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Latest & greatest articles for penicillin
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Penicillin Top results for penicillin - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for penicillin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms
Evaluation and Management of Penicillin Allergy: A Review. β-Lactam antibiotics are among the safest and most effective antibiotics. Many patients report allergies to these drugs that limit their use, resulting in the use of broad-spectrum antibiotics that increase the risk for antimicrobial resistance and adverse events.Approximately 10% of the US population has reported allergies to the β-lactam agent penicillin, with higher rates reported by older and hospitalized patients. Although many (...) patients report that they are allergic to penicillin, clinically significant IgE-mediated or T lymphocyte-mediated penicillin hypersensitivity is uncommon (<5%). Currently, the rate of IgE-mediated penicillin allergies is decreasing, potentially due to a decreased use of parenteral penicillins, and because severe anaphylactic reactions to oral amoxicillin are rare. IgE-mediated penicillin allergy wanes over time, with 80% of patients becoming tolerant after a decade. Cross-reactivity between penicillin
Are Short-Term Late-Generation Antibiotics Equivalent to Standard Penicillin Therapy in the Resolution of Symptoms in Acute Strep Throat in Children? Systematic Review Snapshot TAKE-HOME MESSAGE Although antibiotics are not the best agent for symptomatic management of streptococcal pharyngitis, according to limited data, short-course antibiotics appear to reduce the duration of symptoms more effectively than longer-course therapy. Are Short-Term Late-Generation Antibiotics Equivalent (...) to Standard Penicillin Therapy in the Resolution of Symptoms in Acute Strep Throat in Children? EBEM Commentators Anand Swaminathan, MD, MPH New York University School of Medicine/Bellevue Hospital Center Department of Emergency Medicine New York, NY Jeffrey Hom, MD, MPH Stony Brook University School of Medicine Departments of Pediatrics (Emergency) and Emergency Medicine Stony Brook, NY Results Table 1. Short (3 days) versus standard (7 days) antibiotic course. Symptom Number of Subjects Difference
ASCIA Penicillin Allergy Guide for health professionals • In severe penicillin allergy (e.g. anaphylaxis, bronchospasm, urticaria, angioedema), avoid ALL penicillins, cephalosporins and other beta-lactam antibiotics • In non-severe penicillin allergy (e.g. mild rash) use cephalosporins and carbapenems with caution • Some reactions (e.g. nausea) are not considered allergies and do not warrant prohibiting penicillin use Contraindicated At all times where reasonable evidence of penicillin allergy (...) exists Caution Avoid if severe penicillin allergy (e.g. anaphylaxis) Use with caution if non-severe allergy (e.g. minor rash) Seek specialist advice Considered Safe In the absence of other contraindications Cefaclor Cefepime Cefotaxime Cefoxitin Ceftazidime Ceftriaxone Cefuroxime Cephalexin Cephazolin Doripenem, ertapenem, imipenem, meropenem Aztreonam Azithromycin, erythromycin, roxithromycin, clarithromycin Ciprofloxacin, norfloxacin, moxifloxacin Clindamycin, lincomycin Doxycycline, minocycline
The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes. Objective A 7-day course of a penicillin (PCN) and macrolide is standard of care (SAR) in preterm premature rupture of membranes (PPROM). Data regarding alternative antibiotic regimens are limited. We sought to assess the impact of non-PCN regimens on neonatal outcomes. Study Design Secondary analysis of randomized controlled trial of antenatal magnesium sulfate. Singleton
2019AJP ReportsControlled trial quality: predicted high
Penicillin Allergy Is Not Necessarily Forever 28672303 2017 08 22 2018 11 13 1538-3598 318 1 2017 Jul 04 JAMA JAMA Penicillin Allergy Is Not Necessarily Forever. 82-83 10.1001/jama.2017.6510 Trubiano Jason A JA Department of Infectious Diseases, Austin Hospital, Melbourne, Victoria, Australia2Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Adkinson N Franklin NF John Hopkins Asthma and Allergy Centre, Baltimore, Maryland. Phillips Elizabeth Jane (...) EJ Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee5Institute for Immunology and Infectious Diseases, Murdoch University, Western Australia, Australia. eng P50 GM115305 GM NIGMS NIH HHS United States Journal Article United States JAMA 7501160 0098-7484 0 Penicillins 37341-29-0 Immunoglobulin E AIM IM JAMA. 2017 Nov 7;318(17 ):1714 29114824 Diagnosis, Differential Drug Hypersensitivity diagnosis immunology Exanthema chemically induced Humans Immunoglobulin E
Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing (...) boards Evidence Education * Associated Topics Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acute streptococcal pharyngitis Shukan Kanuga, DDS, MSD . Overview Systematic Review Conclusion Three to 6 days of short-term late-generation antibiotics have comparable treatment efficacy as a 10-day course of oral penicillin in children with acute group A β-hemolytic streptococcus (GABHS) pharyngitis. Critical Summary Assessment On the basis of good
Clinical experience: respiratory tract. Trimethoprim-sulfamethoxazole versus penicillin G in the treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis. 4585968 1974 01 30 2013 11 21 0022-1899 128 1973 Nov The Journal of infectious diseases J. Infect. Dis. Clinical experience: respiratory tract. Trimethoprim-sulfamethoxazole versus penicillin G in the treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis. Suppl:693-5 p Trickett P C PC Dineen P P (...) Mogabgab W W eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States J Infect Dis 0413675 0022-1899 0 Drug Combinations 0 Placebos AN164J8Y0X Trimethoprim JE42381TNV Sulfamethoxazole Q42T66VG0C Penicillin G AIM IM Adolescent Clinical Trials as Topic Drug Combinations Humans Penicillin G therapeutic use Pharyngitis drug therapy Pharynx microbiology Placebos Recurrence Streptococcal Infections drug therapy Streptococcus isolation & purification Sulfamethoxazole
'Warning: allergic to penicillin': association between penicillin allergy status in 2.3 million NHS general practice electronic health records, antibiotic prescribing and health outcomes. The prevalence of reported penicillin allergy (PenA) and the impact these records have on health outcomes in the UK general population are unknown. Without such data, justifying and planning enhanced allergy services is challenging.To determine: (i) prevalence of PenA records; (ii) patient characteristics (...) , mortality, MRSA infection/colonization and Clostridioides difficile infection.PenA prevalence was 5.9% (IQR = 3.8%-8.2%). PenA records were more common in older people, females and those with a comorbidity, and were affected by GP practice. Antibiotic prescribing varied significantly: penicillins were prescribed less frequently in those with a PenA record [relative risk (RR) = 0.15], and macrolides (RR = 4.03), tetracyclines (RR = 1.91) nitrofurantoin (RR = 1.09), trimethoprim (RR = 1.04
Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study. To determine whether total exposure to penicillin V can be reduced while maintaining adequate clinical efficacy when treating pharyngotonsillitis caused by group A streptococci.Open label, randomised controlled non-inferiority study.17 primary healthcare centres in Sweden between September (...) 2015 and February 2018.Patients aged 6 years and over with pharyngotonsillitis caused by group A streptococci and three or four Centor criteria (fever ≥38.5°C, tender lymph nodes, coatings of the tonsils, and absence of cough).Penicillin V 800 mg four times daily for five days (total 16 g) compared with the current recommended dose of 1000 mg three times daily for 10 days (total 30 g).Primary outcome was clinical cure five to seven days after the end of antibiotic treatment. The non-inferiority
ASCIA Penicillin Allergy Guide for health professionals ASCIA Penicillin Allergy Guide for health professionals - Australasian Society of Clinical Immunology and Allergy (ASCIA) | | ASCIA Penicillin Allergy Guide for health professionals Site last updated: 21 Sep 2020 Member Login Remember Me Log in ASCIA Update Information for the community about allergic diseases, immunodeficiencies and other immune diseases. Join our mailing list: ASCIA News About ASCIA ASCIA is the peak professional body
Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy. Introduction: Ten percent of hospitalized patients report penicillin allergy; however, recent studies indicate that ∼98% of these patients are not acutely hypersensitive. Unconfirmed penicillin allergy poses public health risks, and an evaluation of penicillin allergy labels is recommended to improve antibiotic stewardship. Although the most widely (...) accepted protocol is penicillin skin testing, followed by oral amoxicillin challenge, time constraints and resources may preclude this. Recent literature supports the safety and efficacy of direct oral amoxicillin challenge in individuals at low risk. Methods: We retrospectively evaluated direct oral challenge acceptance and outcomes in eligible adult outpatients with allergy and with a penicillin allergy label over a 6-month period. Direct oral amoxicillin challenge was recommended in patients
Efficacy of high doses of penicillin versus amoxicillin in the treatment of uncomplicated community acquired pneumonia in adults. A non-inferiority controlled clinical trial. Community-acquired pneumonia (CAP) is treated with penicillin in some northern European countries.To evaluate whether high-dose penicillin V is as effective as high-dose amoxicillin for the treatment of non-severe CAP.Multicentre, parallel, double-blind, controlled, randomized clinical trial.31 primary care centers (...) in Spain.Patients from 18 to 75 years of age with no significant associated comorbidity and with symptoms of lower respiratory tract infection and radiological confirmation of CAP were randomized to receive either penicillin V 1.6 million units, or amoxicillin 1000mg three times per day for 10 days.The main outcome was clinical cure at 14 days, and the primary hypothesis was that penicillin V would be non-inferior to amoxicillin with regard to this outcome, with a margin of 15% for the difference in proportions
Estimating Benzathine Penicillin Need for the Treatment of Pregnant Women Diagnosed with Syphilis during Antenatal Care in High-Morbidity Countries Congenital syphilis continues to be a preventable cause of global stillbirth and neonatal morbidity and mortality. Shortages of injectable penicillin, the only recommended treatment for pregnant women and infants with syphilis, have been reported by high-morbidity countries. We sought to estimate current and projected annual needs for benzathine (...) penicillin in antenatal care settings for 30 high morbidity countries that account for approximately 33% of the global burden of congenital syphilis.Proportions of antenatal care attendance, syphilis screening coverage in pregnancy, syphilis prevalence among pregnant women, and adverse pregnancy outcomes due to untreated maternal syphilis reported to WHO were applied to 2012 birth estimates for 30 high syphilis burden countries to estimate current and projected benzathine penicillin need for prevention
Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02712307 Recruitment Status : Completed First Posted : March 18, 2016 Last Update Posted : November 14, 2018 Sponsor: Ass. Prof
Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES) Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Penicillin (...) by (Responsible Party): The Leeds Teaching Hospitals NHS Trust Study Details Study Description Go to Brief Summary: Penicillin antibiotics are safe and inexpensive, and target selected bacteria rather than killing a broad range. Unfortunately, around 10% of the population are labelled as 'penicillin allergic'. This is often based on side effects such as rash and diarrhoea, and 90-95% of people with the label are not actually allergic to the drug. The label leads to the use of alternative antibiotics, which
Phenoxymethyl Penicillin (Penicillin V) in the Treatment of Streptococcal Tonsillitis 13511274 2000 07 01 2018 12 01 0008-4409 78 3 1958 Feb 01 Canadian Medical Association journal Can Med Assoc J Phenoxymethyl penicillin (penicillin V) in the treatment of streptococcal tonsillitis. 186-9 FRASER P K PK eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Penicillins Z61I075U2W Penicillin V OM Acute Disease Humans Penicillin V Penicillins therapeutic use Scarlet Fever Streptococcal (...) Infections therapy Tonsillitis therapy 5834:3619:447:569:599 PENICILLIN/therapeutic use STREPTOCOCCAL INFECTIONS/therapy TONSILLITIS/therapy 1958 2 1 1958 2 1 0 1 1958 2 1 0 0 ppublish 13511274 PMC1829503 Am J Med. 1954 Dec;17(6):749-56 13207156 J Am Med Assoc. 1951 Dec 1;147(14):1335-6 14873680 Lancet. 1957 Jan 5;272(6958):8-11 13386263 Milbank Mem Fund Q. 1954 Jan;32(1):5-21 13132564 Pediatrics. 1953 Jan;11(1):7-13 13026346 N Engl J Med. 1954 Sep 16;251(12):466-71 13194096 Antibiotic Med Clin Ther (New
Implementation of a pharmacist-led penicillin allergy de-labelling service in a public hospital. Inaccurate allergy labelling results in inappropriate antimicrobial management of the patient, which may affect clinical outcome, increase the risk of adverse events and increase costs. Inappropriate use of alternative antibiotics has implications for antimicrobial stewardship programmes and microbial resistance.All adult inpatients labelled as penicillin allergic were identified and screened (...) for eligibility by the study pharmacist. An accurate allergy and medication history was taken. Patients were 'de-labelled', underwent oral challenge or were referred to an immunology clinic, if study criteria were met. All patients included in the study were followed-up 1 year after intervention.Two hundred and fifty eligible patients with a label of 'penicillin allergy' were identified. The prevalence of reported penicillin allergy at Middlemore Hospital was 11%. We found that 80% of study patients could
The Challenge of De-labeling Penicillin Allergy. Even though 8-25% of most populations studied globally are labeled as penicillin allergic, most diagnoses of penicillin allergy are made in childhood and relate to events that are either not allergic in nature, are low-risk for immediate hypersensitivity, or are a potential true allergy that has waned over time. Penicillin allergy labels directly impact antimicrobial stewardship by leading to use of less effective and broader spectrum (...) antimicrobials and are associated with antimicrobial resistance. They may also delay appropriate antimicrobial therapy, and lead to increased risk of specific adverse healthcare outcomes. Operationalizing penicillin allergy de-labeling into a new arm of antimicrobial stewardship programs (ASPs) has become an increasing global focus. We performed an evidence-based narrative review of the literature of penicillin allergy label carriage, the adverse effects of penicillin allergy labels and current approaches