Latest & greatest articles for sepsis

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Top results for sepsis

21. A Comparison of the Quick Sequential (Sepsis-Related) Organ Failure Assessment Score and the National Early Warning Score in Non-ICU Patients With/Without Infection

A Comparison of the Quick Sequential (Sepsis-Related) Organ Failure Assessment Score and the National Early Warning Score in Non-ICU Patients With/Without Infection 30130262 2018 08 21 1530-0293 2018 Aug 20 Critical care medicine Crit. Care Med. A Comparison of the Quick Sequential (Sepsis-Related) Organ Failure Assessment Score and the National Early Warning Score in Non-ICU Patients With/Without Infection. 10.1097/CCM.0000000000003359 The Sepsis-3 task force recommended the quick Sequential (...) (Sepsis-Related) Organ Failure Assessment score for identifying patients with suspected infection who are at greater risk of poor outcomes, but many hospitals already use the National Early Warning Score to identify high-risk patients, irrespective of diagnosis. We sought to compare the performance of quick Sequential (Sepsis-Related) Organ Failure Assessment and National Early Warning Score in hospitalized, non-ICU patients with and without an infection. Retrospective cohort study. Large U.K. General

EvidenceUpdates2018

22. Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis

Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis 29979221 2018 08 16 1530-0293 46 9 2018 Sep Critical care medicine Crit. Care Med. Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis. 1411-1420 10.1097/CCM.0000000000003262 This systematic review and meta-analysis addresses the efficacy and safety of corticosteroids in critically ill patients with sepsis. We updated a comprehensive search of MEDLINE, EMBASE, CENTRAL, and LILACS, and unpublished (...) sources for randomized controlled trials that compared any corticosteroid to placebo or no corticosteroid in critically ill children and adults with sepsis. Reviewers conducted duplicate screening of citations, data abstraction, and, using a modified Cochrane risk of bias tool, individual study risk of bias assessment. A parallel guideline committee provided input on the design and interpretation of the systematic review, including the selection of outcomes important to patients. We assessed overall

EvidenceUpdates2018

23. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2018

24. Use of plasma exchange in pediatric severe sepsis in children's hospitals

Use of plasma exchange in pediatric severe sepsis in children's hospitals PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2018

25. Sepsis

Sepsis Top results for sepsis - Trip Database or use your Google+ account Turning Research Into Practice My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for sepsis The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory

Trip Latest and Greatest2018

26. Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis.

Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis. Importance: The death of a pediatric patient with sepsis motivated New York to mandate statewide sepsis treatment in 2013. The mandate included a 1-hour bundle of blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus. Whether completing the bundle elements within 1 hour improves outcomes is unclear. Objective: To determine the risk-adjusted association between (...) completing the 1-hour pediatric sepsis bundle and individual bundle elements with in-hospital mortality. Design, Settings, and Participants: Statewide cohort study conducted from April 1, 2014, to December 31, 2016, in emergency departments, inpatient units, and intensive care units across New York State. A total of 1179 patients aged 18 years and younger with sepsis and septic shock reported to the New York State Department of Health who had a sepsis protocol initiated were included. Exposures

JAMA2018

27. Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome

Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2018

28. Steroids in Sepsis and Septic Shock

Steroids in Sepsis and Septic Shock Emergency Medicine > Journal Club > Archive > May 2018 Toggle navigation May 2018 Steroids in Sepsis and Septic Shock Vignette You're working the weekend shift in TCC when you get a page: triage patient to 3L for low BP. You meet the patient in the room and find a critically ill-appearing 55 year-old female with one week of cough and increased shortness of breath. Her vital signs are: HR 125 BP 65/30 Sp02 89% on room air RR 28 She is struggling to breathe (...) antibiotics), the patient's blood pressure still only 80/45. You place a right-sided internal jugular central line under ultrasound guidance and start a norepinephrine drip. Your deftly placed arterial line begins to demonstrate an improved BP and MAP and you find the patient a bed in the medical ICU. As the patient is being transferred, you begin to wonder whether steroids would be beneficial in this patient with clear septic shock. After all, you know that much of the problem in sepsis

Washington University Emergency Medicine Journal Club2018

29. Derivation and Validation of a Biomarker-Based Clinical Algorithm to Rule Out Sepsis From Noninfectious Systemic Inflammatory Response Syndrome at Emergency Department Admission: A Multicenter Prospective Study

Derivation and Validation of a Biomarker-Based Clinical Algorithm to Rule Out Sepsis From Noninfectious Systemic Inflammatory Response Syndrome at Emergency Department Admission: A Multicenter Prospective Study 29742588 2018 05 09 1530-0293 2018 May 07 Critical care medicine Crit. Care Med. Derivation and Validation of a Biomarker-Based Clinical Algorithm to Rule Out Sepsis From Noninfectious Systemic Inflammatory Response Syndrome at Emergency Department Admission: A Multicenter Prospective (...) Study. 10.1097/CCM.0000000000003206 To derive and validate a predictive algorithm integrating a nomogram-based prediction of the pretest probability of infection with a panel of serum biomarkers, which could robustly differentiate sepsis/septic shock from noninfectious systemic inflammatory response syndrome. Multicenter prospective study. At emergency department admission in five University hospitals. Nine-hundred forty-seven adults in inception cohort and 185 adults in validation cohort. None

EvidenceUpdates2018

30. Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients.

Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients. BACKGROUND: Sepsis is a life-threatening condition that is usually diagnosed when a patient has a suspected or documented infection, and meets two or more criteria for systemic inflammatory response syndrome (SIRS). The incidence of sepsis is higher among people admitted to critical care settings such as the intensive care unit (ICU) than among people in other settings. If left untreated (...) sepsis can quickly worsen; severe sepsis has a mortality rate of 40% or higher, depending on definition. Recognition of sepsis can be challenging as it usually requires patient data to be combined from multiple unconnected sources, and interpreted correctly, which can be complex and time consuming to do. Electronic systems that are designed to connect information sources together, and automatically collate, analyse, and continuously monitor the information, as well as alerting healthcare staff when

Cochrane2018

31. Sepsis and septic shock.

Sepsis and septic shock. Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive, long-term morbidity. Increased awareness of the condition resulting from ongoing campaigns and the evidence arising from research in the past 10 years have increased understanding of this problem among clinicians and lay people, and have led to improved outcomes. The World Health Assembly and WHO made sepsis a global health priority in 2017 and have (...) adopted a resolution to improve the prevention, diagnosis, and management of sepsis. In 2016, a new definition of sepsis (Sepsis-3) was developed. Sepsis is now defined as infection with organ dysfunction. This definition codifies organ dysfunction using the Sequential Organ Failure Assessment score. Ongoing research aims to improve definition of patient populations to allow for individualised management strategies matched to a patient's molecular and biochemical profile. The search continues

Lancet2018

32. Prediction of pediatric sepsis mortality within 1 h of intensive care admission

Prediction of pediatric sepsis mortality within 1 h of intensive care admission PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

PedsCCM Evidence-Based Journal Club2018

33. Predictive Validity of Sepsis-3 Definitions and Sepsis Outcomes in Critically Ill Patients: A Cohort Study in 49 ICUs in Argentina

Predictive Validity of Sepsis-3 Definitions and Sepsis Outcomes in Critically Ill Patients: A Cohort Study in 49 ICUs in Argentina 29742584 2018 05 09 1530-0293 2018 May 08 Critical care medicine Crit. Care Med. Predictive Validity of Sepsis-3 Definitions and Sepsis Outcomes in Critically Ill Patients: A Cohort Study in 49 ICUs in Argentina. 10.1097/CCM.0000000000003208 The new Sepsis-3 definitions have been scarcely assessed in low- and middle-income countries; besides, regional information (...) of sepsis outcomes is sparse. Our objective was to evaluate Sepsis-3 definition performance in Argentina. Cohort study of 3-month duration beginning on July 1, 2016. Forty-nine ICUs. Consecutive patients admitted to the ICU with suspected infection that triggered blood cultures and antibiotic administration. None. Patients were classified as having infection, sepsis (infection + change in Sequential Organ Failure Assessment ≥ 2 points), and septic shock (vasopressors + lactate > 2 mmol/L). Patients

EvidenceUpdates2018

34. Clinical Evaluation of Sepsis-1 and Sepsis-3 in the ICU

Clinical Evaluation of Sepsis-1 and Sepsis-3 in the ICU 28711593 2018 05 07 1931-3543 153 5 2018 May Chest Chest Clinical Evaluation of Sepsis-1 and Sepsis-3 in the ICU. 1169-1176 S0012-3692(17)31240-0 10.1016/j.chest.2017.06.037 There has been considerable controversy between sepsis-1 and sepsis-3 criteria. Patients with infection meeting two or more systemic inflammatory response syndrome (SIRS) criteria (sepsis-1) or a Sequential Organ Failure Assessment (SOFA) score ≥ 2 (sepsis-3 (...) ) on the first day after ICU admission were selected from the Medical Information Mart for Intensive Care-III database, and their outcomes were compared using all-cause death as the end point. Subgroup analysis was also performed based on prior chronic organ dysfunction. There were 21,491 infected patients included. Of those meeting the diagnostic criteria for sepsis-1, 13.42% did not satisfy sepsis-3 criteria, and this population had a 21-day mortality rate of 6.96%. In contrast, 7.00% of the patients

EvidenceUpdates2018

35. Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries.

Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries. Importance: The quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score has not been well-evaluated in low- and middle-income countries (LMICs). Objective: To assess the association of qSOFA with excess hospital death among patients with suspected infection in LMICs and to compare qSOFA (...) ]) or SIRS criteria (range, 0 [best] to 4 [worst]) within 24 hours of presentation to study hospital. Main Outcomes and Measures: Predictive validity (measured as incremental hospital mortality beyond that predicted by baseline risk factors, as a marker of sepsis or analogous severe infectious course) of the qSOFA score (primary) and SIRS criteria (secondary). Results: The cohorts were diverse in enrollment criteria, demographics (median ages, 29-54 years; males range, 36%-76%), HIV prevalence (range, 2

JAMA2018

36. Giving antibiotics immediately reduces deaths from sepsis

Giving antibiotics immediately reduces deaths from sepsis NIHR DC | Signal - Giving immediate antibiotics reduces deaths from sepsis Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Giving immediate antibiotics reduces deaths from sepsis Published on 18 April 2017 Giving immediate antibiotics (defined as within one hour) when people present to emergency departments with suspected sepsis reduces their risk of dying by a third compared with later administration. This meta (...) -analysis of observational data from 23,596 people in emergency department settings confirmed that giving antibiotics within one hour was linked to a lower risk of in-hospital mortality compared with giving antibiotics later. This adds weight to recommendations from NICE and other organisations that antibiotics should be administered straight away in people with suspected sepsis. However, in practice up to a third of people in the UK do not receive antibiotics within the hour. NHS England and the UK

NIHR Dissemination Centre2018

37. A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers

A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers NIHR DC | Signal - A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers Published on 23 December 2015 Contrary to a previous review of trials, this large, NIHR-funded trial (...) found that probiotic treatment did not prevent two common life-threatening conditions in very premature babies. The conditions were necrotising enterocolitis, which is a severe gut inflammation/infection that can result in the death of intestinal tissue, and sepsis (blood poisoning) from bacteria that have crossed from the gut into the bloodstream. This trial used a single strain of a harmless bacterium, known as a “probiotic”, prepared to high quality standards fit for medicines, and chosen because

NIHR Dissemination Centre2018

38. Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis

Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis NIHR DC | Signal - Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis Dissemination Centre Discover Portal NIHR DC Discover Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis Published on 31 January 2018 The risk of death in adults with sepsis was 30% lower when each dose of antibiotic was given intravenously over (...) three hours compared to a bolus or less than 60 minutes. This systematic review included adults on intensive care units with a range of ages, severity of sepsis and other symptoms. A variety of antibiotics of the anti-pseudomonal beta-lactam class were used in the trials. These included carbapenems, penicillins and cephalosporins. In the UK, current guidance for intravenous use of these drugs is to give them over a period of up to 30 minutes. This review provides high-quality evidence that suggests

NIHR Dissemination Centre2018

39. Blood test could shorten antibiotic treatment in newborns with suspected sepsis

Blood test could shorten antibiotic treatment in newborns with suspected sepsis NIHR DC | Signal - Blood test could shorten antibiotic treatment in newborns with suspected sepsis Dissemination Centre Discover Portal NIHR DC Discover Blood test could shorten antibiotic treatment in newborns with suspected sepsis Published on 28 November 2017 Measuring procalcitonin levels in newborns with suspected sepsis in the first days of life reduced antibiotic duration by 10 hours compared with standard (...) care. There was no increase in the risk of re-infection or death. Systemic infection can be rapidly life-threatening in newborn babies, so those with risk factors are often treated pre-emptively with intravenous antibiotics. If sepsis is not confirmed by blood culture the decision whether to discontinue antibiotics needs to be made, but results of the blood culture takes time. Procalcitonin is released into the blood in response to inflammation, and low levels may give an earlier indication

NIHR Dissemination Centre2018

40. A focus on treating fever does not improve survival in sepsis

A focus on treating fever does not improve survival in sepsis NIHR DC | Signal - A focus on treating fever does not improve survival in sepsis Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal A focus on treating fever does not improve survival in sepsis Published on 27 June 2017 Specifically treating fever in adults with sepsis did not reduce the number of people dying within 28 days. It also had no effect on the frequency of hospital-acquired infections, reversing septic shock (...) , lowering heart rate or improving breathing. Sepsis is a rare complication of an infection. Among the 123,000 people a year in England who develop sepsis around 30% will die from it, so improving our understanding of how to treat sepsis is clearly important. Early treatment of sepsis is important for a number of reasons, but the findings of this review imply that it is not necessary to specifically treat fever. We don’t know whether there might be benefits for people with very high temperatures. Why

NIHR Dissemination Centre2018