Latest & greatest articles for pregnancy

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Top results for pregnancy

82. Managing infants born to mothers who have used opioids during pregnancy

Managing infants born to mothers who have used opioids during pregnancy The incidence of infant opioid withdrawal has grown rapidly in many countries, including Canada, in the last decade, presenting significant health and early brain development concerns. Increased prenatal exposure to opioids reflects rising prescription opioid use as well as the presence of both illegal opiates and opioid-substitution therapies. Infants are at high risk for experiencing symptoms of abstinence

Canadian Paediatric Society2018

84. General surgery is mostly safe during pregnancy

General surgery is mostly safe during pregnancy NIHR DC | Signal - General surgery is mostly safe during pregnancy Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal General surgery is mostly safe during pregnancy Published on 10 January 2017 Routine data from English hospitals show that general surgery during pregnancy, such as removing the appendix or gallbladder, does not commonly harm mother or baby. This suggests that surgery in pregnant women is generally safe (...) , but that mothers could be provided with more specific estimates of the risks. This large observational study assessed the “real world” outcomes of nearly 6.5 million pregnancies at hospitals in England over a 10-year period. Women who had surgery during pregnancy for a condition unrelated to pregnancy were slightly more likely to experience miscarriage, preterm or caesarean delivery or a long stay in hospital. Babies were more also slightly more likely to be low birthweight or stillborn. However, the actual

NIHR Dissemination Centre2018

85. No clear “best” treatment of mild or severe sickness in pregnancy

No clear “best” treatment of mild or severe sickness in pregnancy NIHR DC | Signal - No clear “best” treatment of mild or severe sickness in pregnancy Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal No clear “best” treatment of mild or severe sickness in pregnancy Published on 3 January 2017 Pregnant women could benefit from simple, cheap, “self-help” remedies for mild nausea and vomiting. Ginger, vitamin B6 and possibly acupressure wrist-bands might relieve symptoms for some (...) women, according to a recent overview of research in this area. The review has identified some promising areas for future research. For sickness that doesn’t respond to “self-help” remedies, prescribed medication like antihistamines or anti-sickness tablets may help. Hospital treatment, including combinations of drugs and intravenous fluids, may be indicated if this doesn’t work. The review assessed 73 studies that measured how well 33 types of treatment worked for pregnant women experiencing nausea

NIHR Dissemination Centre2018

86. Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection

Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection NIHR DC | Signal - Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection Published on 23 May 2017 Inducing labour may halve the risk of infection in the womb when waters (...) ? Premature rupture of membranes (PROM) at full term (37 weeks or more) occurs in 8% of pregnancies. Spontaneous onset of labour within 24 hours occurs in approximately 95% of cases. Labour can be delayed for up to seven days if it does not start within 24 hours. The risk of maternal or neonatal infection and the need for caesarean section are increased by PROM. Untreated infections can lead to complications with reproductive organs, problems with fertility and general health. PROM at term is managed

NIHR Dissemination Centre2018

87. One type of drug for depression during pregnancy may be linked to a small increase in pre-term births

One type of drug for depression during pregnancy may be linked to a small increase in pre-term births NIHR DC | Signal - One type of drug for depression during pregnancy may be linked to a small increase in pre-term births Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal One type of drug for depression during pregnancy may be linked to a small increase in pre-term births Published on 9 August 2016 Women who are depressed during pregnancy and who take selective serotonin (...) inhibitors (SSRIs) may be more likely to have a pre-term birth than those who do not take SSRIs. Pre-term birth occurred in 6.8% of women with depression during pregnancy treated with SSRIs compared to 5.8% of depressed women who were treated with talking therapies alone. However, because this is a review of observational (cohort) studies rather than randomised controlled trials it is not possible to say that SSRIs cause pre-term birth. For example, it is possible that women who had worse depression were

NIHR Dissemination Centre2018

88. Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle

Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle NIHR DC | Signal - Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle Published on 6 June 2016 This NIHR funded study found that antipsychotic use (...) during pregnancy was not associated with worse child outcomes after poorer health and riskier lifestyles were taken into account. For pregnant women these were things like other medications, obesity, smoking, alcohol and taking illicit drugs. The study also provides further evidence against the use of valproate during pregnancy for epilepsy, bipolar disorder or schizophrenia because of the increased risk of poor outcomes for the child. The risk was double that of taking the alternatives, lamotrigine

NIHR Dissemination Centre2018

89. Donor eggs may be linked to higher risk of pregnancy complications following IVF

Donor eggs may be linked to higher risk of pregnancy complications following IVF NIHR DC | Signal - Donor eggs may be linked to higher risk of pregnancy complications following IVF Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Donor eggs may be linked to higher risk of pregnancy complications following IVF Published on 26 May 2016 Women who use donor eggs in their IVF may have significantly higher rates of pregnancy complications than those who use their own eggs (...) , a systematic review and meta-analysis has found. Use of donor eggs was linked to up to four times the risk of developing high blood pressure in pregnancy. Other risks associated with donor eggs were low birth weight in the baby, caesarean section and premature delivery. It is always possible that other factors, such as the age of women who use donor eggs, may have influenced the study results. Advanced maternal age is itself associated with pregnancy complications, including high blood pressure

NIHR Dissemination Centre2018

90. Imaging is the only way to diagnose blood clots in pregnancy

Imaging is the only way to diagnose blood clots in pregnancy NIHR DC | Signal - Imaging is the only way to diagnose blood clots in pregnancy Dissemination Centre Discover Portal NIHR DC Discover Imaging is the only way to diagnose blood clots in pregnancy Published on 13 March 2018 No blood test can accurately tell if a pregnant or recently pregnant woman has a blood clot. All pregnant women with a suspected clot should continue to have imaging investigations as per current UK guidelines (...) . This NIHR-funded study recruited 328 pregnant or postpartum women with a suspected blood clot in the lung (pulmonary embolism) or leg (deep vein thrombosis). They had a blood test to measure the levels of 13 biomarkers, such as the D-dimer, to see if they could rule a blood clot in or out. It was hoped that this could reduce the number of women who would need confirmation from a scan, and so decrease their exposure to radiation. None of the tests were accurate enough. The range of levels for each

NIHR Dissemination Centre2018

91. Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy

Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy NIHR DC | Signal - Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy Published on 31 October 2017 Giving low dose aspirin to high-risk women reduced their risk of pre-eclampsia before 37 weeks of pregnancy. Preterm pre-eclampsia developed in 1.6% of women given (...) 150mg aspirin daily compared with 4.3% who took a placebo. Pre-eclampsia is a condition which can harm mother and baby. In the mother, it causes high blood pressure and protein in the urine, which can show in pregnancy after 20 weeks. Women with risk factors, such as previous pre-eclampsia, diabetes or high blood pressure, are often prescribed 75mg aspirin from 12 weeks onwards. This study aimed to test double this dose (still classified as a `low dose’) after using a new risk assessment

NIHR Dissemination Centre2018

92. Treating subclinical thyroid dysfunction in pregnancy probably has no benefit

Treating subclinical thyroid dysfunction in pregnancy probably has no benefit NIHR DC | Signal - Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Published on 8 August 2017 Testing for and then treating pregnant women with mild or “subclinical” underactive thyroid did not improve pregnancy outcomes, newborn baby outcomes (...) , or the child’s IQ at three to five years. A clearly underactive thyroid (clinical hypothyroidism) in pregnancy has been linked with various adverse outcomes for the mother and baby, including pre-eclampsia, preterm birth, congenital defects and neurodevelopmental delay. This needs treatment. However, there has been debate around the harms and benefits from treating only mildly abnormal blood test results in women who do not show signs of thyroid problems, subclinical hypothyroidism. These two linked trials

NIHR Dissemination Centre2018

93. The impact of a daily smartphone-based feedback system among women with gestational diabetes on compliance, glycemic control, satisfaction, and pregnancy outcome: a randomized controlled trial

The impact of a daily smartphone-based feedback system among women with gestational diabetes on compliance, glycemic control, satisfaction, and pregnancy outcome: a randomized controlled trial 29425836 2018 03 30 1097-6868 218 4 2018 Apr American journal of obstetrics and gynecology Am. J. Obstet. Gynecol. The impact of a daily smartphone-based feedback system among women with gestational diabetes on compliance, glycemic control, satisfaction, and pregnancy outcome: a randomized controlled (...) trial. 453.e1-453.e7 S0002-9378(18)30133-9 10.1016/j.ajog.2018.01.044 Patient compliance and tight glycemic control have been demonstrated to improve outcome in pregnancies complicated by gestational diabetes mellitus. The use of advanced technological tools, including smartphone-based platforms, to improve medical care and outcomes has been demonstrated in various fields of medicine, but only a few small studies were performed with gestational diabetes mellitus patients. We aimed to study

EvidenceUpdates2018

94. Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis

Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis 29489823 2018 03 20 1549-1676 15 2 2018 Feb PLoS medicine PLoS Med. Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis. e1002507 10.1371/journal.pmed.1002507 There is uncertainty about the influence of diet during pregnancy and infancy on a child's immune development. We assessed whether variations in maternal (...) January 1946 and July 2013 for observational studies and until December 2017 for intervention studies that evaluated the relationship between diet during pregnancy, lactation, or the first year of life and future risk of allergic or autoimmune disease. We identified 260 original studies (964,143 participants) of milk feeding, including 1 intervention trial of breastfeeding promotion, and 173 original studies (542,672 participants) of other maternal or infant dietary exposures, including 80 trials

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

98. Tubal Ectopic Pregnancy

Tubal Ectopic Pregnancy Tubal Ectopic Pregnancy - ACOG Menu ▼ Tubal Ectopic Pregnancy Page Navigation ▼ INTERIM UPDATE Number 193, March 2018 (Replaces Practice Bulletin Number 191, February 2018) Committee on Practice Bulletins—Gynecology . This Practice Bulletin was developed by the Committee on Practice Bulletins—Gynecology in collaboration with Kurt T. Barnhart, MD, MSCE; and Jason M. Franasiak, MD, TS (ABB). This information is designed as an educational resource to aid clinicians (...) on the assessment of hCG levels after uterine aspiration in women with a pregnancy of unknown location. Tubal Ectopic Pregnancy Ectopic pregnancy is defined as a pregnancy that occurs outside of the uterine cavity. The most common site of ectopic pregnancy is the fallopian tube. Most cases of tubal ectopic pregnancy that are detected early can be treated successfully either with minimally invasive surgery or with medical management using methotrexate. However, tubal ectopic pregnancy in an unstable patient

American College of Obstetricians and Gynecologists2018

99. Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies.

Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies. BACKGROUND: In order to overcome the low effectiveness of assisted reproductive technologies (ART) and the high incidence of multiple births, metabolomics is proposed as a non-invasive method to assess oocyte quality, embryo viability, and endometrial receptivity, and facilitate a targeted subfertility treatment. OBJECTIVES: To evaluate the effectiveness and safety of metabolomic assessment (...) of oocyte quality, embryo viability, and endometrial receptivity for improving live birth or ongoing pregnancy rates in women undergoing ART, compared to conventional methods of assessment. SEARCH METHODS: We searched the Cochrane Gynaecology and Fertility Group Trials Register, CENTRAL, MEDLINE, Embase, CINAHL and two trial registers (Feburary 2018). We also examined the reference lists of primary studies and review articles, citation lists of relevant publications, and abstracts of major scientific

Cochrane2018

100. Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas.

Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas. BACKGROUND: The risk of congenital neurologic defects related to Zika virus (ZIKV) infection has ranged from 6 to 42% in various reports. The aim of this study was to estimate this risk among pregnant women with symptomatic ZIKV infection in French territories in the Americas. METHODS: From March 2016 through November 2016, we enrolled in this prospective cohort study pregnant women with symptomatic ZIKV infection (...) that was confirmed by polymerase-chain-reaction (PCR) assay. The analysis included all data collected up to April 27, 2017, the date of the last delivery in the cohort. RESULTS: Among the 555 fetuses and infants in the 546 pregnancies included in the analysis, 28 (5.0%) were not carried to term or were stillborn, and 527 were born alive. Neurologic and ocular defects possibly associated with ZIKV infection were seen in 39 fetuses and infants (7.0%; 95% confidence interval, 5.0 to 9.5); of these, 10 were

NEJM2018