Latest & greatest articles for prednisolone

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on prednisolone or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on prednisolone and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for prednisolone

21. Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial.

Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial. IMPORTANCE: Prednisolone or pentoxifylline is recommended for severe alcoholic hepatitis, a life-threatening disease. The benefit of their combination is unknown. OBJECTIVE: To determine whether the addition of pentoxifylline to prednisolone is more effective than prednisolone alone. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, randomized, double-blind clinical (...) assigned to receive either a combination of 40 mg of prednisolone once a day and 400 mg of pentoxifylline 3 times a day (n=133) for 28 days, or 40 mg of prednisolone and matching placebo (n=137) for 28 days. MAIN OUTCOMES AND MEASURES: Six-month survival, with secondary end points of development of hepatorenal syndrome and response to therapy based on the Lille model, which defines treatment nonresponders after 7 days of initiation of treatment. RESULTS: In intention-to-treat analysis, 6-month survival

JAMA2013

22. Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles.

Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles. BACKGROUND: Dose intensification with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) every 2 weeks improves outcomes in patients older than 60 years with diffuse large B-cell lymphoma compared with CHOP every 3 weeks. We (...) was intravenous cyclophosphamide 750 mg/m(2), doxorubicin 50 mg/m(2), vincristine 1·4 mg/m(2) (maximum dose 2 mg), and rituximab 375 mg/m(2) on day 1, and oral prednisolone 40 mg/m(2) on days 1-5, administered every 21 days for a total of eight cycles. R-CHOP-14 was intravenous cyclophosphamide 750 mg/m(2), doxorubicin 50 mg/m(2), vincristine 2 mg, rituximab 375 mg/m(2) on day 1, and oral prednisolone 100 mg on days 1-5, administered every 14 days for six cycles, followed by two further infusions of rituximab

Lancet2013

23. Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome

Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome 23274956 2012 12 31 2013 03 04 2015 02 19 1533-3450 24 1 2013 Jan Journal of the American Society of Nephrology : JASN J. Am. Soc. Nephrol. Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome. 149-59 10.1681/ASN.2012070646 Prolonged prednisolone treatment for the initial episode of childhood nephrotic syndrome may reduce relapse rate, but whether this results from (...) the increased duration of treatment or a higher cumulative dose remains unclear. We conducted a randomized, double-blind, placebo-controlled trial in 69 hospitals in The Netherlands. We randomly assigned 150 children (9 months to 17 years) presenting with nephrotic syndrome to either 3 months of prednisolone followed by 3 months of placebo (n=74) or 6 months of prednisolone (n=76), and median follow-up was 47 months. Both groups received equal cumulative doses of prednisolone (approximately 3360 mg/m(2

EvidenceUpdates2013 Full Text: Link to full Text with Trip Pro

24. A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis

A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis 22956551 2012 12 03 2013 02 01 2016 11 22 1462-0332 51 12 2012 Dec Rheumatology (Oxford, England) Rheumatology (Oxford) A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis. 2286-94 10.1093/rheumatology/kes219 Anti-inflammatory therapies are effective analgesics for OA. This study determined whether low (...) -dose oral prednisolone (PNL) was an effective analgesic for hand OA. This was a randomized, double-blind, placebo-controlled trial of people with ACR criteria hand OA and baseline hand pain visual analogue scale (VAS) of >40/100 mm. Participants received 5 mg PNL or placebo daily for 4 weeks. Pain VAS, disease activity VAS, Australian/Canadian Hand Osteoarthritis Index and joint counts were performed at baseline, 4 and 12 weeks. Primary outcome was the change in hand pain VAS at 4 weeks. Analysis

EvidenceUpdates2013

25. Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial.

Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial. 24026598 2013 09 12 2013 09 17 2016 10 17 1538-3598 310 10 2013 Sep 11 JAMA JAMA Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial. 1033-41 10.1001/jama.2013.276300 Prednisolone or pentoxifylline is recommended for severe alcoholic hepatitis, a life-threatening disease. The benefit (...) of their combination is unknown. To determine whether the addition of pentoxifylline to prednisolone is more effective than prednisolone alone. Multicenter, randomized, double-blind clinical trial conducted between December 2007 and March 2010 in 1 Belgian and 23 French hospitals of 270 patients aged 18 to 70 years who were heavy drinkers with severe biopsy-proven alcoholic hepatitis, as indicated by recent onset of jaundice in the prior 3 months and a Maddrey score of at least 32. Duration of follow-up was 6

JAMA2013

26. Abiraterone (Zytiga) - with prednisone or prednisolone for the treatment of metastatic castration resistant prostate cancer (mCRPC)

Abiraterone (Zytiga) - with prednisone or prednisolone for the treatment of metastatic castration resistant prostate cancer (mCRPC)

Scottish Medicines Consortium2012

27. Treatment of Bell's Palsy - Should antivirals be added to prednisolone?

Treatment of Bell's Palsy - Should antivirals be added to prednisolone? BestBets: Treatment of Bell's Palsy - Should antivirals be added to prednisolone? Treatment of Bell's Palsy - Should antivirals be added to prednisolone? Report By: Saba Mattar - ENT Clinical Fellow Search checked by Muhammad Azam Majeed and Bernard A Foex - SpR Emergency Medicine and Consultant in Emergency Medicine Institution: St Michael's Hospital, Bristol, UK Original institution: Queen Elizabeth Hospital, Birmingham (...) , UK and Manchester Royal Infirmary, Manchester, UK Date Submitted: 31st July 2011 Date Completed: 12th June 2012 Last Modified: 12th June 2012 Status: Green (complete) Three Part Question Is [Bell�s Palsy] best treated with [prednisolone] or [prednisolone combined with an antiviral agent]? Clinical Scenario A 49 year old gentleman presents with weakness of the entire right side of his face. He has no other neurological features to suggest a stroke. You diagnose idiopathic facial paralysis (Bell�s

BestBETS2012

28. Abiraterone (Zytiga) - with prednisone or prednisolone for the treatment of metastatic castration-resistant prostate cancer (mCRPC)

Abiraterone (Zytiga) - with prednisone or prednisolone for the treatment of metastatic castration-resistant prostate cancer (mCRPC)

Scottish Medicines Consortium2012

29. Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.

Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. 22405251 2012 04 30 2012 05 14 2015 06 16 1474-547X 379 9826 2012 Apr 28 Lancet (London, England) Lancet Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. 1613-20 10.1016/S0140 (...) -6736(11)61930-2 Evidence indicates that corticosteroid therapy might be beneficial for the primary treatment of severe Kawasaki disease. We assessed whether addition of prednisolone to intravenous immunoglobulin with aspirin would reduce the incidence of coronary artery abnormalities in patients with severe Kawasaki disease. We did a multicentre, prospective, randomised, open-label, blinded-endpoints trial at 74 hospitals in Japan between Sept 29, 2008, and Dec 2, 2010. Patients with severe

Lancet2012

30. Cabazitaxel (Jevtana) - In combination with prednisone or prednisolone, cabazitaxel is licensed for the treatment of patients with hormone refractory metastatic prostate cancer

Cabazitaxel (Jevtana) - In combination with prednisone or prednisolone, cabazitaxel is licensed for the treatment of patients with hormone refractory metastatic prostate cancer

Scottish Medicines Consortium2011

31. Is oral prednisolone as effective as oral dexamethasone in treating mild to moderate croup? An update

Is oral prednisolone as effective as oral dexamethasone in treating mild to moderate croup? An update BestBets: Is oral prednisolone as effective as oral dexamethasone in treating mild to moderate croup? An update Is oral prednisolone as effective as oral dexamethasone in treating mild to moderate croup? An update Report By: Lucinda C Winckworth - SpR Paediatrics Search checked by Arabella Simpkin - SHO Paediatrics Institution: The Whittington Hospital NHS Trust, London UK Date Submitted: 17th (...) July 2010 Date Completed: 3rd May 2011 Last Modified: 3rd June 2011 Status: Green (complete) Three Part Question In [children under 6 years old with mild or moderate croup] does [a single dose of oral prednisolone] as effective as dexamethasone in [reducing the symptoms and severity of croup] Clinical Scenario A 3 year old with croup presents to A&E with inspiratory stridor. You want to treat with a steroid, and know dexamethasone is commonly used. Having recently used prednisolone in asthma, you

BestBETS2011

32. Dexamethasone versus prednisolone in asthma

Dexamethasone versus prednisolone in asthma BestBets: Dexamethasone versus prednisolone in asthma Dexamethasone versus prednisolone in asthma Report By: Sophie White - Medical Student Search checked by Laura Keck - Institution: University of California at Davis Medical Center, Sacramento, California, USA and Vincent Medical Center, Portland, Oregon, USA Date Submitted: 24th August 2009 Date Completed: 7th September 2010 Last Modified: 8th September 2010 Status: Green (complete) Three Part (...) you wonder if an IM dose of dexamethasone before discharge would be as effective as an oral course of prednisone at home. Search Strategy Medline 1950�2010 March Week 2 and EMBASE 1980�2010 Week 1 via the Ovid interface ((corticosteroid$ or steroid$).mp. OR exp Dexamethasone/ or dexamethasone.mp. or exp Methylprednisolone/ or methylprednisolone.mp. or exp Prednisone/ or prednisone.mp. or exp Prednisolone/ or prednisolone.mp.) AND (exp Injections, Intramuscular/ or intramuscular.mp

BestBETS2010

33. Oral prednisolone did not improve outcomes in preschool children with an attack of virus-induced wheezing

Oral prednisolone did not improve outcomes in preschool children with an attack of virus-induced wheezing Oral prednisolone did not improve outcomes in preschool children with an attack of virus-induced wheezing | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name (...) or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Oral prednisolone did not improve outcomes in preschool children with an attack of virus-induced wheezing Article Text Treatment Oral prednisolone did not improve outcomes in preschool children with an attack of virus-induced wheezing Statistics from

Evidence-Based Nursing (Requires free registration)2010

34. Can montelukast shorten prednisolone therapy in children with mild to moderate acute asthma? A randomized controlled trial

Can montelukast shorten prednisolone therapy in children with mild to moderate acute asthma? A randomized controlled trial 19656525 2009 11 16 2010 01 07 2013 11 21 1097-6833 155 6 2009 Dec The Journal of pediatrics J. Pediatr. Can montelukast shorten prednisolone therapy in children with mild to moderate acute asthma? A randomized controlled trial. 795-800 10.1016/j.jpeds.2009.06.008 To examine whether outpatient post-stabilization therapy with montelukast produces more treatment failures than (...) prednisolone. In this randomized, double-blind, double-dummy non-inferiority trial, 130 children 2 to 17 years of age with mild to moderate acute asthma stabilized with prednisolone in the emergency department received 5 daily treatments with either prednisolone or montelukast after discharge. The primary outcome was treatment failure within 8 days (ie, an asthma-related unscheduled visit, hospitalization, or additional systemic corticosteroids). The rates of treatment failure were 7.9% in the prednisolone

EvidenceUpdates2010

35. Parent initiated prednisolone for acute asthma in children of school age: randomised controlled crossover trial.

Parent initiated prednisolone for acute asthma in children of school age: randomised controlled crossover trial. 20194353 2010 03 02 2010 03 19 2014 12 04 1756-1833 340 2010 Mar 01 BMJ (Clinical research ed.) BMJ Parent initiated prednisolone for acute asthma in children of school age: randomised controlled crossover trial. c843 10.1136/bmj.c843 bmj.c843 To evaluate the efficacy of a short course of parent initiated oral prednisolone for acute asthma in children of school age. Double blind (...) , randomised, placebo controlled, crossover trial in which episodes of asthma, rather than participants, were randomised to treatment. The Barwon region of Victoria, Australia. Children aged 5-12 years with a history of recurrent episodes of acute asthma. A short course of parent initiated treatment with prednisolone (1 mg/kg a day) or placebo. The primary outcome measure was the mean daytime symptom score over seven days. Secondary outcome measures were mean night time symptom score over seven days, use

BMJ2010 Full Text: Link to full Text with Trip Pro

36. A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study

A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found

NIHR HTA programme2009

37. Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell`s palsy

Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell`s palsy 19244470 2009 03 16 2009 06 25 2016 11 25 1460-2229 26 2 2009 Apr Family practice Fam Pract Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy. 137-44 10.1093/fampra/cmn107 Bell's palsy (BP), which causes facial paralysis, affects 11-40 people per 100 000 per annum in the UK. Its cause is unknown but as many as 30% of patients (...) have continuing facial disfigurement, psychological difficulties and occasionally facial pain. We present an randomised controlled trial (RCT)-based economic evaluation of the early administration of steroids (prednisolone) and/or antivirals (acyclovir) compared to placebo, for treatment of BP. The RCT was not powered to detect differences in the cost-effectiveness; therefore, we adopted a decision analytic model approach as a way of gaining precision in our cost-effectiveness comparisons [e.g

EvidenceUpdates2009

38. Does daily prednisolone reduce the risk of relapse secondary to viral infections in steroid-dependant nephrotic syndrome?

Does daily prednisolone reduce the risk of relapse secondary to viral infections in steroid-dependant nephrotic syndrome? BestBets: Does daily prednisolone reduce the risk of relapse secondary to viral infections in steroid-dependant nephrotic syndrome? Does daily prednisolone reduce the risk of relapse secondary to viral infections in steroid-dependant nephrotic syndrome? Report By: Fyeza Hasan - Dr Institution: Molecular Haematology and Cancer Biology Unit, Institute of Child Health, London (...) Date Submitted: 21st October 2005 Date Completed: 6th February 2009 Last Modified: 6th February 2009 Status: Green (complete) Three Part Question In [a child with steroid-dependent nephrotic syndrome on alternate daily prednisolone with a viral upper respiratory tract infection], does [changing to daily steroids compared to placebo or continuing alternate daily prednisolone] reduce [the risk of relapse]? Clinical Scenario A 4-year-old boy with steroid-dependent minimal change disease has symptoms

BestBETS2009

39. Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy

Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy Hernandez R A, Sullivan F, Donnan P, Swan I, Vale L Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS (...) EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study investigated the cost-effectiveness of treating patients with Bell’s Palsy with prednisolone alone, compared with acyclovir alone or in combination. The authors concluded that prednisolone alone was likely to be cost-effective, as it produced lower costs and higher effects than its

NHS Economic Evaluation Database.2009

40. A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study

A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study Sullivan FM, Swan IRC, Donnan PT, Morrison JM, Smith BH, McKinstry B, Davenport RJ, Vale LD, Clarkson JE (...) of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study. Health Technology Assessment 2009; 13(47): 1-154 Authors' conclusions Study supports the early use of oral prednisolone in Bell's palsy as an effective and cost-effective treatment, and shows no effect for aciclovir, either alone or in combination with steroids Project page URL INAHTA brief and checklist Indexing Status Subject indexing assigned by NLM MeSH Acyclovir /therapeutic use; Administration, Oral; Adult

Health Technology Assessment (HTA) Database.2009