Latest & greatest articles for side effects

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Top results for side effects

1. Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects

Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects Signal - Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects Dissemination Centre Discover Portal NIHR DC Discover Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects Published on 8 November 2016 Double-balloon catheters seem to be as effective as vaginal prostaglandin drugs (...) for inducing labour, while also avoiding overstimulation of the womb. The catheter is a device inserted through the cervix, where inflated balloons put pressure on the cervix helping it to “ripen” and start contractions. Prostaglandin drugs are the current recommended induction method, but uterine (womb) overstimulation, where contractions become too frequent or long, is a recognised side effect. This trial found that with either method half of women went on to a vaginal delivery within 24 hours

2019 NIHR Dissemination Centre

2. Fewer side-effects and similar benefits from shorter chemotherapy after bowel cancer surgery

Fewer side-effects and similar benefits from shorter chemotherapy after bowel cancer surgery Fewer side-effects and similar benefits from shorter chemotherapy after bowel cancer surgery Dissemination Centre Discover Portal NIHR DC Discover Fewer side-effects and similar benefits from shorter chemotherapy after bowel cancer surgery Published on 12 June 2018 A three-month course of chemotherapy after surgery for bowel cancer seems no less effective than the standard six-month course, and half (...) as many people suffered from nerve damage as a side-effect. Three-quarters of people survived to three years without disease progression on either treatment. This international trial, part funded by the NIHR, included over 6,000 people with high-risk stage II or III bowel cancer that had spread through the bowel wall or to nearby lymph nodes. Standard treatment after surgery is usually six months of an oxaliplatin-containing regimen. This study evaluated a shorter course. Oxaliplatin is known

2019 NIHR Dissemination Centre

3. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature

Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature 30190274 2018 10 26 1399-3003 52 4 2018 Oct The European respiratory journal Eur. Respir. J. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. 1800703 10.1183/13993003.00703-2018 This review provides an overview of the role of long (...) -term treatment of severe asthma with oral corticosteroids (OCS) and its associated side-effects in adults. It is based on a systematic literature search conducted in MEDLINE, Embase and the Cochrane Library to identify relevant studies. After a short overview of severe asthma and its treatment we present studies showing a dose-response relationship in asthmatic patients treated with OCS and then consider by organ systems the undesired effects demonstrated in clinical and epidemiological studies

2018 EvidenceUpdates

4. Adverse side effects of dexamethasone in surgical patients. (PubMed)

Adverse side effects of dexamethasone in surgical patients. BACKGROUND: In the perioperative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting (PONV), for pain management, and to facilitate early discharge after ambulatory surgery.Long-term treatment with steroids has many side effects, such as adrenal insufficiency, increased infection risk, hyperglycaemia, high blood pressure, osteoporosis, and development of diabetes mellitus. However (...) , whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied. OBJECTIVES: To assess the effects of a steroid load of dexamethasone on postoperative systemic or wound infection, delayed wound healing, and blood glucose change in adult surgical patients (with planned subgroup analysis of patients with and without diabetes). SEARCH METHODS: We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL

2018 Cochrane

5. Moxibustion for alleviating side effects of chemotherapy or radiotherapy in people with cancer. (PubMed)

Moxibustion for alleviating side effects of chemotherapy or radiotherapy in people with cancer. BACKGROUND: Moxibustion, a common treatment in traditional Chinese medicine, involves burning herbal preparations containing Artemisia vulgaris on or above the skin at acupuncture points. Its intended effect is to enhance body function, and it could reduce the side effects of chemotherapy or radiotherapy and improve quality of life (QoL) in people with cancer. OBJECTIVES: To assess the effects (...) of moxibustion for alleviating side effects associated with chemotherapy, radiotherapy or both in people with cancer. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE via Ovid, Embase via Ovid and AMED (Allied and Complementary Medicine Database) from their inception to February 2018. We also searched databases in China including the Chinese BioMedical Literature Database (CBM), Chinese Medical Current Contents (CMCC), TCMonline

2018 Cochrane

6. Adverse side effects of dexamethasone in surgical patients. (PubMed)

Adverse side effects of dexamethasone in surgical patients. BACKGROUND: In the perioperative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting (PONV), for pain management, and to facilitate early discharge after ambulatory surgery.Long-term treatment with steroids has many side effects, such as adrenal insufficiency, increased infection risk, hyperglycaemia, high blood pressure, osteoporosis, and development of diabetes mellitus. However (...) , whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied. OBJECTIVES: To assess the effects of a steroid load of dexamethasone on postoperative systemic or wound infection, delayed wound healing, and blood glucose change in adult surgical patients (with planned subgroup analysis of patients with and without diabetes). SEARCH METHODS: We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL

2018 Cochrane

7. Safety and Side Effects of Rifampin versus Isoniazid in Children. (PubMed)

Safety and Side Effects of Rifampin versus Isoniazid in Children. BACKGROUND: The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life-threatening forms of tuberculosis disease. The current standard treatment - 9 months of isoniazid - has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been shown to be safer (...) and to have higher completion rates than 9 months of isoniazid. METHODS: In this multicenter, open-label trial, we randomly assigned 844 children (<18 years of age) with latent M. tuberculosis infection to receive either 4 months of rifampin or 9 months of isoniazid. The primary outcome was adverse events of grade 1 to 5 that resulted in the permanent discontinuation of a trial drug. Secondary outcomes were treatment adherence, side-effect profile, and efficacy. Independent review panels whose members

2018 NEJM

8. Side effects

Side effects Top results for side effects - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for side effects The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

2018 Trip Latest and Greatest

9. Second-generation antipsychotics and metabolic side-effects: Canadian population-based study (PubMed)

Second-generation antipsychotics and metabolic side-effects: Canadian population-based study 29998821 2018 11 14 2056-4724 4 4 2018 Jul BJPsych open BJPsych Open Second-generation antipsychotics and metabolic side-effects: Canadian population-based study. 256-261 10.1192/bjo.2018.33 Use of second-generation antipsychotics (SGA) has increased in recent years; however, their use and effect on metabolic outcomes has been poorly characterised in population-level studies.AimsThis study aimed (...) , Department of Community Health Sciences,Hotchkiss Brain Institute,Department of Clinical Neurosciences, andO'Brien Institute of Public Health, University of Calgary,Canada. Pringsheim Tamara T Associate Professor, Department of Community Health Sciences,Hotchkiss Brain InstituteandDepartment of Clinical Neurosciences,University of Calgary,Canada. eng Journal Article England BJPsych Open 101667931 2056-4724 Second-generation antipsychotics epidemiology metabolic side-effects population 2018 7 13 6 0 2018

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2018 BJPsych open

10. Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial

Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial 29645317 2018 05 25 1553-2712 2018 Apr 12 Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Acad Emerg Med Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial. 10.1111/acem.13428 We compared (...) the analgesic efficacy and incidence of side effects when low-dose (0.3 mg/kg) ketamine (LDK) is administered as a slow infusion (SI) over 15 minutes versus an intravenous push (IVP) over 1 minute. This was a prospective, randomized, double-blind, double-dummy, placebo-controlled trial of adult ED patients presenting with moderate to severe pain (numerical rating scale [NRS] score ≥ 5). Patients received 0.3 mg/kg ketamine administered either as a SI or a IVP. Our primary outcome was the proportion

2018 EvidenceUpdates

11. Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects

Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects NIHR DC | Signal - Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects Published on 8 November 2016 Double-balloon catheters seem to be as effective as vaginal (...) prostaglandin drugs for inducing labour, while also avoiding overstimulation of the womb. The catheter is a device inserted through the cervix, where inflated balloons put pressure on the cervix helping it to “ripen” and start contractions. Prostaglandin drugs are the current recommended induction method, but uterine (womb) overstimulation, where contractions become too frequent or long, is a recognised side effect. This trial found that with either method half of women went on to a vaginal delivery within

2018 NIHR Dissemination Centre

12. Early and Late Onset Side Effects of Photodynamic Therapy (PubMed)

Early and Late Onset Side Effects of Photodynamic Therapy biomedicines Review Early and Late Onset Side Effects of Photodynamic Therapy Francesco Borgia *, Roberta Giuffrida, Emanuela Caradonna, Mario Vaccaro ID , Fabrizio Guarneri and Sera?nella P . Cannavò Section of Dermatology—Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy; robgiuffrida@unime.it (R.G.); emanuela.caradonna79@gmail.com (E.C.); mario.vaccaro@unime.it (M.V .); f.guarneri@tiscali.it (...) (F.G.); patrizia.cannavo@unime.it (S.P .C.) * Correspondence: fborgia@unime.it; Tel.: +39-347-9143476 Received: 31 December 2017; Accepted: 25 January 2018; Published: 29 January 2018 Abstract: Photodynamic Therapy (PDT) is a non-invasive treatment successfully used for neoplastic, in?ammatory and infectious skin diseases. One of its strengths is represented by the high safety pro?le, even in elderly and/or immuno-depressed subjects. PDT, however, may induce early and late onset side effects

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2018 Biomedicines

13. “Side effects affected my daily activities a lot”: a qualitative exploration of the impact of contraceptive side effects in Bangladesh (PubMed)

“Side effects affected my daily activities a lot”: a qualitative exploration of the impact of contraceptive side effects in Bangladesh 29386952 2018 11 13 1179-1527 8 2017 Open access journal of contraception Open Access J Contracept "Side effects affected my daily activities a lot": a qualitative exploration of the impact of contraceptive side effects in Bangladesh. 45-52 10.2147/OAJC.S140214 In a country like Bangladesh that has made great progress in contraceptive use with one (...) of the lowest levels of fertility and highest levels of contraceptive use, understanding what factors influence women's decisions to discontinue a contraceptive method and not switch to a new method is critical in designing interventions and programs that will help enable Bangladesh to reach its FP2020 goals. Research on side effects has focused on physical manifestations like headaches, moodiness, abdominal pain, and menstrual irregularities. While physical effects alone may stop women from continuing

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2017 Open access journal of contraception

14. e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns

e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns - GOV.UK GOV.UK uses cookies to make the site simpler. Search e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns From: Published: 21 June 2017 Use the Yellow Card Reporting Scheme to support the safety of e-cigarettes and refill containers (e-liquids (...) ). Contents What and how to report Members of the public and healthcare professionals can use the to report any suspected side effects or safety concerns with e-cigarettes and the e-liquids used for vaping. These issues could include: • suspected side-effects that occurred after the use of e-cigarettes and e-liquids • harm to children or non-users, including accidental poisoning • safety issues or defects with e-cigarette devices Your information will aid us in identifying previously unrecognised side

2017 MHRA Drug Safety Update

15. [How to evaluate side effects in a clinical trial?] (PubMed)

[How to evaluate side effects in a clinical trial?] 28236990 2017 02 26 2017 02 26 0013-7006 42 6S 2016 Dec L'Encephale Encephale [How to evaluate side effects in a clinical trial?] S30-S32 S0013-7006(17)30051-9 10.1016/S0013-7006(17)30051-9 Adverse effects of psychotropic medications must be systematically assessed during a clinical trial. This systematic and mandatory evaluation, for the patient safety first, will also allow to establish for the tested molecule, an efficiency/tolerance ratio (...) which could be compared to preexisting medications, and guide the clinician prescriptions. These side effects are closely related to the pharmacological profile of the tested molecule, in particular its monoamine binding profile. Antipsychotics are taken as an example, with a focus on classical clinical side effects related to each monoamine transmission blocking. © L’Encéphale, Paris, 2016. Maurel M M SHU Psychiatrie Adultes, Hôpital Sainte Marguerite, 13274 Marseille Cedex 9, France. Electronic

2017 L'Encephale

16. Evidence of ocular side effects of SSRIs and new warnings

Evidence of ocular side effects of SSRIs and new warnings Evidence of ocular side effects of SSRIs and new warnings | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Evidence of ocular side effects of SSRIs and new warnings Article Text Outcomes Evidence of ocular side effects of SSRIs and new warnings Julia Kirkham , Dallas Seitz Statistics from Altmetric.com ABSTRACT FROM: Chen H , Lin C , Lai S , et al . Association of selective serotonin reuptake inhibitor use and acute angle-closure glaucoma . What is already known on this topic Acute angle

2017 Evidence-Based Mental Health

17. Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association (PubMed)

Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association 28725477 2018 11 13 2056-7189 2 2016 NPJ systems biology and applications NPJ Syst Biol Appl Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association. 16023 (...) 10.1038/npjsba.2016.23 Fatty acid amide hydrolase (FAAH) is a promising therapeutic target for the treatment of pain and CNS disorders. However, the development of potent and safe FAAH inhibitors is hindered by their off-target mediated side effect that leads to brain cell death. Its physiological off-targets and their associations with phenotypes may not be characterized using existing experimental and computational techniques as these methods fail to have sufficient proteome coverage and/or ignore

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2016 NPJ systems biology and applications

19. Apomorphine with domperidone: minimising risk of cardiac side effects

Apomorphine with domperidone: minimising risk of cardiac side effects Apomorphine with domperidone: minimising risk of cardiac side effects - GOV.UK GOV.UK uses cookies to make the site simpler. Search Apomorphine with domperidone: minimising risk of cardiac side effects From: Published: 18 April 2016 Therapeutic area: and Patients receiving apomorphine and domperidone require an assessment of cardiac risk factors and ECG monitoring to reduce the risk of serious arrhythmia related to QT (...) -prolongation. Contents Advice for healthcare professionals: Before starting treatment, carefully consider whether the benefits of concomitant apomorphine and domperidone treatment outweigh the small increased risk of cardiac side effects Discuss the benefits and risks of apomorphine with patients and carers and advise them to contact their doctor immediately if they develop palpitations or syncopal symptoms during treatment Check the QT-interval before starting domperidone, during the apomorphine

2016 MHRA Drug Safety Update

20. Improving symptoms and side effects in older patients with schizophrenia with decreasing dopamine D2/3 receptor occupancy following risperidone and olanzapine dose reduction

Improving symptoms and side effects in older patients with schizophrenia with decreasing dopamine D2/3 receptor occupancy following risperidone and olanzapine dose reduction Improving symptoms and side effects in older patients with schizophrenia with decreasing dopamine D2/3 receptor occupancy following risperidone and olanzapine dose reduction | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Improving symptoms and side effects in older patients with schizophrenia with decreasing dopamine D2/3 receptor occupancy following risperidone

2015 Evidence-Based Mental Health