Latest & greatest articles for proton pump inhibitors

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Top results for proton pump inhibitors

41. Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Proton Pump Inhibitors Full Text available with Trip Pro

Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Proton Pump Inhibitors Subacute cutaneous lupus erythematosus (SCLE) is an autoimmune disease that may be induced by proton pump inhibitors (PPIs) in at-risk populations. The US FDA does not recognize SCLE as an adverse event associated with PPIs. We queried the FDA Adverse Event Reporting System database, which contains adverse event case reports submitted by the public as well as by industry, and analyzed the data to quantify

2016 Drugs - real world outcomes

42. Pre-Endoscopic Intravenous Proton Pump Inhibitors for Emergency Department Patients with Upper Gastrointestinal Bleeds: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines

Pre-Endoscopic Intravenous Proton Pump Inhibitors for Emergency Department Patients with Upper Gastrointestinal Bleeds: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines Pre-Endoscopic Intravenous Proton Pump Inhibitors for Emergency Department Patients with Upper Gastrointestinal Bleeds: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Pre-Endoscopic Intravenous Proton Pump Inhibitors for Emergency Department (...) Patients with Upper Gastrointestinal Bleeds: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines Pre-Endoscopic Intravenous Proton Pump Inhibitors for Emergency Department Patients with Upper Gastrointestinal Bleeds: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines Published on: February 5, 2016 Project Number: RC0740-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

43. Dyspepsia - unidentified cause: Proton pump inhibitors (PPIs)

Dyspepsia - unidentified cause: Proton pump inhibitors (PPIs) Proton pump inhibitors (PPIs) | Prescribing information | Dyspepsia - unidentified cause | CKS | NICE Search CKS… Menu Proton pump inhibitors (PPIs) Dyspepsia - unidentified cause: Proton pump inhibitors (PPIs) Last revised in October 2018 Proton pump inhibitors (PPIs) Choice of proton pump inhibitor Table 1 shows the recommended doses of proton pump inhibitors (PPIs) for the management of people with dyspepsia symptoms. Table 1 (...) breakfast and (if needed) 30 minutes before the evening meal, to provide optimal control of gastric pH. * Off-label dose for GORD. † This is lower than the licensed starting dose in GORD, but is considered to be dose-equivalent to other PPIs. ‡ This dose is recommended for double dose, because the 20 mg dose of esomeprazole is considered to be equivalent to omeprazole 20 mg. Data from: [ ] Contraindications and cautions Proton pump inhibitors (PPIs) should not be prescribed to people: With alarm

2016 NICE Clinical Knowledge Summaries

44. Are We Overusing Proton Pump Inhibitors?

Are We Overusing Proton Pump Inhibitors? Are We Overusing Proton Pump Inhibitors? – Clinical Correlations Search Are We Overusing Proton Pump Inhibitors? November 13, 2015 7 min read [1]. PPIs are the most potent inhibitors of gastric secretion and are used to treat common upper gastrointestinal disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcer disease. The effectiveness of PPIs and their perceived low toxicity profile have led to their popularity and even inappropriate (...) such as ranitidine. PPIs work by irreversibly inhibiting the parietal cell H+K+ATPase, a pump that actively secretes protons into the gastric lumen in exchange for potassium ions. Because PPIs take several days to cut down maximal acid output, [2]. Upon discontinuation of the drug, patients can experience rebound acid hypersecretion due to hypergastrinemia, leading to worsening of GERD symptoms. These are reasons that many physicians simply keep patients on daily PPIs indefinitely. Currently

2015 Clinical Correlations

45. [Notice of the impact of the decrease of the maximum payable amount for the class of proton pump inhibitors]

[Notice of the impact of the decrease of the maximum payable amount for the class of proton pump inhibitors] Avis sur l'impact de la baisse du prix maximal payable sur la classe des inhibiteurs de la pompe à protons [Notice of the impact of the decrease of the maximum payable amount for the class of proton pump inhibitors] Avis sur l'impact de la baisse du prix maximal payable sur la classe des inhibiteurs de la pompe à protons [Notice of the impact of the decrease of the maximum payable amount (...) for the class of proton pump inhibitors] Jehanno C, Robitaille J, Bouchard S Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Jehanno C, Robitaille J, Bouchard S. Avis sur l'impact de la baisse du prix maximal payable sur la classe des inhibiteurs de la pompe à protons. [Notice of the impact of the decrease of the maximum payable amount for the class

2015 Health Technology Assessment (HTA) Database.

46. Proton pump inhibitors: very low risk of subacute cutaneous lupus erythematosus

Proton pump inhibitors: very low risk of subacute cutaneous lupus erythematosus Proton pump inhibitors: very low risk of subacute cutaneous lupus erythematosus - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Proton pump inhibitors: very low risk of subacute cutaneous lupus erythematosus Proton pump inhibitors (PPIs) are associated with very infrequent cases of subacute cutaneous lupus erythematosus (SCLE), a non-scarring dermatosis that can develop in sun-exposed areas (...) . Published 8 September 2015 From: Therapeutic area: , Contents If a patient treated with a proton pump inhibitor ( Proton pump inhibitors A review of medical records of patients at a dermatology unit in a university hospital in Denmark identified 19 cases of A further 17 cases of Cumulatively, of the cases reviewed from literature and from case reports submitted by Sandholdt LH and others. Proton pump inhibitor-induced subacute cutaneous lupus erythematosus. Br J Dermatol 2014; 170: 342–51. Almebayadh M

2015 MHRA Drug Safety Update

47. Proton Pump Inhibitors for Gastrointestinal Conditions

of Clinical Effectiveness and Cost-Effectiveness DATE: 19 June 2015 CONTEXT AND POLICY ISSUES Proton pump inhibitors (PPIs) reduce acid secretion by irreversibly inhibiting the hydrogen potassium ATPase (also known as proton pump) in the gastric parietal cells. They are the most effective agents available for reducing acid secretion, and they are widely used to treat various acid-related disorders such as peptic ulcer disease, eradication of Helicobacter pylori (H. pylori), treatment and prevention (...) Proton Pump Inhibitors for Gastrointestinal Conditions Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should be considered along

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

48. Proton Pump Inhibitors in Upper GI Bleeds

Proton Pump Inhibitors in Upper GI Bleeds Emergency Medicine > Journal Club > Archive > August 2015 Toggle navigation August 2015 Proton Pump Inhibitors in Upper GI Bleeds Vignette You're working a shift in EM-­‐2 one day when you pick up a patient with the chief\ complaint of "bloody emesis." The patient is a 45 year old male with a history of chronic low back pain who takes daily naproxen (250 mg BID). His pain worsened two months ago when he was in an MVC, and he has been taking ibuprofen (...) PT/INR and PTT are normal. An NG tube is placed and returns coffee grounds with streaks of blood that do not clear after lavage with one liter of normal saline. You order a type and screen and cross him for 4 units (just incase). You call the GI fellow, thinking that the patient probably needs an upper endoscopy. The GI fellow asks that you start the patient on a continuous infusion of intravenous antoprazole. You wonder how useful IV proton pump inhibitors actually are in the setting of upper GI

2015 Washington University Emergency Medicine Journal Club

49. Change in the Proton Pump Inhibitors (PPI) terms for coverage: a follow-up

Change in the Proton Pump Inhibitors (PPI) terms for coverage: a follow-up Suivi de la mesure de remboursement des inhibiteurs de la pompe à protons (IPP) [Change in the Proton Pump Inhibitors (PPI) terms for coverage: a follow-up] Suivi de la mesure de remboursement des inhibiteurs de la pompe à protons (IPP) [Change in the Proton Pump Inhibitors (PPI) terms for coverage: a follow-up] Régie de l'assurance maladie du Québec, Jehanno C, Baril J, Chamberland C Record Status (...) This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Régie de l'assurance maladie du Québec, Jehanno C, Baril J, Chamberland C. Suivi de la mesure de remboursement des inhibiteurs de la pompe à protons (IPP). [Change in the Proton Pump Inhibitors (PPI) terms for coverage: a follow-up] Quebec: Institut national d'excellence en sante et en services sociaux (INESSS). 2014 Authors

2014 Health Technology Assessment (HTA) Database.

50. Proton Pump Inhibitors Versus Histamine 2 Receptor Antagonists for Stress Ulcer Prophylaxis in Critically Ill Patients: A Systematic Review and Meta-Analysis

Proton Pump Inhibitors Versus Histamine 2 Receptor Antagonists for Stress Ulcer Prophylaxis in Critically Ill Patients: A Systematic Review and Meta-Analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2014 PedsCCM Evidence-Based Journal Club

51. Proton Pump Inhibitors: Acid Suppression with a Nutritional Cost

Proton Pump Inhibitors: Acid Suppression with a Nutritional Cost Proton Pump Inhibitors: Acid Suppression with a Nutritional Cost – Clinical Correlations Search Proton Pump Inhibitors: Acid Suppression with a Nutritional Cost June 13, 2014 5 min read By Dana Zalkin Peer Reviewed In the late 1970s evidence began to emerge that a newly discovered pump, [1]. With this discovery, further research [2]. We now have drugs that do just that: the proton pump inhibitors (PPIs). Proton pump inhibitors (...) Nutr. 1997;66(4):750-759. 7. Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19:357-377. 8. Dharmarajan TS, Kanagala MR, Murakonda P, Lebelt AS, Norkus EP. Do acid-lowering agents affect vitamin B12 status in older adults? J Am Med Dir Assoc. 2008;9(3):162-167. doi: 10.1016/j.jamda.2007.10.004. 9. Valuck RJ, Ruscin JM. A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults. J Clin Epidemiol

2014 Clinical Correlations

52. Proton Pump Inhibitors and Clostridium Difficile Infection

Proton Pump Inhibitors and Clostridium Difficile Infection Proton Pump Inhibitors and Clostridium Difficile Infection – Clinical Correlations Search Proton Pump Inhibitors and Clostridium Difficile Infection March 20, 2014 4 min read By Aaron Smith, MD Peer Reviewed First introduced in the late 1980s, proton pump inhibitors (PPIs) have revolutionized the treatment of gastric acid-related disorders and have been described as a miracle drug by patients and physicians alike. As is often the case (...) al. Nosocomial Clostridium difficile colonisation and disease. Lancet. 1990;336(8707):97–100. [3] [4] Gurian L, Ward TT, Katon RM. Possible foodborne transmission in a case of pseudomembranous colitis due to Clostridium difficile: influence of gastrointestinal secretions on Clostridium difficile infection. Gastroenterology. 1982;83(2):465-469. [5] Kaur S, Vaishnavi C, Prasad KK, Ray P, Kochhar R. Comparative role of antibiotic and proton pump inhibitor in experimental Clostridium difficile

2014 Clinical Correlations

53. Histamine-2 Receptor Antagonists vs Proton Pump Inhibitors on Gastrointestinal Tract Hemorrhage and Infectious Complications in the Intensive Care Unit Full Text available with Trip Pro

Histamine-2 Receptor Antagonists vs Proton Pump Inhibitors on Gastrointestinal Tract Hemorrhage and Infectious Complications in the Intensive Care Unit IMPORTANCE Histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are commonly used to prevent gastrointestinal tract (GI) hemorrhage in critically ill patients. The stronger acid suppression of PPIs may reduce the rate of bleeding but enhance infectious complications, specifically pneumonia and Clostridium difficile (...) %; P < .001) occurred less frequently in the H2RA group. After adjusting for propensity score and covariates, odds ratios of GI hemorrhage (2.24; 95% CI, 1.81-2.76), pneumonia (1.2; 95% CI, 1.03-1.41), and CDI (1.29; 95% CI, 1.04-1.64) were greater with PPIs. Similar results were obtained in the propensity-matched models of 8799 patients in each cohort. CONCLUSIONS AND RELEVANCE Proton pump inhibitors are associated with greater risks of GI hemorrhage, pneumonia, and CDI than H2RAs

2014 EvidenceUpdates

54. [Notice on the reimbursement of proton pump inhibitors]

[Notice on the reimbursement of proton pump inhibitors] Avis sur le remboursement des inhibiteurs de la pompe à protons [Notice on the reimbursement of proton pump inhibitors] Avis sur le remboursement des inhibiteurs de la pompe à protons [Notice on the reimbursement of proton pump inhibitors] Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database (...) . Citation Avis sur le remboursement des inhibiteurs de la pompe à protons . [Notice on the reimbursement of proton pump inhibitors] Quebec: Institut national d'excellence en sante et en services sociaux (INESSS). ETMIS; 9(2). 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Humans; Proton Pump Inhibitors Language Published French Country of organisation Canada Province or state Quebec English summary An English language summary is available. Address for correspondence

2014 Health Technology Assessment (HTA) Database.

55. Randomised controlled trial: For proton pump inhibitor-dependent gastro-oesophageal reflux, laparoscopic fundoplication is superior to medical therapy at 5?years of follow-up

Randomised controlled trial: For proton pump inhibitor-dependent gastro-oesophageal reflux, laparoscopic fundoplication is superior to medical therapy at 5?years of follow-up For proton pump inhibitor-dependent gastro-oesophageal reflux, laparoscopic fundoplication is superior to medical therapy at 5 years of follow-up | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any (...) time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here For proton pump inhibitor-dependent gastro-oesophageal reflux

2014 Evidence-Based Medicine

56. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. Full Text available with Trip Pro

Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. Proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) suppress the production of gastric acid and thus may lead to malabsorption of vitamin B12. However, few data exist regarding the associations between long-term exposure to these medications and vitamin B12 deficiency in large population-based studies.To study the association between use of PPIs and H2RAs and vitamin B12 deficiency (...) less than 0.75 pills/d (OR, 1.63 [95% CI, 1.48-1.78]; P = .007 for interaction).Previous and current gastric acid inhibitor use was significantly associated with the presence of vitamin B12 deficiency. These findings should be considered when balancing the risks and benefits of using these medications.

2013 JAMA

57. Canadian Association of Gastroenterology position statement: Hip fracture and proton pump inhibitor therapy ? a 2013 update

Canadian Association of Gastroenterology position statement: Hip fracture and proton pump inhibitor therapy ? a 2013 update CANADIAN ASSOCIATION OF GASTROENTEROLOGY L’ASSOCIATION CANADIENNE DE GASTROENTEROLOGIE CAG/ACG National Office, 224 – 1540 Cornwall Road, Oakville, ON, Canada L6J 7W5 Telephone: 905.829.2504 Toll free: 1.888.780.0007 Fax: 905.829.0242 E-mail: CAGOffice@cag-acg.org Website: http://www.cag-acg.org CAG Position Statement: Hip fracture and proton pump inhibitor therapy (...) – a 2013 update Paul Moayyedi, Bsc, MB ChB, PhD, MPH, FRCP, FRCPC, AGAF, FACG Yuhong Yuan, MSc, MD, PhD Grigorios Leontiadis, MD, PhD on behalf of the CAG Clinical Affairs Health Canada have recently provided an information update on proton pump inhibitor (PPI) therapy and risk of fracture in April 2013 (1) stating “Several scientific studies suggest that PPI therapy may be associated with a small increased risk for fractures of the hip, wrist, or spine related to osteoporosis, a disease resulting

2013 CPG Infobase

58. Adverse cardiovascular effects of concomitant use of proton pump inhibitors and clopidogrel in patients with coronary artery disease: a systematic review and meta-analysis

Adverse cardiovascular effects of concomitant use of proton pump inhibitors and clopidogrel in patients with coronary artery disease: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2013 DARE.

59. Are proton pump inhibitors associated with the development of community-acquired pneumonia? A meta-analysis

Are proton pump inhibitors associated with the development of community-acquired pneumonia? A meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2013 DARE.

60. Systematic review with meta-analysis: Proton pump inhibitor use may be associated with an increased risk of Clostridium difficile infection

Systematic review with meta-analysis: Proton pump inhibitor use may be associated with an increased risk of Clostridium difficile infection Proton pump inhibitor use may be associated with an increased risk of Clostridium difficile infection | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using (...) your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Proton pump inhibitor use may be associated with an increased risk of Clostridium difficile infection Article Text Aetiology Systematic review

2013 Evidence-Based Medicine