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. Association of male circumcision with risk of prostatecancer: a meta-analysis. ProstateCancerProstatic Dis, 2015. 18: 352. 73. Rider, J.R., et al. Ejaculation Frequency and Risk of ProstateCancer: Updated Results with an Additional Decade of Follow-up. Eur Urol, 2016. 70: 974. 74. Brierley, J.D., et al., TNM classification of malignanttumors. UICC International Union Against Cancer. 8th edn. 2017. 75. Cooperberg, M.R., et al. The University of California, San Francisco Cancer of the Prostate Risk (...) of atypical small acinar proliferation. Can J Urol, 2017. 24: 8714. 219. Epstein, J.I., et al. Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care. J Urol, 2006. 175: 820. 220. Merrimen, J.L., et al. Multifocal high grade prostatic intraepithelial neoplasia is a significant risk factor for prostaticadenocarcinoma. J Urol, 2009. 182: 485. 221. Kronz, J.D., et al. High-grade prostatic intraepithelial neoplasia
, prostate biopsy, prostatecancer diagnosis, and definitive local treatment were determined using associated International Classification of Diseases, Ninth Revision and Current Procedural Terminology, Fourth Edition codes. RESULTS: There were approximately 6 million qualifying men with a full year of data. PSA 2018 8. Harms of Prostate -Specific Antigen ( PSA ) screening in prostatecancer : a rapid review Harms of Prostate -Specific Antigen ( PSA ) screening in prostatecancer : a rapid review Harms (...) Prostatecancer screening Top results for prostatecancer screening - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search
Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostatecancer. Multiparametric magnetic resonance imaging (MRI), with or without MRI-targeted biopsy, is an alternative test to systematic transrectal ultrasonography-guided biopsy in men suspected of having prostatecancer. At present, evidence on which test to use is insufficient to inform detailed evidence-based decision-making.To determine the diagnostic accuracy of the index tests MRI only, MRI (...) -targeted biopsy, the MRI pathway (MRI with or without MRI-targeted biopsy) and systematic biopsy as compared to template-guided biopsy as the reference standard in detecting clinically significant prostatecancer as the target condition, defined as International Society of Urological Pathology (ISUP) grade 2 or higher. Secondary target conditions were the detection of grade 1 and grade 3 or higher-grade prostatecancer, and a potential change in the number of biopsy procedures.We performed
has published a white paper to provide some guidance regarding periprocedural prophylaxis. Since prostate biopsies are also an important part of some active surveillance programs, understanding these risks and communicating them to patients is not only integral to informed consent for prostatecancer screening but also for consideration of treatment options. Once diagnosed with prostatecancer, a man is faced with the risk of overtreatment of indolent disease due to the assumption that diagnosis (...) with a malignancy must necessarily result in treatment of this malignancy. Estimates of overdiagnosis vary widely from less than 5% to more than 75% depending upon the population used with lead times of 5 to 15 years. Although prostatecancer specific mortality and the need for related palliative care is decreased by screening, quality of life may be impaired as a result due to lasting impairment in urinary, bowel, and sexual function. There is considerable distress involved in the decision making process
of malignanttumors. UICC International Union Against Cancer. 8th edn. 2017. 73. Cooperberg, M.R., et al. The University of California, San Francisco Cancer of the Prostate Risk Assessment score: a straightforward and reliable preoperative predictor of disease recurrence after radical prostatectomy. J Urol, 2005. 173: 1938. 74. Epstein, J.I., et al. The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of ProstaticCarcinoma. Am J Surg Pathol, 2005. 29: 1228 (...) as predictors for prostatecancer. J Clin Oncol, 2009. 27: 398. 133. Stephan, C., et al. The influence of prostate volume on the ratio of free to total prostate specific antigen in serum of patients with prostatecarcinoma and benign prostate hyperplasia. Cancer, 1997. 79: 104. 134. Catalona, W.J., et al. Use of the percentage of free prostate-specific antigen to enhance differentiation of prostatecancer from benign prostaticdisease: a prospective multicenter clinical trial. JAMA, 1998. 279: 1542. 135
to be followed. Monitor more closely men with abnormal findings on pre-biopsy digital rectal examination, and those whose biopsy findings included either atypical small acinar proliferation or high-grade prostatic intra-epithelial neoplasia. In addition to further PSA testing and digital rectal examination, consider prostate imaging with investigations that can help to localise the site of cancer within the prostate, and repeat biopsy using a targeted approach. EBR (D) 3.2 8.1, 8.2xiii SUMMARY OF CLINICAL (...) men per 1000 at a cost of 230 unnecessary biopsies per 1,000 men tested; and with testing at 55-70 years and a testing interval of 1 year, the reduction in metastatic disease at diagnosis was 2.6 men per 1,000 at a cost of 185 unnecessary biopsies per 1000 men tested. Expressed in approximately equivalent terms to those of Table 2.3, increasing the frequency of testing from four- yearly to yearly increases the probability that diagnosis with metastatic prostatecancer is prevented by 0.06
imaging (MRI), bone scan, and computed tomography, are often also performed, especially in men presenting with higher risk disease, to check for disease spread. Screening controversy For many reasons, PSA screening remains controversial. Advocates often base their opinions on the European Randomised study of Screening for ProstateCancer (ERSPC), which suggests that screening may reduce the long term risk of prostatecancer-specific mortality by at least 9% (relative reduction). They also note (...) that substantial observational evidence indicates a reduction in advanced disease and reduction in prostatecancer mortality, which they attribute to the introduction of PSA screening. Opponents of PSA screening highlight the indolent natural course of prostatecancer, citing systematic reviews that reported little or no impact of PSA screening on overall and prostatecancer-specific mortality. Opponents also suggest that the harms and burden from overdiagnosis and overtreatment resulting in unnecessary
the disease, while preserving continence and, if possible, potency  (B0001). Radiation therapy (RT) is another definitive treatment strategy in which a therapeutic dose of radi- ation is delivered to the tumour (either as external beam, brachytherapy, or a combination of both) while minimising the radiation to normal tissue. External beam RT (EBRT) utilises an external source of radiation to treat the prostate gland and a margin of adjacent normal tissue. Brachy- therapy directly implants a radioactive (...) source within the prostate, thus providing the highest dose of radiation. Its aim is to maximise irradiation of the tumour while minimising radiation to normal tissue  (B0001). Health problem PCa is the most common non-skin cancer in men in Europe . Localised PCa is often indolent, and has no impact on health, even without treatment [12-14] (A0002). The incidence of PCa is higher in Northern and Western Europe compared with other areas of Europe, whereas incidence rates in Eastern and Southern
Prostate-Specific Antigen Testing for ProstateCancer: Clinical Utility and Guidelines Prostate-Specific Antigen Testing for ProstateCancer: Clinical Utility and Guidelines | CADTH.ca Find the information you need Prostate-Specific Antigen Testing for ProstateCancer: Clinical Utility and Guidelines Prostate-Specific Antigen Testing for ProstateCancer: Clinical Utility and Guidelines Last updated: August 22, 2019 Project Number: RA1060-000 Product Line: Research Type: Devices and Systems (...) Report Type: Reference List Result type: Report Question What is the clinical utility of prostate-specific antigen testing for prostatecancer? What are the evidence-based guidelines on the use of prostate-specific antigen testing for prostatecancer screening? Key Message Two systematic reviews were identified regarding the clinical utility of prostate-specific antigen testing for prostatecancer. In addition, five evidence-based guidelines were identified regarding the use of prostate-specific
trends.MarketScan claims, which capture >30 million privately insured patients in the United States, were queried for all men aged 40-64 years for the years 2008-2014. PSA testing, prostate biopsy, prostatecancer diagnosis, and definitive local treatment were determined using associated International Classification of Diseases, Ninth Revision and Current Procedural Terminology, Fourth Edition codes.There were approximately 6 million qualifying men with a full year of data. PSA testing, prostate biopsy (...) PSA screening, prostate biopsy, and treatment of prostatecancer in the years surrounding the USPSTF recommendation against prostatecancer screening. The 2012 United States Preventive Services Task Force recommendation against screening for prostatecancer has impacted rates of prostate-specific antigen (PSA) screening and appears to be associated with declining prostatecancer incidence. Our objective was to characterize health care utilization that may explain these observed
Prostate-Specific Antigen (PSA)?based population screening for prostatecancer: an evidence-based analysis Prostate-Specific Antigen (PSA)–based population screening for prostatecancer: an evidence-based analysis Prostate-Specific Antigen (PSA)–based population screening for prostatecancer: an evidence-based analysis Pron G Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been (...) made for the HTA database. Citation Pron G. Prostate-Specific Antigen (PSA)–based population screening for prostatecancer: an evidence-based analysis. Toronto: Health Quality Ontario (HQO). Ontario Health Technology Assessment Series; 15(10). 2015 Authors' conclusions None of the systematic reviews of the randomized controlled screening trials for PC found a statistically significant reduction in relative risk of PC mortality or overall mortality with PSA-based population screening programs
Fluorine- or gallium- prostate-specific membrane antigen (PSMA) positron emission tomography (PET) radiotracers in the investigation of recurrent prostatecancer Fluorine- or gallium- prostate-specific membrane antigen positron emission tomography radiotracers - Health Technology Wales > Fluorine- or gallium- prostate-specific membrane antigen positron emission tomography radiotracers Fluorine- or gallium- prostate-specific membrane antigen positron emission tomography radiotracers Topic Status (...) Incomplete Fluorine- or gallium- prostate-specific membrane antigen (PSMA) positron emission tomography (PET) radiotracers in the investigation of recurrent prostatecancer. Outcome of the appraisal The adoption of 68 Ga prostate-specific membrane antigen (PSMA) positron emission tomography (PET) for the diagnosis of recurrent prostatecancer is partially supported by the evidence. The use of 68 Ga PSMA PET provides a high degree of diagnostic accuracy on which to base management decisions as compared
-staging 29 18.104.22.168 Alkaline phosphatase 29 22.214.171.124 Bone scan 29 5.3.4 New imaging modalities 29 126.96.36.199 Nodal metastases 29 188.8.131.52 Bone metastasis 30 5.3.5 Guidelines for staging of prostatecancer 30 6. DISEASE MANAGEMENT 30 6.1 Treatment: Deferred treatment (active surveillance/watchful waiting) 30 6.1.1 Introduction 30 184.108.40.206 Definition 30 220.127.116.11.1 Active surveillance 30 18.104.22.168.2 Watchful waiting 31 6.1.2 Deferred treatment of localised PCa (stage T1/T2, Nx/N0, M0) 31 22.214.171.124 Active (...) advanced Conclusions and recommendations have been rephrased and added to throughout the current document. Changed or new conclusions and recommendations can be found in sections: 126.96.36.199 Guidelines for imaging LE GR When clinical suspicion of PCa persists in spite of negative biopsies, MRI-targeted biopsies are recommended. 2b B10 PROSTATECANCER - UPDATE MARCH 2015 Table 5.2.4: Recommended terminology for reporting prostate biopsies  • Benign/negative for malignancy. If appropriate, include
for prostatecancer using prostate-specific antigen (PSA) testing. STATEMENT OF THE CLINICAL ISSUE Section: Prostatecancer is the second leading cause of cancer deaths among men in the United States, , with the estimated number of deaths exceeding 28,000 in 2012. The rationale for screening asymptomatic men for prostatecancer in the general population is the potential for reducing mortality rates through early detection of the disease. However, much controversy exists between the potential harms (...) will ultimately be diagnosed with low-risk disease, which may not have presented itself clinically over their lifetimes. For men with low-risk disease who seek treatment, it is not clear if the risk of dying as a result of prostatecancer, or any other cause, is reduced compared with men who chose active surveillance. , In the Swedish study in which men were randomly assigned to surgery or watchful waiting, cancer-specific survival was higher among men who underwent surgery. However, the study patients did
Early Detection of ProstateCancerProstateCancer: Early Detection Guideline - American Urological Association advertisement Toggle navigation About Us About the AUA Membership AUA Governance Industry Relations Education AUAUniversity Education Products & Resources Normal Histology and Important Histo-anatomic Structures Urinary Bladder Prostate Kidney Renovascular Diseases Andrenal Gland Testis Paratesticular Tumors Penis Retroperitoneum Cytology Online Learning For Medical Students Exams/LLL (...) and Quality of Care Accreditations and Reporting Patient Education Early Detection of ProstateCancer (2018) Published 2013; Reviewed and Validity Confirmed 2018 The clinical guideline on Early Detection of ProstateCancer discusses the detection of disease at an early, pre-symptomatic stage through the use of screening tools, such as PSA. Early detection allows for more conservative management, if needed, via means such as active surveillance and watchful waiting. [pdf] Panel Members H. Ballentine Carter
to nutritional sources of calcium, such as dairy products. Although more than half of the U.S. population uses and mineral supplements (at an annual cost of over 11 billion dollars), few studies include supplement use in the association of disease risk, including prostatecancer or mortality rates.[ , ] (Refer to the summary on for more information.) Preclinical/Animal Studies In vitro studies were treated with bovine milk, almond milk, milk, casein, or in a 2011 study. Treatment with bovine milk resulted (...) the impact of dietary and calcium on prostatecancer growth in . The mice were with human prostatecancer cells and were randomly assigned to receive specific diets (e.g., high calcium/vitamin D or normal calcium/no vitamin D). The mice that received the normal calcium/vitamin D-deficient diet exhibited significantly greater ( P < .05) tumor volumes than did mice that received the other diets.[ ] Human Studies Epidemiologic studies Several studies have found an association between high intakes of calcium
Clinical practice guidelines PSA Testing and Early Management of Test-Detected ProstateCancer Clinical practice guidelines PSA Testing and Early Management of Test-Detected ProstateCancer - Cancer Guidelines Wiki Skip Links Personal tools Search Navigation Cancer Council guidelines Methodology Hosted cancer guidelines Adolescents and Young Adult (AYA) guidelines Prevention Policies Social links Page actions Cite this guideline ProstateCancer Foundation of Australia and Cancer Council (...) Australia PSA Testing Guidelines Expert Advisory Panel. Clinical practice guidelines PSA Testing and Early Management of Test-Detected ProstateCancer. Sydney: Cancer Council Australia. [Version URL: , cited 2019 Mar 29]. Available from: . National Health and Medical Research Council These guidelines (recommendations) in the web-version of this guideline were approved by the Chief Executive Officer of the National Health and Medical Research Council (NHMRC) on 2 November 2015 under section 14A
that there are fewer people with undetected metastases who would otherwise be labelled as having non- metastatic disease. NICE technology appraisal guidance already recommends enzalutamide for hormone-relapsed metastatic prostatecancer before and after treatment with docetaxel. This appraisal relates to using enzalutamide at an earlier point in the treatment pathway. The committee noted that NHS England's policy stipulates that either enzalutamide or abiraterone (another antiandrogen) is to be offered only once (...) stopping treatment may speed up metastasis. The clinical experts commented that bicalutamide and dexamethasone are sometimes used for hormone-relapsed non-metastatic disease, but that the evidence for their effectiveness is limited. The committee considered ADT to be the standard of care in patients with hormone-relapsed prostatecancer, and the relevant comparator in this appraisal. The compan The company's definition of high risk does not closely match what is considered high y's definition of high