Latest & greatest articles for pulmonary embolism

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Top results for pulmonary embolism

161. Randomised controlled trial: Oral treatment of acute pulmonary embolism with a fixed dose of rivaroxaban is non-inferior to standard treatment

Randomised controlled trial: Oral treatment of acute pulmonary embolism with a fixed dose of rivaroxaban is non-inferior to standard treatment Oral treatment of acute pulmonary embolism with a fixed dose of rivaroxaban is non-inferior to standard treatment | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Oral treatment of acute pulmonary embolism with a fixed dose of rivaroxaban is non-inferior to standard treatment Article Text

2013 Evidence-Based Medicine (Requires free registration)

162. Cardiovascular Risk Assessment of Pulmonary Embolism With the GRACE Risk Score (PubMed)

Cardiovascular Risk Assessment of Pulmonary Embolism With the GRACE Risk Score Despite the existence of several risk scores, the accurate prediction of the prognosis in pulmonary embolism (PE) remains a challenge. The Global Registry of Acute Coronary Events (GRACE) risk score has a high diagnostic performance for adverse outcomes in acute coronary syndrome. We aimed to assess the applicability and extend the use of the GRACE risk score to PE. A case-control study of 206 consecutive patients (...) admitted with PE was performed. The GRACE, Geneva, Simplified Pulmonary Embolism Severity Index, Shock Index, and European Society of Cardiology risk scores were tested for the prediction of the primary end point: all-cause 30-day mortality. Comparisons between GRACE and the other risk scores were performed using receiver operating characteristic area under the curve and the integrated discrimination improvement index. All-cause 30-day mortality was observed in 18.9% of the patients. Unlike the other

2013 EvidenceUpdates

163. Rivaroxaban for treating pulmonary embolism and preventing recurrent venous thromboembolism (TA287)

Rivaroxaban for treating pulmonary embolism and preventing recurrent venous thromboembolism (TA287) Overview | Rivaroxaban for treating pulmonary embolism and preventing recurrent venous thromboembolism | Guidance | NICE Rivaroxaban for treating pulmonary embolism and preventing recurrent venous thromboembolism Technology appraisal guidance [TA287] Published date: 26 June 2013 Share Save Guidance on rivaroxaban (Xarelto) for treating pulmonary embolism and for preventing a further deep vein (...) thrombosis or pulmonary embolism in adults. Guidance development process Is this guidance up to date? . We found nothing new that affects the recommendations in this guidance. Next review: This guidance will be reviewed if there is new evidence that is likely to change the recommendations. Your responsibility The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected

2013 National Institute for Health and Clinical Excellence - Technology Appraisals

164. Moderate Pulmonary Embolism Treated With Thrombolysis (from the MOPETT Trial) (PubMed)

Moderate Pulmonary Embolism Treated With Thrombolysis (from the MOPETT Trial) The role of low-dose thrombolysis in the reduction of pulmonary artery pressure in moderate pulmonary embolism (PE) has not been investigated. Because the lungs are very sensitive to thrombolysis, we postulated that effective and safe thrombolysis might be achieved by a lower dose of tissue plasminogen activator. The purpose of the present study was to evaluate the role of this "safe dose" thrombolysis (...) in the reduction of pulmonary artery pressure in moderate PE. During a 22-month period, 121 patients with moderate PE were randomized to receive a "safe dose" of tissue plasminogen activator plus anticoagulation (thrombolysis group [TG], n = 61 patients) or anticoagulation alone (control group [CG], n = 60). The primary end points consisted of pulmonary hypertension and the composite end point of pulmonary hypertension and recurrent PE at 28 months. Pulmonary hypertension and the composite end point developed

2013 EvidenceUpdates Controlled trial quality: uncertain

165. Long-term prognostic value of residual pulmonary vascular obstruction at discharge in patients with intermediate- to high-risk pulmonary embolism (PubMed)

Long-term prognostic value of residual pulmonary vascular obstruction at discharge in patients with intermediate- to high-risk pulmonary embolism We evaluated prognostic value at 6 months of residual pulmonary vascular obstruction (RPVO) measured before discharge in patients with intermediate- or high-risk pulmonary embolism (PE).Prospective registry including 416 consecutive patients with intermediate- or high-risk PE who survived the acute phase. Patients with previous cardiopulmonary disease (...) were excluded. Perfusion lung scans were performed within 6-8 days after the onset of treatment. Residual pulmonary vascular obstruction was graded as the proportion of the lung not perfused. Primary objective was a combined endpoint at 6 months, including death, recurrent PE, and appearance of signs of heart failure. At 6 months, 32 patients (7.7%) had at least one adverse event: 12 deaths (2.9%), 12 recurrent PE (2.9%), and 14 (3.4%) heart failure. Independent predictors of combined endpoint were

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2012 EvidenceUpdates

166. Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study. (PubMed)

Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study. To validate the use of the Wells clinical decision rule combined with a point of care D-dimer test to safely exclude pulmonary embolism in primary care.Prospective cohort study.Primary care across three different regions of the Netherlands (Amsterdam, Maastricht, and Utrecht).598 adults with suspected pulmonary embolism in primary care.Doctors scored patients (...) according to the seven variables of the Wells rule and carried out a qualitative point of care D-dimer test. All patients were referred to secondary care and diagnosed according to local protocols. Pulmonary embolism was confirmed or refuted on the basis of a composite reference standard, including spiral computed tomography and three months' follow-up.Diagnostic accuracy (sensitivity and specificity), proportion of patients at low risk (efficiency), number of missed patients with pulmonary embolism

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2012 BMJ

167. Cook celect vena cava filter (Cook Medical Inc.) for prophylaxis and treatment of pulmonary embolism

Cook celect vena cava filter (Cook Medical Inc.) for prophylaxis and treatment of pulmonary embolism Cook celect vena cava filter (Cook Medical Inc.) for prophylaxis and treatment of pulmonary embolism Cook celect vena cava filter (Cook Medical Inc.) for prophylaxis and treatment of pulmonary embolism Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Cook celect (...) vena cava filter (Cook Medical Inc.) for prophylaxis and treatment of pulmonary embolism. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2012 Authors' conclusions Venous thromboembolism (VTE), the formation of blood clots in veins, is a leading cause of disability and death. The syndrome refers to both deep vein thrombosis (DVT) and pulmonary embolism (PE). Each year an estimated 300,000 to 600,000 people in the United States are affected by VTE (1 to 2 per 1000

2012 Health Technology Assessment (HTA) Database.

168. Rivaroxaban - Deep-Vein Thrombosis (treatment), without Symptomatic Pulmonary Embolism

Rivaroxaban - Deep-Vein Thrombosis (treatment), without Symptomatic Pulmonary Embolism Common Drug Review CDEC Meeting – July 18, 2012 Notice of CDEC Final Recommendation – August 16, 2012 Page 1 of 5 © 2012 CADTH CDEC FINAL RECOMMENDATION RIVAROXABAN (Xarelto – Bayer Inc.) New Indication: Deep Vein Thrombosis (Treatment) without Symptomatic Pulmonary Embolism Recommendation: The Canadian Drug Expert Committee (CDEC) recommends that rivaroxaban be listed for the treatment of deep vein (...) thrombosis (DVT) in patients without symptomatic pulmonary embolism (PE), for a duration not to exceed six months. Reasons for the Recommendation: 1. In one large randomized controlled trial (RCT) of patients with acute symptomatic DVT without symptomatic PE (the EINSTEIN DVT trial), rivaroxaban was reported to be non- inferior to a regimen of enoxaparin plus a vitamin K antagonist (VKA) based on the incidence of recurrent DVT or PE. The majority of patients received treatment for six months or less

2012 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

169. Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period

Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period - MCLINTOCK - 2012 - Australian and New Zealand Journal of Obstetrics and Gynaecology - Wiley Online Library Search within Search term Search term Opinion Recommendations for the diagnosis and treatment of deep venous (...) thrombosis and pulmonary embolism in pregnancy and the postpartum period National Women’s Health, Auckland City Hospital, Grafton, Auckland, New Zealand Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales Clinical Haematology Department, Monash Medical Centre, Clayton Australian Centre for Blood Diseases, Monash University, Prahran, Victoria Discipline of Obstetrics and Gynaecology, University of Adelaide, Lyell McEwin Hospital Department of Obstetrics and Gynaecology, Women’s

2012 Clinical Practice Guidelines Portal

170. Diagnostic Accuracy of Pulmonary Embolism Rule-Out Criteria: A Systematic Review and Meta-analysis (PubMed)

Diagnostic Accuracy of Pulmonary Embolism Rule-Out Criteria: A Systematic Review and Meta-analysis To perform a systematic review and meta-analysis to define the diagnostic performance of pulmonary embolism rule-out criteria (PERC) in deferring the need for D-dimer testing to rule out pulmonary embolism in the emergency department (ED).We searched EMBASE, MEDLINE, Scopus, Web of Knowledge, and all the evidence-based medicine reviews that included the Cochrane Database of Systematic Reviews (...) ratios.We found 12 qualifying cohorts (studying 13,885 patients with 1,391 pulmonary embolism diagnoses), 10 prospective and 2 retrospective, from 6 countries. Pooled sensitivity, specificity, positive likelihood ratios, and negative likelihood ratios for 10 included studies were 0.97 (95% confidence interval [CI] 0.96 to 0.98), 0.23 (95% CI 0.22 to 0.24), 1.24 (95% CI 1.18 to 1.30), and 0.17 (95% CI 0.13 to 0.23), respectively. Significant heterogeneity was observed in specificity (I(2)=97.2

2012 EvidenceUpdates

171. Pulmonary embolism and deep vein thrombosis. (PubMed)

Pulmonary embolism and deep vein thrombosis. Pulmonary embolism is the third most common cause of death from cardiovascular disease after heart attack and stroke. Sequelae occurring after venous thromboembolism include chronic thromboembolic pulmonary hypertension and post-thrombotic syndrome. Venous thromboembolism and atherothrombosis share common risk factors and the common pathophysiological characteristics of inflammation, hypercoagulability, and endothelial injury. Clinical probability (...) assessment helps to identify patients with low clinical probability for whom the diagnosis of venous thromboembolism can be excluded solely with a negative result from a plasma D-dimer test. The diagnosis is usually confirmed with compression ultrasound showing deep vein thrombosis or with chest CT showing pulmonary embolism. Most patients with venous thromboembolism will respond to anticoagulation, which is the foundation of treatment. Patients with pulmonary embolism should undergo risk stratification

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2012 Lancet

172. Managing pulmonary embolism using prognostic models: future concepts for primary care (PubMed)

Managing pulmonary embolism using prognostic models: future concepts for primary care 22143233 2012 04 13 2018 11 13 1488-2329 184 3 2012 Feb 21 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Managing pulmonary embolism using prognostic models: future concepts for primary care. 305-10 10.1503/cmaj.110213 Geersing Geert-Jan GJ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (...) . G.J.Geersing@umcutrecht.nl Oudega Ruud R Hoes Arno W AW Moons Karel G M KG eng Journal Article Research Support, Non-U.S. Gov't Review 2011 12 05 Canada CMAJ 9711805 0820-3946 0 Anticoagulants AIM IM Aged Anticoagulants therapeutic use Female Humans Male Models, Statistical Primary Health Care standards Prognosis Pulmonary Embolism diagnosis drug therapy therapy Risk Factors Secondary Prevention Severity of Illness Index 2011 12 7 6 0 2011 12 7 6 0 2012 4 14 6 0 ppublish 22143233 cmaj.110213 10.1503/cmaj

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2012 EvidenceUpdates

173. Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic review

Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic review Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic review Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended (...) or hip, were eligible for inclusion. Eligible inpatients had to be over 18 years of age. Eligible venous thromboembolism prophylactic regimens were low-molecular weight heparin or direct and indirect Xa and IIa factor inhibitors. Deep vein thrombosis had to be confirmed by venography or ultrasonography (with or without impedance plethysmography). Clinical diagnosis of pulmonary embolism had to be confirmed by perfusion/ventilation scintigraphy, pulmonary angiography, spiral computed tomography

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2012 DARE.

174. Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic review. (PubMed)

Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic review. Symptomatic venous thromboembolism (VTE) after total or partial knee arthroplasty (TPKA) and after total or partial hip arthroplasty (TPHA) are proposed patient safety indicators, but its incidence prior to discharge is not defined.To establish a literature-based estimate of symptomatic VTE event rates prior to hospital (...) discharge in patients undergoing TPHA or TPKA.Search of MEDLINE, EMBASE, and the Cochrane Library (1996 to 2011), supplemented by relevant articles.Reports of incidence of symptomatic postoperative pulmonary embolism or deep vein thrombosis (DVT) before hospital discharge in patients who received VTE prophylaxis with either a low-molecular-weight heparin or a subcutaneous factor Xa inhibitor or oral direct inhibitor of factors Xa or IIa.Meta-analysis of randomized clinical trials and observational

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2012 JAMA

175. Systematic review: Thromboprophylaxis in medical inpatients reduces pulmonary embolism, increases the risk of major haemorrhage and does not reduce total mortality, producing questionable net clinical benefit

Systematic review: Thromboprophylaxis in medical inpatients reduces pulmonary embolism, increases the risk of major haemorrhage and does not reduce total mortality, producing questionable net clinical benefit Thromboprophylaxis in medical inpatients reduces pulmonary embolism, increases the risk of major haemorrhage and does not reduce total mortality, producing questionable net clinical benefit | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content (...) are here Thromboprophylaxis in medical inpatients reduces pulmonary embolism, increases the risk of major haemorrhage and does not reduce total mortality, producing questionable net clinical benefit Article Text Therapeutics Systematic review Thromboprophylaxis in medical inpatients reduces pulmonary embolism, increases the risk of major haemorrhage and does not reduce total mortality, producing questionable net clinical benefit Mark Crowther 1 , David G Gracia 2 Statistics from Altmetric.com

2012 Evidence-Based Medicine (Requires free registration)

176. Are Thrombolytics Indicated for Pulmonary Embolism?

Are Thrombolytics Indicated for Pulmonary Embolism? SystematicReviewSnapshot TAKE-HOME MESSAGE There is a lack of evidence to support the routine administration of thrombolytics for the undifferentiated pulmonary embolism patient. METHODS DATA SOURCES The Cochrane Peripheral Vascular Diseases Review Group searched their Specialized Register in April 2009 and CENTRAL in The Cochrane Library through issue 2, 2009. The authorship group also hand searched private databases and bibliographies (...) of relevant articles. STUDY SELECTION Randomized controlled trials comparing thrombolytic therapy with heparin or placebo or surgi- cal intervention in patients pre- senting with pulmonary embolism. Trials comparing 2 different thrombolytic agents or different doses of the same drug were not included. The review included only patients who were hemody- namically stable. DATA EXTRACTION AND ANALYSIS Two authors collected the data with a standardized form. The 2 authors graded the quality and reliability

2012 Annals of Emergency Medicine Systematic Review Snapshots

177. Can selected patients with newly diagnosed pulmonary embolism be safely treated without hospitalization? A systematic review

Can selected patients with newly diagnosed pulmonary embolism be safely treated without hospitalization? A systematic review Can selected patients with newly diagnosed pulmonary embolism be safely treated without hospitalization? A systematic review Can selected patients with newly diagnosed pulmonary embolism be safely treated without hospitalization? A systematic review Vinson DR, Zehtabchi S, Yealy DM CRD summary This generally well-conducted review concluded that data on exclusive (...) outpatient management of acute symptomatic pulmonary embolism were limited but that the existing evidence supported the feasibility and safety of this approach in carefully selected low-risk patients. The authors acknowledged that the available evidence was limited. The conclusion is reflective of the evidence presented. Authors' objectives To assess the safety of initial outpatient management of patients with newly diagnosed pulmonary embolism and their demographics, comorbidities, risk stratification

2012 DARE.

178. Pulmonary embolism rule-out criteria (PERC) in pulmonary embolism ? revisited: a systematic review and meta-analysis

Pulmonary embolism rule-out criteria (PERC) in pulmonary embolism ? revisited: a systematic review and meta-analysis Pulmonary embolism rule-out criteria (PERC) in pulmonary embolism — revisited: a systematic review and meta-analysis Pulmonary embolism rule-out criteria (PERC) in pulmonary embolism — revisited: a systematic review and meta-analysis Singh B, Mommer SK, Patricia EJ, Mascarenhas SS, Parsaik AK CRD summary This review concluded that because of their high sensitivity and low (...) negative likelihood ratio, the pulmonary embolism rule-out criteria could be used confidently in settings where patients have low clinical probability. Given the potential overestimation of accuracy, in the included studies, and the calculation of pooled estimates of accuracy in separate analyses, the conclusions should be treated with caution. Authors' objectives To determine the diagnostic performance of pulmonary embolism rule-out criteria (PERC), to rule out pulmonary embolism, without the need

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2012 DARE.

179. Randomised controlled trial: In selected lower risk patients with acute pulmonary embolism, outpatient treatment is not associated with increased risk of adverse outcomes compared with standard inpatient care

Randomised controlled trial: In selected lower risk patients with acute pulmonary embolism, outpatient treatment is not associated with increased risk of adverse outcomes compared with standard inpatient care In selected lower risk patients with acute pulmonary embolism, outpatient treatment is not associated with increased risk of adverse outcomes compared with standard inpatient care | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising (...) In selected lower risk patients with acute pulmonary embolism, outpatient treatment is not associated with increased risk of adverse outcomes compared with standard inpatient care Article Text Therapeutics Randomised controlled trial In selected lower risk patients with acute pulmonary embolism, outpatient treatment is not associated with increased risk of adverse outcomes compared with standard inpatient care Philip Stephen Wells Statistics from Altmetric.com Commentary on: Aujesky D , Roy PM

2012 Evidence-Based Medicine (Requires free registration)

180. Predictive value of the high-sensitivity troponin T assay and the simplified pulmonary embolism severity index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study (PubMed)

Predictive value of the high-sensitivity troponin T assay and the simplified pulmonary embolism severity index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study The new, high-sensitivity troponin T (hsTnT) assay may improve risk stratification of normotensive patients with acute pulmonary embolism (PE). We externally validated the prognostic value of hsTnT, and of the simplified Pulmonary Embolism Severity Index (sPESI), in a large multicenter

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2012 EvidenceUpdates