Latest & greatest articles for promethazine

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on promethazine or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on promethazine and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for promethazine

1. Promethazine

Promethazine Top results for promethazine - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for promethazine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you

2018 Trip Latest and Greatest

2. Promethazine

Promethazine USE OF PROMETHAZINE IN PREGNANCY 0344 892 0909 USE OF PROMETHAZINE IN PREGNANCY (Date of issue: September 2015 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary (...) patient may be eligible to enrol in a randomised control trial to investigate the best treatment for Hyperemesis Gravidarum (severe pregnancy sickness). Please visit the to find out more. ………………………………………………………………………………………………………………………………………………………… Promethazine is a first generation (sedating) phenothiazine antihistamine used in the treatment of nausea and vomiting, allergy such as hay fever and urticaria, emergency treatment of anaphylactic reactions, and for sedation. Studies (including two small

2014 UK Teratology Information Service

3. Rapid tranquillisation in mental health settings: promethazine hydrochloride

Rapid tranquillisation in mental health settings: promethazine hydrochloride Rapid tr Rapid tranquillisation in mental health settings: anquillisation in mental health settings: promethazine h promethazine hy ydrochloride drochloride Evidence summary Published: 11 March 2014 nice.org.uk/guidance/esuom28 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2014. See summaries of product characteristics (SPCs), British (...) national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary A Cochrane review (Huf et al. 2009; 4 randomised controlled trials [RCTs], n=1117) provides limited evidence that intramuscular haloperidol plus promethazine is effective for the rapid tranquillisation of people with agitation or aggression associated with mental illness. However, it is difficult to draw any firm conclusions because the results are heterogeneous. In addition, the results were not relevant to UK

2014 National Institute for Health and Clinical Excellence - Advice

4. Haloperidol plus promethazine for psychosis-induced aggression. (PubMed)

Haloperidol plus promethazine for psychosis-induced aggression. Health services often manage agitated or violent people, and such behaviour is particularly prevalent in emergency psychiatric services (10%). The drugs used in such situations should ensure that the person becomes calm swiftly and safely.To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression.On 6 May 2015 we searched the Cochrane Schizophrenia Group's Register of Trials, which (...) is compiled by systematic searches of major resources (including MEDLINE, EMBASE, AMED, BIOSIS, CINAHL, PsycINFO, PubMed, and registries of clinical trials) and their monthly updates, handsearches, grey literature, and conference proceedings.All randomised clinical trials with useable data focusing on haloperidol plus promethazine for psychosis-induced aggression.We independently extracted data. For binary outcomes, we calculated risk ratio (RR) and its 95% confidence interval (CI), on an intention

Full Text available with Trip Pro

2016 Cochrane

5. Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children

Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01118884 Recruitment Status : Unknown Verified April 2010 by Shahid Beheshti University. Recruitment status

2010 Clinical Trials

6. Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. (PubMed)

Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. Frequently, patients identified as high risk for postoperative nausea and vomiting (PONV) are treated prophylactically with intravenous (IV) ondansetron and postoperatively with IV promethazine. The purpose of this study was to determine if using an aromatic therapy of 70% isopropyl alcohol (IPA) would be more (...) effective than promethazine in resolution of breakthrough PONV symptoms in groups of high-risk patients administered prophylactic ondansetron. All subjects enrolled were identified as high risk for PONV, administered general anesthesia and a prophylactic antiemetic of 4 mg of IV ondansetron, and randomized to receive IPA or promethazine for treatment of breakthrough PONV Demographics, verbal numeric rating scale (VNRS) scores for nausea, time to 50% reduction in VNRS scores, and overall antiemetic

2009 AANA journal

7. Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine. (PubMed)

Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine. To determine whether haloperidol alone results in swifter and safer tranquillisation and sedation than haloperidol plus promethazine.Pragmatic randomised open trial (January-July 2004).Psychiatric emergency room, Rio de Janeiro, Brazil.316 patients who needed urgent intramuscular sedation because of agitation (...) , dangerous behaviour, or both.Open treatment with intramuscular haloperidol 5-10 mg or intramuscular haloperidol 5-10 mg plus intramuscular promethazine up to 50 mg; doses were at the discretion of the prescribing clinician.The primary outcome was proportion tranquil or asleep by 20 minutes. Secondary outcomes were asleep by 20 minutes; tranquil or asleep by 40, 60, and 120 minutes; physically restrained or given additional drugs within 2 hours; severe adverse events; another episode of agitation

Full Text available with Trip Pro

2007 BMJ

8. Haloperidol plus promethazine effective for psychosis induced aggression

Haloperidol plus promethazine effective for psychosis induced aggression Haloperidol plus promethazine effective for psychosis induced aggression | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username (...) * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Haloperidol plus promethazine effective for psychosis induced aggression Article Text Therapeutics Haloperidol plus promethazine effective for psychosis induced aggression Statistics from Altmetric.com Question Question: Is haloperidol plus

2010 Evidence-Based Mental Health

9. Promethazine and Oral Midazolam Preanesthetic Children Medication. (PubMed)

Promethazine and Oral Midazolam Preanesthetic Children Medication. Several kinds of drugs have been investigated in preschool children as a preanesthetic sedation after various routes of administration for surgeries. This study aims to compare the efficacy of promethazine and oral midazolam for premedication in children aged 3 to 9 years who were scheduled for surgeries.This is a double-blind randomized controlled study conducted on 93 patients between the age of 3 and 9 years at Loresten (...) University of Medical Sciences Teaching Hospital, Khoramabad, Iran. The subjects were grouped into P (promethazine), M (midazolam), and C (control). About 0.3 mg/kg of oral promethazine was administered to patients in group P, 0.5 mg/kg of oral midazolam was administered to patients in group M, and 3 mL of normal saline as placebo was administered to patients in group C. Patient satisfaction, sedation and emotional score, systolic blood pressure (SBP), diastolic blood pressure, respiratory rate (RR

2018 Pediatric Emergency Care

10. Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. (PubMed)

Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. A battery of evoked pain tasks (PainCart) was developed to investigate the pharmacodynamic properties of novel analgesics in early-phase clinical research. As part of its clinical validation, compounds with different pharmacological mechanisms of actions are investigated. The aim was to investigate the analgesic effects of classic and nonclassic analgesics compared to a sedating (...) negative control in a randomized placebo-controlled crossover study in 24 healthy volunteers using the PainCart.The PainCart consisted of pain tasks eliciting electrical, pressure, heat, cold and inflammatory pain. Subjective scales for cognitive functioning and psychotomimetic effects were included. Subjects were administered each of the following oral treatments: paracetamol (1000 mg), Δ9-THC (10 mg), promethazine (50 mg) or matching placebo. Pharmacodynamic measurements were performed at baseline

2018 European Journal of Pain

11. Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? (PubMed)

Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? Vertigo is a common annoying complaint needing emergent treatment. There are various treatment options for this condition with different outcomes and side effects.Assessment and comparison of the effectiveness of Ondansetron and Promethazine in the treatment of acute peripheral vertigo.This clinical trial was conducted in an academic hospital in the north of Iran in 2017. A total of 170 eligible (...) patients were randomly allocated to groups A: received intramuscular (IM) promethazine; and B: received intravenous (IV) Ondansetron, using quadripartite blocks. The severity of vertigo, nausea, blood pressure, heart rate, side-effects, need for re-administration, and the time to become asymptomatic were assessed before the injections, 30 min after and 2 h after the injections.Excellent improvement in vertigo occurred in both groups (P < 0.001), with a more significant reduction in the promethazine

2018 American Journal of Otolaryngology

12. Ionophore-Based Potentiometric Sensors for the Flow-Injection Determination of Promethazine Hydrochloride in Pharmaceutical Formulations and Human Urine (PubMed)

Ionophore-Based Potentiometric Sensors for the Flow-Injection Determination of Promethazine Hydrochloride in Pharmaceutical Formulations and Human Urine Plasticised poly(vinyl chloride)-based membranes containing the ionophores (α-, β- and γ-cyclodextrins (CD), dibenzo-18-crown-6 (DB18C6) and dibenzo-30-crown-10 (DB30C10) were evaluated for their potentiometric response towards promethazine (PM) in a flow injection analysis (FIA) set-up. Good responses were obtained when β- and γ-CDs

Full Text available with Trip Pro

2011 Sensors (Basel, Switzerland)

13. Chloral Hydrate, Chloral Hydrate - Promethazine and Chloral Hydrate -Hydroxyzine Efficacy in Electroencephalography Sedation. (PubMed)

Chloral Hydrate, Chloral Hydrate - Promethazine and Chloral Hydrate -Hydroxyzine Efficacy in Electroencephalography Sedation. To compare efficacy and safety of chloral hydrate (CH), chloral hydrate and promethazine (CH + P) and chloral hydrate and hydroxyzine (CH + H) in electroencephalography (EEG) sedation.In a parallel single-blinded randomized clinical trial, ninety 1-7 y-old uncooperative kids who were referred to Pediatric Neurology Clinic of Shahid Sadoughi University, Yazd, Iran from (...) April through August 2012, were randomly assigned to receive 40 mg/kg of chloral hydrate or 40 mg/kg of chloral hydrate and 1 mg/kg of promethazine or 40 mg/kg of chloral hydrate and 2 mg/kg of hydroxyzine. The primary endpoint was efficacy in sufficient sedation (obtaining four Ramsay sedation score) and successful completion of EEG. Secondary endpoint was clinical adverse events.Thirty nine girls (43.3 %) and 51 boys (56.7 %) with mean age of 3.34 ± 1.47 y were assessed. Sufficient sedation

2014 Indian journal of pediatrics

14. Comparing the safety, efficacy and recovery of intranasal midazolam vs. oral chloral hydrate and promethazine. (PubMed)

Comparing the safety, efficacy and recovery of intranasal midazolam vs. oral chloral hydrate and promethazine. The purpose of this study was to compare the safety, efficacy and recovery time of intranasal midazolam spray administered using an atomizer to orally administered chloral hydrate and promethazine for the sedation of pediatric dental patients.A randomized double-blind crossover study design was utilized in which 31 patients (mean age 41.8 months, range 26-58 months) underwent two (...) restorative dental appointments. At one appointment, subjects received 0.2 mg/kg intranasal midazolam; at the other appointment subjects received 62.5 mg/kg chloral hydrate with 12.5 mg promethazine. Administered at each appointment was 25%-50% N(2)0/0(2). Physiologic parameters (heart rate, blood pressure, respiratory rate, oxygen saturation) and behavior assessments (crying, movement, sleep) using the Houpt Sedation Rating Scale were recorded at baseline and every five minutes during treatment. Overall

2001 Pediatric dentistry

15. Ketorolac versus meperidine-plus-promethazine treatment of migraine headache: evaluations by patients. (PubMed)

Ketorolac versus meperidine-plus-promethazine treatment of migraine headache: evaluations by patients. This study was designed to compare and contrast the speed and efficacy of meperidine (75 mg)/promethazine (25 mg) intramuscularly to ketorolac (60 mg) intramuscularly, in a double-blind study in reducing the symptoms of migraine headache. Forty-two patients who presented to the emergency department between July 1992 and February 1993, with previous diagnoses of migraine headache, were (...) considered for this study. Patients subjectively evaluated parameters of their migraine headaches (eg, pain and nausea) using a numeric scale and were later asked to reevaluate these same parameters at 30, 60, and 360 minutes after a single intramuscular injection of either ketorolac (60 mg) or meperidine (75 mg)/promethazine (25 mg). Sixty-eight percent of patients given meperidine/promethazine responded whereas 55% of patients given ketorolac responded. The responder group showed a statistically

1995 American Journal of Emergency Medicine

16. A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults. (PubMed)

A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults. The objective of the study was to assess whether ondansetron has superior nausea reduction compared with metoclopramide, promethazine, or saline placebo in emergency department (ED) adults.This randomized, placebo-controlled, double-blinded superiority trial was intended to enroll a convenience sample of 600 patients. Nausea was evaluated on a 100-mm visual analog scale (VAS) at baseline and 30 (...) minutes after treatment. Patients with a minimum preenrollment VAS of 40 mm were randomized to intravenous ondansetron 4 mg, metoclopramide 10 mg, promethazine 12.5 mg, or saline placebo. A 12-mm VAS improvement in nausea severity was deemed clinically important. We measured potential drug adverse effects at baseline and 30 minutes. Patients received approximately 500 mL of saline hydration during the initial 30 minutes.Of 180 subjects who consented, 163 completed the study. The median age was 32

2011 American Journal of Emergency Medicine

17. Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone. (PubMed)

Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone. To compare the effectiveness of intramuscular olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone as the first medication(s) used to treat patients with agitation and aggressive behavior.One hundred fifty patients with agitation caused (...) by psychotic or bipolar disorder were randomly assigned under double-blind conditions to receive olanzapine, ziprasidone, haloperidol plus midazolam, haloperidol plus promethazine or haloperidol alone. The Overt Agitation Severity Scale, Overt Aggression Scale and Ramsay Sedation Scale were applied within 12 hours after the first dosage.All medications produced a calming effect within one hour of administration, but only olanzapine and haloperidol reduced agitation by less than 10 points, and only

2011 Revista brasileira de psiquiatria (São Paulo, Brazil : 1999)

18. Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine. (PubMed)

Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine. To compare two widely used drug treatments for people with aggression or agitation due to mental illness.Pragmatic, randomised clinical trial.Three psychiatric emergency rooms in Rio de Janeiro, Brazil.301 aggressive or agitated people.Open treatment with intramuscular midazolam or intramuscular haloperidol plus promethazine.Patients tranquil (...) or sedated at 20 minutes.patients tranquil or asleep by 40, 60, and 120 minutes; restrained or given extra drugs within 2 hours; severe adverse events; another episode of agitation or aggression; needing extra visits from doctor during first 24 hours; overall antipsychotic load in first 24 hours; and not discharged by two weeks.151 patients were randomised to midazolam, and 150 to haloperidol-promethazine mix. Follow up for the primary outcome was available for 298 (99%): 134/151 (89%) of patients given

Full Text available with Trip Pro

2003 BMJ

19. Rapid tranquillisation in psychiatric emergency settings in India: pragmatic randomised controlled trial of intramuscular olanzapine versus intramuscular haloperidol plus promethazine. (PubMed)

Rapid tranquillisation in psychiatric emergency settings in India: pragmatic randomised controlled trial of intramuscular olanzapine versus intramuscular haloperidol plus promethazine. To compare the effect of intramuscular olanzapine with intramuscular haloperidol plus promethazine on rapid tranquillisation of agitated or violent people with mental illness.Pragmatic, allocation concealed, randomised controlled trial.Emergency services of a general hospital psychiatry department in Vellore (...) improved at 15, 30, 60, 120, and 240 minutes; additional medical interventions and adverse effects over four hours; and compliance with oral drugs and adverse effects over two weeks.Of 300 people randomised to receive either intramuscular olanzapine or intramuscular haloperidol plus promethazine, follow-up data were available for primary outcomes for 298 (99%). Both treatments resulted in similar proportions of people being tranquil or asleep at 15 minutes (olanzapine 131/150 (87%), haloperidol plus

Full Text available with Trip Pro

2007 BMJ

20. Efficacy of Chloral Hydrate and Promethazine for Sedation during Electroencephalography in Children; a Randomised Clinical Trial. (PubMed)

Efficacy of Chloral Hydrate and Promethazine for Sedation during Electroencephalography in Children; a Randomised Clinical Trial. The purpose of this study was to compare efficacy and safety of oral chloral hydrate (CH) and promethazine (PZ) for sedation during electroencephalography (EEG) in children.In a parallel single-blinded randomized clinical trial, sixty 1-10 year old children referred to EEG Unit of Shahid Sadoughi Hospital from January 2010 to February 2011 in Yazd, Iran, were (...) evaluated. They were randomized to receive orally 70 mg/kg chloral hydrate or promethazine 1 mg/kg. The primary outcome was efficacy in adequate sedation and successful recording of EEG. Secondary outcome included clinical side effects, time from administration of the drug to adequate sedation, caregiver's satisfaction on a Likert scale, and total stay time in EEG Unit.Twenty four cases with mean age 2.9±1.9 years were evaluated. Adequate sedation (Ramsay sedation score of four) was obtained in 43.3

Full Text available with Trip Pro

2013 Iranian journal of pediatrics