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Latest & greatest articles for sepsis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on sepsis or other clinical topics then use Trip today.
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Prediction of Sepsis in the Intensive Care Unit With Minimal Electronic Health Record Data: A Machine Learning Approach 27694098 2018 11 13 2291-9694 4 3 2016 Sep 30 JMIR medical informatics JMIR Med Inform Prediction of Sepsis in the Intensive Care Unit With Minimal Electronic Health Record Data: A Machine Learning Approach. e28 Sepsis is one of the leading causes of mortality in hospitalized patients. Despite this fact, a reliable means of predicting sepsis onset remains elusive. Early (...) and accurate sepsis onset predictions could allow more aggressive and targeted therapy while maintaining antimicrobial stewardship. Existing detection methods suffer from low performance and often require time-consuming laboratory test results. To study and validate a sepsis prediction method, InSight, for the new Sepsis-3 definitions in retrospective data, make predictions using a minimal set of variables from within the electronic health record data, compare the performance of this approach with existing
Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype 27513537 2016 08 11 2017 02 24 1530-0293 44 11 2016 Nov Critical care medicine Crit. Care Med. Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype. 2010-2017 The Pediatric Sepsis Biomarker Risk Model (PERSEVERE), a pediatric sepsis risk model, uses biomarkers to estimate baseline mortality risk
Practice Patterns and Outcomes Associated With Use of Anticoagulation Among Patients With Atrial Fibrillation During Sepsis 27487456 2018 09 27 2018 11 13 2380-6591 1 6 2016 09 01 JAMA cardiology JAMA Cardiol Practice Patterns and Outcomes Associated With Use of Anticoagulation Among Patients With Atrial Fibrillation During Sepsis. 682-90 10.1001/jamacardio.2016.2181 Atrial fibrillation (AF) during sepsis is associated with an increased risk of ischemic stroke during hospitalization, but risks (...) and benefits associated with anticoagulation for AF during sepsis are unclear. To determine clinician practice patterns and patient risk of stroke and bleeding associated with use of anticoagulation for AF during sepsis. A retrospective cohort study using enhanced administrative claims data from approximately 20% of patients hospitalized in the United States July 1, 2010, to June 30, 2013, examined patients with AF during sepsis who did not have additional indications for therapeutic anticoagulation
Recognition and Diagnosis of Sepsis in Rural or Remote Areas: A Review of Clinical and Cost-Effectiveness and Guidelines Recognition and Diagnosis of Sepsis in Rural or Remote Areas: A Review of Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Recognition and Diagnosis of Sepsis in Rural or Remote Areas: A Review of Clinical and Cost-Effectiveness and Guidelines Recognition and Diagnosis of Sepsis in Rural or Remote Areas: A Review of Clinical and Cost (...) -Effectiveness and Guidelines Published on: August 11, 2016 Project Number: RC0804-000 Product Line: Research Type: Other Diagnostics Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of processes used for the assessment for and recognition of sepsis in adults with suspected sepsis in rural or remote areas? What is the clinical effectiveness of tests used for sepsis diagnosis in adults with suspected sepsis in rural or remote areas? What is the cost
Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial 27428731 2016 09 07 2017 02 03 2168-6114 176 9 2016 Sep 01 JAMA internal medicine JAMA Intern Med Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. 1266-76 10.1001/jamainternmed.2016.2514 High-dose intravenous (...) administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis of sepsis, but effect on outcome is unclear. To determine whether high-dose intravenous sodium selenite treatment and procalcitonin-guided anti-infectious therapy in patients with severe sepsis affect mortality. The Placebo-Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (SISPCT
Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis 27355527 2016 09 17 2017 05 15 2017 05 15 1530-0293 44 10 2016 Oct Critical care medicine Crit. Care Med. Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis. 1851-60 10.1097/CCM.0000000000001827 To examine (...) the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. To investigate the effect of nonrenal organ dysfunction on tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in this population. In this ancillary analysis, we included patients with sepsis who were enrolled in either of two trials including 39 ICUs across Europe and North America. The primary
Clinical Criteria to Identify Patients With Sepsis 27458952 2016 08 22 2018 11 13 1538-3598 316 4 2016 Jul 26 JAMA JAMA Clinical Criteria to Identify Patients With Sepsis. 453 10.1001/jama.2016.6407 Makam Anil N AN Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Nguyen Oanh Kieu OK Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. eng KL2 TR001103 TR NCATS NIH HHS United States R24 HS022418 HS AHRQ HHS United (...) States Comment Letter United States JAMA 7501160 0098-7484 AIM IM JAMA. 2016 Jul 26;316(4):454 27458955 JAMA. 2016 Feb 23;315(8):762-74 26903335 Circulation. 2007 Feb 20;115(7):928-35 17309939 Circ Cardiovasc Qual Outcomes. 2014 Sep;7(5):778-9 25097213 JAMA. 2016 Feb 23;315(8):762-74 26903335 JAMA. 2014 Apr 9;311(14):1416-23 24681960 N Engl J Med. 2015 Apr 2;372(14):1301-11 25776532 Female Hospital Mortality Humans Male Organ Dysfunction Scores Sepsis diagnosis mortality 2016 7 27 6 0 2016 7 28 6 0
Sepsis: the LightCycler SeptiFast Test MGRADE, SepsiTest and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi ? a systematic review and economic evaluation Journals Library Journals Library An error has occurred in processing the XML document An error has occurred in processing the XML document An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry
Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. IMPORTANCE: Survivors of sepsis face long-term sequelae that diminish health-related quality of life and result in increased care needs in the primary care setting, such as medication, physiotherapy, or mental health care. OBJECTIVE: To examine if a primary care-based intervention improves mental health-related quality of life. DESIGN, SETTING (...) , AND PARTICIPANTS: Randomized clinical trial conducted between February 2011 and December 2014, enrolling 291 patients 18 years or older who survived sepsis (including septic shock), recruited from 9 intensive care units (ICUs) across Germany. INTERVENTIONS: Participants were randomized to usual care (n = 143) or to a 12-month intervention (n = 148). Usual care was provided by their primary care physician (PCP) and included periodic contacts, referrals to specialists, and prescription of medication, other
Risk of Recurrence After Surviving Severe Sepsis: A Matched Cohort Study 27120256 2016 09 17 2017 05 15 2017 05 15 1530-0293 44 10 2016 Oct Critical care medicine Crit. Care Med. Risk of Recurrence After Surviving Severe Sepsis: A Matched Cohort Study. 1833-41 10.1097/CCM.0000000000001824 To examine the risk of recurrence in adults who survived first-episode severe sepsis for at least 3 months. A matched cohort study. Inpatient claims data from Taiwan's National Health Insurance Research (...) Database. We analyzed 10,818 adults who survived first-episode severe sepsis without recurrence for at least 3 months in 2000 (SS group; mean age, 62.7 yr; men, 54.7%) and a group of age/sex-matched (1:1) population controls who had no prior history of severe sepsis. All subjects were followed from the study entry to the occurrence of end-point, death, or until December 31, 2008, whichever date came first. None. Primary end-point was severe sepsis that occurred after January 1, 2001 (the study entry
Sepsis: pathophysiology and clinical management. Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune dysfunction and catabolism. Much has been learnt (...) about the pathogenesis of sepsis at the molecular, cell, and intact organ level. Despite uncertainties in hemodynamic management and several treatments that have failed in clinical trials, investigational therapies increasingly target sepsis induced organ and immune dysfunction. Outcomes in sepsis have greatly improved overall, probably because of an enhanced focus on early diagnosis and fluid resuscitation, the rapid delivery of effective antibiotics, and other improvements in supportive care
Severe sepsis caused by Capnocytophaga canimorsus complicated by thrombotic microangiopathy in an immunocompetent patient 29123842 2018 11 13 2052-8817 4 1 2017 01 Acute medicine & surgery Acute Med Surg Severe sepsis caused by Capnocytophaga canimorsus complicated by thrombotic microangiopathy in an immunocompetent patient. 97-100 10.1002/ams2.222 A 61-year-old man with an unremarkable medical history was admitted with fever 7 days after being bitten by his dog. On day 3, he showed altered (...) mental status, and laboratory data showed progressive hemolytic anemia, thrombocytopenia, hyperbilirubinemia, renal dysfunction, coagulopathy, and schistocytosis. Severe sepsis complicated with thrombotic microangiopathy caused by Capnocytophaga canimorsus was suspected. Plasma exchange was applied to treat the thrombotic microangiopathy and resulted in platelet count increase and improved renal function, hyperbilirubinemia, and schistocytosis. Blood culture results confirmed the presence of C
Late mortality after sepsis: propensity matched cohort study. OBJECTIVES: To determine whether late mortality after sepsis is driven predominantly by pre-existing comorbid disease or is the result of sepsis itself. DEIGN: Observational cohort study. SETTING: US Health and Retirement Study. PARTICIPANTS: 960 patients aged ≥65 (1998-2010) with fee-for-service Medicare coverage who were admitted to hospital with sepsis. Patients were matched to 777 adults not currently in hospital, 788 patients (...) admitted with non-sepsis infection, and 504 patients admitted with acute sterile inflammatory conditions. MAIN OUTCOME MEASURES: Late (31 days to two years) mortality and odds of death at various intervals. RESULTS: Sepsis was associated with a 22.1% (95% confidence interval 17.5% to 26.7%) absolute increase in late mortality relative to adults not in hospital, a 10.4% (5.4% to 15.4%) absolute increase relative to patients admitted with non-sepsis infection, and a 16.2% (10.2% to 22.2%) absolute
Splenic volume in severe sepsis is associated with disease severity and pneumococcal infection 29123809 2018 11 13 2052-8817 3 4 2016 10 Acute medicine & surgery Acute Med Surg Splenic volume in severe sepsis is associated with disease severity and pneumococcal infection. 339-344 10.1002/ams2.204 A small spleen, which is occasionally found in patients with pneumococcal sepsis, may increase pneumococcal susceptibility because of splenic malfunction. However, a small spleen may also originate (...) from severe disease. We carried out a retrospective study to evaluate the association between splenic volume and severe pneumococcal sepsis or disease severity. We reviewed the medical records of 23 patients with severe pneumococcal sepsis treated at our institution between January 2004 and September 2015 (pneumococcal group) and 61 patients with severe non-pneumococcal bacteremia treated between April 2011 and September 2015 (control group). Splenic volume measured by abdominal computed tomography