibliographic record published 31/12/2000 Date abstract record published 31/12/2000 Record Status This is a critical abstract of a systematic review that meets

DARE.1999

94. Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial.

Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial. 9929018 1999 02 09 1999 02 09 2015 06 16 0140-6736 353 9149 1999 Jan 23 Lancet (London, England) Lancet Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial. 267-72 Radical radiotherapy is commonly used to treat localised prostate cancer. Late chronic side-effects limit the dose that can be given, and may (...) be linked to the volume of normal tissues irradiated. Conformal radiotherapy allows a smaller amount of rectum and bladder to be treated, by shaping the high-dose volume to the prostate. We assessed the ability of this new technology to lessen the risk of radiation-related effects in a randomised controlled trial of conformal versus conventional radiotherapy. We recruited men with prostate cancer for treatment with a standard dose of 64 Gy in daily 2 Gy fractions. The men were randomly assigned

Lancet1999

95. Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects

Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Curatolo M, Petersen-Felix S, Scaramozzino P, Zbinden A M (...) in the review Patients undergoing surgery (orthopaedic or lower abdominal) with planned epidural block, without general analgesia. Women in labour were not included unless they were having Caesarean section. Outcomes assessed in the review Inadequate analgesia and the occurrence of side-effects were assessed. Inadequate analgesia was defined as pain at any intensity at the site of surgery, occurring during operation. The side-effects included respiratory depression, nausea/vomiting, pruritis, sedation

DARE.1998

96. Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients

Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Cantarovich M, Besner J G, Fitchett D H, Latter D A Record Status This is a critical abstract of an economic evaluation (...) progressively decreased since its introduction into clinical practice as side-effects such as hypertension and renal dysfunction were frequently reported after heart transplantation. You, as a user of this database, should consider whether this is a widely used health technology in your own setting. Validity of estimate of measure of benefit No summary benefit measure was used in the analysis and as such the principal benefits centred around reductions in dose and therefore cost. The data have not been used

NHS Economic Evaluation Database.1997

97. Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed patients: a qualitative analysis of the literature on their efficacy and side-effects

Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed patients: a qualitative analysis of the literature on their efficacy and side-effects Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed patients: a qualitative analysis of the literature on their efficacy and side-effects Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed patients: a qualitative analysis of the literature on their efficacy (...) and side-effects Menting J E, Honig A, Verhey F R, Hartmans M, Rozendaal N, de Vet H C, van Praag H M Authors' objectives To assess the efficacy and side-effects of selective serotonin re-uptake inhibitors (SSRIs) for the treatment of elderly people with depression. Searching MEDLINE was searched from January 1980 until December 1994 using the keywords 'fluvoxamine', 'paroxetine', 'fluoxetine' and 'sertraline' combined with 'aged', 'elderly' or 'geriatric'. The citations in all of the identified papers

DARE.1996

98. Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis

Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis Barbui C, Saraceno B Authors' objectives To quantify the overall extrapyramidal side-effect improvement in patients treated with low doses of neuroleptics, compared with those receiving (...) doses varied between 10, 20 and 50% of the standard dose. Participants included in the review Patients with a standardised diagnosis of schizophrenia (RDC, American Psychiatric Association DSM III) and/or schizoaffective disorder (details taken from the meta-analysis of effectiveness by the same authors, see Other Publications of Related Interest). The mean age of the patients was 34 years with a mean history of disease of over 131 months. Outcomes assessed in the review Extrapyramidal side-effects

DARE.1996

99. Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research

Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research Vermeulen J, Aldenkamp A P Authors' objectives To assess the cognitive side effects of long-term anti-epileptic drug treatments. Searching Computerised and manual searches of English language literature (...) types were examined and reported separately: healthy volunteer studies, monotherapy studies, polytherapy studies, studies with a non-randomised post-test only design, studies providing insufficient information. No tests for heterogeneity were used, methodological and statistical issues were discussed. Results of the review Ninety-four articles representing 89 non-overlapping studies were included. The total patient numbers were not given. No clear results were shown on the cognitive side-effects

DARE.1995

100. Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic agents.

Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic agents. 7646670 1995 07 17 1995 07 17 2015 06 16 0140-6736 345 8965 1995 Jun 24 Lancet (London, England) Lancet Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic agents. 1604-6 Topical timolol given for the treatment or chronic simple glaucoma may cause unrecognised bronchospasm among elderly people. We recruited 80 patients aged over 60 (...) years, who were without a history of airways disease and already used timolol, into a randomised crossover study comparing the effects on spirometry and exercise tolerance of changing to betaxolol or dipivefrine therapy. Results showed an increase of 13% and 8% in mean peak flow rate and forced expiratory volume in 1 s (FEV1), respectively, when using betaxolol; and of 14% and 11% when using dipivefrine. There was also improved exercise tolerance with both agents. More than a quarter of the patients

Lancet1995