Latest & greatest articles for promethazine

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on promethazine or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on promethazine and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for promethazine

1. Promethazine

Promethazine Top results for promethazine - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for promethazine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you

2018 Trip Latest and Greatest

2. Promethazine

Promethazine USE OF PROMETHAZINE IN PREGNANCY 0344 892 0909 USE OF PROMETHAZINE IN PREGNANCY (Date of issue: September 2015 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary (...) patient may be eligible to enrol in a randomised control trial to investigate the best treatment for Hyperemesis Gravidarum (severe pregnancy sickness). Please visit the to find out more. ………………………………………………………………………………………………………………………………………………………… Promethazine is a first generation (sedating) phenothiazine antihistamine used in the treatment of nausea and vomiting, allergy such as hay fever and urticaria, emergency treatment of anaphylactic reactions, and for sedation. Studies (including two small

2014 UK Teratology Information Service

3. Rapid tranquillisation in mental health settings: promethazine hydrochloride

Rapid tranquillisation in mental health settings: promethazine hydrochloride Rapid tr Rapid tranquillisation in mental health settings: anquillisation in mental health settings: promethazine h promethazine hy ydrochloride drochloride Evidence summary Published: 11 March 2014 nice.org.uk/guidance/esuom28 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2014. See summaries of product characteristics (SPCs), British (...) national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary A Cochrane review (Huf et al. 2009; 4 randomised controlled trials [RCTs], n=1117) provides limited evidence that intramuscular haloperidol plus promethazine is effective for the rapid tranquillisation of people with agitation or aggression associated with mental illness. However, it is difficult to draw any firm conclusions because the results are heterogeneous. In addition, the results were not relevant to UK

2014 National Institute for Health and Clinical Excellence - Advice

4. Haloperidol plus promethazine for psychosis-induced aggression. (PubMed)

Haloperidol plus promethazine for psychosis-induced aggression. Health services often manage agitated or violent people, and such behaviour is particularly prevalent in emergency psychiatric services (10%). The drugs used in such situations should ensure that the person becomes calm swiftly and safely.To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression.On 6 May 2015 we searched the Cochrane Schizophrenia Group's Register of Trials, which (...) is compiled by systematic searches of major resources (including MEDLINE, EMBASE, AMED, BIOSIS, CINAHL, PsycINFO, PubMed, and registries of clinical trials) and their monthly updates, handsearches, grey literature, and conference proceedings.All randomised clinical trials with useable data focusing on haloperidol plus promethazine for psychosis-induced aggression.We independently extracted data. For binary outcomes, we calculated risk ratio (RR) and its 95% confidence interval (CI), on an intention

Full Text available with Trip Pro

2016 Cochrane

5. Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi

Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12.5 mg) with hydrocodone 7.5 mg

2019 EvidenceUpdates

6. Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? (PubMed)

Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? Vertigo is a common annoying complaint needing emergent treatment. There are various treatment options for this condition with different outcomes and side effects.Assessment and comparison of the effectiveness of Ondansetron and Promethazine in the treatment of acute peripheral vertigo.This clinical trial was conducted in an academic hospital in the north of Iran in 2017. A total of 170 eligible (...) patients were randomly allocated to groups A: received intramuscular (IM) promethazine; and B: received intravenous (IV) Ondansetron, using quadripartite blocks. The severity of vertigo, nausea, blood pressure, heart rate, side-effects, need for re-administration, and the time to become asymptomatic were assessed before the injections, 30 min after and 2 h after the injections.Excellent improvement in vertigo occurred in both groups (P < 0.001), with a more significant reduction in the promethazine

2018 American Journal of Otolaryngology Controlled trial quality: uncertain

7. A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoper (PubMed)

A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoper Postoperative nausea and vomiting (PONV) is among the most common distressing complications of surgery under anesthesia. Previous studies have demonstrated that patients who undergo craniotomy have incidences of nausea and vomiting as high (...) as 50-70%. The main purpose of this pilot study is to assess the incidence of PONV by using two different prophylactic regimens in subjects undergoing a craniotomy. Thus, we designed this study to assess the efficacy and safety of triple therapy with the combination of dexamethasone, promethazine, and aprepitant versus ondansetron to reduce the incidence of PONV in patients undergoing craniotomy.This is a prospective, single center, two-armed, randomized, double-dummy, double-blind, pilot study

Full Text available with Trip Pro

2016 Frontiers in medicine Controlled trial quality: predicted high

8. Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. (PubMed)

Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. Frequently, patients identified as high risk for postoperative nausea and vomiting (PONV) are treated prophylactically with intravenous (IV) ondansetron and postoperatively with IV promethazine. The purpose of this study was to determine if using an aromatic therapy of 70% isopropyl alcohol (IPA) would be more (...) effective than promethazine in resolution of breakthrough PONV symptoms in groups of high-risk patients administered prophylactic ondansetron. All subjects enrolled were identified as high risk for PONV, administered general anesthesia and a prophylactic antiemetic of 4 mg of IV ondansetron, and randomized to receive IPA or promethazine for treatment of breakthrough PONV Demographics, verbal numeric rating scale (VNRS) scores for nausea, time to 50% reduction in VNRS scores, and overall antiemetic

2009 AANA journal Controlled trial quality: uncertain

9. Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine. (PubMed)

Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine. To determine whether haloperidol alone results in swifter and safer tranquillisation and sedation than haloperidol plus promethazine.Pragmatic randomised open trial (January-July 2004).Psychiatric emergency room, Rio de Janeiro, Brazil.316 patients who needed urgent intramuscular sedation because of agitation (...) , dangerous behaviour, or both.Open treatment with intramuscular haloperidol 5-10 mg or intramuscular haloperidol 5-10 mg plus intramuscular promethazine up to 50 mg; doses were at the discretion of the prescribing clinician.The primary outcome was proportion tranquil or asleep by 20 minutes. Secondary outcomes were asleep by 20 minutes; tranquil or asleep by 40, 60, and 120 minutes; physically restrained or given additional drugs within 2 hours; severe adverse events; another episode of agitation

Full Text available with Trip Pro

2007 BMJ Controlled trial quality: predicted high

10. Promethazine

Promethazine Promethazine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Promethazine Promethazine Aka: Promethazine , Phenergan From (...) Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours Maximum: 25 mg per dose VIII. Efficacy Less effective than ( ) in ER patients Sedation may delay Emergency Department discharge IX. References Johnson (1993) Harriet Lane, Mosby, p. 521 (2002) Tarascon Pocket Pharmacopoeia, p. 67 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Promethazine." Click on the image (or right click) to open the source website in a new browser window. Related

2018 FP Notebook

11. Promethazine and Oral Midazolam Preanesthetic Children Medication. (PubMed)

Promethazine and Oral Midazolam Preanesthetic Children Medication. Several kinds of drugs have been investigated in preschool children as a preanesthetic sedation after various routes of administration for surgeries. This study aims to compare the efficacy of promethazine and oral midazolam for premedication in children aged 3 to 9 years who were scheduled for surgeries.This is a double-blind randomized controlled study conducted on 93 patients between the age of 3 and 9 years at Loresten (...) University of Medical Sciences Teaching Hospital, Khoramabad, Iran. The subjects were grouped into P (promethazine), M (midazolam), and C (control). About 0.3 mg/kg of oral promethazine was administered to patients in group P, 0.5 mg/kg of oral midazolam was administered to patients in group M, and 3 mL of normal saline as placebo was administered to patients in group C. Patient satisfaction, sedation and emotional score, systolic blood pressure (SBP), diastolic blood pressure, respiratory rate (RR

2018 Pediatric Emergency Care Controlled trial quality: uncertain

12. Promethazine

Promethazine Promethazine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Promethazine Promethazine Aka: Promethazine , Phenergan From (...) Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours Maximum: 25 mg per dose VIII. Efficacy Less effective than ( ) in ER patients Sedation may delay Emergency Department discharge IX. References Johnson (1993) Harriet Lane, Mosby, p. 521 (2002) Tarascon Pocket Pharmacopoeia, p. 67 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Promethazine." Click on the image (or right click) to open the source website in a new browser window. Related

2015 FP Notebook

13. Haloperidol plus promethazine effective for psychosis induced aggression

Haloperidol plus promethazine effective for psychosis induced aggression Haloperidol plus promethazine effective for psychosis induced aggression | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username (...) * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Haloperidol plus promethazine effective for psychosis induced aggression Article Text Therapeutics Haloperidol plus promethazine effective for psychosis induced aggression Statistics from Altmetric.com Question Question: Is haloperidol plus

2010 Evidence-Based Mental Health

14. Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment

Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01814189 Recruitment Status : Completed First Posted : March 19, 2013 Last Update Posted : July 30, 2013 Sponsor: Shahid Beheshti University of Medical

2013 Clinical Trials

15. Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED

Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00655642 Recruitment Status : Terminated (Conditional analysis

2008 Clinical Trials

16. Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. (PubMed)

Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. Addicted patients present difficulties for pain management because they have another problem besides their pain. Adding adjuvants to opioid pumps to intensify quality, control other problems, lengthen analgesia, and reduce side effects has been considered in the field.The objective of this study was to evaluate the analgesic effects (...) of adding clonidine, promethazine, chlorpromazine, and midazolam to morphine in patient-controlled intravenous analgesia (PCIA) in orthopedic patients with addiction problems.90 patients with histories of substance abuse were enrolled in this randomized controlled trial. Patients were randomly divided into three groups. The first group received 20 mg of morphine sulfate +50 mg of chlorpromazine + 50 mg of promethazine +10 mg of midazolam (M20P). The second group received the first group's regimen plus

Full Text available with Trip Pro

2015 Anesthesiology and pain medicine Controlled trial quality: uncertain

17. Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children

Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01118884 Recruitment Status : Unknown Verified April 2010 by Shahid Beheshti University. Recruitment status

2010 Clinical Trials

18. Comparison Effect of Promethazine/Dexamethasone and Metoclopramide /Dexamethasone on Postoperative Nausea and Vomiting after Laparascopic Gastric Placation: A Randomized Clinical Trial (PubMed)

Comparison Effect of Promethazine/Dexamethasone and Metoclopramide /Dexamethasone on Postoperative Nausea and Vomiting after Laparascopic Gastric Placation: A Randomized Clinical Trial Laparoscopic gastric plication (LGP) is a technique in the restrictive category of bariatric procedures that reduces the gastric volume and increases intragastric pressure. Nausea and vomiting are the most common complications after this procedure. The goal of this research is to compare the combined effect (...) of promethazine/dexamethasone versus Metoclopramide/ dexamethasone on the prevention of nausea and vomiting after LGP.In recovery, the patients were divided into two groups, the Metoclopramide group which was given Metoclopramide 10 mg plus dexamethasone 4 mg/8 hours intravenous for 48 hours, and the promethazine group which was given promethazine 50 mg /12 hours, intramuscular for the first 24 hours and then promethazine 25 mg/12 hours for the next 24 hours plus dexamethasone 4 mg/8 hours intravenous for 48

Full Text available with Trip Pro

2017 Anesthesiology and pain medicine Controlled trial quality: uncertain

19. Cochrane review suggests adding promethazine to haloperidol to rapidly tranquillise psychotic patients with fewer side effects

Cochrane review suggests adding promethazine to haloperidol to rapidly tranquillise psychotic patients with fewer side effects Cochrane review suggests adding promethazine to haloperidol to rapidly tranquillise psychotic patients with fewer side effects Search National Elf Service Search National Elf Service » » » » Cochrane review suggests adding promethazine to haloperidol to rapidly tranquillise psychotic patients with fewer side effects Dec 4 2012 Posted by The hallucinations and delusions (...) , n = 67, RR 8.25, CI 0.46 to 147.45; required antiparkinson medication RR 2.74, CI 0.81 to 9.25) 1 more reliable RCT compared haloperidol alone with promethazine and haloperidol in combination and found: More patients on haloperidol alone were not tranquil or asleep by 20 minutes (RR 1.60, CI 1.18 to 2.16) Significantly more patients on haloperidol alone experienced one or more side effects (RR 11.28, CI 1.47 to 86.35) Acute dystonia for patients just taking haloperidol was so common

2012 The Mental Elf

20. A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults. (PubMed)

A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults. The objective of the study was to assess whether ondansetron has superior nausea reduction compared with metoclopramide, promethazine, or saline placebo in emergency department (ED) adults.This randomized, placebo-controlled, double-blinded superiority trial was intended to enroll a convenience sample of 600 patients. Nausea was evaluated on a 100-mm visual analog scale (VAS) at baseline and 30 (...) minutes after treatment. Patients with a minimum preenrollment VAS of 40 mm were randomized to intravenous ondansetron 4 mg, metoclopramide 10 mg, promethazine 12.5 mg, or saline placebo. A 12-mm VAS improvement in nausea severity was deemed clinically important. We measured potential drug adverse effects at baseline and 30 minutes. Patients received approximately 500 mL of saline hydration during the initial 30 minutes.Of 180 subjects who consented, 163 completed the study. The median age was 32

2011 American Journal of Emergency Medicine Controlled trial quality: predicted high