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Latest & greatest articles for sedation
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Randomized, Double-Blinded, Clinical Trial of Propofol, 1:1 Propofol/Ketamine, and 4:1 Propofol/Ketamine for Deep Procedural Sedation in the Emergency Department 25441247 2015 04 27 2015 06 25 2015 04 27 1097-6760 65 5 2015 May Annals of emergency medicine Ann Emerg Med Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department. 479-488.e2 10.1016/j.annemergmed.2014.08.046 S0196-0644(14)01258 (...) -X We compare the frequency of airway and respiratory adverse events leading to an intervention between propofol with 1:1 and 4:1 mixtures of propofol and ketamine (ketofol). We performed a randomized, double-blinded trial in which emergency department adults undergoing deep sedation received propofol, 1:1 propofol and ketamine, or 4:1 propofol and ketamine. Our primary outcome was the frequency of airway and respiratory adverse events leading to an intervention. Other outcomes included sedation
The complexity of nurses' attitudes and practice of sedation at the end of life: a systematic literature review The complexity of nurses' attitudes and practice of sedation at the end of life: a systematic literature review The complexity of nurses' attitudes and practice of sedation at the end of life: a systematic literature review Abarshi EA, Papavasiliou ES, Preston N, Brown J, Payne S, EURO IMPACT CRD summary This review explored nurses' attitudes and practice relating to the sedation (...) of patients at the end of their life. The authors concluded that most nurses administered sedation, until death, only where it was necessary to control refractory symptoms and suffering; some nurses experienced burdens when delivering sedation. Reporting limitations restrict the confidence in the reliability of this conclusion. Authors' objectives To explore nurses' attitudes and practice relating to the sedation of patients at the end of their life. Searching Eight electronic databases (including PubMed
Comparison of the bispectral index monitor with the Comfort score in assessing level of sedation of critically ill children PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
State Behavioral Scale: A sedation assessment instrument for infants and young children supported on mechanical ventilation PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Opioid-sparing effect of preemptive bolus low-dose ketamine for moderate sedation in opioid abusers undergoing extracorporeal shock wave lithotripsy: a randomized clinical trial 23223117 2012 12 24 2013 02 15 2013 11 21 1526-7598 116 1 2013 Jan Anesthesia and analgesia Anesth. Analg. Opioid-sparing effect of preemptive bolus low-dose ketamine for moderate sedation in opioid abusers undergoing extracorporeal shock wave lithotripsy: a randomized clinical trial. 75-80 10.1213/ANE.0b013e31826f0622 (...) Ketamine has been used as part of a multimodal analgesia regime in opioid abusers undergoing general anesthesia. We studied the opioid-sparing effect of a very low-dose bolus of ketamine as part of moderate sedation for opioid abuse patients undergoing extracorporeal shock wave lithotripsy. In this randomized, placebo-controlled clinical trial, 190 opioid abusers were enrolled. They were stratified into 2 blocks based on their daily opioid consumption. Both blocks were then randomized to receive 0.1 mg
Propofol-based versus dexmedetomidine-based sedation in cardiac surgery patients Propofol-based versus dexmedetomidine-based sedation in cardiac surgery patients Propofol-based versus dexmedetomidine-based sedation in cardiac surgery patients Curtis JA, Hollinger MK, Jain HB Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed (...) critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study aimed to evaluate the clinical outcomes and costs of sedation regimens, containing propofol or dexmedetomidine, after cardiac surgery. The authors concluded that dexmedetomidine-based sedation was clinically beneficial, with similar mortality and total hospital charges. The study methods and results were well reported, apart from the cost details. The results were susceptible to bias, and the authors
Dexmedetomidine for sedation of cardiac surgical patients Dexmedetomidine for sedation of cardiac surgical patients Dexmedetomidine for sedation of cardiac surgical patients Mitchell MD, Fishman N, Umscheid CA Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Fishman N, Umscheid CA. Dexmedetomidine for sedation of cardiac surgical patients
Procedural Sedation for Diagnostic Imaging in Children by Pediatric Hospitalists using Propofol: Analysis of the Nature, Frequency, and Predictors of Adverse Events and Interventions PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Palliative sedation in end-of-life care and survival: a systematic review Palliative sedation in end-of-life care and survival: a systematic review Palliative sedation in end-of-life care and survival: a systematic review Maltoni M, Scarpi E, Rosati M, Derni S, Fabbri L, Martini F, Amadori D, Nanni O CRD summary The review found that palliative sedation in terminally ill adults with cancer, when appropriately indicated and used correctly, did not appear to have a detrimental effect on survival (...) . The reliability of the authors' conclusions is unclear because of the low quality of the included studies, lack of reporting of study quality details and some limitations of the review process. Authors' objectives To evaluate the effect of palliative sedation on survival in patients with advanced cancer. Searching MEDLINE and EMBASE were searched from January 1980 to December 2010 to identify studies published in English. Search terms were reported. A manual search of the bibliographies of identified articles
Sedation versus general anaesthesia for provision of dental treatment in under 18 year olds. BACKGROUND: A significant proportion of children have caries requiring restorations or extractions, and some of these children will not accept this treatment under local anaesthetic. Historically this has been managed in children by the use of a general anaesthetic, however use of sedation may lead to reduced morbidity and cost. The aim of this review is to compare the efficiency of sedation versus (...) general anaesthesia for the provision of dental treatment for children and adolescents aged under 18 years.This review was originally published in 2009 and updated in 2012. OBJECTIVES: We evaluated the intra- and postoperative morbidity, effectiveness and cost effectiveness of sedation versus general anaesthesia for the provision of dental treatment for under 18 year olds. SEARCH METHODS: In this updated review we searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane
Chloral hydrate or midazolam: which is better for sedating children for painless diagnostic imaging? BestBets: Chloral hydrate or midazolam: which is better for sedating children for painless diagnostic imaging? Chloral hydrate or midazolam: which is better for sedating children for painless diagnostic imaging? Report By: Dr Michelle Hare - Consultant in Paediatrics Institution: Sheffield Children's Hospital, Western Bank, Sheffield, South Yorkshire, UK Date Submitted: 14th September 2012 Last (...) Modified: 14th September 2012 Status: Green (complete) Three Part Question In [children who require sedation for painless diagnostic imaging] is [chloral hydrate better than midazolam] in achieving [effective and safe sedation]? Clinical Scenario A 2-year-old child is acutely admitted at night to a district general hospital following a prolonged focal seizure. A CT scan of the head without sedation fails as the child is too active and distressed, and as the on-call paediatric registrar, you
Safe and effective procedural sedation for gastrointestinal endoscopy in children Safe and effective procedural sedation for gastrointestinal endoscopy in children Safe and effective procedural sedation for gastrointestinal endoscopy in children Van Beek EJ, Leroy PL CRD summary The review concluded that propofol-based therapy was the most effective regimen for procedural sedation during gastrointestinal endoscopy in children. Given the potential for bias in the review process, limitations (...) in quality assessments, and variation in study outcomes, the authors' conclusions may not be reliable. Authors' objectives To assess the safety and effectiveness of procedural sedation in children undergoing gastrointestinal endoscopy. Searching MEDLINE, EMBASE and The Cochrane Library were searched for published studies from January 1995 up to January 2011; search terms were reported. Reference lists of retrieved articles, reviews, editorials and guidelines were also searched. Study selection Studies
Conscious Sedation in Dentistry Scottish Dental Clinical Effectiveness Programme - SDCEP Scottish Dental Clinical Effectiveness Programme Navigate this website Welcome The Scottish Dental Clinical Effectiveness Programme (SDCEP) is an initiative of the National Dental Advisory Committee (NDAC) and part of the within (NES’s) Dental Directorate . SDCEP provides user-friendly, evidence-based guidance to support dental teams to provide high quality healthcare that is safe, effective and person
In IV sedation used for dental surgery, neither fentanyl or nalbuphine more effective as an analgesic UTCAT2298, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title In IV Sedation Used for Dental Surgery, Neither Fentanyl or Nalbuphine More Effective As An Analgesic Clinical Question In a patient undergoing IV moderate conscious sedation associated with dental surgery, is fentanyl or nalbuphine more effective as a peri (...) -operative analgesic? Clinical Bottom Line Neither fentanyl or nalbuphine is shown to have a clinical advantage as a peri-operative analgesic associated with IV moderate sedation in the dental office. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Dolan/1998 50 patients, ASA 1 or 2 RCT Key results Dental surgery patients who required IV sedation, were given equipotent doses of either fentanyl or nalbuphine
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?