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Latest & greatest articles for rheumatoid arthritis
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Stopping biological drugs for rheumatoidarthritis can lead to twice the relapse rate Stopping biological drugs for rheumatoidarthritis can lead to twice the relapse rate Discover Portal Discover Portal Stopping biological drugs for rheumatoidarthritis can lead to twice the relapse rate Published on 24 January 2018 doi: It seems safer to reduce the dose of biological drugs, rather than to stop them if people with rheumatoidarthritis and their doctors want to avoid relapse. Stopping (...) these powerful drugs caused the disease to recur in 58% of people compared with 29% who continued them. Reducing the dose also led to more relapses for people in remission, but did not cause those with low-grade disease activity to worsen. Rheumatoidarthritis is a chronic disease which causes pain, swelling and stiffness in the small joints of the hands and feet. It can cause more widespread inflammation. The disease has episodes of improvement and deterioration so judging the effects of treatment can
Effectiveness of a Referral Program for rheumatoidarthritis and axial spondyloarthritis Diagnosis at Primary Care Centers in Portugal - SIARA STUDY. Early diagnosis and treatment of RheumatoidArthritis (RA) and axial Spondylarthritis (axial SpA) can limit the impact of disease outcomes. This study evaluated the effectiveness of a referral program on the identification of patients with RA and axial SpA.This was an observational, prospective, randomized (by clusters) study conducted in Portugal (...) or axial SpA cases confirmed by the rheumatologist of the reference hospital.RA-Substudy: A total of 340 patients were recruited (144 in the RSA-exposed group; 196 in the control). RA diagnosis confirmation was 7.3% (95%CI, 2.1-12.5%) in RSA group versus 2.7% (95%CI, 0.0-5.7%) in control group RSA effect was positive but moderate (4.6%) and not statistically significant (95% CI, 0.0%-11.8%; p=0.222, adjusted for clustering effect). Rate of confirmed arthritis of any type was 16.9% (n=14/83) in the RSA
Comparative effectiveness of rituximab, abatacept, and tocilizumab in adults with rheumatoidarthritis and inadequate response to TNF inhibitors: prospective cohort study. To compare the effectiveness and safety of three non-tumour necrosis factor (TNF) α inhibitors (rituximab, abatacept, and tocilizumab) in the treatment of rheumatoid arthritis.Population based prospective study.53 university and 54 non-university clinical centres in France.3162 adults (>18 years) with rheumatoidarthritis (...) according to 1987 American College of Rheumatology criteria, enrolled in one of the three French Society of Rheumatology registries; who had no severe cardiovascular disease, active or severe infections, or severe immunodeficiency, with follow-up of at least 24 months.Initiation of intravenous rituximab, abatacept, or tocilizumab for rheumatoid arthritis.The primary outcome was drug retention without failure at 24 months. Failure was defined as all cause death; discontinuation of rituximab, abatacept
Decreased Injection Site Pain Associated with Phosphate-Free Etanercept Formulation in RheumatoidArthritis or Psoriatic Arthritis Patients: A Randomized Controlled Trial. Etanercept, a tumor necrosis factor inhibitor, is used to treat rheumatoidarthritis (RA) and psoriatic arthritis (PsA), and is administered via subcutaneous injection. Injection site pain (ISP) associated with subcutaneous administration may affect compliance or hinder initiation of prescribed medications. To improve
Immunogenicity of Sarilumab Monotherapy in Patients with RheumatoidArthritis Who Were Inadequate Responders or Intolerant to Disease-Modifying Antirheumatic Drugs. This open-label study evaluated the immunogenicity, safety, and efficacy of sarilumab monotherapy in patients with active, moderate-to-severe rheumatoidarthritis (RA) and inadequate response or intolerance to prior conventional synthetic disease-modifying antirheumatic drugs.Adults with RA (n = 132) were randomized to receive
Relative Impact of Pain and Fatigue on Work Productivity in Patients with RheumatoidArthritis from the RA-BEAM Baricitinib Trial. To explore the relationship of pain and fatigue with daily activity and work productivity in rheumatoidarthritis (RA) patients from the baricitinib clinical trial, RA-BEAM.In RA-BEAM, a double-blind phase 3 study, patients were randomized 3:3:2 to placebo (n = 488), baricitinib 4 mg once daily (n = 487), or adalimumab 40 mg biweekly (n = 330) with background
Two-Year Safety and Effectiveness of Peficitinib in Moderate-To-Severe RheumatoidArthritis: A Phase IIb, Open-Label Extension Study. Peficitinib is a novel orally bioavailable, once-daily Janus kinase (JAK) inhibitor approved in Japan for the treatment of rheumatoidarthritis (RA). This 2-year extension study of two global phase IIb trials investigated the long-term safety and effectiveness of peficitinib.All eligible patients with moderate-to-severe RA including patients in the placebo group
Baricitinib (Olumiant) - moderate to severe rheumatoidarthritis (RA) Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product. The for is located below. Recent Activity for SBDs written for approved after
Effects of B-cell directed therapy on the preclinical stage of rheumatoidarthritis: the PRAIRI study We explored the effects of B-cell directed therapy in subjects at risk of developing autoantibodypositive rheumatoidarthritis (RA), who never experienced inflammatory arthritis before, and explored biomarkers predictive of arthritis development.Individuals positive for both anti-citrullinated peptide antibodies and rheumatoid factor but without arthritis were included in a randomised, double (...) -blind, placebo-controlled study to receive a single infusion of 1000 mg rituximab or placebo.Eighty-one individuals received treatment and were followed up for a mean of 29.0 (0-54) months, during which 30/81 (37%) individuals developed arthritis. The observed risk of developing arthritis in the placebo-treated group was 40%, which was decreased by 55% (HR 0.45, 95% CI 0.154 to 1.322) in the rituximab-treated group at 12 months. Rituximab treatment caused a delay in arthritis development of 12
RheumatoidArthritis. Rheumatoidarthritis (RA) is a common systemic inflammatory autoimmune disease characterized by painful, swollen joints that can severely impair physical function and quality of life. The presenting symptoms of musculoskeletal pain, swelling, and stiffness are common in clinical practice, so familiarity with diagnosing and managing RA is crucial. Patients with RA are at greater risk for serious infection, respiratory disease, osteoporosis, cardiovascular disease, cancer
RheumatoidarthritisRheumatoidarthritis - NICE CKS Share Rheumatoidarthritis: Summary Rheumatoidarthritis (RA) is a chronic systemic inflammatory disease. RA typically presents as inflammatory arthritis affecting the small joints of the hands and the feet (usually both sides equally and symmetrically) although any synovial joint can be involved. As RA progresses, any system of the body may be affected, leading to an increased risk of premature death. RA is associated with a number (...) and Care Excellence (NICE) guidelines Rheumatoidarthritis in adults: management [ ], Rheumatoidarthritis: national clinical guideline for management and treatment in adults [ ], the American College of Rheumatology (ACR) Guideline for the treatment of rheumatoidarthritis [ ], the European League Against Rheumatism (EULAR) 2016 update of the EULAR recommendations for the management of early arthritis [ ], the British Medical Journal (BMJ) best practice guide RheumatoidArthritis [ ], expert opinion
Is dry heat treatment (fluidotherapy) effective in improving hand function in patients with rheumatoidarthritis? A randomized controlled trial To evaluate the efficacy of dry heat treatment (fluidotherapy) in improving hand function in patients with rheumatoid arthritis.Prospective randomized controlled trial.Departments of Physical Medicine and Rehabilitation and Rheumatology in a university hospital.Patients with rheumatoid arthritis.All patients were randomly divided into two groups. Group (...) = 0.039).Dry heat treatment (fluidotherapy) was not effective in improving hand function in patients with rheumatoidarthritis. Moreover, no positive effect on any other clinical parameters was observed.
Dose reduction of baricitinib in patients with rheumatoidarthritis achieving sustained disease control: results of a prospective study This study investigated the effects of dose step-down in patients with rheumatoidarthritis (RA) who achieved sustained disease control with baricitinib 4 mg once a day.Patients who completed a baricitinib phase 3 study could enter a long-term extension (LTE). In the LTE, patients who received baricitinib 4 mg for ≥15 months and maintained CDAI low disease
Sarilumab (rheumatoidarthritis) ? Benefit assessment according to §35a Social Code Book V Extract 1 Translation of Sections 2.1 to 2.6 of the dossier assessment Sarilumab (RheumatoideArthritis) – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 13 November 2017). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. IQWiG Reports – Commission No. A17-39 (...) Sarilumab (rheumatoidarthritis) – Benefit assessment according to §35a Social Code Book V 1 Extract of dossier assessment A17-39 Version 1.0 Sarilumab (rheumatoidarthritis) 13 November 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Sarilumab (rheumatoidarthritis) – Benefit assessment according to §35a Social Code Book V Commissioning agency: Federal Joint Committee Commission awarded
Performance of the Expanded Cardiovascular Risk Prediction Score for RheumatoidArthritis Is Not Superior to the ACC/AHA Risk Calculator Cardiovascular (CV) risk estimation calculators for the general population do not perform well in patients with rheumatoidarthritis (RA). An RA-specific risk calculator has been developed, but did not perform better than a risk calculator for the general population when validated in a heterogeneous multinational cohort.In a cohort of patients with new-onset (...) RA from northern Sweden (n = 665), the risk of CV disease was estimated by the Expanded Cardiovascular Risk Prediction Score for RheumatoidArthritis (ERS-RA) and the American College of Cardiology/American Heart Association algorithm (ACC/AHA). The ACC/AHA estimation was analyzed, both as crude data and when adjusted according to the recommendations by the European League Against Rheumatism (ACC/AHA × 1.5). ERS-RA was calculated using 2 variants: 1 from patient and physician reports
Intensive therapy and remissions in rheumatoidarthritis: a systematic review We systematically reviewed the effectiveness of intensive treatment strategies in achieving remission in patients with both early and established RheumatoidArthritis (RA).A systematic literature review and meta-analysis evaluated trials and comparative studies reporting remission in RA patients treated intensively with disease modifying anti-rheumatic drugs (DMARDs), biologics and Janus Kinase (JAK) inhibitors