Latest & greatest articles for sepsis

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Top results for sepsis

81. Respiratory extracorporeal membrane oxygenation for severe sepsis and septic shock in adults: a propensity score analysis in a multicenter retrospective observational study

Respiratory extracorporeal membrane oxygenation for severe sepsis and septic shock in adults: a propensity score analysis in a multicenter retrospective observational study 29123901 2018 11 13 2052-8817 4 4 2017 10 Acute medicine & surgery Acute Med Surg Respiratory extracorporeal membrane oxygenation for severe sepsis and septic shock in adults: a propensity score analysis in a multicenter retrospective observational study. 408-417 10.1002/ams2.296 This multicenter retrospective observational (...) study aimed to evaluate the efficacy of extracorporeal membrane oxygenation (ECMO) support for septic patients with severe respiratory failure using propensity score analyses. The data of severe sepsis patients from 42 intensive care units between January 2011 and December 2013 were retrospectively collected. Propensity score matching analyses were undertaken for severe respiratory failure patients with/without veno-venous ECMO support. The main outcome was in-hospital all-cause mortality. Of 3195

Acute medicine & surgery2017 Full Text: Link to full Text with Trip Pro

82. Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns).

Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns). BACKGROUND: Up to 7% of term and late-preterm neonates in high-income countries receive antibiotics during the first 3 days of life because of suspected early-onset sepsis. The prevalence of culture-proven early-onset sepsis is 0·1% or less in high-income countries, suggesting substantial overtreatment. We assess whether (...) procalcitonin-guided decision making for suspected early-onset sepsis can safely reduce the duration of antibiotic treatment. METHODS: We did this randomised controlled intervention trial in Dutch (n=11), Swiss (n=4), Canadian (n=2), and Czech (n=1) hospitals. Neonates of gestational age 34 weeks or older, with suspected early-onset sepsis requiring antibiotic treatment were stratified into four risk categories by their treating physicians and randomly assigned [1:1] using a computer-generated list

Lancet2017

83. The Timing of Early Antibiotics and Hospital Mortality in Sepsis

The Timing of Early Antibiotics and Hospital Mortality in Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

84. Lactate Clearance and Normalization and Prolonged Organ Dysfunction in Pediatric Sepsis

Lactate Clearance and Normalization and Prolonged Organ Dysfunction in Pediatric Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

85. Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis

Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

86. Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial

Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

87. Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis

Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

88. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis.

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. Background In 2013, New York began requiring hospitals to follow protocols for the early identification and treatment of sepsis. However, there is controversy about whether more rapid treatment of sepsis improves outcomes in patients. Methods We studied data from patients with sepsis and septic shock that were reported to the New York State Department of Health from April 1, 2014, to June 30, 2016. Patients had a sepsis (...) protocol initiated within 6 hours after arrival in the emergency department and had all items in a 3-hour bundle of care for patients with sepsis (i.e., blood cultures, broad-spectrum antibiotic agents, and lactate measurement) completed within 12 hours. Multilevel models were used to assess the associations between the time until completion of the 3-hour bundle and risk-adjusted mortality. We also examined the times to the administration of antibiotics and to the completion of an initial bolus

NEJM2017 Full Text: Link to full Text with Trip Pro

89. Maternal sepsis: Opportunity for improvement

Maternal sepsis: Opportunity for improvement 29225677 2018 12 01 1753-495X 10 4 2017 Dec Obstetric medicine Obstet Med Maternal sepsis: Opportunity for improvement. 174-176 10.1177/1753495X17704362 Firoz Tabassum T Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA. The Miriam Hospital, Women's Medicine Collaborative, Providence, RI, USA. Woodd Susannah L SL Department of Epidemiology and Population Health, London School of Hygiene & Tropical

Obstetric medicine2017 Full Text: Link to full Text with Trip Pro

90. Blood purification and mortality in sepsis: a meta-analysis of randomized trials

Blood purification and mortality in sepsis: a meta-analysis of randomized trials PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

91. Neonatal sepsis.

Neonatal sepsis. Neonatal sepsis is the cause of substantial morbidity and mortality. Precise estimates of neonatal sepsis burden vary by setting. Differing estimates of disease burden have been reported from high-income countries compared with reports from low-income and middle-income countries. The clinical manifestations range from subclinical infection to severe manifestations of focal or systemic disease. The source of the pathogen might be attributed to an in-utero infection, acquisition (...) from maternal flora, or postnatal acquisition from the hospital or community. The timing of exposure, inoculum size, immune status of the infant, and virulence of the causative agent influence the clinical expression of neonatal sepsis. Immunological immaturity of the neonate might result in an impaired response to infectious agents. This is especially evident in premature infants whose prolonged stays in hospital and need for invasive procedures place them at increased risk for hospital-acquired

Lancet2017

92. Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial.

Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial. Importance: Dexmedetomidine provides sedation for patients undergoing ventilation; however, its effects on mortality and ventilator-free days have not been well studied among patients with sepsis. Objectives: To examine whether a sedation strategy with dexmedetomidine can improve clinical outcomes in patients with sepsis undergoing ventilation (...) . Design, Setting, and Participants: Open-label, multicenter randomized clinical trial conducted at 8 intensive care units in Japan from February 2013 until January 2016 among 201 consecutive adult patients with sepsis requiring mechanical ventilation for at least 24 hours. Interventions: Patients were randomized to receive either sedation with dexmedetomidine (n = 100) or sedation without dexmedetomidine (control group; n = 101). Other agents used in both groups were fentanyl, propofol, and midazolam

JAMA2017 Full Text: Link to full Text with Trip Pro

93. Lemierre's Syndrome – A rare cause of disseminated sepsis requiring multi-organ support

Lemierre's Syndrome – A rare cause of disseminated sepsis requiring multi-organ support 29123565 2018 11 13 1751-1437 18 4 2017 Nov Journal of the Intensive Care Society J Intensive Care Soc Lemierre's Syndrome - A rare cause of disseminated sepsis requiring multi-organ support. 329-333 10.1177/1751143717698978 Lemierre's syndrome is a rare complication of acute pharyngitis characterised by septicaemia with infective thrombophlebitis of the internal jugular vein, most commonly due (...) to Fusobacterium necrophorum . It characteristically affects healthy young adults causing persistent pyrexia and systemic sepsis presenting several days after an initial pharyngitis. Septic emboli seed via the bloodstream to distant sites including the lung, joints, skin, liver, spleen and brain. Prolonged antimicrobial therapy is required and admission to intensive care common. This once rare condition is increasing in incidence but awareness amongst clinicians is low. We present a classic case in a young man

Journal of the Intensive Care Society2017 Full Text: Link to full Text with Trip Pro

94. Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit

Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

95. Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability

Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

96. Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department.

Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department. Importance: An international task force recently redefined the concept of sepsis. This task force recommended the use of the quick Sequential Organ Failure Assessment (qSOFA) score instead of systemic inflammatory response syndrome (SIRS) criteria to identify patients at high risk of mortality. However, these new criteria have not been prospectively (...) validated in some settings, and their added value in the emergency department remains unknown. Objective: To prospectively validate qSOFA as a mortality predictor and compare the performances of the new sepsis criteria to the previous ones. Design, Settings, and Participants: International prospective cohort study, conducted in France, Spain, Belgium, and Switzerland between May and June 2016. In the 30 participating emergency departments, for a 4-week period, consecutive patients who visited

JAMA2017 Full Text: Link to full Text with Trip Pro

97. Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines

Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines | CADTH.ca Find the information you need Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines Published on: January 13, 2017 Project Number: RC0841-000 Product Line: Research Type: Other Diagnostics Report Type (...) : Summary with Critical Appraisal Result type: Report Question What are the evidence-based guidelines regarding the use of tests or procedures for the recognition and diagnosis of sepsis in adults with suspected sepsis? Key Message Six evidence-based guidelines were identified for diagnostic tests or processes for the recognition and detection of sepsis in adult populations. Three of these guidelines explored the recognition and detection of sepsis in broader populations, while three others focused

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

98. Management of term infants at increased risk for early onset bacterial sepsis

Management of term infants at increased risk for early onset bacterial sepsis Management of term infants at increased risk for early onset bacterial sepsis | Position statements and practice points | Management of term infants at increased risk for early onset bacterial sepsis | Canadian Paediatric Society Protecting and promoting the health and well-being of children and youth CPS Member Login | Who We Are What We Do Get Involved Education/CPD Publications Careers > Share POSITION STATEMENT (...) Management of term infants at increased risk for early onset bacterial sepsis Posted: Jan 13 2017 The Canadian Paediatric Society gives permission to print single copies of this document from our website. For permission to reprint or reproduce multiple copies, please see our . Principal author(s) Ann L Jefferies, Canadian Paediatric Society , Abstract Early-onset neonatal bacterial sepsis (EOS) is sepsis occurring within the first seven days of life. This statement provides updated recommendations

Canadian Paediatric Society2017