Latest & greatest articles for pregnancy

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Top results for pregnancy

1. American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy

American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy 30482767 2018 11 28 2473-9537 2 22 2018 Nov 27 Blood advances Blood Adv American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy. 3317-3359 10.1182/bloodadvances.2018024802 Venous thromboembolism (VTE) complicates ∼1.2 of every 1000 deliveries. Despite these low absolute (...) risks, pregnancy-associated VTE is a leading cause of maternal morbidity and mortality. These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians and others in decisions about the prevention and management of pregnancy-associated VTE. ASH formed a multidisciplinary guideline panel balanced to minimize potential bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline development process, including

Blood advances2018 Full Text: Link to full Text with Trip Pro

4. Clinic-Based Programs to Prevent Repeat Teen Pregnancy: A Systematic Review

Clinic-Based Programs to Prevent Repeat Teen Pregnancy: A Systematic Review 30342636 2018 10 21 1873-2607 55 5 2018 Nov American journal of preventive medicine Am J Prev Med Clinic-Based Programs to Prevent Repeat Teen Pregnancy: A Systematic Review. 736-746 S0749-3797(18)32121-4 10.1016/j.amepre.2018.08.001 The purpose of this paper is to synthesize and evaluate the evidence on the effectiveness of repeat teen pregnancy prevention programs offered in clinical settings. Multiple databases were (...) one short-term (e.g., increased knowledge); medium-term (e.g., increased contraceptive use); or long-term (e.g., decreased repeat teen pregnancy) outcome, or identified contextual barriers or facilitators for providing adolescent-focused family planning services. Standardized abstraction methods and tools were used to synthesize the evidence and assess its quality. Only studies of clinic-based programs focused on repeat teen pregnancy prevention were included in this review. The search strategy

EvidenceUpdates2018

6. Ectopic pregnancy

Ectopic pregnancy Ectopic pregnancy - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Ectopic pregnancy Last reviewed: October 2018 Last updated: October 2018 Summary Typically presents 6-8 weeks after last normal menstrual period, but can present earlier or later. Risk increases with prior ectopic pregnancy, tubal surgery, history of sexually transmitted infections, smoking, in vitro fertilisation, or if pregnant (...) of referred pain from intraperitoneal blood. Definition A fertilised ovum implanting and maturing outside of the uterine endometrial cavity, with the most common site being the fallopian tube (97%), followed by the ovary (3.2%) and the abdomen (1.3%). Bouyer J, Coste J, Fernandez H, et al. Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum Reprod. 2002 Dec;17(12):3224-30. http://humrep.oxfordjournals.org/content/17/12/3224.full http://www.ncbi.nlm.nih.gov/pubmed/12456628?tool

BMJ Best Practice2018

7. No clear “best” treatment of mild or severe sickness in pregnancy

No clear “best” treatment of mild or severe sickness in pregnancy Signal - No clear “best” treatment of mild or severe sickness in pregnancy Dissemination Centre Discover Portal NIHR DC Discover No clear “best” treatment of mild or severe sickness in pregnancy Published on 3 January 2017 Pregnant women could benefit from simple, cheap, “self-help” remedies for mild nausea and vomiting. Ginger, vitamin B6 and possibly acupressure wrist-bands might relieve symptoms for some women, according (...) to a recent overview of research in this area. The review has identified some promising areas for future research. For sickness that doesn’t respond to “self-help” remedies, prescribed medication like antihistamines or anti-sickness tablets may help. Hospital treatment, including combinations of drugs and intravenous fluids, may be indicated if this doesn’t work. The review assessed 73 studies that measured how well 33 types of treatment worked for pregnant women experiencing nausea and vomiting. Severity

NIHR Dissemination Centre2018

8. General surgery is mostly safe during pregnancy

General surgery is mostly safe during pregnancy Signal - General surgery is mostly safe during pregnancy Dissemination Centre Discover Portal NIHR DC Discover General surgery is mostly safe during pregnancy Published on 10 January 2017 Routine data from English hospitals show that general surgery during pregnancy, such as removing the appendix or gallbladder, does not commonly harm mother or baby. This suggests that surgery in pregnant women is generally safe, but that mothers could be provided (...) with more specific estimates of the risks. This large observational study assessed the “real world” outcomes of nearly 6.5 million pregnancies at hospitals in England over a 10-year period. Women who had surgery during pregnancy for a condition unrelated to pregnancy were slightly more likely to experience miscarriage, preterm or caesarean delivery or a long stay in hospital. Babies were more also slightly more likely to be low birthweight or stillborn. However, the actual risks of negative outcomes

NIHR Dissemination Centre2018

9. Imaging is the only way to diagnose blood clots in pregnancy

Imaging is the only way to diagnose blood clots in pregnancy Signal - Imaging is the only way to diagnose blood clots in pregnancy Dissemination Centre Discover Portal NIHR DC Discover Imaging is the only way to diagnose blood clots in pregnancy Published on 13 March 2018 No blood test can accurately tell if a pregnant or recently pregnant woman has a blood clot. All pregnant women with a suspected clot should continue to have imaging investigations as per current UK guidelines. This NIHR (...) -funded study recruited 328 pregnant or postpartum women with a suspected blood clot in the lung (pulmonary embolism) or leg (deep vein thrombosis). They had a blood test to measure the levels of 13 biomarkers, such as the D-dimer, to see if they could rule a blood clot in or out. It was hoped that this could reduce the number of women who would need confirmation from a scan, and so decrease their exposure to radiation. None of the tests were accurate enough. The range of levels for each biomarker

NIHR Dissemination Centre2018

10. Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy

Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy Signal - Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy Dissemination Centre Discover Portal NIHR DC Discover Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy Published on 31 October 2017 Giving low dose aspirin to high-risk women reduced their risk of pre-eclampsia before 37 weeks of pregnancy. Preterm pre-eclampsia developed in 1.6% of women given 150mg aspirin daily (...) compared with 4.3% who took a placebo. Pre-eclampsia is a condition which can harm mother and baby. In the mother, it causes high blood pressure and protein in the urine, which can show in pregnancy after 20 weeks. Women with risk factors, such as previous pre-eclampsia, diabetes or high blood pressure, are often prescribed 75mg aspirin from 12 weeks onwards. This study aimed to test double this dose (still classified as a `low dose’) after using a new risk assessment with additional clinical tests

NIHR Dissemination Centre2018

11. Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection

Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection Signal - Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection Dissemination Centre Discover Portal NIHR DC Discover Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection Published on 23 May 2017 Inducing labour may halve the risk of infection in the womb when waters break from 37 weeks (...) was this study needed? Premature rupture of membranes (PROM) at full term (37 weeks or more) occurs in 8% of pregnancies. Spontaneous onset of labour within 24 hours occurs in approximately 95% of cases. Labour can be delayed for up to seven days if it does not start within 24 hours. The risk of maternal or neonatal infection and the need for caesarean section are increased by PROM. Untreated infections can lead to complications with reproductive organs, problems with fertility and general health. PROM

NIHR Dissemination Centre2018

12. Treating subclinical thyroid dysfunction in pregnancy probably has no benefit

Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Signal - Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Dissemination Centre Discover Portal NIHR DC Discover Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Published on 8 August 2017 Testing for and then treating pregnant women with mild or “subclinical” underactive thyroid did not improve pregnancy outcomes, newborn baby outcomes, or the child’s IQ (...) at three to five years. A clearly underactive thyroid (clinical hypothyroidism) in pregnancy has been linked with various adverse outcomes for the mother and baby, including pre-eclampsia, preterm birth, congenital defects and neurodevelopmental delay. This needs treatment. However, there has been debate around the harms and benefits from treating only mildly abnormal blood test results in women who do not show signs of thyroid problems, subclinical hypothyroidism. These two linked trials randomised

NIHR Dissemination Centre2018

13. Donor eggs may be linked to higher risk of pregnancy complications following IVF

Donor eggs may be linked to higher risk of pregnancy complications following IVF Signal - Donor eggs may be linked to higher risk of pregnancy complications following IVF Dissemination Centre Discover Portal NIHR DC Discover Donor eggs may be linked to higher risk of pregnancy complications following IVF Published on 26 May 2016 Women who use donor eggs in their IVF may have significantly higher rates of pregnancy complications than those who use their own eggs, a systematic review and meta (...) -analysis has found. Use of donor eggs was linked to up to four times the risk of developing high blood pressure in pregnancy. Other risks associated with donor eggs were low birth weight in the baby, caesarean section and premature delivery. It is always possible that other factors, such as the age of women who use donor eggs, may have influenced the study results. Advanced maternal age is itself associated with pregnancy complications, including high blood pressure. Nevertheless it seems likely from

NIHR Dissemination Centre2018

14. One type of drug for depression during pregnancy may be linked to a small increase in pre-term births

One type of drug for depression during pregnancy may be linked to a small increase in pre-term births Signal - One type of drug for depression during pregnancy may be linked to a small increase in pre-term births Dissemination Centre Discover Portal NIHR DC Discover One type of drug for depression during pregnancy may be linked to a small increase in pre-term births Published on 9 August 2016 Women who are depressed during pregnancy and who take selective serotonin inhibitors (SSRIs) may be (...) more likely to have a pre-term birth than those who do not take SSRIs. Pre-term birth occurred in 6.8% of women with depression during pregnancy treated with SSRIs compared to 5.8% of depressed women who were treated with talking therapies alone. However, because this is a review of observational (cohort) studies rather than randomised controlled trials it is not possible to say that SSRIs cause pre-term birth. For example, it is possible that women who had worse depression were more likely

NIHR Dissemination Centre2018

15. Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle

Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle Signal - Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle Dissemination Centre Discover Portal NIHR DC Discover Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle Published on 6 June 2016 This NIHR funded study found that antipsychotic use during pregnancy (...) was not associated with worse child outcomes after poorer health and riskier lifestyles were taken into account. For pregnant women these were things like other medications, obesity, smoking, alcohol and taking illicit drugs. The study also provides further evidence against the use of valproate during pregnancy for epilepsy, bipolar disorder or schizophrenia because of the increased risk of poor outcomes for the child. The risk was double that of taking the alternatives, lamotrigine or carbamazapine during

NIHR Dissemination Centre2018

16. No benefit from monitoring antiepileptic drug levels in pregnancy

No benefit from monitoring antiepileptic drug levels in pregnancy No benefit from monitoring antiepileptic drug levels in pregnancy Dissemination Centre Discover Portal NIHR DC Discover No benefit from monitoring antiepileptic drug levels in pregnancy Published on 9 October 2018 doi: Regular monitoring of antiepileptic drug levels in pregnant women with epilepsy does not improve seizure control compared with clinical features-based monitoring. This NIHR-funded study was conducted across 50 UK (...) hospitals and is the largest randomised trial in pregnant women with epilepsy. Just over 260 pregnant women with unstable antiepileptic drug levels were assigned to ongoing monthly blood checks or clinical features monitoring. There were no differences in seizures or other pregnancy outcomes between the two strategies. But umbilical cord blood showed that babies whose mothers received blood checks were exposed to higher levels of antiepileptic drugs. The study provides important information about

NIHR Dissemination Centre2018

17. β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study.

β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study. Background: β-Blockers are a class of antihypertensive medications that are commonly used in pregnancy. Objective: To estimate the risks for major congenital malformations associated with first-trimester exposure to β-blockers. Design: Cohort study. Setting: Health registries in the 5 Nordic countries and the U.S. Medicaid database. Patients: Pregnant women with a diagnosis of hypertension and (...) their offspring. Measurements: First-trimester exposure to β-blockers was assessed. Outcomes were any major congenital malformation, cardiac malformations, cleft lip or palate, and central nervous system (CNS) malformations. Propensity score stratification was used to control for potential confounders. Results: Of 3577 women with hypertensive pregnancies in the Nordic cohort and 14 900 in the U.S. cohort, 682 (19.1%) and 1668 (11.2%), respectively, were exposed to β-blockers in the first trimester

Annals of Internal Medicine2018

18. Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial.

Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial. BACKGROUND: Preterm delivery during pregnancy (<37 weeks' gestation) is a leading cause of perinatal mortality and morbidity. Treating bacterial vaginosis during pregnancy can reduce poor outcomes, such as preterm birth. We aimed to investigate whether treatment of bacterial vaginosis decreases late miscarriages or spontaneous very preterm birth. METHODS: PREMEVA (...) was a double-blind randomised controlled trial done in 40 French centres. Women aged 18 years or older with bacterial vaginosis and low-risk pregnancy were eligible for inclusion and were randomly assigned (2:1) to three parallel groups: single-course or triple-course 300 mg clindamycin twice-daily for 4 days, or placebo. Women with high-risk pregnancy outcomes were eligible for inclusion in a high-risk subtrial and were randomly assigned (1:1) to either single-course or triple-course clindamycin

Lancet2018

19. Valproate Pregnancy Prevention Programme: actions required now from GPs, specialists, and dispensers

Valproate Pregnancy Prevention Programme: actions required now from GPs, specialists, and dispensers Valproate Pregnancy Prevention Programme: actions required now from GPs, specialists, and dispensers - GOV.UK GOV.UK uses cookies to make the site simpler. Search Valproate Pregnancy Prevention Programme: actions required now from GPs, specialists, and dispensers Valproate medicines must not be used in women of childbearing potential unless the Pregnancy Prevention Programme is in place. If you (...) and girls on valproate who may be of childbearing potential provide the Patient Guide to the patient (or her parents or responsible person as necessary) check they have been reviewed by a specialist in the last year (ie, they have an in-date Risk Acknowledgement Form) and are on highly effective contraception Actions for specialists book in review appointments at least annually with women and girls under the Pregnancy Prevention Programme and re-evaluate treatment as necessary explain clearly

MHRA Drug Safety Update2018

20. The Relationship Between Fish Oil Supplementation During Pregnancy and Incidence of Asthma in Children

The Relationship Between Fish Oil Supplementation During Pregnancy and Incidence of Asthma in Children "The Relationship Between Fish Oil Supplementation During Pregnancy and" by JesAnne Tageson-Ramirez < > > > > > Title Author Date of Graduation Summer 8-11-2018 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: The incidence of asthma is increasing in the United States. Some researchers believe this rise is due to higher (...) , wheezing, asthma, respiratory sounds, pregnancy, and perinatal. Studies were assessed for quality based on GRADE criteria. Results: There were 264 articles that were screened, 5 of which applied to the clinical question with only 2 articles meeting the eligibility criteria. One study found a significant decrease in the incidence of asthma in children when mothers were supplemented with high dose fish oil during pregnancy. The other study found no significant difference in the incidence of asthma

Pacific University EBM Capstone Project2018