Latest & greatest articles for pregabalin

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Top results for pregabalin

1. Cognitive Effects of Perioperative Pregabalin: Secondary Exploratory Analysis of a Randomized Placebo-controlled Study

Cognitive Effects of Perioperative Pregabalin: Secondary Exploratory Analysis of a Randomized Placebo-controlled Study 30335626 2018 10 26 1528-1175 2018 Oct 17 Anesthesiology Anesthesiology Cognitive Effects of Perioperative Pregabalin: Secondary Exploratory Analysis of a Randomized Placebo-controlled Study. 10.1097/ALN.0000000000002473 WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Pregabalin has shown opioid sparing and analgesic effects in the early postoperative period; however (...) , perioperative effects on cognition have not been studied. A randomized, parallel group, placebo-controlled investigation in 80 donor nephrectomy patients was previously performed that evaluated the analgesic, opioid-sparing, and antihyperalgesic effects of pregabalin. This article describes a secondary exploratory analysis that tested the hypothesis that pregabalin would impair cognitive function compared to placebo. Eighty patients scheduled for donor nephrectomy participated in this randomized, placebo

EvidenceUpdates2018

2. Prophylactic Pregabalin to Decrease Pain During Medication Abortion: A Randomized Controlled Trial

Prophylactic Pregabalin to Decrease Pain During Medication Abortion: A Randomized Controlled Trial 30095762 2018 08 24 1873-233X 132 3 2018 Sep Obstetrics and gynecology Obstet Gynecol Prophylactic Pregabalin to Decrease Pain During Medication Abortion: A Randomized Controlled Trial. 612-618 10.1097/AOG.0000000000002787 To evaluate whether prophylactic pregabalin reduces pain experienced with medication abortion. We conducted a randomized, double-blind, placebo-controlled trial of women (...) initiating medication abortion with mifepristone and buccal misoprostol up to 70 days of gestation. Participants were randomized to 300 mg oral pregabalin or a placebo immediately before misoprostol. The primary outcome was maximum pain on an 11-point numerical rating scale, reported using real-time electronic surveys over 72 hours. Secondary outcomes included pain at each time point, ibuprofen and narcotic use, side effects, and satisfaction. We estimated that 110 women would be required to have 80

EvidenceUpdates2018

3. Pregabalin

Pregabalin Top results for pregabalin - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search (...) button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for pregabalin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory

Trip Latest and Greatest2018

4. The effect of pregabalin or duloxetine on arthritis pain: a clinical and mechanistic study in people with hand osteoarthritis

The effect of pregabalin or duloxetine on arthritis pain: a clinical and mechanistic study in people with hand osteoarthritis 29066930 2017 12 19 1178-7090 10 2017 Journal of pain research J Pain Res The effect of pregabalin or duloxetine on arthritis pain: a clinical and mechanistic study in people with hand osteoarthritis. 2437-2449 10.2147/JPR.S147640 Osteoarthritis (OA) is the most prevalent arthritis worldwide and is characterized by chronic pain and impaired physical function. We (...) hypothesized that heightened pain in hand OA could be reduced with duloxetine or pregabalin. In this prospective, randomized clinical study, we recruited 65 participants, aged 40-75 years, with a Numerical Rating Scale (NRS) for pain of at least 5. Participants were randomized to one of the following three groups: duloxetine, pregabalin, and placebo. The primary endpoint was the NRS pain score, and the secondary endpoints included the Australian and Canadian Hand Osteoarthritis Index (AUSCAN) pain

EvidenceUpdates2017 Full Text: Link to full Text with Trip Pro

5. Trial of Pregabalin for Acute and Chronic Sciatica.

Trial of Pregabalin for Acute and Chronic Sciatica. Background Sciatica can be disabling, and evidence regarding medical treatments is limited. Pregabalin is effective in the treatment of some types of neuropathic pain. This study examined whether pregabalin may reduce the intensity of sciatica. Methods We conducted a randomized, double-blind, placebo-controlled trial of pregabalin in patients with sciatica. Patients were randomly assigned to receive either pregabalin at a dose of 150 mg per (...) year. Results A total of 209 patients underwent randomization, of whom 108 received pregabalin and 101 received placebo; after randomization, 2 patients in the pregabalin group were determined to be ineligible and were excluded from the analyses. At week 8, the mean unadjusted leg-pain intensity score was 3.7 in the pregabalin group and 3.1 in the placebo group (adjusted mean difference, 0.5; 95% confidence interval [CI], -0.2 to 1.2; P=0.19). At week 52, the mean unadjusted leg-pain intensity

NEJM2017

7. Pregabalin for Acute Pain: A Review of the Clinical Effectiveness

Pregabalin for Acute Pain: A Review of the Clinical Effectiveness Pregabalin for Acute Pain: A Review of the Clinical Effectiveness | CADTH.ca Find the information you need Pregabalin for Acute Pain: A Review of the Clinical Effectiveness Pregabalin for Acute Pain: A Review of the Clinical Effectiveness Published on: January 24, 2017 Project Number: RC0843-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical (...) effectiveness of pregabalin for acute pain? What is the comparative effectiveness of concurrent pregabalin and opioid use versus opioids alone for the management of acute or post-operative pain? Key Message One randomized controlled trial (RCT) demonstrated that compared to opioids alone, a single pre-operative dose of pregabalin in combination with post-operative opioids significantly reduced post-operative opioid consumption, pain scores and use of breakthrough analgesia at 48 hours. A second RCT

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

8. Systematic review and meta-analysis: Pregabalin is effective in reducing fibromyalgia pain

Systematic review and meta-analysis: Pregabalin is effective in reducing fibromyalgia pain Pregabalin is effective in reducing fibromyalgia pain | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Pregabalin is effective in reducing fibromyalgia pain Article Text Therapeutics/Prevention Systematic review and meta-analysis Pregabalin is effective in reducing fibromyalgia pain Charles Argoff Statistics from Altmetric.com Commentary on: Derry S , Cording M , Wiffen PJ , et al . Pregabalin for pain in fibromyalgia in adults . Request permissions If you wish

Evidence-Based Medicine (Requires free registration)2017

9. Pregabalin for essential tremor.

Pregabalin for essential tremor. BACKGROUND: Essential tremor is one of the most common movement disorders. Treatment primarily consists of pharmacological agents. While primidone and propranolol are well-established treatments in clinical practice, they may be ineffective in 25% to 55% of patients and can produce serious adverse events in a large percentage of them. For these reasons, it is worth evaluating the treatment alternatives for essential tremor. Some specialists have suggested (...) that pregabalin could be a potentially useful agent, but there is uncertainty about its efficacy and safety. OBJECTIVES: To assess the effects of pregabalin versus placebo or other treatment for essential tremor in adults. SEARCH METHODS: We performed a systematic search without language restrictions to identify all relevant trials up to December 2015. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, NICE, ClinicalTrials.gov, and the World Health Organization

Cochrane2016

10. Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes

Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes 27521437 2016 09 20 2017 05 08 2017 05 08 1526-632X 87 12 2016 Sep 20 Neurology Neurology Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes. 1242-9 10.1212/WNL.0000000000003118 To evaluate the comparative safety and adjunctive efficacy of pregabalin and gabapentin in reducing seizure frequency in patients with partial-onset seizures based on prestudy (...) modeling showing superior efficacy for pregabalin. The design of this comparative efficacy and safety study of pregabalin and gabapentin as adjunctive treatment in adults with refractory partial-onset seizures was randomized, flexible dose, double blind, and parallel group. The study included a 6-week baseline and a 21-week treatment phase. The primary endpoint was the percentage change from baseline in 28-day seizure rate to the treatment phase. A total of 484 patients were randomized to pregabalin (n

EvidenceUpdates2016 Full Text: Link to full Text with Trip Pro

11. Pregabalin for pain in fibromyalgia in adults.

Pregabalin for pain in fibromyalgia in adults. BACKGROUND: This review updates part of an earlier Cochrane review on 'Pregabalin for acute and chronic pain in adults' (Moore 2009), and considers only fibromyalgia pain.Antiepileptic drugs have been used in pain management since the 1960s. Pregabalin is an antiepileptic drug also used in management of chronic pain conditions, including fibromyalgia. Pain response with pregabalin is associated with major benefits for other symptoms, and improved (...) quality of life and function in people with chronic painful conditions. OBJECTIVES: To assess the analgesic efficacy and adverse events of pregabalin for pain in fibromyalgia in adults, compared with placebo or any active comparator. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE for randomised controlled trials from inception to May 2009 for the original review and to 16 March 2016 for this update. We also searched the reference lists

Cochrane2016

12. Prior Opioid Use Does Not Impact the Response to Pregabalin in Patients With Fibromyalgia

Prior Opioid Use Does Not Impact the Response to Pregabalin in Patients With Fibromyalgia 25756560 2016 06 09 2017 03 24 2017 03 24 1536-5409 32 7 2016 07 The Clinical journal of pain Clin J Pain Prior Opioid Use Does Not Impact the Response to Pregabalin in Patients With Fibromyalgia. 555-61 10.1097/AJP.0000000000000232 Fibromyalgia (FM) is a chronic pain disorder for which pregabalin is an approved treatment in the United States. Although opioids are not a recommended treatment option (...) , they continue to be used by many FM patients. The impact of patients' prior opioid use on their subsequent response to pregabalin has not been assessed. This was a pooled analysis of 4 clinical trials to assess the efficacy of pregabalin in FM patients both with and without prior opioid use. Patients were divided into those using opioids prior to the trial and those who were not. The change in least squares mean pain score (assessed by 0 to 10 numeric rating scale) with pregabalin compared with placebo

EvidenceUpdates2016

13. Pregnancy outcome following maternal exposure to pregabalin may call for concern

Pregnancy outcome following maternal exposure to pregabalin may call for concern 27194385 2016 06 14 2017 05 05 2017 05 05 1526-632X 86 24 2016 Jun 14 Neurology Neurology Pregnancy outcome following maternal exposure to pregabalin may call for concern. 2251-7 10.1212/WNL.0000000000002767 To investigate pregnancy outcomes following maternal use of pregabalin. This multicenter, observational prospective cohort study compared pregnancy outcomes in women exposed to pregabalin with those of matched (...) controls (not exposed to any medications known to be teratogenic or to any antiepileptic drugs). Teratology Information Services systematically collected data between 2004 and 2013. Data were collected from 164 exposed pregnancies and 656 controls. A significantly higher major birth defect rate in the pregabalin group was observed after exclusion of chromosomal aberration syndromes, and when cases with exposure during first trimester of pregnancy were analyzed separately (7/116 [6.0%] vs 12/580 [2.1

EvidenceUpdates2016

14. Pregabalin and Speech Pathology Combination Therapy for Refractory Chronic Cough: A Randomized Controlled Trial

Pregabalin and Speech Pathology Combination Therapy for Refractory Chronic Cough: A Randomized Controlled Trial 26447687 2016 03 11 2016 07 19 2016 03 11 1931-3543 149 3 2016 Mar Chest Chest Pregabalin and Speech Pathology Combination Therapy for Refractory Chronic Cough: A Randomized Controlled Trial. 639-48 10.1378/chest.15-1271 S0012-3692(15)00046-X Chronic refractory cough (CRC) is a difficult problem to treat. Speech pathology treatment (SPT) improves symptoms but resolution is incomplete (...) . Centrally acting neuromodulators also improve cough symptoms, but not cough reflex sensitivity, and the effect is short-lived. We hypothesized that combined SPT and centrally acting neuromodulators would have a superior outcome than SPT alone. Our goal was to determine whether combined pregabalin and SPT is more effective than SPT alone. Randomized placebo controlled trial. Forty patients with CRC were randomly assigned to receive either combined SPT and pregabalin 300 mg daily or combined SPT

EvidenceUpdates2016

15. Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy Using an NSAID for Other Pain Conditions: A Double-Blind Crossover Study

Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy Using an NSAID for Other Pain Conditions: A Double-Blind Crossover Study 25968451 2016 02 06 2016 10 27 2016 12 30 1536-5409 32 3 2016 Mar The Clinical journal of pain Clin J Pain Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy Using an NSAID for Other Pain Conditions: A Double-Blind Crossover Study. 203-10 10.1097/AJP.0000000000000254 To evaluate pregabalin's efficacy and safety versus placebo to reduce pain (...) in patients with diabetic peripheral neuropathy (DPN) using a concomitant nonsteroidal anti-inflammatory drug. In a randomized, double-masked, 14-week, 2-period, crossover study, patients with painful DPN using a nonsteroidal anti-inflammatory drug for non-DPN-related pain received 150 to 300 mg/d pregabalin or placebo (period 1); 14-day washout; then, the opposite therapy (period 2). Endpoints included weekly change in DPN pain score, sleep interference, adverse events, and patient-reported outcomes

EvidenceUpdates2016

16. Pregabalin for decreasing pancreatic pain in chronic pancreatitis.

Pregabalin for decreasing pancreatic pain in chronic pancreatitis. BACKGROUND: Chronic abdominal pain is one of the major symptoms in people with chronic pancreatitis. The role of pregabalin in people with chronic pancreatic pain due to chronic pancreatitis is uncertain. OBJECTIVES: To assess the benefits and harms of pregabalin in people with chronic abdominal pain due to chronic pancreatitis. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL (...) identified trials and independently extracted data. We calculated the risk ratio (RR) or mean difference (MD) with 95% confidence intervals (CI) with RevMan 5, based on intention-to-treat analysis. MAIN RESULTS: Only one study, funded by Pfizer, met the inclusion criteria for the review. A total of 64 participants (with chronic pain due to chronic pancreatitis) were randomly assigned to receive escalating doses of pregabalin (150 mg per day to 600 mg per day; 34 participants) or matching placebo (30

Cochrane2016

17. Efficacy and Safety of Pregabalin in the Treatment of Patients With Painful Diabetic Peripheral Neuropathy and Pain on Walking

Efficacy and Safety of Pregabalin in the Treatment of Patients With Painful Diabetic Peripheral Neuropathy and Pain on Walking 25565583 2015 10 02 2016 07 01 2015 10 02 1536-5409 31 11 2015 Nov The Clinical journal of pain Clin J Pain Efficacy and Safety of Pregabalin in the Treatment of Patients With Painful Diabetic Peripheral Neuropathy and Pain on Walking. 946-58 10.1097/AJP.0000000000000198 This randomized, double-blind, placebo-controlled, multicenter, 2-period crossover study (two 6-week (...) treatment periods separated by a 2-week washout period) evaluated the efficacy and safety of pregabalin (150 to 300 mg/d) for treatment of pain and pain on walking in patients with painful diabetic peripheral neuropathy (DPN) who experienced pain while walking. Co-primary efficacy endpoints were: (1) mean pain score (last 7 daily pain diary scores, 0 to 10 numeric rating scale at end of each treatment period) and (2) DPN pain on walking (0 to 10 numeric rating scale immediately after walking 50 feet

EvidenceUpdates2015

18. Imipramine and pregabalin combination for painful polyneuropathy: a randomized controlled trial

Imipramine and pregabalin combination for painful polyneuropathy: a randomized controlled trial 25719617 2015 04 18 2016 01 26 2015 04 18 1872-6623 156 5 2015 May Pain Pain Imipramine and pregabalin combination for painful polyneuropathy: a randomized controlled trial. 958-66 10.1097/j.pain.0000000000000143 Monotherapy with first-line drugs for neuropathic pain often fails to provide sufficient pain relief or has unacceptable side effects because of the need for high doses. The aim (...) of this trial was to test whether the combination of imipramine and pregabalin in moderate doses would relieve pain more effectively than monotherapy with either of the drugs. This was a randomized, double-blind, placebo-controlled, crossover, multicenter trial consisting of four 5-week treatment periods in patients with painful polyneuropathy. Treatment arms were imipramine 75 mg/d vs pregabalin 300 mg/d vs combination therapy vs placebo. Patients with polyneuropathy and symptoms for more than 6 months

EvidenceUpdates2015