Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for sepsis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on sepsis or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on sepsis and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via email@example.com
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (Jâ€SSCG 2016) Guideline The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016) Osamu Nishida, 1 Hiroshi Ogura, 2 Moritoki Egi, 3 Seitaro Fujishima, 4 Yoshiro Hayashi, 5 Toshiaki Iba, 6 Hitoshi Imaizumi, 7 Shigeaki Inoue, 8 Yasuyuki Kakihana, 9 Joji Kotani, 10 Shigeki Kushimoto, 11 Yoshiki Masuda, 12 Naoyuki Matsuda, 13 Asako Matsushima, 14 Taka-aki Nakada (...) This article is abridged and translated from Japanese with permission from the Japanese Association of Acute Medicine and the Japanese Society for Intensive Care Medicine. The original Japanese version “The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG2016)” was published in the Journal of Japanese Association for Acute Medicine, 2017; Volume 28 (supplement 1) http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc and Journal of JSICM, 2017
Development and External Validation of an Automated Computer-Aided Risk Score for Predicting Sepsis in Emergency Medical Admissions Using the Patient`s First Electronically Recorded Vital Signs and Blood Test Results 29369828 2018 01 25 1530-0293 2018 Jan 24 Critical care medicine Crit. Care Med. Development and External Validation of an Automated Computer-Aided Risk Score for Predicting Sepsis in Emergency Medical Admissions Using the Patient's First Electronically Recorded Vital Signs (...) and Blood Test Results. 10.1097/CCM.0000000000002967 To develop a logistic regression model to predict the risk of sepsis following emergency medical admission using the patient's first, routinely collected, electronically recorded vital signs and blood test results and to validate this novel computer-aided risk of sepsis model, using data from another hospital. Cross-sectional model development and external validation study reporting the C-statistic based on a validated optimized algorithm to identify
Utility of Early-Onset Sepsis Risk Calculator for Neonates Born to Mothers with Chorioamnionitis 29275925 2017 12 25 1097-6833 2017 Dec 22 The Journal of pediatrics J. Pediatr. Utility of Early-Onset Sepsis Risk Calculator for Neonates Born to Mothers with Chorioamnionitis. S0022-3476(17)31601-3 10.1016/j.jpeds.2017.11.045 To evaluate the performance of the early-onset sepsis (EOS) risk calculator in a cohort of neonates born to mothers with clinical chorioamnionitis, and to compare (...) EOS. Data for calculation of EOS risk were available for 896 neonates, including the 5 neonates with culture-proven EOS. The management recommendation based on the calculator was no empiric antibiotic treatment for 67% of the neonates, including 2 of the 5 with EOS. All neonates with culture-proven EOS had abnormal complete blood counts and C-reactive protein levels at 6-12 hours. Three of the 5 neonates with EOS had clinical signs of sepsis. The risk of EOS in neonates born to mothers
Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis 29271844 2017 12 22 1530-0293 2017 Dec 21 Critical care medicine Crit. Care Med. Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis. 10.1097/CCM.0000000000002928 Sepsis is a leading cause of mortality in noncoronary ICUs. Although immediate start of antibiotics reduces sepsis-related (...) patients with sepsis. PubMed and the Cochrane Database of Systematic Reviews. English-language randomized controlled trials evaluating procalcitonin use among adult patients with suspected or confirmed sepsis published between January 2004 and May 2016. Inverse-variance weighting fixed and random effects meta-analyses were performed on the following efficacy and safety endpoints: antibiotic duration, all-cause mortality, and length of ICU stay. Two reviewers independently extracted data elements from
Economic burden of neonatal sepsis in sub-Saharan Africa 1 Ranjeva SL, et al. BMJ Glob Health 2018;3:e000347. doi:10.1136/bmjgh-2017-000347 Economic burden of neonatal sepsis in sub-Saharan Africa Sylvia L Ranjeva, 1,2 Benjamin C Warf, 3,4 Steven J Schiff 2,5 Research To cite: Ranjeva SL, Warf BC, Schiff SJ. Economic burden of neonatal sepsis in sub- Saharan Africa. BMJ Glob Health 2018;3:e000347. doi:10.1136/ bmjgh-2017-000347 Handling editor Seye Abimbola ? Additional material is published (...) years of age by 2030, cannot be met without substantial reduction of infection-specific neonatal mortality in the developing world. Neonatal infections are estimated to account for 26% of annual neonatal deaths, with mortality rates highest in sub-Saharan Africa (SSA). Reliable and comprehensive estimates of the incidence and aetiology surrounding neonatal sepsis in SSA remain incompletely available. We estimate the economic burden of neonatal sepsis in SSA. Methods Data available through global
Enhancing Recovery From Sepsis: A Review. Importance: Survival from sepsis has improved in recent years, resulting in an increasing number of patients who have survived sepsis treatment. Current sepsis guidelines do not provide guidance on posthospital care or recovery. Observations: Each year, more than 19 million individuals develop sepsis, defined as a life-threatening acute organ dysfunction secondary to infection. Approximately 14 million survive to hospital discharge and their prognosis (...) ), depression (29%), or posttraumatic stress disorder (44%). About 40% of patients are rehospitalized within 90 days of discharge, often for conditions that are potentially treatable in the outpatient setting, such as infection (11.9%) and exacerbation of heart failure (5.5%). Compared with patients hospitalized for other diagnoses, those who survive sepsis (11.9%) are at increased risk of recurrent infection than matched patients (8.0%) matched patients (P < .001), acute renal failure (3.3% vs 1.2%, P
Sepsis in adults Sepsis in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Sepsis in adults Last reviewed: August 2018 Last updated: July 2018 Important updates Sepsis patients who receive prolonged infusion of anti-pseudomonal beta-lactam antibiotics are 30% less likely to die, meta-analysis finds There has been long-running debate over whether prolonged infusion of intravenous antibiotics, including beta (...) -lactams, is more effective than standard infusion in improving outcomes in sepsis. Now a meta-analysis has found that patients with sepsis who received their intravenous anti-pseudomonal beta-lactam infusion over at least 3 hours were 30% less likely to die than those who received beta-lactam either as a bolus or as a short-term infusion over 1 hour or less (RR 0.7, 95% CI 0.56 to 0.87). The meta-analysis included 22 randomised controlled trials totalling 1876 patients. The authors concluded
Sepsis in children Sepsis in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Sepsis in children Last reviewed: August 2018 Last updated: August 2018 Summary Initial clinical presentation may be non-specific (especially in younger age groups). Given the time-critical nature of severe sepsis and septic shock, when sepsis is suspected on clinical grounds it is usually best to initiate sepsis investigations (...) and treatment, including administering antibiotics and fluid resuscitation. These should continue until sepsis has been excluded. Progression to organ failure and shock is often very rapid, so early recognition and treatment is crucial. Empirical broad-spectrum antibiotic therapy (based on the most probable pathogens) should be administered as soon as possible, and always within the first hour following recognition. Other treatments are primarily supportive, and should be delivered according
New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality. A Validation and Clinical Decision-Making Study 28613918 2017 12 04 2017 12 13 1535-4970 196 10 2017 Nov 15 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality. A Validation and Clinical Decision-Making Study. 1287-1297 10.1164/rccm.201611-2262OC The Sepsis-3 Task Force updated the clinical criteria (...) for sepsis, excluding the need for systemic inflammatory response syndrome (SIRS) criteria. The clinical implications of the proposed flowchart including the quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) and SOFA scores are unknown. To perform a clinical decision-making analysis of Sepsis-3 in patients with community-acquired pneumonia. This was a cohort study including adult patients with community-acquired pneumonia from two Spanish university hospitals. SIRS, qSOFA, the Confusion
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Retrospective analysis of cancer patients admitted to a tertiary centre with suspected neutropenic sepsis: Are C-reactive protein and neutrophil count useful prognostic biomarkers? 29796070 2018 11 14 1751-1437 19 2 2018 May Journal of the Intensive Care Society J Intensive Care Soc Retrospective analysis of cancer patients admitted to a tertiary centre with suspected neutropenic sepsis: Are C-reactive protein and neutrophil count useful prognostic biomarkers? 132-137 10.1177/1751143717741248 (...) Historically, neutropenic sepsis has been associated with high mortality rates. However, there has been limited research into cancer patients admitted with suspected sepsis who are found to be non-neutropenic. C-reactive protein has been shown to be raised in cancer patients for reasons other than infection and there have been limited studies to look as its utility as a prognostic biomarker in suspected sepsis in this population. This study looked at 749 patients admitted to a tertiary cancer centre
Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial. Importance: The effect of an early resuscitation protocol on sepsis outcomes in developing countries remains unknown. Objective: To determine whether an early resuscitation protocol with administration of intravenous fluids, vasopressors, and blood transfusion decreases mortality among Zambian adults with sepsis and hypotension compared with usual care (...) . Design, Setting, and Participants: Randomized clinical trial of 212 adults with sepsis (suspected infection plus ≥2 systemic inflammatory response syndrome criteria) and hypotension (systolic blood pressure ≤90 mm Hg or mean arterial pressure ≤65 mm Hg) presenting to the emergency department at a 1500-bed referral hospital in Zambia between October 22, 2012, and November 11, 2013. Data collection concluded December 9, 2013. Interventions: Patients were randomized 1:1 to either (1) an early
Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children 28783810 2017 08 07 2017 10 06 2017 10 06 2168-6211 171 10 2017 Oct 02 JAMA pediatrics JAMA Pediatr Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children. e172352 10.1001/jamapediatrics.2017.2352 The Third International Consensus Definitions (...) for Sepsis and Septic Shock (Sepsis-3) uses the Sequential Organ Failure Assessment (SOFA) score to grade organ dysfunction in adult patients with suspected infection. However, the SOFA score is not adjusted for age and therefore not suitable for children. To adapt and validate a pediatric version of the SOFA score (pSOFA) in critically ill children and to evaluate the Sepsis-3 definitions in patients with confirmed or suspected infection. This retrospective observational cohort study included all
Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections 28860348 2017 09 01 2017 09 01 1468-3288 2017 Aug 31 Gut Gut Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections. gutjnl-2017-314324 10.1136/gutjnl-2017-314324 Patients with cirrhosis have a high risk of sepsis, which confers a poor prognosis. The systemic inflammatory response syndrome (SIRS) criteria have several limitations in cirrhosis. Recently (...) , new criteria for sepsis (Sepsis-3) have been suggested in the general population (increase of Sequential Organ Failure Assessment (SOFA) ≥2 points from baseline). Outside the intensive care unit (ICU), the quick SOFA (qSOFA (at least two among alteration in mental status, systolic blood pressure ≤100 mm Hg or respiratory rate ≥22/min)) was suggested to screen for sepsis. These criteria have never been evaluated in patients with cirrhosis. The aim of the study was to assess the ability of Sepsis-3