Latest & greatest articles for sepsis

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Top results for sepsis

61. New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality. A Validation and Clinical Decision-Making Study

New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality. A Validation and Clinical Decision-Making Study 28613918 2017 12 04 2017 12 13 1535-4970 196 10 2017 Nov 15 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality. A Validation and Clinical Decision-Making Study. 1287-1297 10.1164/rccm.201611-2262OC The Sepsis-3 Task Force updated the clinical criteria (...) for sepsis, excluding the need for systemic inflammatory response syndrome (SIRS) criteria. The clinical implications of the proposed flowchart including the quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) and SOFA scores are unknown. To perform a clinical decision-making analysis of Sepsis-3 in patients with community-acquired pneumonia. This was a cohort study including adult patients with community-acquired pneumonia from two Spanish university hospitals. SIRS, qSOFA, the Confusion

EvidenceUpdates2018

62. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial

Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2018

63. Sepsis in children

Sepsis in children Sepsis in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in children Last reviewed: August 2018 Last updated: August 2018 Summary Initial clinical presentation may be non-specific (especially in younger age groups). Given the time-critical nature of severe sepsis and septic shock, when sepsis is suspected on clinical grounds it is usually best to initiate sepsis investigations (...) and treatment, including administering antibiotics and fluid resuscitation. These should continue until sepsis has been excluded. Progression to organ failure and shock is often very rapid, so early recognition and treatment is crucial. Empirical broad-spectrum antibiotic therapy (based on the most probable pathogens) should be administered as soon as possible, and always within the first hour following recognition. Other treatments are primarily supportive, and should be delivered according

BMJ Best Practice2018

64. Sepsis in adults

Sepsis in adults Sepsis in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in adults Last reviewed: August 2018 Last updated: July 2018 Important updates Sepsis patients who receive prolonged infusion of anti-pseudomonal beta-lactam antibiotics are 30% less likely to die, meta-analysis finds There has been long-running debate over whether prolonged infusion of intravenous antibiotics, including beta (...) -lactams, is more effective than standard infusion in improving outcomes in sepsis. Now a meta-analysis has found that patients with sepsis who received their intravenous anti-pseudomonal beta-lactam infusion over at least 3 hours were 30% less likely to die than those who received beta-lactam either as a bolus or as a short-term infusion over 1 hour or less (RR 0.7, 95% CI 0.56 to 0.87). The meta-analysis included 22 randomised controlled trials totalling 1876 patients. The authors concluded

BMJ Best Practice2018

66. Retrospective analysis of cancer patients admitted to a tertiary centre with suspected neutropenic sepsis: Are C-reactive protein and neutrophil count useful prognostic biomarkers?

Retrospective analysis of cancer patients admitted to a tertiary centre with suspected neutropenic sepsis: Are C-reactive protein and neutrophil count useful prognostic biomarkers? 29796070 2018 11 14 1751-1437 19 2 2018 May Journal of the Intensive Care Society J Intensive Care Soc Retrospective analysis of cancer patients admitted to a tertiary centre with suspected neutropenic sepsis: Are C-reactive protein and neutrophil count useful prognostic biomarkers? 132-137 10.1177/1751143717741248 (...) Historically, neutropenic sepsis has been associated with high mortality rates. However, there has been limited research into cancer patients admitted with suspected sepsis who are found to be non-neutropenic. C-reactive protein has been shown to be raised in cancer patients for reasons other than infection and there have been limited studies to look as its utility as a prognostic biomarker in suspected sepsis in this population. This study looked at 749 patients admitted to a tertiary cancer centre

Journal of the Intensive Care Society2017 Full Text: Link to full Text with Trip Pro

67. A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis

A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

68. A combined preventive strategy could reduce late sepsis in the premature child

A combined preventive strategy could reduce late sepsis in the premature child A combined preventive strategy could reduce late sepsis in the premature child - Evidencias en pediatría Searching, please wait Show menu Library Management You did not add any article to your library yet. | Search Evidence-Based decision making Evidence-Based decision making Show menu Library Management You did not add any article to your library yet. × User Password Log in × Reset password If you need to reset your (...) password please enter your email and click the Send button. You will receive an email to complete the process. Email Send × Library Management × September 2017. Volume 13. Number 3 A combined preventive strategy could reduce late sepsis in the premature child Rating: 0 (0 Votes) | Newsletter Free Subscription Regularly recieve most recent articles by e-mail Subscribe × Newsletter subscription: Email Confirm email I accept the journal’s privacy policy. Subscribe × Warnings and privacy policy To whom

Evidencias en Pediatría2017

69. Natural history of anorectal sepsis

Natural history of anorectal sepsis 28857130 2017 08 31 2017 11 16 1365-2168 104 13 2017 Dec The British journal of surgery Br J Surg Natural history of anorectal sepsis. 1857-1865 10.1002/bjs.10614 Progression from anorectal abscess to fistula is poorly described and it remains unclear which patients develop a fistula following an abscess. The aim was to assess the burden of anorectal abscess and to identify risk factors for subsequent fistula formation. The Hospital Episode Statistics (...) to diagnosis was 14 months. The burden of anorectal sepsis is high, with subsequent fistula formation nearly three times more common in Crohn's disease than idiopathic disease, and female sex is an independent predictor of fistula formation following abscess drainage. Most fistulas form within the first year of presentation with an abscess. © 2017 BJS Society Ltd Published by John Wiley & Sons Ltd. Sahnan K K http://orcid.org/0000-0003-3885-5752 Surgical Epidemiology, Trials and Outcome Centre, St Mark's

EvidenceUpdates2017

70. Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial.

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial. Importance: The effect of an early resuscitation protocol on sepsis outcomes in developing countries remains unknown. Objective: To determine whether an early resuscitation protocol with administration of intravenous fluids, vasopressors, and blood transfusion decreases mortality among Zambian adults with sepsis and hypotension compared with usual care (...) . Design, Setting, and Participants: Randomized clinical trial of 212 adults with sepsis (suspected infection plus ≥2 systemic inflammatory response syndrome criteria) and hypotension (systolic blood pressure ≤90 mm Hg or mean arterial pressure ≤65 mm Hg) presenting to the emergency department at a 1500-bed referral hospital in Zambia between October 22, 2012, and November 11, 2013. Data collection concluded December 9, 2013. Interventions: Patients were randomized 1:1 to either (1) an early

JAMA2017 Full Text: Link to full Text with Trip Pro

71. Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children

Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children 28783810 2017 08 07 2017 10 06 2017 10 06 2168-6211 171 10 2017 Oct 02 JAMA pediatrics JAMA Pediatr Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children. e172352 10.1001/jamapediatrics.2017.2352 The Third International Consensus Definitions (...) for Sepsis and Septic Shock (Sepsis-3) uses the Sequential Organ Failure Assessment (SOFA) score to grade organ dysfunction in adult patients with suspected infection. However, the SOFA score is not adjusted for age and therefore not suitable for children. To adapt and validate a pediatric version of the SOFA score (pSOFA) in critically ill children and to evaluate the Sepsis-3 definitions in patients with confirmed or suspected infection. This retrospective observational cohort study included all

EvidenceUpdates2017

72. Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections

Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections 28860348 2017 09 01 2017 09 01 1468-3288 2017 Aug 31 Gut Gut Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections. gutjnl-2017-314324 10.1136/gutjnl-2017-314324 Patients with cirrhosis have a high risk of sepsis, which confers a poor prognosis. The systemic inflammatory response syndrome (SIRS) criteria have several limitations in cirrhosis. Recently (...) , new criteria for sepsis (Sepsis-3) have been suggested in the general population (increase of Sequential Organ Failure Assessment (SOFA) ≥2 points from baseline). Outside the intensive care unit (ICU), the quick SOFA (qSOFA (at least two among alteration in mental status, systolic blood pressure ≤100 mm Hg or respiratory rate ≥22/min)) was suggested to screen for sepsis. These criteria have never been evaluated in patients with cirrhosis. The aim of the study was to assess the ability of Sepsis-3

EvidenceUpdates2017

73. A Rapid Test for Microbial Identification in Patients With Suspected Sepsis

A Rapid Test for Microbial Identification in Patients With Suspected Sepsis A Rapid Test for Microbial Identification in Patients With Suspected Sepsis | CADTH.ca CADTH Document Viewer A Rapid Test for Microbial Identification in Patients With Suspected Sepsis Table of Contents Search this document A Rapid Test for Microbial Identification in Patients With Suspected Sepsis September 2017 Summary The FilmArray Blood Culture Identification (FA-BCID) panel is a multiplex polymerase chain reaction (...) –based rapid diagnostic test that can detect 24 sepsis-related pathogens (bacteria and yeast) and three antimicrobial resistance genes in patients with suspected sepsis. An initial blood culture is still required, as the FA-BCID panel must be performed on blood cultures that have tested positive (indicating initial microbial growth). The FA-BCID panel can identify specific pathogens from positive blood cultures with a turnaround time of approximately one hour; this is significantly faster than

CADTH - Issues in Emerging Health Technologies2017

74. Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014.

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. Importance: Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time. Objective: To estimate the US national incidence of sepsis and trends using detailed clinical data from the electronic health (...) record (EHR) systems of diverse hospitals. Design, Setting, and Population: Retrospective cohort study of adult patients admitted to 409 academic, community, and federal hospitals from 2009-2014. Exposures: Sepsis was identified using clinical indicators of presumed infection and concurrent acute organ dysfunction, adapting Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria for objective and consistent EHR-based surveillance. Main Outcomes and Measures: Sepsis

JAMA2017 Full Text: Link to full Text with Trip Pro

75. Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS

Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS Hawlik K, Wild C Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Hawlik K, Wild C. Extracorporeal cytokine haemadsorption (...) in patients with sepsis or SIRS. Vienna: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBIHTA). Decision Support Document. 2017 Authors' objectives Extracorporeal cytokine adsorption therapy (ECAT) aims to reduce the cytokine concentration in the blood, thereby stabilising the overall immune response in sepsis and SIRS (Systemic Inflammatory Response Syndrome). We investigated the efficacy and safety of ECAT in its two main indications: to treat sepsis and to prevent SIRS during

Health Technology Assessment (HTA) Database.2017

76. Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children

Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

77. Sepsis in the burn patient: a different problem than sepsis in the general population

Sepsis in the burn patient: a different problem than sepsis in the general population REVIEW Open Access Sepsis in the burn patient: a different problem than sepsis in the general population David G. Greenhalgh 1,2,3 Abstract Sepsis has recently been defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. A great amount of effort has been made to develop early treatments for sepsis through the Surviving Sepsis Campaign. There are similar but slightly (...) different recommendations for the treatment of sepsis in the pediatric population. These international efforts have led to earlier diagnosis and treatments for sepsis that have led to improvements in survival. Sepsis is also the leading cause of death in the burn patient but most clinical sepsis studies have excluded burns. The reason for the exclusion is that the sepsis found in burn patients is different than that of the general population. The early treatment strategies, such as those directed

Burns & trauma2017 Full Text: Link to full Text with Trip Pro

78. Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis

Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2017

79. Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores

Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores 28737573 2017 07 24 2017 07 24 1530-0293 2017 Jul 21 Critical care medicine Crit. Care Med. Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores (...) . 10.1097/CCM.0000000000002648 Studies in sepsis are limited by heterogeneity regarding what constitutes suspicion of infection. We sought to compare potential suspicion criteria using antibiotic and culture order combinations in terms of patient characteristics and outcomes. We further sought to determine the impact of differing criteria on the accuracy of sepsis screening tools and early warning scores. Observational cohort study. Academic center from November 2008 to January 2016. Hospitalized

EvidenceUpdates2017

80. Early evaluation of severity in patients with severe sepsis: a comparison with “septic shock” — subgroup analysis of the Japanese Association for Acute Medicine Sepsis Registry (JAAM‐SR)

Early evaluation of severity in patients with severe sepsis: a comparison with “septic shock” — subgroup analysis of the Japanese Association for Acute Medicine Sepsis Registry (JAAM‐SR) 29123903 2018 11 13 2052-8817 4 4 2017 10 Acute medicine & surgery Acute Med Surg Early evaluation of severity in patients with severe sepsis: a comparison with "septic shock" - subgroup analysis of the Japanese Association for Acute Medicine Sepsis Registry (JAAM-SR). 426-431 10.1002/ams2.299 (...) The purpose of this subgroup analysis of a Japanese multicenter registry, the Japanese Association for Acute Medicine Sepsis Registry Advanced (JAAM-SR-Advanced), was to identify early outcome indicators for severe sepsis that are useful and more objective than "septic shock." Among 624 patients with severe sepsis registered in JAAM-SR-Advanced, 554 with valid serum lactate data were retrospectively studied. Hypotension before and after fluid resuscitation and the highest lactate values over the initial

Acute medicine & surgery2017 Full Text: Link to full Text with Trip Pro