Latest & greatest articles for penicillin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on penicillin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on penicillin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for penicillin

21. Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study.

Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study. OBJECTIVE: To explore the impact on mortality and morbidity of parenteral penicillin given to children before admission to hospital with suspected meningococcal disease. DESIGN: Retrospective comparison of fatal and non-fatal cases. SETTING: England, Wales, and Northern Ireland; December 1997 to February 1999. PARTICIPANTS: 158 children aged 0-16 years (26 died, 132 survived) in whom (...) a general practitioner had made the diagnosis of meningococcal disease before hospital admission. RESULTS: Administration of parenteral penicillin by general practitioners was associated with increased odds ratios for death (7.4, 95% confidence interval 1.5 to 37.7) and complications in survivors (5.0, 1.7 to 15.0). Children who received penicillin had more severe disease on admission (median Glasgow meningococcal septicaemia prognostic score (GMSPS) 6.5 v 4.0, P = 0.002). Severity on admission did

BMJ2006 Full Text: Link to full Text with Trip Pro

23. Penicillin V did not shorten symptoms in children with sore throat

Penicillin V did not shorten symptoms in children with sore throat Penicillin V did not shorten symptoms in children with sore throat | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Penicillin V did not shorten symptoms in children with sore throat Article Text Therapeutics Penicillin V did not shorten symptoms in children with sore throat Free Morten Lindbaek , MD Statistics from Altmetric.com No Altmetric data available for this article. Zwart S, Rovers MM, de Melker RA, et al . Penicillin for acute sore throat in children: randomised, double blind

Evidence-Based Medicine (Requires free registration)2005

24. Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis.

Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. 16177249 2005 09 22 2005 09 27 2013 11 21 1533-4406 353 12 2005 Sep 22 The New England journal of medicine N. Engl. J. Med. Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. 1236-44 Pilot studies suggest that a single, 2-g oral dose of azithromycin may be an alternative to a 2.4-MU intramuscular dose of penicillin G benzathine in the prevention and treatment (...) of syphilis. We evaluated the efficacy of treatment with azithromycin in a developing country. A total of 328 subjects, 25 with primary and 303 with high-titer (a titer of at least 1:8 on a rapid plasmin reagin [RPR] test) latent syphilis, were recruited through screening of high-risk populations in Mbeya, Tanzania, and randomly assigned to receive 2 g of azithromycin orally (163 subjects) or 2.4 million units of penicillin G benzathine intramuscularly (165 subjects). The primary outcome was treatment

NEJM2005

25. Oral amoxicillin versus injectable penicillin for severe pneumonia in children aged 3 to 59 months: a randomised multicentre equivalency study.

Oral amoxicillin versus injectable penicillin for severe pneumonia in children aged 3 to 59 months: a randomised multicentre equivalency study. 15451221 2004 09 28 2004 10 13 2015 06 16 1474-547X 364 9440 2004 Sep 25-Oct 1 Lancet (London, England) Lancet Oral amoxicillin versus injectable penicillin for severe pneumonia in children aged 3 to 59 months: a randomised multicentre equivalency study. 1141-8 Injectable penicillin is the recommended treatment for WHO-defined severe pneumonia (lower (...) chest indrawing). If oral amoxicillin proves equally effective, it could reduce referral, admission, and treatment costs. We aimed to determine whether oral amoxicillin and parenteral penicillin were equivalent in the treatment of severe pneumonia in children aged 3-59 months. This multicentre, randomised, open-label equivalency study was undertaken at tertiary-care centres in eight developing countries in Africa, Asia, and South America. Children aged 3-59 months with severe pneumonia were admitted

Lancet2004

26. Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins.

Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins. BACKGROUND: In patients with documented IgE-mediated hypersensitivity to penicillins, data on sensitization to cephalosporins vary. Administering cephalosporins to such patients is often deferred because of the risk for cross-reactivity. OBJECTIVE: To assess the cross-reactivity with cephalosporins and its potential determinants in patients with documented penicillin allergy. DESIGN (...) : Prospective study in patients without clinical indications for cephalosporin treatment. SETTING: Italy. PATIENTS: 128 consecutive patients who sustained anaphylactic shock (n = 81) or urticaria (n = 47) and had positive results on skin tests for at least 1 of the penicillin reagents tested. MEASUREMENTS: All patients were skin tested with cephalothin, cefamandole, cefuroxime, ceftazidime, ceftriaxone, and cefotaxime. Patients with negative results for the last 4 cephalosporins were challenged

Annals of Internal Medicine2004

27. Penicillins for the prophylaxis of bacterial endocarditis in dentistry.

Penicillins for the prophylaxis of bacterial endocarditis in dentistry. BACKGROUND: Many dental procedures cause bacteraemia and it is believed that this may lead to bacterial endocarditis (BE) in a few people. Guidelines in many countries recommend that prior to invasive dental procedures antibiotics are administered to people at high risk of endocarditis. However, it is unclear whether the potential risks of this prophylaxis outweigh the potential benefits. OBJECTIVES: To determine whether (...) prophylactic penicillin administration compared to no such administration or placebo before invasive dental procedures in people at increased risk of BE influences mortality, serious illness or endocarditis incidence. SEARCH STRATEGY: The search strategy was developed on MEDLINE and adapted for use on the Cochrane Oral Health, Heart and Infectious Diseases Groups' Trials Registers (to October 2003), as well as the following databases: Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane

Cochrane2004

28. Intramuscular penicillin for the prevention of early onset group B streptococcal infection in newborn infants.

Intramuscular penicillin for the prevention of early onset group B streptococcal infection in newborn infants. BACKGROUND: Early-onset group B streptococcal disease (EOGBSD) is the most frequent cause of serious infection in the newborn period. Current strategies used to prevent EOGBSD are focused upon maternal antibiotic prophylaxis to reduce transmission of GBS to the infant. Observational studies have suggested that the administration of intramuscular penicillin to the newborn immediately (...) following delivery may be an effective strategy to reduce the incidence of EOGBSD. OBJECTIVES: To determine if the administration of intramuscular penicillin to newborns at birth is a safe and effective method to prevent morbidity and mortality from EOGBSD. SEARCH STRATEGY: The standard search strategy of the Neonatal Review Group was used. This included searches of electronic databases: Oxford Database of Perinatal Trials, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library

Cochrane2004

29. Penicillin for acute sore throat in children: randomised, double blind trial.

Penicillin for acute sore throat in children: randomised, double blind trial. 14656841 2003 12 05 2003 12 22 2014 06 10 1756-1833 327 7427 2003 Dec 06 BMJ (Clinical research ed.) BMJ Penicillin for acute sore throat in children: randomised, double blind trial. 1324 To assess the effectiveness of penicillin for three days and treatment for seven days compared with placebo in resolving symptoms in children with sore throat. Randomised, double blind, placebo controlled trial. 43 family practices (...) in the Netherlands. 156 children aged 4-15 who had a sore throat for less than seven days and at least two of the four Centor criteria (history of fever, absence of cough, swollen tender anterior cervical lymph nodes, and tonsillar exudate). Interventions Patients were randomly assigned to penicillin for seven days, penicillin for three days followed by placebo for four days, or placebo for seven days. Duration of symptoms, mean consumption of analgesics, number of days of absence from school, occurrence

BMJ2003 Full Text: Link to full Text with Trip Pro

30. Effect of beta lactam antibiotic use in children on pneumococcal resistance to penicillin: prospective cohort study.

Effect of beta lactam antibiotic use in children on pneumococcal resistance to penicillin: prospective cohort study. OBJECTIVE: To examine the relation between use of antibiotics in a cohort of preschool children and nasal carriage of resistant strains of pneumococcus. DESIGN AND PARTICIPANTS: Prospective cohort study over two years of 461 children aged under 4 years living in Canberra, Australia. MAIN OUTCOME MEASURES: Use of drugs, respiratory symptoms, and visits to doctors were documented (...) in a daily diary by parents of the children during 25 months of observation. Isolates of pneumococci, which were cultured from nasal swabs collected approximately six monthly, were tested for antibiotic resistance. RESULTS: From the four swab collections 631 positive pneumococcal isolates from 461 children were found, of which 13.6% were resistant to penicillin. Presence of penicillin resistant pneumococci was significantly associated with children's use of a beta lactam antibiotic in the two months

BMJ2002 Full Text: Link to full Text with Trip Pro

31. Oral pristinamycin versus standard penicillin regimen to treat erysipelas in adults: randomised, non-inferiority, open trial.

Oral pristinamycin versus standard penicillin regimen to treat erysipelas in adults: randomised, non-inferiority, open trial. 12386036 2002 10 18 2002 11 22 2014 06 11 1756-1833 325 7369 2002 Oct 19 BMJ (Clinical research ed.) BMJ Oral pristinamycin versus standard penicillin regimen to treat erysipelas in adults: randomised, non-inferiority, open trial. 864 To assess the efficacy and safety of oral pristinamycin versus intravenous then oral penicillin to treat erysipelas in patients (...) in hospital. Multicentre, parallel group, open labelled, randomised non-inferiority trial. 22 French hospitals. 289 adults admitted to hospital with erysipelas. At follow up (day 25-45) the cure rate (primary efficacy end point) for the per protocol populations was 81% (83/102) for pristinamycin and 67% (68/102) for penicillin. The planned interim analysis (global one sided type I error 5%) showed that the one sided 97.06% confidence interval of the observed difference (pristinamycin-penicillin) between

BMJ2002 Full Text: Link to full Text with Trip Pro

32. Penicillin for secondary prevention of rheumatic fever.

Penicillin for secondary prevention of rheumatic fever. BACKGROUND: People with a history of rheumatic fever are at high risk of recurrent attacks of rheumatic fever and developing rheumatic heart disease following a streptococcal throat infection. Giving penicillin to these people can prevent recurrent attacks of rheumatic fever and subsequent rheumatic heart disease. However, there is no agreement on the most effective method of giving penicillin. OBJECTIVES: To assess the effects (...) of penicillin compared to placebo and the effects of different penicillin regimens and formulations for preventing streptococcal infection and rheumatic fever recurrence. SEARCH STRATEGY: We searched the Controlled Trials Register (Cochrane Library Issue 2, 2001), MEDLINE (1997 to July 2000), EMBASE (1998 to July 2000), reference lists of articles and we contacted experts in the field. SELECTION CRITERIA: Randomised and quasi-randomised studies comparing (i) penicillin with control, (ii) oral

Cochrane2002

33. The impact of dosing frequency on the efficacy of 10-day penicillin or amoxicillin therapy for streptococcal tonsillopharyngitis: a meta-analysis

The impact of dosing frequency on the efficacy of 10-day penicillin or amoxicillin therapy for streptococcal tonsillopharyngitis: a meta-analysis The impact of dosing frequency on the efficacy of 10-day penicillin or amoxicillin therapy for streptococcal tonsillopharyngitis: a meta-analysis The impact of dosing frequency on the efficacy of 10-day penicillin or amoxicillin therapy for streptococcal tonsillopharyngitis: a meta-analysis Lan A J, Colford J M Authors' objectives To compare cure (...) rates between once- or twice-daily (s.i.d. and b.i.d., respectively) and more frequent dosing schedules in the treatment of streptococcal tonsillopharyngitis. Searching MEDLINE and Dissertation Abstracts were searched to August 1998. For MEDLINE, the keywords were 'tonsillopharyngitis', 'pharyngitis', 'penicillin', 'amoxicillin' and 'clinical trials. For Dissertation Abstracts, combinations of the following words were used: 'streptococcus' or 'streptococcal' and 'penicillin' or 'amoxicillin

DARE.2000

34. Treatment of pneumonia with penicillins: oral or intravenous?

Treatment of pneumonia with penicillins: oral or intravenous? Penicillinbehandling ved pneumoni: oralt eller intravenøst? [Treatment of pneumonia with penicillins: oral or intravenous?] Penicillinbehandling ved pneumoni: oralt eller intravenøst? [Treatment of pneumonia with penicillins: oral or intravenous?] Danish Centre for Evaluation and Health Technology Assessment Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Danish Centre for Evaluation and Health Technology Assessment. Penicillinbehandling ved pneumoni: oralt eller intravenøst? [Treatment of pneumonia with penicillins: oral or intravenous?] Copenhagen: Danish Centre for Evaluation and Health Technology Assessment (DACEHTA). 2000 Authors' objectives The aim of this report is to consider the implications of giving penicillin by oral or intravenous administration to patients

Health Technology Assessment (HTA) Database.2000

35. Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behçet's disease: a randomised trial.

Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behçet's disease: a randomised trial. 10696980 2000 03 22 2000 03 22 2016 11 24 0140-6736 355 9204 2000 Feb 19 Lancet (London, England) Lancet Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behçet's disease: a randomised trial. 605-9 Sight-threatening eye involvement is a serious complication of Behçet's disease. Extraocular (...) subcutaneously every other day for the first 6 months plus 1.5 mg colchicine orally daily and 1.2 million units benzathine penicillin intramuscularly every 3 weeks (n=67), or colchicine and benzathine penicillin alone (n=68). The primary endpoint was visual-acuity loss. Analysis was by intention to treat. Significantly fewer patients who were treated with interferon had eye involvement than did patients who did not receive interferon (eight vs 27, relative risk 0.21 [95% CI 0.09-0.50], p<0.001). Ocular

Lancet2000

36. Penicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adults.

Penicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adults. 10634735 2000 02 16 2000 02 16 2017 02 19 0959-8138 320 7228 2000 Jan 15 BMJ (Clinical research ed.) BMJ Penicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adults. 150-4 To assess whether treatment with penicillin for three days and the traditional treatment for seven days were equally as effective (...) at accelerating resolution of symptoms in patients with sore throat compared with placebo. Randomised double blind placebo controlled trial. 43 family practices in the Netherlands. 561 patients, aged 15-60 years, with sore throat for less than seven days and at least three of the four Centor criteria-that is, history of fever, absence of cough, swollen tender anterior cervical lymph nodes, and tonsillar exudate. 142 patients were excluded for medical reasons and 73 needed penicillin. Patients were randomly

BMJ2000 Full Text: Link to full Text with Trip Pro

37. Questionable history of immediate-type hypersensitivity to penicillin in Staphylococcal endocarditis: treatment based on skin-test results versus empirical alternative treatment - a decision analysis

Questionable history of immediate-type hypersensitivity to penicillin in Staphylococcal endocarditis: treatment based on skin-test results versus empirical alternative treatment - a decision analysis Questionable history of immediate-type hypersensitivity to penicillin in Staphylococcal endocarditis: treatment based on skin-test results versus empirical alternative treatment - a decision analysis Questionable history of immediate-type hypersensitivity to penicillin in Staphylococcal (...) results was compared with empirical treatment (no skin testing) in patients who had infective endocarditis (Staphylococcus aureus), susceptible to cloxacillin, and who had a questionable history of immediate-type hypersensitivity to penicillin. Type of intervention Screening. Economic study type Cost-utility analysis. Study population The study population comprised a hypothetical cohort of patients with infective endocarditis due to Staphylococcus aureus that was susceptible to cloxacillin and who had

NHS Economic Evaluation Database.1999

38. Elective penicillin skin testing and amoxicillin challenge: effect on outpatient antibiotic use, cost, and clinical outcomes

Elective penicillin skin testing and amoxicillin challenge: effect on outpatient antibiotic use, cost, and clinical outcomes Elective penicillin skin testing and amoxicillin challenge: effect on outpatient antibiotic use, cost, and clinical outcomes Elective penicillin skin testing and amoxicillin challenge: effect on outpatient antibiotic use, cost, and clinical outcomes Macy E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED (...) . Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Elective penicillin skin testing (PenSTs) in advance of acute antibiotic need and (optional) amoxicillin challenge (AC) in patients with negative skin test responses. Patients were previously entered in a study of new penicillin reagents and received at least 1 prescription drug over a 2-year period

NHS Economic Evaluation Database.1998

39. Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures

Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures Heit J M, Stevens M R, Jeffords K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Ceftriaxone and penicillin for antibiotic prophylaxis for compound mandible fracture. Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Male and female patients with compound mandible fractures. Setting Hospital. The economic study was carried out in Miami, Florida, USA. Dates to which

NHS Economic Evaluation Database.1997

40. Randomised, double blind, placebo controlled trial of penicillin V and amoxycillin in treatment of acute sinus infections in adults.

Randomised, double blind, placebo controlled trial of penicillin V and amoxycillin in treatment of acute sinus infections in adults. 8760738 1996 09 25 1996 09 25 2013 11 21 0959-8138 313 7053 1996 Aug 10 BMJ (Clinical research ed.) BMJ Randomised, double blind, placebo controlled trial of penicillin V and amoxycillin in treatment of acute sinus infections in adults. 325-9 To compare the effectiveness of penicillin V and amoxycillin with placebo in treatment of adult patients with acute (...) sinusitis. Randomised, double blind, placebo controlled trial. Norwegian general practice. 130 adult patients with a clinical diagnosis of acute sinusitis confirmed by computed tomography. Subjective status after three and 10 days of treatment, difference in clinical severity score between day 0 and day 10 as evaluated by the general practitioner, difference in score from computed tomography on day 0 and day 10, and duration of sinusitis. Amoxycillin and penicillin V led to significantly faster

BMJ1996 Full Text: Link to full Text with Trip Pro