Latest & greatest articles for phenytoin

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Top results for phenytoin

1. Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. BACKGROUND: This is an updated version of the Cochrane Review previously published in 2013. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment, up to 70% of individuals (...) with active epilepsy have the potential to become seizure-free and go into long-term remission shortly after starting drug therapy with a single antiepileptic drug in monotherapy.Worldwide, phenytoin is a commonly used antiepileptic drug. It is important to know how newer drugs, such as oxcarbazepine, compare with commonly used standard treatments. OBJECTIVES: To review the time to treatment failure, remission and first seizure with oxcarbazepine compared to phenytoin, when used as monotherapy in people

Cochrane2018

2. Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review.

Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. BACKGROUND: Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment up to 70% of individuals with active epilepsy have the potential to become seizure-free, and to go into long-term remission shortly after starting drug therapy with a single antiepileptic drug (...) in monotherapy.Worldwide, sodium valproate and phenytoin are commonly used antiepileptic drugs for monotherapy treatment. It is generally believed that phenytoin is more effective for focal onset seizures, and that sodium pvalproate is more effective for generalised onset tonic-clonic seizures (with or without other generalised seizure types). This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons. This is the latest updated version of the review first published in 2001

Cochrane2018

3. Phenytoin versus levetiracetam as prophylaxis for postcraniotomy seizure in patients with no history of seizures: systematic review and meta-analysis

Phenytoin versus levetiracetam as prophylaxis for postcraniotomy seizure in patients with no history of seizures: systematic review and meta-analysis 30004278 2018 07 13 1933-0693 2018 Jul 13 Journal of neurosurgery J. Neurosurg. Phenytoin versus levetiracetam as prophylaxis for postcraniotomy seizure in patients with no history of seizures: systematic review and meta-analysis. 1-8 10.3171/2018.4.JNS1891 OBJECTIVE De novo seizure following craniotomy (DSC) for nontraumatic pathology may (...) adversely affect medical and neurological outcomes in patients with no history of seizures who have undergone craniotomies. Antiepileptic drugs (AEDs) are commonly used prophylactically in patients undergoing craniotomy; however, evidence supporting this practice is limited and mixed. The authors aimed to collate the available evidence on the efficacy and tolerability of levetiracetam monotherapy and compare it with that of the classic AED, phenytoin, for DSC. METHODS PubMed, Embase, Web of Science

EvidenceUpdates2018

4. Phenytoin

Phenytoin Top results for phenytoin - Trip Database or use your Google+ account Turning Research Into Practice My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for phenytoin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

Trip Latest and Greatest2018

6. Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours: a phase II prospective, randomised study

Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours: a phase II prospective, randomised study 25511789 2015 09 15 2015 12 14 2015 09 15 1468-330X 86 10 2015 Oct Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatr. Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours: a phase II prospective, randomised study. 1158-62 10.1136/jnnp-2014-308584 Phenytoin (PHT (...) etiracetam 6158TKW0C5 Phenytoin ZH516LNZ10 Piracetam IM Adolescent Adult Aged Aged, 80 and over Anticonvulsants adverse effects therapeutic use Brain Neoplasms complications surgery Cohort Studies Craniotomy adverse effects Female Humans Male Middle Aged Neurosurgical Procedures adverse effects Phenytoin adverse effects therapeutic use Piracetam adverse effects analogs & derivatives therapeutic use Postoperative Complications prevention & control Prospective Studies Seizures prevention & control

EvidenceUpdates2015

7. Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.

Genetic variants associated with phenytoin-related severe cutaneous adverse reactions. IMPORTANCE: The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basis of phenytoin-related severe cutaneous adverse reactions remains unknown. OBJECTIVE: To investigate (...) the genetic factors associated with phenytoin-related severe cutaneous adverse reactions. DESIGN, SETTING, AND PARTICIPANTS: Case-control study conducted in 2002-2014 among 105 cases with phenytoin-related severe cutaneous adverse reactions (n=61 Stevens-Johnson syndrome/toxic epidermal necrolysis and n=44 drug reactions with eosinophilia and systemic symptoms), 78 cases with maculopapular exanthema, 130 phenytoin-tolerant control participants, and 3655 population controls from Taiwan, Japan, and Malaysia

JAMA2014

9. Requirement for cardiac telemetry during intravenous phenytoin infusion: guideline fact or fiction?

Requirement for cardiac telemetry during intravenous phenytoin infusion: guideline fact or fiction? 22947413 2013 01 17 2013 07 01 2013 11 21 1445-5994 43 1 2013 Jan Internal medicine journal Intern Med J Requirement for cardiac telemetry during intravenous phenytoin infusion: guideline fact or guideline fiction? 7-17 10.1111/j.1445-5994.2012.02935.x Guidelines recommend the use of cardiac telemetry when phenytoin is administered intravenously. Clinical areas where telemetry is available may (...) not always be the most suitable place to monitor and treat these sick patients. We sought to clarify the evidence regarding the need for cardiac telemetry during intravenous infusion of phenytoin. © 2012 The Authors; Internal Medicine Journal © 2012 Royal Australasian College of Physicians. Siebert W J WJ Division of Pharmacy, Flinders Medical Centre; School of Medicine, Adelaide, South Australia, Australia. wendy.siebert@health.sa.gov.au McGavigan A D AD eng Journal Article Review Australia Intern Med J

Clinical Practice Guidelines Portal2013

10. Precision, Bias, and Clinical Utility of the Sheiner-Tozer Equation to Guide Phenytoin Dosing in Critically Ill Adults

Precision, Bias, and Clinical Utility of the Sheiner-Tozer Equation to Guide Phenytoin Dosing in Critically Ill Adults 23436385 2013 03 28 2013 10 17 2013 11 21 1552-4604 53 4 2013 Apr Journal of clinical pharmacology J Clin Pharmacol Precision, bias, and clinical utility of the Sheiner-Tozer equation to guide phenytoin dosing in critically ill adults. 451-5 10.1002/jcph.27 Bolt Jennifer J Pharmacy Services, Interior Health Authority, #200-1835 Gordon Dr., Kelowna, BC V1Y3H5. Gorman Sean K SK (...) eng Journal Article Review 2013 02 22 England J Clin Pharmacol 0366372 0091-2700 0 Anticonvulsants 6158TKW0C5 Phenytoin IM Adult Algorithms Anticonvulsants administration & dosage pharmacokinetics Critical Illness Dose-Response Relationship, Drug Humans Phenytoin administration & dosage pharmacokinetics 2011 12 08 2012 07 15 2013 2 26 6 0 2013 2 26 6 0 2013 10 18 6 0 ppublish 23436385 10.1002/jcph.27

EvidenceUpdates2013

11. A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury

A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury Pieracci FM, Moore EE, Beauchamp K, Tebockhorst S, Barnett CC, Bensard DD, Burlew CC, Biffl WL, Stoval RT (...) , Johnson JL Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the clinical and economic impact of levetiracetam, compared with phenytoin, to prevent early seizures after traumatic brain injury. The authors concluded

NHS Economic Evaluation Database.2013

12. Phenytoin for neuropathic pain and fibromyalgia in adults.

Phenytoin for neuropathic pain and fibromyalgia in adults. BACKGROUND: Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Phenytoin is an established antiepileptic drug that has been used occasionally to treat intractable trigeminal neuralgia. OBJECTIVES: To assess the analgesic efficacy and adverse effects of the antiepileptic drug phenytoin in neuropathic pain and fibromyalgia. SEARCH METHODS: We (...) searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 2), MEDLINE, and EMBASE to 28 February 2012, together with reference lists of retrieved papers and reviews, and ClinicalTrials.gov. SELECTION CRITERIA: We planned to include randomised, double-blind studies of eight weeks duration or longer, comparing phenytoin with placebo or another active treatment in chronic neuropathic pain or fibromyalgia. DATA COLLECTION AND ANALYSIS: Two review authors would

Cochrane2012

13. The use of Levetiracetam and Phenytoin for Seizure Prophylaxis in the Setting of Severe Traumatic Brain Injury

The use of Levetiracetam and Phenytoin for Seizure Prophylaxis in the Setting of Severe Traumatic Brain Injury "The use of Levetiracetam and Phenytoin for Seizure Prophylaxis in the " by Gregg V. Kosloff < > > > > > Title Author Date of Award Summer 8-11-2012 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Mark Pedemonte, MD Second Advisor Annjanette Sommers, PA-C, MS Rights . Abstract Background: Each year in the United States (...) an estimated 1.7 million people suffer a traumatic brain injury (TBI). Current standard of care for these patients is seven days of phenytoin (PHT) for seizure prophylaxis. Given the known side effect profile and drug interactions associated with the use of PHT, levetiracetam (LEV) has been proposed as an alternative for seizure prophylaxis. This systematic review examined available literature to determine whether or not there is sufficient evidence to recommend the use of LEV in lieu of PHT. Method

Pacific University EBM Capstone Project2012

14. Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?

Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant? BestBets: Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant? Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant? Report By: Subramanian Ganesan, Nahin Hussain - Specialist Registrars in Paediatrics Institution: Department of Paediatric Neurology, University (...) products Regulatory Agency (MHRA) and the UK Commission on Human Medicines) issued an alert on the antiepileptic drug (AED) phenytoin (PHT) regarding an increased risk of Steven�Johnson syndrome (SJS) associated with the presence of the HLA-B*1502 genetic variant in patients of Asian origin. Likewise, the US Federal Drug Agency (FDA) recommended genotyping for the allele in all Asian patients before starting carbamazepine (CBZ). We wanted to explore the implications of this for our clinical practice

BestBETS2011

15. Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children

Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children 21482950 2011 04 12 2011 06 07 2016 12 15 1526-632X 76 15 2011 Apr 12 Neurology Neurology Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. 1338-43 10.1212/WNL.0b013e3182152844 Gingival overgrowth is an important adverse effect of phenytoin (PHT) therapy, occurring in about half of the patients. This study aimed to evaluate the effect of oral folic acid supplementation (0.5 (...) , Ansari Nagar, New Delhi 110 029, India. Gulati S S Kabra M M Sahu J K JK Kalra V V eng ClinicalTrials.gov NCT00781196 Comparative Study Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Neurology 0401060 0028-3878 0 Anticonvulsants 12001-76-2 Vitamin B Complex 6158TKW0C5 Phenytoin 935E97BOY8 Folic Acid AIM IM J Indian Soc Pedod Prev Dent. 2002 Jun;20(2):73-80 12435021 Pediatr Dent. 2008 Sep-Oct;30(5):439-42 18942606

EvidenceUpdates2011 Full Text: Link to full Text with Trip Pro

16. Phenytoin: risk of Stevens-Johnson syndrome associated with HLA-B*1502 allele in patients of Thai or Han Chinese ethnic origin

Phenytoin: risk of Stevens-Johnson syndrome associated with HLA-B*1502 allele in patients of Thai or Han Chinese ethnic origin Phenytoin: risk of Stevens-Johnson syndrome associated with HLA-B*1502 allele in patients of Thai or Han Chinese ethnic origin Drug Safety Update - GOV.UK GOV.UK uses cookies to make the site simpler. Search Phenytoin: risk of Stevens-Johnson syndrome associated with HLA-B*1502 allele in patients of Thai or Han Chinese ethnic origin From: Published: 11 January 2010 (...) Therapeutic area: If patients are known to be HLA-B*1502-positive, phenytoinshould be avoided when alternative therapy can be given. Article date: January 2010 Phenytoin (brand leader Epanutin) is a commonly used antiepileptic drug. Phenytoin is one of the most common causes of antiepileptic-related cutaneous adverse reactions, including life-threatening Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). A recent study has shown a significant association between the human leukocyte

MHRA Drug Safety Update2010

17. Cost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumatic brain injury

Cost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumatic brain injury Cost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumatic brain injury Cost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumatic brain (...) injury Kazerooni R, Bounthavong M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the cost-effectiveness of intravenous levetiracetam, compared with conventional intravenous phenytoin, as prophylaxis against seizures

NHS Economic Evaluation Database.2010

18. Cost-effectiveness of oral phenytoin, intravenous phenytoin, and intravenous fosphenytoin in the emergency department

Cost-effectiveness of oral phenytoin, intravenous phenytoin, and intravenous fosphenytoin in the emergency department Cost-effectiveness of oral phenytoin, intravenous phenytoin, and intravenous fosphenytoin in the emergency department Cost-effectiveness of oral phenytoin, intravenous phenytoin, and intravenous fosphenytoin in the emergency department Rudis M I, Touchette D R, Swadron S P, Chiu A P, Orlinsky M Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of oral phenytoin (poP), intravenous phenytoin (ivP), and intravenous fosphenytoin (ivF) for the treatment of patients presenting to the emergency department (ED) with seizures and sub-therapeutic phenytoin concentrations. poP was administered in increments

NHS Economic Evaluation Database.2004

19. Magnesium sulphate versus phenytoin for eclampsia.

Magnesium sulphate versus phenytoin for eclampsia. BACKGROUND: Eclampsia, the occurrence of a convulsion (fit) in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants are used to control eclamptic fits and to prevent further convulsions. OBJECTIVES: The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia. Magnesium sulphate (...) is compared with diazepam and with lytic cocktail in other Cochrane reviews. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth trials register (28 November 2002) and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 4, 2002). SELECTION CRITERIA: Randomised trials comparing magnesium sulphate (intravenous or intramuscular administration) with phenytoin for women with a clinical diagnosis of eclampsia. DATA COLLECTION AND ANALYSIS: Both reviewers assessed trial

Cochrane2003

20. Carbamazepine versus phenytoin monotherapy for epilepsy.

Carbamazepine versus phenytoin monotherapy for epilepsy. BACKGROUND: Worldwide, carbamazepine and phenytoin are commonly used antiepileptic drugs. This review summarizes evidence from randomized controlled trials in which these two drugs have been compared. OBJECTIVES: To review the best evidence comparing carbamazepine and phenytoin when used as monotherapy in subjects with partial onset seizures, or generalized onset tonic-clonic seizures with or without other generalized seizure types (...) have included a comparison of carbamazepine monotherapy with phenytoin monotherapy. DATA COLLECTION AND ANALYSIS: This was an individual patient data review. Outcomes were time to (a) withdrawal of allocated treatment, (b) 12 month remission, (c) six month remission, and (d) first seizure post randomization. Data were analysed using a stratified logrank analysis with results expressed as hazard ratios (HR) and 95% confidence intervals (95% CI), where a HR>1 indicates an event is more likely

Cochrane2002