Latest & greatest articles for proton pump inhibitors

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Top results for proton pump inhibitors

121. Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux

Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non

Evidence-Based Nursing (Requires free registration)2007

122. Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors

Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors Hunfeld N G, Geus W P, Kuipers E J CRD summary This review evaluated the incidence of rebound acid hypersecretion after the discontinuation of proton-pump inhibitors (PPIs). The authors concluded that the available evidence is too (...) limited to confirm a clinically relevant acid hypersecretion after the withdrawal of PPIs. This review has some methodological weaknesses, but the authors' cautious conclusions seem to reflect the limited evidence presented and are likely to be reliable. Authors' objectives To evaluate the incidence of rebound acid hypersecretion after the discontinuation of proton-pump inhibitors (PPIs). Searching PubMed, EMBASE and the Cochrane CENTRAL Register were searched to October 2005 for published trials

DARE.2007

123. Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease

Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease Gatta L, Vaira D, Sorrenti G, Zucchini S, Sama C, Vakil N CRD summary This review concluded that treatment using high-dose (...) proton-pump inhibitors is no more effective than placebo for the improvement or resolution of symptoms in adult patients experiencing laryngo-pharyngeal symptoms assumed to be related to gastro-oesophageal reflux disease. However, the between-study differences mean that the reliability of the authors’ conclusions is uncertain. Authors' objectives To determine the effectiveness of treatment for reflux disease in adult patients with laryngeal or pharyngeal symptoms attributed to gastro-oesophageal reflux disease (GERD

DARE.2007

124. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy in patients with endoscopically documented acute bleeding from a peptic ulcer

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy in patients with endoscopically documented acute bleeding from a peptic ulcer Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy in patients with endoscopically documented acute bleeding from a peptic ulcer Systematic reviews of the clinical (...) effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy in patients with endoscopically documented acute bleeding from a peptic ulcer Leontiadis G I, Sreedharan A, Dorward S, Barton P, Delaney B, Howden C W, Orhewere M, Gisbert J, Sharma V K, Rostom A, Moayyedi P, Forman D CRD summary The authors concluded that proton pump inhibitors reduced re-bleeding; no overall effect was observed on mortality. Overall, this was a well-conducted review

DARE.2007

125. Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials

Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials Wang W H, Huang J Q, Zheng G F, Xia H H, Wong W M, Liu X G, Karlberg J, Wong B C CRD summary The authors concluded that for patients with ulcer-like (...) and reflux-like dyspepsia, proton-pump inhibitors are more effective than placebo. This was a well-conducted review and the authors' conclusions are likely to be reliable. Authors' objectives To evaluate the efficacy of proton-pump inhibitors (PPIs) for the treatment of patients with functional dyspepsia. Searching PubMed, MEDLINE, EMBASE, CINAHL and the Cochrane Controlled Trials Register were searched through September 2005 without any language restrictions; the search terms were reported. In addition

DARE.2007

126. Meta-analysis: duration of first-line proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication

Meta-analysis: duration of first-line proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication Meta-analysis: duration of first-line proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication Meta-analysis: duration of first-line proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication Fuccio L, Minardi M E, Zagari R M, Grilli D, Magrini N, Bazzoli F CRD summary This well-conducted review concluded that extending (...) proton-pump inhibitor-based triple therapy beyond 7 days for the eradication of Helicobacter pylori is unlikely to be clinically useful. This conclusion is supported by the data presented, but it may not be reliable given the poor methodological quality of the included studies. Authors' objectives To evaluate the efficacy of different durations of proton-pump inhibitor (PPI)-based triple therapy for the eradication of Helicobacter pylori (H. pylori). Searching PubMed, EMBASE and the Cochrane Library were searched

DARE.2007

128. The clinical- and cost-effectiveness of proton pump inhibitors in acute upper gastro-intestinal bleeding

The clinical- and cost-effectiveness of proton pump inhibitors in acute upper gastro-intestinal bleeding Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding Leontiadis GI, Sreedharan A, Dorward S, Barton P, Delaney B, Howden CW, Orhewere M, Gisbert J, sharma VK, Rostom (...) A, Moayyedi P, Forman D Record Status This is a bibliographic record of an ongoing health technology assessment being undertaken by a member of INAHTA. Links to the published report and any other relevant documentation will be added when available. Citation Leontiadis GI, Sreedharan A, Dorward S, Barton P, Delaney B, Howden CW, Orhewere M, Gisbert J, sharma VK, Rostom A, Moayyedi P, Forman D. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper

Health Technology Assessment (HTA) Database.2007

129. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication versus proton pump inhibitors

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication versus proton pump inhibitors Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication versus proton pump inhibitors Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper (...) gastrointestinal bleeding: H. pylori eradication versus proton pump inhibitors Leontiadis G I, Sreedharan A, Dorward S, Barton P, Delaney B, Howden C W, Orhewere M, Gisbert J, Sharma V K, Rostom A, Moayyedi P, Forman D CRD summary This review found no direct evidence to determine whether long-term aspirin or non-aspirin NSAID use prevented further upper gastrointestinal bleeding. There were no treatment differences between proton pump inhibitor and H. pylori eradication therapy in patients diagnosed with H

DARE.2007

130. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: Prophylactic PPI therapy

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: Prophylactic PPI therapy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: Prophylactic PPI therapy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: Prophylactic PPI therapy (...) Leontiadis G I, Sreedharan A, Dorward S, Barton P, Delaney B, Howden C W, Orhewere M, Gisbert J, Sharma V K, Rostom A, Moayyedi P, Forman D CRD summary This review concluded that H 2 RAs effectively reduced the risk of gastric and/or duodenal ulcers resulting from NSAID use, but standard-dose H 2 RAs were inferior to proton pump inhibitors and misoprostol. The authors' conclusions appeared to reflect the evidence presented, but the reliability of the conclusions is unclear due to limitations of the data

DARE.2007

131. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication therapy

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication therapy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication therapy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori (...) ' conclusions H. pylori eradication therapy reduced rates of bleeding compared to non-eradication antisecretory therapy, including proton pump inhibitors (PPI), with or without subsequent long-term maintenance antisecretory therapy. It was not possible to draw conclusions for the comparison of different types of antisecretory therapies with each other or placebo, particularly in H. pylori negative patients, due to a paucity of evidence. CRD commentary The review question was clear and was supported by clear

DARE.2007

132. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy initiated prior to endoscopy

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy initiated prior to endoscopy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy initiated prior to endoscopy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal (...) bleeding: PPI therapy initiated prior to endoscopy Leontiadis G I, Sreedharan A, Dorward S, Barton P, Delaney B, Howden C W, Orhewere M, Gisbert J, Sharma V K, Rostom A, Moayyedi P, Forman D CRD summary This review found limited evidence that proton pump inhibitor (PPI) therapy prior to endoscopy for upper gastrointestinal bleeding may reduce the incidence of stigmata of recent haemorrhage, but not other outcomes. Despite some concerns about potential differences between studies and the risk

DARE.2007

133. Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD

Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your (...) user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD Article Text Therapeutics Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy

Evidence-Based Medicine (Requires free registration)2007

134. Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial.

Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. 17499604 2007 05 14 2007 05 24 2015 11 19 1474-547X 369 9573 2007 May 12 Lancet (London, England) Lancet Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. 1621-6 Guidelines on pain (...) management recommend that patients at risk of ulcers receive either a cyclo-oxygenase (COX 2) inhibitor or a non-steroidal anti-inflammatory drug (NSAID) with a proton-pump inhibitor (PPI). These two treatments have similar effectiveness, but they are insufficient for protection of patients at very high risk for ulcer bleeding. We aimed to test the hypothesis that in patients with previous ulcer bleeding induced by non-selective NSAIDs, combined treatment with the COX 2 inhibitor celecoxib and the PPI esomeprazole

Lancet2007

135. Long-term proton pump inhibitor therapy and risk of hip fracture.

Long-term proton pump inhibitor therapy and risk of hip fracture. CONTEXT: Proton pump inhibitors (PPIs) may interfere with calcium absorption through induction of hypochlorhydria but they also may reduce bone resorption through inhibition of osteoclastic vacuolar proton pumps. OBJECTIVE: To determine the association between PPI therapy and risk of hip fracture. DESIGN, SETTING, AND PATIENTS: A nested case-control study was conducted using the General Practice Research Database (1987-2003 (...) ), which contains information on patients in the United Kingdom. The study cohort consisted of users of PPI therapy and nonusers of acid suppression drugs who were older than 50 years. Cases included all patients with an incident hip fracture. Controls were selected using incidence density sampling, matched for sex, index date, year of birth, and both calendar period and duration of up-to-standard follow-up before the index date. For comparison purposes, a similar nested case-control analysis

JAMA2006

136. Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials

Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials Gralnek I M, Dulai G S, Fennerty M B, Spiegel B M CRD summary This review concluded that while there was a statistically significant (...) improvement with esomeprazole compared with other proton-pump inhibitors in healing and symptoms, the clinical benefit was modest and may be more important in severe than mild erosive esophagitis. The overall conclusion appears reliable but the conclusion about the influence of disease severity should be viewed with caution. Authors' objectives To assess the effect of esomeprazole compared with other proton- pump inhibitors (PPIs) on healing rates, symptom relief and adverse events in the treatment

DARE.2006

137. A meta-analysis: comparison of esomeprazole and other proton pump inhibitors in eradicating Helicobacter pylori

A meta-analysis: comparison of esomeprazole and other proton pump inhibitors in eradicating Helicobacter pylori A meta-analysis: comparison of esomeprazole and other proton pump inhibitors in eradicating Helicobacter pylori A meta-analysis: comparison of esomeprazole and other proton pump inhibitors in eradicating Helicobacter pylori Wang X, Fang J Y, Lu R, Sun D F CRD summary The authors concluded that esomeprazole-based triple therapy may be as effective as omeprazole-based therapy (...) in eradicating Helicobacter pylori, and was well tolerated. There were limitations to this review that appear to undermine the reliability of these conclusions. Authors' objectives To compare the effects of esomeprazole-based therapy and alternative proton-pump inhibitor (PPI)-based therapy on Helicobacter pylori (H. pylori) eradication rates. Searching MEDLINE, EMBASE, the Cochrane Library and the Chinese Biomedical Database were searched from 2000 to 2005 using the reported search terms. In addition

DARE.2006

138. A systematic review of the role of proton pump inhibitors for symptoms of laryngopharyngeal reflux

A systematic review of the role of proton pump inhibitors for symptoms of laryngopharyngeal reflux A systematic review of the role of proton pump inhibitors for symptoms of laryngopharyngeal reflux A systematic review of the role of proton pump inhibitors for symptoms of laryngopharyngeal reflux Sen P, Georgalas C, Bhattacharyya A K CRD summary This review assessed the efficacy of proton-pump inhibitors in the treatment of laryngopharyngeal reflux in adults. The authors concluded (...) that there was insufficient evidence on which to base conclusions regarding the effectiveness of the intervention, and further randomised trials are required. Despite limitations to this review, the authors' cautious conclusions are justified give the data available. Authors' objectives To assess the efficacy of proton-pump inhibitors (PPIs) in the treatment of laryngopharyngeal reflux in adults. Searching MEDLINE (from 1966), EMBASE (from 1980) and the Cochrane Controlled Trials Register were searched up to October 2004

DARE.2006

139. Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review

Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review Karkos P D, Wilson J A CRD summary This review evaluated the use of proton-pump inhibitors (PPIs) for the treatment of laryngopharyngeal reflux and found no evidence to demonstrate superiority of PPIs over placebo (...) . Limitations in the reporting of the included studies and review methodology mean that it is not possible to comment on the robustness of the evidence presented or the authors' conclusion. Authors' objectives To evaluate the treatment of suspected laryngopharyngeal reflux (LPR) symptoms with proton-pump inhibitors (PPIs). Searching MEDLINE, EMBASE, CINAHL and the Cochrane Library were searched for studies published in any language; the search terms were reported. References from relevant articles were also

DARE.2006

140. Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials

Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials Qadeer M A, Phillips C O, Lopez A R, Steward D L, Noordzij J P, Wo J M, Suurna M, Havas T, Howden C W, Vaezi M F CRD summary (...) This review compared proton-pump inhibitors (PPIs) with placebo for treating suspected gastroesophageal reflux disease-related chronic laryngitis in adults. The authors concluded that PPI therapy had a modest but non significant effect over placebo. This was a well-conducted systematic review and the conclusion appears reliable. Authors' objectives To evaluate the efficacy of proton-pump inhibitors (PPIs) for treating suspected gastroesophageal reflux disease (GERD)-related chronic laryngitis. Searching

DARE.2006