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Latest & greatest articles for prostate cancer
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Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostatecancer (SYNERGY trial): a phase 3, multicentre, open-label, randomised trial 28283282 2017 03 11 2017 06 08 2017 06 08 1474-5488 18 4 2017 Apr The Lancet. Oncology Lancet Oncol. Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostatecancer (SYNERGY trial): a phase 3, multicentre, open-label, randomised trial. 473-485 S1470 (...) -2045(17)30168-7 10.1016/S1470-2045(17)30168-7 Clusterin is a chaperone protein associated with treatment resistance and upregulated by apoptotic stressors such as chemotherapy. Custirsen is a second-generation antisense oligonucleotide that inhibits clusterin production. The aim of the SYNERGY trial was to investigate the effect of custirsen in combination with docetaxel and prednisone on overall survival in patients with metastatic castration-resistant prostatecancer. SYNERGY was a phase 3
The Diagnosis and Treatment of ProstateCancer: A Review. Importance: Prostatecancer is the most common cancer diagnosis made in men with more than 160 000 new cases each year in the United States. Although it often has an indolent course, prostatecancer remains the third-leading cause of cancer death in men. Observations: When prostatecancer is suspected, tissue biopsy remains the standard of care for diagnosis. However, the identification and characterization of the disease have become (...) increasingly precise through improved risk stratification and advances in magnetic resonance and functional imaging, as well as from the emergence of biomarkers. Multiple management options now exist for men diagnosed with prostatecancer. Active surveillance (the serial monitoring for disease progression with the intent to cure) appears to be safe and has become the preferred approach for men with less-aggressive prostatecancer, particularly those with a prostate-specific antigen level of less than 10 ng
Abiraterone plus Prednisone in Metastatic, Castration-Sensitive ProstateCancer. Background Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostatecancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostatecancer. Methods In this double-blind, placebo-controlled, phase 3 trial (...) observed in the abiraterone group, including the time until pain progression, next subsequent therapy for prostatecancer, initiation of chemotherapy, and prostate-specific antigen progression (P<0.001 for all comparisons), along with next symptomatic skeletal events (P=0.009). These findings led to the unanimous recommendation by the independent data and safety monitoring committee that the trial be unblinded and crossover be allowed for patients in the placebo group to receive abiraterone. Rates
Abiraterone for ProstateCancer Not Previously Treated with Hormone Therapy. Background Abiraterone acetate plus prednisolone improves survival in men with relapsed prostatecancer. We assessed the effect of this combination in men starting long-term androgen-deprivation therapy (ADT), using a multigroup, multistage trial design. Methods We randomly assigned patients in a 1:1 ratio to receive ADT alone or ADT plus abiraterone acetate (1000 mg daily) and prednisolone (5 mg daily) (combination (...) therapy). Local radiotherapy was mandated for patients with node-negative, nonmetastatic disease and encouraged for those with positive nodes. For patients with nonmetastatic disease with no radiotherapy planned and for patients with metastatic disease, treatment continued until radiologic, clinical, or prostate-specific antigen (PSA) progression; otherwise, treatment was to continue for 2 years or until any type of progression, whichever came first. The primary outcome measure was overall survival
The 4Kscore blood test accurately identifies men with aggressive prostatecancer prior to prostate biopsy with or without DRE information 28497893 2017 05 12 2017 06 14 1742-1241 71 6 2017 Jun International journal of clinical practice Int. J. Clin. Pract. The 4Kscore blood test accurately identifies men with aggressive prostatecancer prior to prostate biopsy with or without DRE information. 10.1111/ijcp.12943 The 4Kscore Test is a prebiopsy blood test that incorporates four prostate protein (...) biomarkers along with patient clinical information to determine a man's risk for high-grade, aggressive (Gleason ≥7) prostatecancer. However, some men likely to benefit from the test may be seen in primary care settings where the digital rectal examination (DRE) information is not always obtained. In this study, we assessed the clinical validity of the 4Kscore Test when the DRE information was not included in the algorithm. The Prospective 4Kscore Validation Study enrolled 1012 men scheduled
Vasectomy and ProstateCancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) 28375714 2017 04 04 2017 04 25 2017 06 09 1527-7755 35 12 2017 Apr 20 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Vasectomy and ProstateCancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC). 1297-1303 10.1200/JCO.2016.70.0062 Purpose Vasectomy is a commonly used form of male sterilization (...) , and some studies have suggested that it may be associated with an increased risk of prostatecancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostatecancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostatecancer. Patients and Methods A total of 84,753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information
Moderate Hypofractionation in High-Risk, Organ-Confined ProstateCancer: Final Results of a Phase III Randomized Trial 28355113 2017 03 29 2017 06 07 1527-7755 35 17 2017 Jun 10 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Moderate Hypofractionation in High-Risk, Organ-Confined ProstateCancer: Final Results of a Phase III Randomized Trial. 1891-1897 10.1200/JCO.2016.70.4189 Purpose To report the final results on treatment outcomes (...) of a randomized trial comparing conventional and hypofractionated radiotherapy in high-risk, organ-confined prostatecancer (PCa). Patients and Methods This single-institution, randomized clinical trial, conducted from January 2003 to December 2007, enrolled 168 patients with high-risk PCa who were randomly assigned in a 1:1 ratio to conventional (80 Gy in 40 fractions in 8 weeks) or hypofractionated radiotherapy (62 Gy in 20 fractions in 5 weeks) to prostate and seminal vesicles. The primary outcome measure
High-Intensity focused ultrasound for salvage therapy of recurrent prostatecancer High-Intensity focused ultrasound for salvage therapy of recurrent prostatecancer High-Intensity focused ultrasound for salvage therapy of recurrent prostatecancer HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. High-Intensity focused ultrasound (...) for salvage therapy of recurrent prostatecancer. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions High-intensity focused ultrasound (HIFU) is a minimally invasive (transrectal) treatment that generates heat through sound energy to destroy tumor tissue. Sound waves produced by an ultrasonic transducer mounted on an endorectal probe penetrate the rectal wall and ablate either the entire prostate gland or focal areas containing tumor while avoiding damage to normal tissue. Rationale
Brachytherapy for Patients with ProstateCancer: American Society of Clinical Oncology/Cancer Care Ontario Joint Guideline Update Genitourinary Cancer | ASCO Search form Search ASCO Family of Sites ASCOconnection.org features blogs from ASCO members, the online version of the membership magazine, a discussion area, working groups, and links to the ASCO Membership Directory, Career Center, and Volunteer Portal. ASCO’s growing roster of cutting-edge journals serves readers as the most credible (...) , authoritative, peer-reviewed resources for significant clinical oncology research and research that informs the delivery of efficient, high-quality cancer care across the globe. ASCO University serves as a comprehensive eLearning and mobile learning center that supports lifelong learning for physicians, advanced practice providers, and patient educators at every stage of their careers. A cutting-edge health information technology platform, CancerLinQ™ enables practitioners to learn from individual patients
Association Between Choice of Radical Prostatectomy, External Beam Radiotherapy, Brachytherapy, or Active Surveillance and Patient-Reported Quality of Life Among Men With Localized ProstateCancer. Importance: Patients diagnosed with localized prostatecancer have to decide among treatment strategies that may differ in their likelihood of adverse effects. Objective: To compare quality of life (QOL) after radical prostatectomy, external beam radiotherapy, and brachytherapy vs active surveillance (...) . Design, Setting, and Participants: Population-based prospective cohort of 1141 men (57% participation among eligible men) with newly diagnosed prostatecancer were enrolled from January 2011 through June 2013 in collaboration with the North Carolina Central Cancer Registry. Median time from diagnosis to enrollment was 5 weeks, and all men were enrolled with written informed consent prior to treatment. Final follow-up date for current analysis was September 9, 2015. Exposures: Treatment with radical
Association Between Radiation Therapy, Surgery, or Observation for Localized ProstateCancer and Patient-Reported Outcomes After 3 Years. Importance: Understanding the adverse effects of contemporary approaches to localized prostatecancer treatment could inform shared decision making. Objective: To compare functional outcomes and adverse effects associated with radical prostatectomy, external beam radiation therapy (EBRT), and active surveillance. Design, Setting, and Participants: Prospective (...) , population-based, cohort study involving 2550 men (≤80 years) diagnosed in 2011-2012 with clinical stage cT1-2, localized prostatecancer, with prostate-specific antigen levels less than 50 ng/mL, and enrolled within 6 months of diagnosis. Exposures: Treatment with radical prostatectomy, EBRT, or active surveillance was ascertained within 1 year of diagnosis. Main Outcomes and Measures: Patient-reported function on the 26-item Expanded ProstateCancer Index Composite (EPIC) 36 months after enrollment
Lutetium 177 PSMA radionuclide therapy for men with prostatecancer: a review of the current literature and discussion of practical aspects of therapy 28303694 2017 04 25 2018 11 13 2051-3909 64 1 2017 Mar Journal of medical radiation sciences J Med Radiat Sci Lutetium 177 PSMA radionuclide therapy for men with prostatecancer: a review of the current literature and discussion of practical aspects of therapy. 52-60 10.1002/jmrs.227 Prostate-specific membrane antigen (PSMA) is a receptor (...) on the surface of prostatecancer cells that is revolutionising the way we image and treat men with prostatecancer. New small molecule peptides with high-binding affinity for the PSMA receptor have allowed high quality, highly specific PET imaging, in addition to the development of targeted radionuclide therapy for men with prostatecancer. This targeted therapy for prostatecancer has, to date, predominately used Lutetium 177 (Lu) labelled PSMA peptides. Early clinical studies evaluating the safety
First Australian experience of treating localised prostatecancer patients with CyberKnife stereotactic radiotherapy: early PSA response, acute toxicity and quality of life 28271639 2018 04 30 2018 11 13 2051-3909 64 3 2017 Sep Journal of medical radiation sciences J Med Radiat Sci First Australian experience of treating localised prostatecancer patients with CyberKnife stereotactic radiotherapy: early PSA response, acute toxicity and quality of life. 180-187 10.1002/jmrs.205 This study (...) is to evaluate biochemical response, acute toxicity and health-related quality-of-life (QOL) outcomes among prostatecancer patients following stereotactic body radiation therapy (SBRT) in the first Australian CyberKnife facility. Forty-five consecutive patients with clinically localised prostatecancer were treated with SBRT using CyberKnife technology and enrolled in this study. Protocol treatment consisted of 36.25 Gy in five fractions. PSA and acute toxicity was assessed at each follow-up visit and QOL
Initial experience with intraâ€fraction motion monitoring using Calypso guided volumetric modulated arc therapy for definitive prostatecancer treatment 28263041 2017 04 25 2018 12 02 2051-3909 64 1 2017 Mar Journal of medical radiation sciences J Med Radiat Sci Initial experience with intra-fraction motion monitoring using Calypso guided volumetric modulated arc therapy for definitive prostatecancer treatment. 25-34 10.1002/jmrs.224 Accurate delivery of radiation while reducing dose (...) Leonards, New South Wales, Australia. Barnes Mardi M Northern Sydney Cancer Centre, Radiation Oncology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia. Booth Jeremy T JT Northern Sydney Cancer Centre, Radiation Oncology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia. eng Journal Article 2017 03 06 United States J Med Radiat Sci 101620352 2051-3895 IM Dose Fractionation, Radiation Humans Male Movement ProstaticNeoplasms physiopathology
Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic Chemotherapy-Naive Castration-Resistant ProstateCancer 28034081 2016 12 30 2017 02 10 1527-7755 35 1 2017 Jan Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic (...) Chemotherapy-Naive Castration-Resistant ProstateCancer. 40-47 Purpose Ipilimumab increases antitumor T-cell responses by binding to cytotoxic T-lymphocyte antigen 4. We evaluated treatment with ipilimumab in asymptomatic or minimally symptomatic patients with chemotherapy-naive metastatic castration-resistant prostatecancer without visceral metastases. Patients and Methods In this multicenter, double-blind, phase III trial, patients were randomly assigned (2:1) to ipilimumab 10 mg/kg or placebo every 3
Diffusion-weighted endorectal MR imaging at 3T for prostatecancer: Correlation with tumor cell density and percentage Gleason pattern on whole mount pathology 27770164 2018 03 28 2018 11 13 2366-0058 42 3 2017 03 Abdominal radiology (New York) Abdom Radiol (NY) Diffusion-weighted endorectal MR imaging at 3T for prostatecancer: correlation with tumor cell density and percentage Gleason pattern on whole mount pathology. 918-925 10.1007/s00261-016-0942-1 To determine if tumor cell density (...) and percentage of Gleason pattern within an outlined volumetric tumor region of interest (TROI) on whole-mount pathology (WMP) correlate with apparent diffusion coefficient (ADC) values on corresponding TROIs outlined on pre-operative MRI. Men with biopsy-proven prostate adenocarcinoma undergoing multiparametric MRI (mpMRI) prior to prostatectomy were consented to this prospective study. WMP and mpMRI images were viewed using 3D Slicer and each TROI from WMP was contoured on the high b-value ADC maps (b0
Pretreatment prostate specific antigen doubling time as prognostic factor in prostatecancer patients 28484728 2018 11 13 2331-4737 4 1-2 2017 Jan Oncoscience Oncoscience Pretreatment prostate specific antigen doubling time as prognostic factor in prostatecancer patients. 7-13 10.18632/oncoscience.337 Despite the prostate-specific antigen (PSA) serum level commonly uses as tumor marker in diagnosis of prostatecancer, it seems that PSA doubling time (PSADT) could be more useful indicator (...) of tumor behavior and of prognosis for patients. The results of hormone and radiation therapy were evaluated for 912 prostatecancer having at least 2 PSA tests before the treatment was started. Clustering procedure (selection of homogenous group) was performed by using PSADT as the classification marker. The rate of PSADT was estimated for different dissemination rate, age, Gleasons's score and education level. PSADT index inversely correlated with the rate of prostatecancer dissemination, Gleason's