Latest & greatest articles for screening

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on screening or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on screening and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for screening

141. Primary cervical screening with high risk human papillomavirus testing: observational study. Full Text available with Trip Pro

Primary cervical screening with high risk human papillomavirus testing: observational study. To provide the first report on the main outcomes from the prevalence and incidence rounds of a large pilot of routine primary high risk human papillomavirus (hrHPV) testing in England, compared with contemporaneous primary liquid based cytology screening.Observational study.The English Cervical Screening Programme.578 547 women undergoing cervical screening in primary care between May 2013 and December (...) 2014, with follow-up until May 2017; 183 970 (32%) were screened with hrHPV testing.Routine cervical screening with hrHPV testing with liquid based cytology triage and two early recalls for women who were hrHPV positive and cytology negative, following the national screening age and interval recommendations.Frequency of referral for a colposcopy; adherence to early recall; and relative detection of cervical intraepithelial neoplasia grade 2 or worse from hrHPV testing compared with liquid based

2019 BMJ

142. Persisting new nodules in incidence rounds of the NELSON CT lung cancer screening study Full Text available with Trip Pro

Persisting new nodules in incidence rounds of the NELSON CT lung cancer screening study The US guidelines recommend low-dose CT (LDCT) lung cancer screening for high-risk individuals. New solid nodules after baseline screening are common and have a high lung cancer probability. Currently, no evidence exists concerning the risk stratification of non-resolving new solid nodules at first LDCT screening after initial detection.In the Dutch-Belgian Randomized Lung Cancer Screening (NELSON) trial (...) , 7295 participants underwent the second and 6922 participants the third screening round. We included participants with solid nodules that were registered as new or <15 mm³ (study detection limit) at previous screens and received additional screening after initial detection, thereby excluding high-risk nodules according to the NELSON management protocol (nodules ≥500 mm3).Overall, 680 participants with 1020 low-risk and intermediate-risk new solid nodules were included. A total of 562 (55%) new solid

2019 EvidenceUpdates

143. Predictive performance of the competing risk model in screening for preeclampsia Full Text available with Trip Pro

Predictive performance of the competing risk model in screening for preeclampsia The established method of screening for preeclampsia is to identify risk factors from maternal demographic characteristics and medical history; in the presence of such factors the patient is classified as high risk and in their absence as low risk. However, the performance of such an approach is poor. We developed a competing risks model, which allows combination of maternal factors (age, weight, height, race (...) of the competing risks model in screening for preeclampsia by a combination of maternal factors, mean arterial pressure, uterine artery pulsatility index, and serum placental growth factor, referred to as the triple test, in a training data set for the development of the model and 2 validation studies.The data for this study were derived from 3 previously reported prospective, nonintervention, multicenter screening studies for preeclampsia in singleton pregnancies at 11+0 to 13+6 weeks' gestation. In all 3

2019 EvidenceUpdates

144. Testing behavioral interventions to optimize participation in a population-based colorectal cancer screening program in Catalonia, Spain Full Text available with Trip Pro

Testing behavioral interventions to optimize participation in a population-based colorectal cancer screening program in Catalonia, Spain The aim of the study was to measure the effect of three cost-neutral behavioral interventions on participation compared to the standard invitation letter in a population-based colorectal cancer screening program in 2014. For that purpose, a four-arm randomized field trial was conducted among 5077 individuals aged 50 to 69 years. Over an 8-week period, each (...) week was randomly allocated to the intervention or the control conditions. Individuals assigned to the intervention conditions additionally received a prompt to write down the date to pick up the screening test in a pharmacy. Two of the three intervention groups also included an additional paragraph in the invitation letter on either: 1) the high proportion of individuals participating regularly (social norms condition) or 2) the importance of regular participation (benefit condition). We measured

2019 EvidenceUpdates

145. AIM Clinical Appropriateness Guidelines for Genetic Testing for Reproductive Carrier Screening and Prenatal Diagnosis

AIM Clinical Appropriateness Guidelines for Genetic Testing for Reproductive Carrier Screening and Prenatal Diagnosis Appropriate.Safe.Affordable © 2019 AIM Specialty Health 2068-0319b Clinical Appropriateness Guidelines Genetic Testing for Reproductive Carrier Screening and Prenatal Diagnosis EFFECTIVE MARCH 31, 2019 PROPRIETARY Guidelines developed by, and used with permission from, Informed Medical Decisions, Inc. © 2019 Informed Medical Decisions, Inc. All Rights Reserved. 2 Table (...) of Contents Scope 3 Appropriate Use Criteria 3 Carrier Screening for Familial Disease 3 Fragile X 3 Carrier Screening for Common and Ethnic Genetic Diseases 3 Cystic Fibrosis 3 Spinal Muscular Atrophy 4 Hemoglobinopathies 4 Ashkenazi Jewish Carrier Screening 4 Other Ethnicities 5 Carrier Screening Not Clinically Appropriate 5 Preimplantation Genetic Screening and Diagnostic Testing of Embryos 5 Preimplantation Genetic Screening for Common Aneuploidy 6 Prenatal Cell-Free DNA Screening 6 Prenatal Molecular

2019 AIM Specialty Health

146. Self-testing kits for HPV could be a useful option to tackle low cervical screening rates in young women

Self-testing kits for HPV could be a useful option to tackle low cervical screening rates in young women Self-testing kits for HPV could be a useful option to tackle low cervical screening rates in young women Discover Portal Discover Portal Self-testing kits for HPV could be a useful option to tackle low cervical screening rates in young women Published on 6 December 2016 doi: Human Papilloma Virus (HPV) self-sampling kits and the opportunity to book appointments had the largest effect (...) in improving cervical screening uptake for those not responding to initial prompts. However, uptake improved only slightly from 27% to 30%, when the kit was sent. A survey of non-attenders showed they value the convenience and privacy of self-testing. This large NIHR trial tested a range of interventions to increase uptake among women eligible for their first cervical screening test. Sending information leaflets or giving online booking options before their first invitation had no effect on uptake within

2019 NIHR Dissemination Centre

147. New screening pathway could help to identify a rare, single-gene form of diabetes

New screening pathway could help to identify a rare, single-gene form of diabetes New screening pathway could help to identify a rare, single-gene form of diabetes Discover Portal Discover Portal New screening pathway could help to identify a rare, single-gene form of diabetes Published on 23 January 2018 doi: A screening pathway using blood and urine tests followed by two genetic (DNA) tests identified all people with a rare subtype of diabetes called monogenic diabetes. The screening pathway (...) study looked at whether a three-step screening process could better identify who should be referred for DNA testing. What did this study do? The UNITED study included 1,418 people in two UK regions diagnosed with diabetes before the age of 30 and currently aged under 50. There were 42 known cases of monogenic diabetes in the sample (previously diagnosed by DNA test). The researchers tested everyone eligible using a three-step diagnostic pathway which included DNA tests for everyone. Firstly

2019 NIHR Dissemination Centre

148. Financial incentives do not increase attendance for diabetic eye screening

Financial incentives do not increase attendance for diabetic eye screening Financial incentives do not increase attendance for diabetic eye screening Discover Portal Discover Portal Financial incentives do not increase attendance for diabetic eye screening Published on 11 July 2017 doi: Two types of financial incentives are not effective at increasing attendance at eye screening for people with diabetes who do not regularly attend screening. Surprisingly, financial incentives may even reduce (...) the numbers of people attending screening. Retinopathy is a type of eye disease common to people with diabetes. Sight deteriorates only in the later stages and early diagnosis and treatment can prevent blindness. Annual eye screening is offered for people with diabetes but take-up could be improved. This trial examined the effectiveness of a small fixed fee incentive and a lottery incentive compared to an invitation letter. Contrary to expectation the financial incentives were worse than the letter

2019 NIHR Dissemination Centre

149. Screen reminders for GPs did not improve anticoagulant prescribing in atrial fibrillation

Screen reminders for GPs did not improve anticoagulant prescribing in atrial fibrillation Screen reminders for GPs did not improve anticoagulant prescribing in atrial fibrillation Discover Portal Discover Portal Screen reminders for GPs did not improve anticoagulant prescribing in atrial fibrillation Published on 18 July 2017 doi: General practice software that generated screen reminders for patients with atrial fibrillation did not increase the proportion taking oral anticoagulants (...) it is important to understand why some patients are not taking preventative medicines. This study addressed this challenge by testing software that generated screen reminders when atrial fibrillation patients were seen in general practice. What did this study do? This cluster-randomised controlled trial assigned 47 general practices in England to either usual practice or to a new proprietary software tool – Automated Risk Assessment for Stroke in Atrial Fibrillation. The software generated screen reminders

2019 NIHR Dissemination Centre

150. Intensive management of diabetes detected early at screening shows similar results to standard care

Intensive management of diabetes detected early at screening shows similar results to standard care Intensive management of diabetes detected early at screening shows similar results to standard care Discover Portal Discover Portal Intensive management of diabetes detected early at screening shows similar results to standard care Published on 1 November 2016 doi: Intensive “early” treatment was similar to national guidance-based treatment at preventing diabetes-related complications or heart (...) disease over five years in this large trial. General practices in the UK (49 practices), Netherlands and Denmark screened 135,000 asymptomatic adults aged 40 to 69 for type 2 diabetes before offering one of two treatment approaches. Intensive management was geared towards achieving targets for blood glucose, blood pressure and cholesterol levels by providing support for GPs, and protected time for delivering extra monitoring, healthy lifestyle advice and medication. The comparison group received

2019 NIHR Dissemination Centre

151. Abdominal aortic aneurysm screening for women is unlikely to be a fair use of NHS resources

Abdominal aortic aneurysm screening for women is unlikely to be a fair use of NHS resources Abdominal aortic aneurysm screening for women not cost effective Discover Portal Discover Portal Abdominal aortic aneurysm screening for women is unlikely to be a fair use of NHS resources Published on 13 November 2018 doi: Nearly 4,000 women would need screening to prevent one death, and a third of aneurysms detected wouldn’t have influenced the individual woman's health or lifespan. Aneurysm rupture (...) is a life-threatening emergency with low survival. Men are known to be at higher risk of an aneurysm and are offered screening at age 65 to allow early diagnosis of aneurysms large enough to warrant surgical repair. However, a third of deaths from rupture are in women. This NIHR-funded study is the first to model the potential benefits, harms and cost-effectiveness of abdominal aortic aneurysm screening in women. All screening scenarios were estimated to exceed the NHS cost-effectiveness threshold

2019 NIHR Dissemination Centre

152. Screening the Blood Supply for Zika Virus in the 50 U.S. States and Puerto Rico: A Cost-Effectiveness Analysis. (Abstract)

Screening the Blood Supply for Zika Virus in the 50 U.S. States and Puerto Rico: A Cost-Effectiveness Analysis. In 2016, universal individual donation nucleic acid testing (ID-NAT) of donated blood for Zika virus began in U.S. states and territories.To assess the cost-effectiveness of universal ID-NAT in the first year of screening compared with alternatives for the 50 states and separately for Puerto Rico.Microsimulation that captured Zika-related harms to transfusion recipients, sexual (...) Puerto Rico, MP-NAT exclusively during high mosquito season was cost-effective at $81 123 per QALY (95% CI, -$49 138 to $978 242 per QALY). No screening policy was cost-effective in the 50 states. Universal ID-NAT cost $341 million per QALY (CI, $125 million to $2.90 billion per QALY) compared with no screening in the 50 states.In Puerto Rico, MP-NAT only during the season of high mosquito activity was most cost-effective in 64% of probabilistic sensitivity analysis iterations. In the 50 states

2019 Annals of Internal Medicine

153. Cost-effectiveness of community-based screening and treatment of moderate acute malnutrition in Mali. Full Text available with Trip Pro

Cost-effectiveness of community-based screening and treatment of moderate acute malnutrition in Mali. Moderate acute malnutrition (MAM) causes substantial child morbidity and mortality, accounting for 4.4% of deaths and 6.0% of disability-adjusted life years (DALY) lost among children under 5 each year. There is growing consensus on the need to provide appropriate treatment of MAM, both to reduce associated morbidity and mortality and to halt its progression to severe acute malnutrition. We

2019 BMJ global health Controlled trial quality: uncertain

154. A systematic review of the association between screen time and sleep in school-aged children and adolescents

A systematic review of the association between screen time and sleep in school-aged children and adolescents Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening

2019 PROSPERO

155. Blastocyst biopsy with comprehensive chromosome screening improves embryo selection: a systematic review and meta-analysis

Blastocyst biopsy with comprehensive chromosome screening improves embryo selection: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) : Screening will be performed in two phases, namely initial screening based on title and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3

2019 PROSPERO

156. Prevention of early-onset Group B streptococcal sepsis in infants, using universal screening versus risk-based protocols for antibiotic prophylaxis: a systematic review and meta-analysis

Prevention of early-onset Group B streptococcal sepsis in infants, using universal screening versus risk-based protocols for antibiotic prophylaxis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility (...) : Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening will be performed in two phases, namely initial screening based on title and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper

2019 PROSPERO

157. The earlier the better: in what ways are men who have sex with men being targeted for acute HIV infection screening in different countries?

The earlier the better: in what ways are men who have sex with men being targeted for acute HIV infection screening in different countries? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration (...) criteria: Example: Screening will be performed in two phases, namely initial screening based on title and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal

2019 PROSPERO

158. The acceptability of self-collected HPV DNA cervical screening: a qualitative meta-synthesis

The acceptability of self-collected HPV DNA cervical screening: a qualitative meta-synthesis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external (...) websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening

2019 PROSPERO

159. Determinants of participation in recommended screening: an umbrella review

Determinants of participation in recommended screening: an umbrella review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email (...) salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening will be performed in two phases

2019 PROSPERO

160. The role of DNA image cytometry in screening high risk oral potentially malignant lesions using brushing: a systematic review

The role of DNA image cytometry in screening high risk oral potentially malignant lesions using brushing: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) : Screening will be performed in two phases, namely initial screening based on title and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3

2019 PROSPERO