Latest & greatest articles for sepsis

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on sepsis or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on sepsis and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Top results for sepsis

1. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock Full Text available with Trip Pro

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock Surviving Sepsis Campaign: International Guidelines for Man... : Critical Care Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account Registered users can (...) & Issues Collections For Authors Journal Info > > Surviving Sepsis Campaign: International Guidelines for Man... Email to a Colleague Colleague's E-mail is Invalid Your Name: (optional) Your Email: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw at Critical Care Medicine. Send a copy to your email Your message has been successfully sent to your colleague. Some error has occurred while processing your request. Please try after some time

2016 European Respiratory Society

2. Sepsis: recognition, diagnosis and early management

Sepsis: recognition, diagnosis and early management Sepsis: recognition, diagnosis and early Sepsis: recognition, diagnosis and early management management NICE guideline Published: 13 July 2016 nice.org.uk/guidance/ng51 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration (...) be inconsistent with complying with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Sepsis: recognition, diagnosis and early management (NG51) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 50Contents Contents Overview 4 Who

2016 National Institute for Health and Clinical Excellence - Clinical Guidelines

3. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock Surviving Sepsis Campaign | SSC Guidelines You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. > Guidelines SSC Guidelines Page Content The fourth edition of "Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016​" are linked below. The fifth edition is in development. ESICM and SCCM (...) have announced that the fifth edition update will be completed in collaboration with the group (Guidelines in Intensive Care, Development and Evaluation) affliated with The Research Institute of St. Joseph's Healthcare and McMaster University, Hamilton, Canada. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016​​ Related Materials A User's Guide to the 2016 Surviving Sepsis Guidelines JAMA Viewpoint JAMA Clinical Guidelines Synopsis Practice

2016 Society of Critical Care Medicine

4. Sepsis in children

Sepsis in children Sepsis in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in children Last reviewed: February 2019 Last updated: October 2018 Summary Initial clinical presentation may be non-specific (especially in younger age groups). Given the time-critical nature of severe sepsis and septic shock, when sepsis is suspected on clinical grounds it is usually best to initiate sepsis investigations (...) and treatment, including administering antibiotics and fluid resuscitation. These should continue until sepsis has been excluded. Progression to organ failure and shock is often very rapid, so early recognition and treatment is crucial. Empirical broad-spectrum antibiotic therapy (based on the most probable pathogens) should be administered as soon as possible, and always within the first hour following recognition. Other treatments are primarily supportive, and should be delivered according

2018 BMJ Best Practice

5. Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)

Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) Intensive Care Medicine GUIDELINES Un-edited accepted proof* © European Society of Intensive Care Medicine and the Society of Critical Care Medicine 2020 1 Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) Authors Waleed Alhazzani 1,2 , Morten Hylander Møller 3,4 , Yaseen M. Arabi 5 , Mark Loeb 1,2 (...) either strong or weak, or in the form of best practice recommendations. Results The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy. Conclusion The Surviving Sepsis Campaign COVID-19 panel

2020 Covid-19 Ad hoc guidelines

7. Sepsis: recognition, diagnosis and early management

Sepsis: recognition, diagnosis and early management Sepsis: recognition, diagnosis and early management bpac nz guidelines www.bpac.org.nz/guidelines June 20182 SEPSIS: RECOGNITION, DIAGNOSIS AND EARLY MANAGEMENT www.bpac.org.nz/guidelines/4 This is a bpac nz contextualisation of NICE Guideline NG51 © NICE 2015 2 Contents Introduction 4 Overview 6 Purpose of this guideline 6 Who is it for 6 1. Recommendations 7 1.1 Identifying people with suspected sepsis 7 1.2 Risk factors for sepsis 8 1.3 (...) Face-to-face assessment of people with suspected sepsis 9 1.4 Stratifying risk of severe illness or death from sepsis 10 1.5 Managing suspected sepsis outside acute hospital settings 18 1.6 Managing and treating suspected sepsis in acute hospital settings 18 1.7 Antibiotic treatment in people with suspected sepsis 26 1.8 Intravenous fluids in people with suspected sepsis 26 1.9 Using oxygen in people with suspected sepsis 27 1.10 Finding the source of infection in people with suspected sepsis 27

2018 Best Practice Advocacy Centre New Zealand

8. Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Full Text available with Trip Pro

Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Mortality from sepsis and septic shock remains high. Results of trials on intravenous immunoglobulins (IVIG) as adjunctive therapy for sepsis have been conflicting. This is an update of a Cochrane review that was originally published in 1999 and updated in 2002 and 2010.To estimate the effects of IVIG as adjunctive therapy in patients with bacterial sepsis or septic shock on mortality, bacteriological failure rates (...) , and duration of stay in hospital.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 6), MEDLINE (1966 to December 2012), and EMBASE (1988 to December 2012). We contacted investigators in the field for unpublished data. The original search was performed in 1999 and updated in 2002 and 2008.We included randomized controlled trials comparing IVIG (monoclonal or polyclonal) with placebo or no intervention in patients of any age with bacterial sepsis

2013 Cochrane

9. Sepsis

Sepsis Top results for sepsis - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for sepsis The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted

2018 Trip Latest and Greatest

10. Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? Full Text available with Trip Pro

Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 4, Pages 363–365 Does the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Improve Survival in Septic Adults? x (...) all Collapse all Article Outline Take-Home Message No high- or moderate-level evidence shows that the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) hemodynamic interventions improve survival in sepsis. Methods Data Sources The authors searched PubMed, EMBASE, Scopus, Web of Science, and without language restrictions from inception to November 28, 2017. They also searched the references of analyzed studies and other review articles. Study Selection Investigators included randomized

2019 Annals of Emergency Medicine Systematic Review Snapshots

11. Sepsis in children

Sepsis in children Sepsis in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in children Last reviewed: February 2019 Last updated: October 2018 Summary Initial clinical presentation may be non-specific (especially in younger age groups). Given the time-critical nature of severe sepsis and septic shock, when sepsis is suspected on clinical grounds it is usually best to initiate sepsis investigations (...) and treatment, including administering antibiotics and fluid resuscitation. These should continue until sepsis has been excluded. Progression to organ failure and shock is often very rapid, so early recognition and treatment is crucial. Empirical broad-spectrum antibiotic therapy (based on the most probable pathogens) should be administered as soon as possible, and always within the first hour following recognition. Other treatments are primarily supportive, and should be delivered according

2018 BMJ Best Practice

12. Appropriate and timely antibiotic administration for neonatal sepsis in Mesoamérica Full Text available with Trip Pro

Appropriate and timely antibiotic administration for neonatal sepsis in Mesoamérica Neonatal sepsis is a leading cause of mortality among children under-5 in Latin America. The Salud Mesoamérica Initiative (SMI), a multicountry results-based aid programme, was designed to improve maternal, newborn and child health in impoverished communities in Mesoamérica. This study examines the delivery of timely and appropriate antibiotics for neonatal sepsis among facilities participating in the SMI (...) project. A multifaceted health facility survey was implemented at SMI inception and approximately 18 months later as a follow-up. A random sample of medical records from neonates diagnosed with sepsis was reviewed, and data regarding antibiotic administration were extracted. In this paper, we present the percentage of patients who received timely (within 2 hours) and appropriate antibiotics. Multilevel logistic regression was used to assess for potential facility-level determinants of timely

2018 BMJ global health

13. Sepsis in adults

Sepsis in adults Sepsis in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in adults Last reviewed: February 2019 Last updated: October 2018 Important updates 18 Sep 2018 Corticosteroids reduce mortality but increase neuromuscular weakness in sepsis and septic shock Corticosteroids reduce mortality (by approximately 2%) but increase the risk of neuromuscular weakness in patients with sepsis or septic (...) shock, according to an international panel that reviewed conflicting recent evidence. The panel concluded that the overall body of evidence offers weak support for the use of corticosteroids in patients with sepsis with or without shock but said a no-steroid approach remained reasonable. Patient values and preferences may help guide the decision on whether or not to use corticosteroids. Patients who would prioritise living over quality-of-life would likely choose to have corticosteroid treatment

2018 BMJ Best Practice

14. Management of Neonates Born at ?34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis

Management of Neonates Born at ?34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis Management of Neonates Born at ≤34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections Sign up (...) for highlighting editor-chosen studies with the greatest impact on clinical care. Management of Neonates Born at ≤34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis Karen M. Puopolo , William E. Benitz , Theoklis E. Zaoutis , COMMITTEE ON FETUS AND NEWBORN , COMMITTEE ON INFECTIOUS DISEASES Abstract Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm

2018 American Academy of Pediatrics

15. Are Balanced Crystalloids the Preferred Resuscitation Fluid for Severe Sepsis and Septic Shock?

Are Balanced Crystalloids the Preferred Resuscitation Fluid for Severe Sepsis and Septic Shock? Systematic Review Snapshot TAKE-HOME MESSAGE Balanced crystalloids in sepsis have been linked indirectly with lower mortality and should be considered as an alternative to unbalanced crystalloids as the initial resuscitation ?uid. Are Balanced Crystalloids the Preferred Resuscitation Fluid for Severe Sepsis and Septic Shock? EBEM Commentators Clark G. Owyang, MD Kaushal H. Shah, MD Department (...) published meta- analyses were screened for relevant citations. STUDY SELECTION Parallel-group randomized controlled trials, including factorial designs, were included. Quasi-randomized and crossover trials were excluded. All studies published by Dr. Joachim Boldt were excluded because of suspected lack of integrity. Included studies involved critically ill adults with either severe sepsis or septic shock who required ?uid resuscitation. Studies in which most patients had systemic in?ammatory response

2015 Annals of Emergency Medicine Systematic Review Snapshots

16. Rapid sepsis detection

Rapid sepsis detection Health Policy Advisory Committee on Technology Technology Brief Rapid sepsis detection December 2016 © State of Queensland (Queensland Department of Health) 2016 This work is licensed under a Creative Commons Attribution Non-Commercial No Derivatives 3.0 Australia licence. In essence, you are free to copy and communicate the work in its current form for non-commercial purposes, as long as you attribute the authors and abide by the licence terms. You may not alter or adapt (...) Health Technology Assessment, University of Adelaide. Rapid sepsis detection: December 2016 i Summary of findings Sepsis is a severe and life-threatening complication of infection, and identifying it early may improve outcomes. The gold-standard for diagnosing sepsis, blood culture, takes several days and may be unreliable (lacking in sensitivity), and broad spectrum antibiotics are frequently used to target all potential organisms. This introduces risks of overtreatment, toxicity, and selection

2016 COAG Health Council - Horizon Scanning Technology Briefs

17. Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines

Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines | CADTH.ca Find the information you need Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines Last updated: August 13 (...) , 2019 Project Number: RA1058-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical utility of screening triage tools and/or management algorithms in adult patients in the emergency department with suspected sepsis? What is the clinical utility of screening triage tools and/or management algorithms in adult inpatients with suspected sepsis? What are the evidence-based guidelines regarding the use of screening triage tools

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

18. Sepsis

Sepsis Sepsis - NICE CKS Share Sepsis Sepsis is a syndrome defined as life-threatening organ dysfunction due to a dysregulated host response to infection. Septic shock is a subset of sepsis, which describes circulatory, cellular, and metabolic abnormalities which are associated with a greater risk of mortality than sepsis alone. It is thought to be a multifactorial response to an infecting pathogen that may be amplified by host factors (such as genetics, age, and co-morbidities), the pathogen (...) (type, virulence, and burden), and the environment. The most common sites of infection leading to sepsis are the respiratory, gastrointestinal, renal and genitourinary tracts. Risk factors for sepsis include extremes of age; people who are frail, immunocompromised or immunosuppressed; people who have had recent trauma or surgery; people with a breach in skin integrity; and women who are pregnant, are post-partum, or have had a recent termination of pregnancy or miscarriage. The incidence of sepsis

2019 NICE Clinical Knowledge Summaries

19. Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines

Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines | CADTH.ca Find the information you need Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines Published on: January 13, 2017 Project Number: RC0841-000 Product Line: Research Type: Other Diagnostics Report Type (...) : Summary with Critical Appraisal Result type: Report Question What are the evidence-based guidelines regarding the use of tests or procedures for the recognition and diagnosis of sepsis in adults with suspected sepsis? Key Message Six evidence-based guidelines were identified for diagnostic tests or processes for the recognition and detection of sepsis in adult populations. Three of these guidelines explored the recognition and detection of sepsis in broader populations, while three others focused

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

20. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta-analysis

Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta-analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2012 PedsCCM Evidence-Based Journal Club